Biotech News Brief

Biotech news for Thursday, June 4, 2026, ranked by our 5-dimension investment framework — regulatory, technology, commercial, manufacturing, and narrative.

Jun 3, 12:53 PM EDT

TG Therapeutics rises on early-stage trial data for Briumvi injectable

TGTX

Md Saiful Islam Khan/iStock via Getty Images TG Therapeutics ( TGTX ) added more than 10% on Wednesday after data from an early-stage trial evaluating a subcutaneously delivered version of its top-selling drug, Briumvi, supported a quarterly dosing regimen cur…

Jun 3, 12:29 PM EDT

Protean Funds makes portfolio changes with additions and exits

OCTVTRUBF

Protean Small Cap gained 5.7% in May, outperforming the Carnegie Nordic Small-Cap Index's 3.3% return. Meanwhile, Protean Select returned 1.4% in May, while Protean Aktiesparfond Norden gained 3.2%, trailing its benchmark index's 4.0% rise. The fund initiated…

Jun 3, 11:30 AM EDT

Rezolute upgraded at Citizens after late-stage trial data for lead asset

RZLT

alexsl Rezolute ( RZLT ) traded higher for the third straight session on Wednesday after Citizens JMP Securities upgraded the stock, highlighting a recent late-stage trial update the company shared for its lead asset, ersodetug. Shares of the rare-disease drug…

Jun 3, 11:09 AM EDT

IDEAYA to work with Roche on combo pancreatic cancer treatment

IDYARHHBY

IDEAYA Bioscience ( IDYA ) and Roche ( RHHBY ) have agreed to jointly evaluate a combination of the former's IDE892 with the latter's RG6505 for MTAP-deleted RAS-mutant pancreatic cancer. Both assets are in phase 1. IDE892 is an MTA-cooperative PRMT5 inhibitor…

Jun 3, 9:52 AM EDT

CytomX gains as licensing deal with Regeneron expands

REGNCTMX

CytomX Therapeutics ( CTMX ) traded higher in the morning hours on Wednesday after the cancer drug developer announced an expanded collaboration and licensing agreement with Regeneron Pharmaceuticals ( REGN ) valued up to $4B. Two companies initially teamed up…

Jun 3, 9:45 AM EDT

Most and least shorted healthcare stocks with market cap up to $2B at the end of May

XLVQUCYIBBPPH

Short interest data from late May indicates varying investor feelings in the healthcare sector, with strong bearish bets concentrated on micro- and small-cap biotechnology names like Quantum Cyber ( QUCY ) and Sensei Biotherapeutics ( SNSE ). Meanwhile, niche…

Jun 3, 9:35 AM EDT

Most and least shorted mid- to mega-cap healthcare stocks at the end of May

XLVRXRXIBBPPH

iQoncept/iStock via Getty Images Short interest data from late May indicates varying investor feelings in the healthcare sector, with strong bearish bets concentrated on speculative biotech plays like Recursion Pharmaceuticals ( RXRX ) and Hims & Hers ( HI…

Jun 3, 9:14 AM EDT

Liminatus Pharma secures $1.9M cash via warrant exercises

LIMNLIMNW

Liminatus Pharma ( LIMN ) has entered into a warrant exercise agreement to exercise certain outstanding warrants to purchase an aggregate of 10.34M shares of common stock of the company for gross proceeds of $1.9M. In consideration for the immediate exercise o…

Jun 3, 9:04 AM EDT

LIXTE Biotechnology prices $16.6M registered direct offering

LIXT

LIXTE Biotechnology Holdings ( NASDAQ: LIXT ) on Wednesday said it entered into definitive agreements with accredited investors for a registered direct offering expected to raise approximately $16.6 million in gross proceeds. The offering consists of 2.63 mill…

Jun 3, 7:41 AM EDT

Celcuity announces $400M convertible notes offering

CELC

Celcuity ( NASDAQ: CELC ) on Wednesday said that it plans to offer $400 million of convertible senior notes due 2032 in an underwritten public offering. The clinical-stage biotechnology company said it expects to grant underwriters a 30-day option to purchase…

Jun 3, 6:36 AM EDT

Restart Life Sciences names Inez Ho CFO; Rebecca Hudson resigns

NMLSF

Restart Life Sciences ( NMLSF ) has appointed Inez Ho as CFO, effective immediately. Ho succeeds Rebecca Hudson, who has resigned from her role to pursue other commitments. Bringing over 12 years of corporate compliance, financial reporting, and capital market…

Jun 3, 6:31 AM EDT

Mineralys Therapeutics prices $150M stock offering

MLYS

Mineralys Therapeutics ( MLYS ) has priced an offering of 5.66M shares of its common stock at a price of $26.50 per share. The gross proceeds from the offering are expected to be around $150M. Mineralys plans to use the net proceeds to fund a

Jun 3, 3:54 AM EDT

Tang Capital takes 10% stake in Aurinia Pharma

AUPH

Tang Capital Management Tuesday said that it acquired 206,005 common shares of Aurinia Pharmaceuticals ( AUPH ) at a price of $15.28 per share for an aggregate purchase price of $3.1M. As a result of the purchase, Tang Capital Management, LLC beneficially owns…

Jun 2, 1:50 PM EDT

Draft FDA guidance could be a boon for gene therapy developers

CRSPNTLACMCKRYS

narvo vexar The US FDA has issued draft guidance intended to accelerate the development of gene and cell therapies. The agency hopes the document will enhance the R&D process for the treatments " by making greater use of existing scientific and regulatory

Jun 2, 1:29 PM EDT

Amgen wins EU approval for Imdylltra in small cell lung cancer

AMGN

Amgen ( AMGN ) has received marketing authorization from the European Commission to market its FDA-approved antitumor agent Imdelltra, also known as tarlatamab, as a late-line option in the EU for adults with certain types of small cell lung cancer. Specifical…