
AbbVie Inc
ABBVHealthcare|Drug Manufacturers - General|USA
$248.08
-1.83 (-0.73%)
DCF (FCF)
$102.04
Earnings Power
$55.26
Clinical Trials (567)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT05144243 Study to Assess Adverse Events and Change in Disease State of Oral Venetoclax in Combination With Subcutaneous (SC) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Intensive Chemotherapy in China | Acute Myeloid Leukemia (AML) | P4 | Active | 44 | Open-label | Venetoclax, Azacitidine |
| NCT05821855 A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China | Open-angle Glaucoma, OAG | P4 | Active | 120 | RCT, Open-label | — |
| NCT04183608 A Trial COmparing staNdard of Care Versus Treat to Target With telemonitoRing and Patient Education in Patients With Ulcerative cOlitis Initiating Adalimumab | Ulcerative Colitis | P4 | Recruiting | 238 | RCT, Open-label | Adalimumab |
| NCT02993523 A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy | Acute Myeloid Leukemia (AML) | P3 | Active | 443 | RCT, Double-blind | Azacitidine, Venetoclax, Placebo |
| NCT05407636 Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD | AMD, nAMD | P3 | Recruiting | 714 | RCT, Double-blind | Aflibercept (EYLEA®) |
| NCT04704921 Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD | AMD, nAMD | P2P3 | Active | 671 | RCT, Double-blind | Ranibizumab (LUCENTIS®) |
| NCT04401748 Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome | Myelodysplastic Syndrome (MDS) | P3 | Active | 531 | RCT, Double-blind | Venetoclax, Azacitidine, Placebo |
| NCT06468228 A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa | Hidradenitis Suppurativa | P3 | Active | 1,400 | RCT, Double-blind | Lutikizumab, Placebo |
| NCT02629159 A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate | Rheumatoid Arthritis | P3 | Active | 1,629 | RCT, Double-blind | Placebo for Adalimumab, Adalimumab, Placebo for Upadacitinib, Upadacitinib |
| NCT05409066 Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma | Follicular Lymphoma (FL) | P3 | Active | 549 | RCT, Open-label | Epcoritamab, Rituximab, Lenalidomide |
| NCT05711394 A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine | Episodic Migraine | P3 | Recruiting | 450 | RCT, Double-blind | Atogepant, Placebo-Matching Atogepant |
| NCT05995340 ELAPR002f Injectable Gel in the Treatment of Atrophic Acne Scars | Atrophic Acne Scars | P3 | Active | 157 | RCT, Double-blind | — |
| NCT07207369 A Study to Assess the Safety and Effectiveness of ELAPR002f Injectable Gel in Adult Participants With Atrophic Acne Scars | Acne Scars | P3 | Recruiting | 395 | RCT, Double-blind | — |
| NCT03671148 A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis Including Those Who Have a History of Inadequate Response or Intolerance to Biologic Therapy(Ies) | Psoriatic Arthritis (PsA) | P3 | Active | 444 | RCT, Double-blind | Placebo, Risankizumab |
| NCT06880744 A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab | Ulcerative Colitis | P3 | Active | 573 | RCT, Open-label | Risankizumab, Risankizumab, Vedolizumab |
| NCT07226752 A Sub-study Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) in China | Diffuse Large B-Cell Lymphoma | P3 | Active | 72 | RCT, Open-label | Epcoritamab, Investigator's Choice Chemotherapy |
| NCT06417775 Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine | Migraine | P3 | Recruiting | 496 | RCT, Double-blind | Ubrogepant, Placebo for Ubrogepant |
| NCT06236438 Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer | P2P3 | Recruiting | 840 | RCT, Double-blind | Livmoniplimab, Budigalimab, Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin, Carboplatin |
| NCT06345339 A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants | Hypothyroidism | P2P3 | Recruiting | 2,800 | RCT, Double-blind | Armour Thyroid, Levothyroxine |
| NCT05843643 Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus | Systemic Lupus Erythematosus | P3 | Active | 1,014 | RCT, Double-blind | Upadacitinib, Placebo |
| NCT07095452 A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant | Multiple Myeloma | P2P3 | Recruiting | 660 | RCT, Open-label | Etentamig, Lenalidomide, Daratumumab, Dexamethasone, Dexamethasone |
| NCT07032597 A Study to Assess Safety and Effectiveness of HArmonyCa Lidocaine Injectable Gel for Restoration and/or Creation of Mid-Face Volume in Adult Participants | Mid Face Volume Deficit | P3 | Active | 252 | RCT, Single-blind | — |
| NCT03398135 A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis | Ulcerative Colitis (UC) | P3 | Active | 1,242 | RCT, Double-blind | risankizumab, placebo for risankizumab |
| NCT07525206 A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer | Colorectal Cancer | P3 | Recruiting | 700 | RCT, Open-label | Telisotuzumab adizutecan, Bevacizumab, Trifluridine/Tipiracil |
| NCT05889182 A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy | Hidradenitis Suppurativa | P3 | Recruiting | 1,328 | RCT, Double-blind | Upadacitinib, Placebo |
| NCT05445778 Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer | Ovarian Cancer, Peritoneal Cancer | P3 | Active | 520 | RCT, Open-label | Mirvetuximab soravtansine plus Bevacizumab, Bevacizumab |
| NCT06109272 A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC) | Hepatocellular Carcinoma | P2P3 | Recruiting | 660 | RCT, Open-label | Livmoniplimab, Budigalimab, Durvalumab, Atezolizumab, Bevacizumab, Tremelimumab |
| NCT06734351 A Study to Evaluate Safety and Effectiveness of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Improvement of Mid-Face Volume | Mid Face Volume Deficit | P3 | Recruiting | 231 | RCT, Double-blind | — |
| NCT06522386 GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma | Mantle Cell Lymphoma | P2 | Active | 50 | Open-label | Pirtobrutinib, Rituximab, Venetoclax |
| NCT04567550 RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME) | Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME) | P2 | Active | 139 | RCT, Single-blind | Topical Steroid, Aflibercept |
| NCT02899052 Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM) | Multiple Myeloma | P2 | Active | 120 | Open-label | Carfilzomib, Venetoclax, Dexamethasone |
| NCT03832361 Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer | Endometrial Cancer | P2 | Recruiting | 50 | Open-label | IMGN853 |
| NCT04514653 RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) | Neovascular Age-Related Macular Degeneration (nAMD) | P2 | Active | 146 | RCT, Single-blind | Ranibizumab, Local Steroid, Topical Steroid |
| NCT07007052 Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm Patients | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | P2 | Recruiting | 33 | Open-label | Venetoclax, Tagraxofusp |
| NCT07024706 Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab | Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) | P2 | Recruiting | 80 | Open-label | Acalabrutinib, Venetoclax |
| NCT05192889 Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax | Refractory Acute Lymphoblastic Leukemia, Relapsed Acute Lymphoblastic Leukemia | P1P2 | Active | 35 | Open-label | Venetoclax, Navitoclax, Dexamethasone, Vincristine, Calaspargase Pegol, Dasatinib, Cytarabine, Blinatumomab, Methotrexate, Mercaptopurine, Cyclophosphamide, Etoposide, Leucovorin, Intrathecal Triples, Pegaspargase, Erwinia asparaginase |
| NCT06972446 A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis | Rheumatoid Arthritis | P2 | Recruiting | 180 | RCT, Double-blind | Lutikizumab, Placebo, Ravagalimab |
| NCT07323641 Telisotuzumab Vedotin and Osimertinib for the Treatment of Progressive, Incurable, Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | P2 | Recruiting | 60 | Open-label | Osimertinib, Telisotuzumab Vedotin |
| NCT04542824 Trial of the Safety and Efficacy of Epcoritamab in Japanese Subjects With Relapsed or Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (R/R B-NHL) | Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma | P1P2 | Active | 78 | Open-label | Epcoritamab (monotherapy), Epcoritamab, Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, Gemcitabine and oxaliplatin, Epcoritamab (maintenance), Rituximab and lenalidomide |
| NCT05451810 A Study to Evaluate Adverse Events of Subcutaneous (SC) Epcoritamab Administered in the Outpatient Setting in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and Classic Follicular Lymphoma | Diffuse Large B-Cell Lymphoma, Classic Follicular Lymphoma | P2 | Active | 184 | Open-label | Epcoritamab |
| NCT03314181 A Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Participants With Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | P2 | Active | 156 | RCT, Open-label | Dexamethasone, Daratumumab, Venetoclax, Bortezomib |
| NCT05783609 Epcoritamab and Rituximab for First-line Follicular Lymphoma | Follicular Lymphoma, Low Grade Non-Hodgkin's Lymphoma, Adult | P2 | Recruiting | 100 | Open-label | Epcoritamab, Rituximab |
| NCT04499248 AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension | Open-angle Glaucoma, Ocular Hypertension | P1P2 | Active | 100 | RCT, Double-blind | AGN-193408 SR, AGN-193408 SR |
| NCT07097363 Epcoritamab With Dose Adjusted Etoposide, Cyclophosphamide, Vincristine, Doxorubicin, Prednisone and Rituximab (EPOCH-R) for the Treatment of Aggressive B-Cell Non-Hodgkin Lymphoma | B-Cell Non-Hodgkin Lymphoma, Burkitt Lymphoma | P2 | Recruiting | 18 | Open-label | Cyclophosphamide, Doxorubicin, Epcoritamab, Etoposide, Prednisone, Rituximab |
| NCT06632951 Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC) | Urothelial Carcinoma | P2 | Active | 150 | RCT, Open-label | Livmoniplimab, Budigalimab, Docetaxel, Paclitaxel, Docetaxel, Paclitaxel, Gemcitabine |
| NCT04801797 Venetoclax + Azacitidine vs. Induction Chemotherapy in AML | Acute Myeloid Leukemia | P2 | Active | 172 | RCT, Open-label | Cytarabine, Idarubicin, Daunorubicin, Liposomal daunorubicin and cytarabine, Venetoclax, Azacitidine |
| NCT03386513 Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN | Blastic Plasmacytoid Dendritic Cell Neoplasm, Myeloproliferative Neoplasm | P1P2 | Active | 179 | Open-label | IMGN632 |
| NCT06953960 A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM) | Multiple Myeloma | P1P2 | Recruiting | 199 | RCT, Open-label | ABBV-453, Daratumumab, Dexamethasone, Pomalidomide |
| NCT07155174 A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer | Small Cell Lung Cancer | P2 | Recruiting | 180 | RCT, Open-label | ABBV-706, Atezolizumab, Etoposide, Carboplatin, Carboplatin, Lurbinectedin |
| NCT06696755 A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder | Bipolar I Disorder, Bipolar II Disorder | P2 | Recruiting | 195 | RCT, Double-blind | Icalcaprant, Placebo for Icalcaprant |
| NCT05283720 A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma | Non-Hodgkin Lymphoma | P2 | Active | 264 | Open-label | Epcoritamab, Lenalidomide, Ibrutinib, Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride [HCl], Prednisone, Polatuzumab Vedotin, CC-99282 |
| NCT07276997 A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder | Major Depressive Disorder | P2 | Recruiting | 195 | RCT, Double-blind | Icalcaprant, Placebo for Icalcaprant |
| NCT07387471 Study to Assess Change in Disease Activity of Oral Venetoclax in Adult Participants With Recurring Relapsed or Refractory (R/R) Waldenström Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL) | Waldenstrom Macroglobulinemia, Lymphoplasmacytic Lymphoma | P2 | Recruiting | 14 | Open-label | Venetoclax |
| NCT05887609 An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib | Ovary Cancer, Peritoneal Cancer | P2 | Recruiting | 53 | Open-label | Mirvetuximab Soravtansine-gynx, Olaparib |
| NCT05099471 Efficacy of Venetoclax in Combination With Rituximab in Waldenström's Macroglobulinemia | Waldenstrom Macroglobulinemia, Treatment Naive | P2 | Recruiting | 80 | RCT, Open-label | Venetoclax; Rituximab, DRC |
| NCT05822752 Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC) | Hepatocellular Carcinoma | P2 | Active | 130 | RCT, Open-label | Budigalimab, Livmoniplimab, Lenvatinib, Sorafenib |
| NCT07230288 Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis | Idiopathic Pulmonary Fibrosis | P2 | Recruiting | 165 | RCT, Double-blind | ABBV-142, Placebo for ABBV-142 |
| NCT05782127 Oral Azacitidine Combined With Venetoclax in Previously Untreated Higher-risk Myelodysplastic Syndromes | Untreated Myelodysplastic Syndrome | P1P2 | Active | 36 | Open-label | Onureg + Venetoclax |
| NCT04797767 Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms | Acute Biphenotypic Leukemia, Acute Myeloid Leukemia | P1P2 | Recruiting | 62 | Open-label | Cladribine, Cytarabine, Mitoxantrone, Recombinant Granulocyte Colony-Stimulating Factor, Venetoclax |
| NCT03379428 Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer | Breast Neoplasms, Malignant Neoplasm of Breast | P1P2 | Active | 34 | Open-label | Trastuzumab, Ibrutinib 560 mg, Ibrutinib 840 mg, Ibrutinib 420 mg |
| NCT02966756 A Study of Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) | P2 | Recruiting | 110 | Open-label | Venetoclax |
| NCT07023289 A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease | Colorectal Cancer | P2 | Recruiting | 140 | Open-label | Telisotuzumab Adizutecan, Standard of Care |
| NCT06820463 A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer | Metastatic Colorectal Cancer | P2 | Recruiting | 390 | RCT, Open-label | Telisotuzumab Adizutecan, Fluorouracil, Oxaliplatin, Leucovorin, Bevacizumab, Panitumumab |
| NCT06628310 A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma | Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | P2 | Recruiting | 180 | RCT, Double-blind | Telisotuzumab Adizutecan, Budigalimab, Fluorouracil, Leucovorin, Oxaliplatin |
| NCT05201248 A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab As Monotherapy or Combined With Standard of Care Therapies in Adult Participants in China With B-Cell Non-Hodgkin Lymphoma | B-Cell Non-Hodgkin Lymphoma | P1P2 | Active | 49 | Open-label | Epcoritamab, Cyclophosphamide, Rituximab, Doxorubicin, Vincristine, Prednisone, Lenalidomide |
| NCT05456685 Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer | High Grade Ovarian Cancer, Primary Peritoneal Cancer | P2 | Active | 125 | Open-label | Mirvetuximab soravtansine, Carboplatin |
| NCT06158854 A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion | Immunoglobulin Light Chain (AL) Amyloidosis | P1P2 | Recruiting | 76 | Open-label | ABBV-383 (Etentamig) |
| NCT04898894 Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia | Acute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse | P1 | Active | 37 | Open-label | Venetoclax, Selinexor, Cytarabine, Fludarabine, Filgrastim, Methotrexate, methotrexate/hydrocortisone/cytarabine |
| NCT03709758 Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML | Acute Myeloid Leukemia | P1 | Active | 50 | Open-label | Venetoclax, Daunorubicin, Cytarabine |
| NCT02942290 A Study Evaluating Venetoclax in Combination With Azacitidine in Participants With Treatment-Naïve Higher-Risk Myelodysplastic Syndromes (MDS) | Myelodysplastic Syndromes (MDS) | P1 | Active | 129 | Open-label | Azacitidine, Venetoclax |
| NCT07570147 A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Ascending Doses of ABBV-1451 Infusions and Injections in Healthy Adult Participants | Healthy Volunteer | P1 | Recruiting | 90 | RCT, Double-blind | ABBV-1451, ABBV-1451 |
| NCT07599761 A Phase 1 Study to Assess the Effect of Itraconazole on ABBV-722 in Healthy Adult Participants | Healthy Volunteers | P1 | Recruiting | 12 | Open-label | ABBV-722, Itraconazole |
| NCT06318273 A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer | Metastatic Castration-Resistant Prostate Cancer | P1 | Active | 152 | Open-label | ABBV-969 |
| NCT05308654 A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets | Relapsed/Refractory Multiple Myeloma | P1 | Active | 34 | Open-label | ABBV-453, Dexamethasone, Daratumumab, Lenalidomide |
| NCT06896916 Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | P1 | Recruiting | 135 | Open-label | Etentamig, Iberdomide |
| NCT06953934 A Mass Balance Study of Oral [14C] ABBV-932 in Healthy Adult Male Participants | Healthy Volunteer | P1 | Active | 8 | Open-label | ABBV-932 |
| NCT06223516 Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | P1 | Active | 60 | Open-label | Subcutaneous (SC) Etentamig, Intravenous (IV) Etentamig |
| NCT05259839 A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma | Relapsed/Refractory Multiple Myeloma | P1 | Active | 283 | Open-label | Etentamig, Dexamethasone, Lenalidomide, Pomalidomide, Daratumumab |
| NCT07219030 A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants | Healthy Volunteer | P1 | Recruiting | 40 | RCT, Double-blind | Emraclidine, Placebo |
| NCT06034470 Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms | Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia | P1 | Active | 30 | Open-label | Cytarabine, Fludarabine, Granulocyte Colony-Stimulating Factor, Idarubicin, Pivekimab Sunirine |
| NCT07567781 A Phase 1 Study to Assess the Effect of ABBV-722 on Midazolam, Digoxin, Pitavastatin, Metformin, and Sitagliptin Drug Levels in Healthy Adults. | Healthy Volunteers | P1 | Recruiting | 12 | Open-label | ABBV-722, Midazolam, Metformin, Digoxin, Pitavastatin, Sitagliptin |
| NCT07222709 A Study to Assess the Adverse Events and How Oral ABBV-1042 Moves Through the Body of Healthy Adult Participants | Healthy Volunteer | P1 | Recruiting | 48 | RCT, Double-blind | ABBV-1042, Placebo |
| NCT05618028 Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets | Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia | P1 | Active | 78 | RCT, Open-label | ABBV-525 |
| NCT07291232 A Study of ABBV-295 Subcutaneous Injections to Assess Adverse Events and Pharmacokinetics in Adult Participants With Obesity | Obesity | P1 | Recruiting | 48 | RCT, Double-blind | ABBV-295, Placebo |
| NCT07232004 A Study to Evaluate How the Study Drug Moves Through the Body, Adverse Events, and How the Body Tolerates ABBV-547 Injections | Healthy Volunteer | P1 | Recruiting | 121 | RCT, Double-blind | ABBV-547, ABBV-547 Placebo |
| NCT05512390 A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL) | Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia | P1 | Recruiting | 154 | Open-label | ABBV-319 |
| NCT07514260 A Study to Assess Adverse Events, Tolerability, and Pharmacokinetics of Subcutaneous Injections of ABBV-295 in Healthy Adult Japanese Participants With Overweight or Obesity. | Healthy Volunteer | P1 | Recruiting | 24 | RCT, Double-blind | ABBV-295, Placebo for ABBV-295 |
| NCT06672705 Epcoritamab for the Treatment of Relapsed or Refractory Post Transplant Lymphoproliferative Disorders | Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder, EBV-Related Post-Transplant Lymphoproliferative Disorder | P1 | Recruiting | 26 | Open-label | Epcoritamab |
| NCT04041050 A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm | Myeloproliferative Neoplasm | P1 | Active | 85 | Open-label | Navitoclax, Ruxolitinib, Celecoxib |
| NCT06858813 A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC) | Hepatocellular Cancer, Squamous-Cell Non-Small Cell Lung Cancer | P1 | Recruiting | 232 | RCT, Open-label | Lenvatinib, ABBV-324 |
| NCT07673120 A Study to Assess Safety, Tolerability, and How Single and Multiple Injections or Infusions of ABBV-313 Affects the Body of Adult Participants | Healthy Volunteers | P1 | Recruiting | 64 | RCT, Double-blind | ABBV-313, Placebo, ABBV-313, Placebo |
| NCT03844815 Study of Venetoclax in Combination With Decitabine in Subjects With Acute Myeloid Leukemia | Acute Myeloid Leukemia | P1 | Active | 26 | Open-label | Decitabine, Venetoclax |
| NCT07425899 A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants | Healthy Volunteer | P1 | Recruiting | 32 | Open-label | ABBV-722, Upadacitinib |
| NCT03725007 A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Upadacitinib in Pediatric Subjects With Polyarticular Course Juvenile Idiopathic Arthritis | Juvenile Idiopathic Arthritis (JIA) | P1 | Active | 124 | Open-label | Upadacitinib |
| NCT03893955 A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors | Cancer, Advanced Solid Tumors | P1 | Active | 150 | Open-label | ABBV-927, ABBV-368, ABBV-181, Carboplatin, Nab-paclitaxel |
| NCT03874052 Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Recurrent Acute Myeloid Leukemia | P1 | Recruiting | 51 | Open-label | Azacitidine, Ruxolitinib, Venetoclax |
| NCT05796388 A Study of Virtual Reality and Linaclotide for IBS-C | Irritable Bowel Syndrome With Constipation | N/A | Recruiting | 65 | RCT, Double-blind | — |
| NCT01277419 German Spondyloarthritis Inception Cohort | Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA) | Recruiting | 1,000 | — | — | |
| NCT00404989 Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People. | HIV Infections, Hepatitis B | Recruiting | 24,258 | — | — | |
| NCT01848028 PsoBest - The German Psoriasis Registry | Psoriasis, Psoriatic-arthritis | Recruiting | 3,500 | — | — | |
| NCT06838845 An Observational Study to Evaluate Effectiveness and Safety of Upadacitinib in Chinese Adult Participants With Moderate to Severely Active Ulcerative Colitis (UC) | Ulcerative Colitis | Recruiting | 80 | — | — | |
| NCT05978622 Observational Study of Adult Participants With Diabetic Macular Edema and Suboptimal Response to Anti-Vascular Endothelial Growth Factor Treated With Dexamethasone Intravitreal Implant | Diabetic Macular Edema | Active | 236 | — | — | |
| NCT06548568 A Real-world Study to Assess Safety of OZURDEX® (Dexamethasone Intravitreal Implant) in Adult Participants With Diabetic Macular Edema in China | Diabetic Macular Edema | Active | 110 | — | — | |
| NCT04159779 A Study of Clinical Outcomes in Chronic Lymphocytic Leukemia (CLL) Patients Treated With Venetoclax in Greece | Chronic Lymphocytic Leukemia | Active | 180 | — | — | |
| NCT03987958 A Study to Describe the Safety and Effectiveness of Venetoclax in Acute Myeloid Leukemia (AML) Patients (REVIVE Study) | Acute Myeloid Leukemia | Active | 100 | — | — | |
| NCT05494606 An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice | Ulcerative Colitis | Active | 785 | — | — | |
| NCT03549416 BioDay Registry: Data Collection Regarding the Use of New Systemic Treatment Options in Patients with Atopic Dermatitis | Atopic Dermatitis | Recruiting | 1,200 | — | — | |
| NCT06639620 Study To Assess Effectiveness and Adverse Events of Foscarbidopa/ Foslevodopa in Adult Participants With Advanced Parkinson Disease in Real Life Setting | Advanced Parkinson Disease | Active | 250 | — | — | |
| NCT07039110 Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-Severe Plaque Psoriasis | Plaque Psoriasis | Recruiting | 700 | — | — | |
| NCT01848561 A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC) | Ulcerative Colitis (UC) | Active | 8,250 | — | — | |
| NCT07382440 A Study to Assess Change in Disease Symptoms in Adult Participants With Advanced Parkinson Disease Using Subcutaneous Foslevodopa/Foscarbidopa in Belgium | Parkinson's Disease | Recruiting | 120 | — | — | |
| NCT06772194 Taiwan Post-Stroke Disability Study | Stroke, Dementia | Recruiting | 2,000 | — | — | |
| NCT07421258 A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting | Crohn's Disease, Ulcerative Colitis | Recruiting | 2,000 | — | — | |
| NCT06603558 Post-Marketing Study to Assess the Safety and Effectiveness of Oral Atogepant in Korean Adult Participants for the Prevention of Chronic or Episodic Migraine | Chronic Migraine, Episodic Migraine | Recruiting | 3,000 | — | Atogepant | |
| NCT06125795 A Study to Assess Change in Functioning and Health Related Quality of Life in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Treatments in Routine Clinical Practice in Spain | Chronic Lymphocytic Leukemia | Active | 146 | — | — | |
| NCT06058741 A Study to Asses Effectiveness and Treatment Management of Oral Venetoclax Tablets + Subcutaneously Injected Azacitidine in Adult Participants Ineligible for Intensive Chemotherapy With de Novo Acute Myeloid Leukemia (AML) in Italy | Acute Myeloid Leukemia | Active | 150 | — | — | |
| NCT05590702 French Observational Study of Patients With Chronic Lymphocytic Leukemia Or Small Lymphocytic Lymphoma in Real-World Settings | CLL/SLL | Active | 1,000 | — | First line therapy | |
| NCT06764706 Study to Assess Change in Disease Activity of Risankizumab Treatment in Adult Participants With Moderate to Severe Ulcerative Colitis | Ulcerative Colitis | Recruiting | 200 | — | — | |
| NCT06830759 Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma | Diffuse Large B-cell Lymphoma, Follicular Lymphoma | Recruiting | 700 | — | — | |
| NCT06937034 Study on Practical ExperienceS of Treatment With Foslevodopa/foScaRbidopa in Advanced Parkinson's Disease | Parkinson's Disease | Recruiting | 2,000 | — | — | |
| NCT06247319 Study to Evaluate the Effectiveness of Risankizumab in Participants With a Recent Diagnosis of Moderate Plaque Psoriasis in a Real-life Setting in Greece | Moderate Plaque Psoriasis, Moderate Psoriasis | Active | 250 | — | — | |
| NCT07073079 A Study to Assess the Effectiveness of Second-Line Therapy of Upadacitinib and Risankizumab in Adult Participants With Crohn's Disease in a Real-World Setting | Crohn's Disease | Recruiting | 250 | — | — | |
| NCT05424562 A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada | Acute Myeloid Leukemia | Active | 210 | — | — | |
| NCT07310290 Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks | Migraine | Recruiting | 189 | — | — | |
| NCT05841537 An Observational Study to Assess Change in Disease Activity and Adverse Events In Adult Participants With Moderate to Severe Active Crohn's Disease (CD) | Crohn's Disease | Active | 1,019 | — | — | |
| NCT03518034 A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men | Hypogonadism, Cardiovascular Diseases | P4 | Completed | 5,246 | RCT, Double-blind | AndroGel®, Placebo |
| NCT01641367 A5288/MULTI-OCTAVE: Management Using Latest Technologies to Optimize Combination Therapy After Viral Failure | HIV-1 Infection | P4 | Completed | 545 | RCT, Open-label | Darunavir, Etravirine, Emtricitabine/tenofovir disoproxil fumarate, Raltegravir, Second line ART regimens - based on a boosted protease inhibitor (bPI) plus two nucleoside analogues (NRTIs), Study provided drugs according to patient resistance profile (DRV, ETR, RTV, FTC/TDF) + any in country available drug as applicable & available |
| NCT00234975 Safety of Lopinavir/Ritonavir (Kaletra) in HIV/HCV Co-infected Subjects vs Baseline Liver Biopsy Metavir Score | HIV Infection | P4 | Completed | 86 | RCT, Open-label | Lopinavir/Ritonavir |
| NCT03781726 Multi-center Study to Transplant Hepatitis-C Infected Kidneys | Renal Failure Chronic, Hepatitis C | P4 | Completed | 30 | Open-label | glecaprevir/pibrentasvir treatment |
| NCT03364725 Toward Elimination of Hepatitis C Virus (HCV): A Pilot Study | Hepatitis C, Addict Heroin | P4 | Unknown | 30 | Open-label | Glecaprevir-pibrentasvir |
| NCT01866592 Vascular Inflammation in Psoriasis - Extension Study | Psoriasis, Cardiovascular Disease | P4 | Completed | 81 | Open-label | Adalimumab |
| NCT02734173 Pilot HCV Direct Acting Antiviral Therapy and Metabolism | Hepatitis C | P4 | Completed | 24 | Open-label | ABT450r-ABT267-ABT333 +/- Ribavirin |
| NCT05507580 A Study to Assess Treat-to-Target and Dosing Flexibility of Oral Upadacitinib Tablets in Adult Participants With Moderate to Severe Atopic Dermatitis | Atopic Dermatitis | P4 | Completed | 461 | RCT, Double-blind | Upadacitinib |
| NCT04274894 A Study of the Effect of Topical Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism | Hypogonadism | P4 | Completed | 246 | Open-label | AndroGel 1.62% |
| NCT05069597 Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon | Cystic Fibrosis, Chronic Pancreatitis | P4 | Completed | 30 | Single-blind | CREON |
| NCT02461745 Real World Study: Genotype 1 Chronic Hepatitis C Virus Treatment and Evaluation of Real World SVR and PRO | Hepatitis C, Chronic | P4 | Completed | 200 | Open-label | ombitasvir, paritaprevir/r, dasabuvir + ribavirin, ombitasvir, paritaprevir/r, dasabuvir |
| NCT02808975 Safety and Efficacy of Adalimumab (Humira) for Hidradenitis Suppurativa (HS) Peri-Surgically | Hidradenitis Suppurativa (HS) | P4 | Completed | 206 | RCT, Double-blind | Placebo, Adalimumab |
| NCT00808509 A Pilot Study of the Feasibility of Discontinuation of Adalimumab in Stable Rheumatoid Arthritis Patients in Clinical Remission | Arthritis, Rheumatoid | P4 | Completed | 33 | RCT, Open-label | adalimumab, methotrexate |
| NCT02148718 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease | Moderate to Severe Crohn's Disease | P4 | Completed | 100 | Open-label | adalimumab |
| NCT02814175 A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL) | Psoriatic Arthritis | P4 | Completed | 246 | RCT, Open-label | methotrexate (MTX), adalimumab (ADA) |
| NCT05969223 Study to Assess the Safety and Efficacy of Subcutaneously Injected Risankizumab in Adult Participants With Genital or Scalp Psoriasis | Genital Psoriasis, Scalp Psoriasis | P4 | Completed | 214 | RCT, Double-blind | Risankizumab, Placebo for Risankizumab |
| NCT00141518 Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact | Advanced Idiopathic Parkinson's Disease | P4 | Completed | 77 | Open-label | Levodopa-carbidopa intestinal gel (LCIG) |
| NCT03924947 A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis | Cystic Fibrosis | P4 | Completed | 36 | RCT, Double-blind | Pancrelipase, Pancrelipase |
| NCT02946034 Viekira Pak or Mavyret Treatment for Patient With Chronic Kidney Disease and Hepatitis C | Chronic Kidney Disease, Chronic Hepatitis C | P4 | Completed | 10 | Open-label | Viekira Pak ± ribavirin, Mavyret |
| NCT02897115 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment | Axial Spondyloarthritis | P4 | Terminated | 22 | RCT, Open-label | Adalimumab |
| NCT05652205 A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation | Functional Constipation (FC), Chronic Idiopathic Constipation (CIC) | P3 | Completed | 123 | RCT, Double-blind | Placebo for Linaclotide, Linaclotide |
| NCT02032277 A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer | Triple Negative Breast Cancer | P3 | Completed | 634 | RCT, Double-blind | Cyclophosphamide, Placebo, Doxorubicin, Paclitaxel, Carboplatin, Veliparib, Placebo |
| NCT02755597 A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy | Relapsed/Refractory Multiple Myeloma | P3 | Completed | 291 | RCT, Double-blind | Venetoclax, Bortezomib, Dexamethasone, Placebo for venetoclax |
| NCT00360568 Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects | Dyskinesias, Parkinson's Disease | P3 | Completed | 62 | Open-label | Levodopa-carbidopa intestinal gel |
| NCT04330690 Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial | COVID-19 | P3 | Unknown | 2,900 | RCT, Open-label | Artesunate, Imatinib, Infliximab, Dexamethasone, LSALT Peptide |
| NCT04026113 Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) | Functional Constipation, Irritable Bowel Syndrome With Constipation | P3 | Completed | 438 | RCT, Double-blind | Linaclotide, Placebo |
| NCT00660387 Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects | Advanced Parkinson's Disease | P3 | Completed | 35 | RCT, Double-blind | Levodopa carbidopa intestinal gel (LCIG), Placebo Gel, Levodopa-carbidopa (LC) oral encapsulated immediate release (IR) tablets, Placebo (PBO) oral capsules |
| NCT04166058 Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C | Irritable Bowel Syndrome With Constipation, Functional Constipation | P3 | Completed | 381 | Open-label | Irritable Bowel Syndrome with Constipation (IBS-C) participants (LIN-MD-63 and LIN-MD-64 completers), Functional Constipation (FC) participants (LIN-MD-62 and LIN-MD-64 completers) |
| NCT00335153 Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease | Advanced Parkinson's Disease | P3 | Completed | 354 | Open-label | Levodopa-carbidopa intestinal gel |
| NCT00357994 Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects | Advanced Parkinson's Disease | P3 | Completed | 36 | RCT, Double-blind | Levodopa carbidopa intestinal gel (LCIG), Placebo gel, Levodopa carbidopa (LC) oral encapsulated immediate release (IR) tablets, Placebo (PBO) oral capsules |
| NCT02881567 Efficacy and Safety of Daclizumab in Participants With RRMS Switching From Natalizumab | Relapsing-Remitting Multiple Sclerosis (RRMS) | P3 | Terminated | 41 | Open-label | Daclizumab |
| NCT04750226 Study To Assess Adverse Events and Change in Disease Activity Of 24-hour Continuous Subcutaneous Infusion Of ABBV-951 In Adult Participants With Advanced Parkinson's Disease | Parkinson's Disease (PD) | P3 | Completed | 118 | Open-label | ABBV-951 |
| NCT01704755 A Study to Evaluate the Safety and Efficacy of ABT-450/Ritonavir/ABT-267; (ABT-267 Also Known as Ombitasvir) and ABT-333 (Also Known as Dasabuvir) Coadministered With Ribavirin (RBV) in Hepatitis C Virus (HCV) Genotype 1-infected Adults With Compensated Cirrhosis | Chronic Hepatitis C Infection, Compensated Cirrhosis | P3 | Completed | 381 | RCT, Open-label | ABT-450/r/ABT-267, ABT-333, Ribavirin (RBV) |
| NCT05741034 A Study to Assess Adverse Events and Effectiveness of Injected JUVÉDERM® VOLITE™ Gel Filler for Change in Neck Lines in Adult Chinese Participants | Neck Lines | P3 | Completed | 159 | RCT, Single-blind | — |
| NCT02023099 Study to Evaluate the Efficacy and Safety of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) in Japanese Adults With Subgenotype 1b Chronic Hepatitis C Virus (HCV) Infection | Chronic Hepatitis C Infection | P3 | Completed | 363 | RCT, Double-blind | ABT-450/r/ABT-267, Placebo |
| NCT02706951 A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY) | Rheumatoid Arthritis | P3 | Completed | 648 | RCT, Double-blind | Methotrexate, Upadacitinib, Placebo Upadacitinib, Placebo Methotrexate |
| NCT03067129 A Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Pediatric Subjects With Genotypes 1-6 Chronic Hepatitis C Virus (HCV) Infection | Hepatitis C Virus (HCV) | P2P3 | Completed | 129 | Open-label | Glecaprevir/Pibrentasvir Adult Formulation, Glecaprevir + Pibrentasvir Pediatric Formulation |
| NCT01773070 A Follow up Study Designed to Obtain Long Term Data on Participants Who Either Achieved a Sustained Virologic Response or Did Not Achieve a Sustained Virologic Response in an AbbVie Sponsored Hepatitis C Study | Hepatitis C | P3 | Completed | 478 | Open-label | ABT-450/ritonavir, ABT-333, ABT-267 |
| NCT03271489 Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women | Heavy Menstrual Bleeding, Uterine Fibroids | P3 | Completed | 478 | RCT, Double-blind | Elagolix, Estradiol /norethindrone acetate (E2/NETA) |
| NCT03069352 A Study of Venetoclax in Combination With Low Dose Cytarabine Versus Low Dose Cytarabine Alone in Treatment Naive Patients With Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy | Acute Myeloid Leukemia (AML) | P3 | Completed | 211 | RCT, Double-blind | Placebo, Venetoclax, Cytarabine |
| NCT03738215 Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone | Major Depressive Disorder | P3 | Completed | 759 | RCT, Double-blind | Cariprazine, Placebo |
| NCT03661138 A Study to Evaluate Safety of Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis | Atopic Dermatitis | P3 | Completed | 272 | RCT, Double-blind | Upadacitinib, Placebo for upadacitinib, Topical Corticosteroids (TCS) |
| NCT01468233 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa | Hidradenitis Suppurativa (HS) | P3 | Completed | 326 | RCT, Double-blind | adalimumab, placebo |
| NCT01960842 A Study to Assess the Efficacy, Safety and Tolerability of ABT-SLV187 Monotherapy in Subjects With Advanced Parkinson's Disease (PD) and Persistent Motor Complications, Despite Optimized Treatment With Available Anti-Parkinsonian Medications | Advanced Parkinson's Disease | P3 | Completed | 31 | Open-label | Levodopa-carbidopa intestinal gel |
| NCT05028569 Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine | Episodic Migraine | P3 | Terminated | 775 | RCT, Double-blind | BOTOX, Placebo |
| NCT00939003 Study of Adalimumab in Patients With Axial Spondyloarthritis | Axial Spondyloarthritis | P3 | Completed | 192 | RCT, Double-blind | Adalimumab, Placebo, Open-label Adalimumab |
| NCT02167945 A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection | Chronic Hepatitis C Virus (HCV) Infection Genotype 1 | P3 | Completed | 615 | Open-label | ABT-450/r/ABT-267, ABT-333, Ribavirin (RBV) |
| NCT04285580 A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension | Open-Angle Glaucoma, Ocular Hypertension | P3 | Completed | 37 | Open-label | Bimatoprost SR, LUMIGAN |
| NCT01646073 Safety and Efficacy Study of Adalimumab in the Treatment of Plaque Psoriasis | Plaque Psoriasis | P3 | Completed | 425 | RCT, Double-blind | Adalimumab, placebo |
| NCT04064827 A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD) | Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT) | P3 | Terminated | 2 | Open-label | Paricalcitol |
| NCT00570986 A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis | Plaque Psoriasis | P3 | Completed | 1,465 | RCT, Double-blind | Placebo, ABT-874, ABT-874 |
| NCT02163694 A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer | Metastatic Breast Cancer | P3 | Completed | 513 | RCT, Double-blind | Veliparib Placebo, Veliparib, Carboplatin, Paclitaxel |
| NCT02651194 A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Renally Impaired Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection | Chronic Hepatitis C Virus (HCV) Infection | P3 | Completed | 104 | Open-label | ABT-493/ABT-530 |
| NCT04666675 A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil | Atopic Dermatitis (AD) | P3 | Withdrawn | — | RCT, Double-blind | Upadacitinib, Placebo for Upadacitinib |
| NCT00679731 A Study of Safety and Efficacy Comparing ABT-874 Versus Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis | Psoriasis | P3 | Completed | 317 | RCT, Double-blind | ABT-874, Methotrexate |
| NCT03222583 A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-Infection | Hepatitis C Virus (HCV) | P3 | Completed | 546 | RCT, Double-blind | Placebo, Glecaprevir/Pibrentasvir |
| NCT02939989 Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study | Hepatitis C Virus Infection | P3 | Completed | 33 | Open-label | Sofosbuvir, Glecaprevir/Pibrentasvir, Ribavirin |
| NCT02499783 Study to Evaluate the Safety and Efficacy of Adalimumab in Chinese Subjects With Moderate to Severe Crohn's Disease | Crohn's Disease | P3 | Completed | 205 | RCT, Double-blind | adalimumab |
| NCT06547125 A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants For the Improvement of Skin Quality | Skin Quality Deficit | P2P3 | Completed | 135 | RCT, Single-blind | — |
| NCT04379050 Extension Study To Evaluate Safety And Tolerability Of 24-Hour Daily Exposure Of Continuous Subcutaneous Infusion of ABBV-951 In Adult Participants With Parkinson's Disease | Parkinson's Disease (PD) | P3 | Completed | 130 | Open-label | ABBV-951 |
| NCT00573794 Long-term Open-label Safety and Efficacy Study of Adalimumab in Subjects With Ulcerative Colitis | Ulcerative Colitis | P3 | Completed | 592 | Open-label | adalimumab |
| NCT04949399 A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence | Platysma Prominence | P3 | Completed | 408 | RCT, Double-blind | OnabotulinumtoxinA, Placebo |
| NCT04161885 A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML) | Acute Myeloid Leukemia (AML), Cancer | P3 | Terminated | 465 | RCT, Open-label | Venetoclax, Azacitidine |
| NCT01235689 Efficacy and Safety of Two Treatment Algorithms in Adults With Moderate to Severe Crohn's Disease | Crohn's Disease | P3 | Completed | 252 | RCT, Open-label | Adalimumab, Prednisone, Azathioprine |
| NCT03104413 A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment | Crohn's Disease | P3 | Completed | 618 | RCT, Double-blind | placebo for risankizumab IV, risankizumab SC, risankizumab IV |
| NCT03941964 A Study of the Effectiveness of Venetoclax in Combination With Azacitidine or Decitabine in an Outpatient Setting in Patients With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy | Acute Myeloid Leukemia (AML), Cancer | P3 | Completed | 60 | Open-label | Venetoclax, Azacitidine, Decitabine |
| NCT03334487 Study Evaluating the Safety of Rovalpituzumab Tesirine for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Small Cell Lung Cancer | Small Cell Lung Cancer | P3 | Withdrawn | — | Open-label | Dexamethasone, Rovalpituzumab tesirine |
| NCT02756611 A Study to Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P3 | Completed | 258 | Open-label | Venetoclax |
| NCT04102007 A Study of the Safety and Efficacy of Risankizumab in Adult Participants With Plaque Psoriasis Who Have Had a Suboptimal Response to Secukinumab or Ixekizumab | Plaque Psoriasis | P3 | Completed | 244 | Open-label | Risankizumab |
| NCT01239797 Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Relapsed or Refractory Multiple Myeloma | Lymphoma, Multiple Myeloma | P3 | Completed | 646 | RCT, Open-label | Lenalidomide, Dexamethasone, Dexamethasone (Oral), Dexamethasone (IV), Elotuzumab (BMS-901608; HuLuc63) |
| NCT02106546 Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer | Squamous Non-Small Cell Lung Cancer | P3 | Completed | 970 | RCT, Double-blind | Carboplatin, Veliparib, Paclitaxel, Placebo to veliparib |
| NCT02507687 Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension | Glaucoma, Open-Angle, Ocular Hypertension | P3 | Completed | 240 | RCT, Double-blind | Bimatoprost SR, Sham Bimatoprost SR |
| NCT04169373 A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis | Spondyloarthritis | P3 | Completed | 734 | RCT, Double-blind | Upadacitinib, Placebo |
| NCT04713592 Study of Subcutaneous (Injected Under the Skin) Risankizumab to Assess Change in Disease Symptoms in Adult Participants With Moderate to Severe Plaque Psoriasis With Palmoplantar Involvement | Psoriasis | P3 | Completed | 174 | RCT, Double-blind | Placebo for Risankizumab, Risankizumab |
| NCT04542499 Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TEMPO-3) | Parkinson Disease | P3 | Completed | 507 | RCT, Double-blind | Tavapadon, Placebo |
| NCT06137287 A Study to Assess Adverse Events and Change of Masseter Muscle Prominence Using BOTOX Injections in Adult Participants | Masseter Muscle Prominence | P3 | Completed | 259 | RCT, Double-blind | BOTOX, Placebo for BOTOX |
| NCT03398148 A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Ulcerative Colitis | Ulcerative Colitis (UC) | P2P3 | Completed | 1,558 | RCT, Double-blind | risankizumab IV, placebo for risankizumab, risankizumab SC |
| NCT01148225 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis | Uveitis | P3 | Completed | 424 | Open-label | adalimumab |
| NCT03235349 Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With Compensated Cirrhosis and With or Without Human Immunodeficiency Virus Co-Infection | Hepatitis C Virus (HCV) | P3 | Completed | 160 | Open-label | Glecaprevir/Pibrentasvir |
| NCT01064856 Study of Adalimumab in Participants With Peripheral Spondyloarthritis (SpA) | Peripheral Spondyloarthritis | P3 | Completed | 165 | RCT, Double-blind | Adalimumab, Placebo |
| NCT02691494 Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study) | Uterine Fibroids, Heavy Menstrual Bleeding | P3 | Completed | 378 | RCT, Double-blind | Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate, Placebo for Elagolix |
| NCT03219437 A Study Comparing the Safety and Efficacy of Risankizumab to Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis | Psoriasis | P3 | Completed | 104 | RCT, Double-blind | risankizumab, methotrexate |
| NCT04976777 A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina | Macular Edema | P3 | Completed | 54 | RCT, Open-label | Dexamethasone |
| NCT06390722 A Study to Assess the Effect of Upadacitinib in Atopic Dermatitis-induced Sleep Disturbance in Adults With Moderate to Severe Atopic Dermatitis | Atopic Dermatitis, Sleep Disturbance | P3 | Withdrawn | — | RCT, Double-blind | Upadacitinib, Placebo for Upadacitinib |
| NCT03875508 A Study to Assess Usability of Risankizumab Autoinjector Combination Product in Participants With Moderate to Severe Plaque Psoriasis | Psoriasis | P3 | Completed | 108 | Open-label | Risankizumab |
| NCT05368558 Study to Assess Adverse Events and Change in Disease Activity of Oral Cariprazine Capsules in Adult Participants With Schizophrenia | Schizophrenia | P3 | Terminated | 34 | RCT, Double-blind | Cariprazine, Placebo |
| NCT05861427 Study of Oral Atogepant Tablets to Assess Change in Disease Activity in Adult Japanese Participants With Episodic Migraine | Migraine | P3 | Completed | 524 | RCT, Double-blind | Atogepant, Placebo for Atogepant |
| NCT00686374 Efficacy and Long Term Safety of Adalimumab in Pediatric Subjects Who Have Demonstrated Clinical Response in M06-806 | Crohn's Disease | P3 | Completed | 100 | Open-label | Adalimumab |
| NCT06399718 A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants | Masseter Muscle Prominence | P3 | Completed | 207 | RCT, Double-blind | BOTOX, Placebo |
| NCT04994535 A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence | Platysma Prominence | P3 | Completed | 426 | RCT, Double-blind | OnabotulinumtoxinA, Placebo |
| NCT02487199 Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir in Adults With Genotype 1a or Genotype 4 Chronic Hepatitis C Virus (HCV) Infection, With Severe Kidney Impairment or End Stage Kidney Disease | Hepatitis C Virus (HCV) | P3 | Completed | 18 | Open-label | ombitasvir/paritaprevir/ritonavir and dasabuvir, ombitasvir/paritaprevir/ritonavir |
| NCT05316220 A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years With Ulcerative Colitis | Ulcerative Colitis (UC) | P3 | Withdrawn | — | RCT, Double-blind | Mesalamine, Placebo |
| NCT00761150 Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP) | Chronic Low Back Pain | P3 | Completed | 308 | RCT, Double-blind | ABT-712, Placebo |
| NCT02806362 Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD) | Chronic Hepatitis C Virus | P3 | Withdrawn | — | Open-label | Ombitasvir/paritaprevir/ritonavir |
| NCT01670240 Adalimumab in the Treatment of Chronic Pouchitis | Ulcerative Colitis, Pouchitis | P3 | Completed | 13 | RCT, Double-blind | Adalimumab, Placebo |
| NCT03653026 A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Ulcerative Colitis | Ulcerative Colitis (UC) | P3 | Completed | 522 | RCT, Double-blind | Placebo, Upadacitinib |
| NCT01020487 Safety and Efficacy of Paricalcitol Capsules in Decreasing Serum Parathyroid Hormone Levels in Children Aged 10-16 With Chronic Kidney Disease (CKD) | Chronic Kidney Disease Stage 3 and 4 | P3 | Completed | 47 | RCT, Double-blind | Paricalcitol, Placebo |
| NCT03061812 Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) | Small Cell Lung Cancer | P3 | Completed | 444 | RCT, Open-label | Rovalpituzumab tesirine, Topotecan, Dexamethasone |
| NCT02642432 A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1, 2, 4, 5 or 6 Infection and Compensated Cirrhosis | Hepatitis C Virus Infection, Chronic Hepatitis C | P3 | Completed | 146 | Open-label | ABT-493/ABT-530 |
| NCT04195698 Open-Label Extension Study of Upadacitinib in Adult Participants With Moderate to Severe Atopic Dermatitis | Atopic Dermatitis | P3 | Completed | 475 | Open-label | Upadacitinib |
| NCT01468207 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa | Hidradenitis Suppurativa (HS) | P3 | Completed | 307 | RCT, Double-blind | adalimumab, placebo |
| NCT02799381 A Study Comparing Efficacy of Levodopa-Carbidopa Intestinal Gel/Carbidopa-Levodopa Enteral Suspension and Optimized Medical Treatment on Dyskinesia in Subjects With Advanced Parkinson's Disease (DYSCOVER) | Parkinson's Disease (PD) | P3 | Completed | 63 | RCT, Open-label | Optimized antiparkinsonian treatment, Levodopa-Carbidopa Intestinal Gel (LCIG) |
| NCT02219503 A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis | Chronic Hepatitis C Infection, Compensated Cirrhosis | P3 | Completed | 60 | Open-label | Ombitasvir/Paritaprevir/Ritonavir, Dasabuvir |
| NCT02819635 A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC) | Ulcerative Colitis (UC) | P2P3 | Completed | 1,302 | RCT, Double-blind | Placebo, Upadacitinib |
| NCT00497146 The PRIMO Study: Paricalcitol Capsules Benefits Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease Stage 3/4 | Chronic Kidney Disease, Left Ventricular Hypertrophy | P3 | Completed | 227 | RCT, Double-blind | paricalcitol, placebo |
| NCT03255382 A Study to Assess the Efficacy of Risankizumab Compared to FUMADERM® in Subjects With Moderate to Severe Plaque Psoriasis Who Are Naïve to and Candidates for Systemic Therapy | Psoriasis | P3 | Completed | 120 | RCT, Open-label | Fumaderm, risankizumab |
| NCT02065622 Study to Evaluate the Safety and Efficacy of Two Adalimumab Dosing Regimens in Subjects With Moderate to Severe Ulcerative Colitis | Ulcerative Colitis (UC) | P3 | Completed | 952 | RCT, Double-blind | Adalimumab |
| NCT03573297 A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features | Bipolar I Disorder, Mania | P3 | Completed | 901 | RCT, Double-blind | Cariprazine, Placebo |
| NCT02694523 BI 655066/ABBV-066 (Risankizumab) Compared to Active Comparator (Adalimumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis | Psoriasis | P3 | Completed | 684 | RCT, Double-blind | risankizumab, adalimumab, placebo for risankizumab, placebo for adalimumab |
| NCT02549092 A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD) | Advanced Parkinson's Disease | P3 | Completed | 89 | RCT, Open-label | Optimized Medical Treatment, Levodopa-Carbidopa Intestinal Gel |
| NCT03219216 A Study to Evaluate the Efficacy and Safety of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults in Brazil With Chronic Hepatitis C Virus (HCV) Genotype 1 - 6 Infection | Hepatitis C Virus (HCV) | P3 | Completed | 100 | Open-label | Glecaprevir/Pibrentasvir |
| NCT02016482 A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis | Nail Psoriasis, Plaque Psoriasis | P3 | Completed | 217 | RCT, Double-blind | Adalimumab |
| NCT02264990 Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) and Who Are Current or Former Smokers | Non-squamous Non-small Cell Lung Cancer | P3 | Completed | 595 | RCT, Open-label | Paclitaxel, Carboplatin, Cisplatin, Veliparib, Pemetrexed |
| NCT03069365 A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection and Renal Impairment | Hepatitis C Virus (HCV) | P3 | Completed | 101 | Open-label | Glecaprevir/pibrentasvir |
| NCT01138657 Efficacy and Safety of Adalimumab in Patients With Active Uveitis | Uveitis | P3 | Completed | 239 | RCT, Double-blind | Adalimumab, Prednisone, Placebo |
| NCT02517528 ABT-450/Ritonavir/ ABT-267 (ABT-450/r/ABT-267) and ABT-333 Co-Administered With Ribavirin (RBV) in Treatment Naïve and Treatment Experienced Asian Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Compensated Cirrhosis | Chronic Hepatitis C Virus (HCV) | P3 | Completed | 104 | Open-label | ABT-450/r/ABT-267, ABT-333, ribavirin |
| NCT05411198 Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma | Open-Angle Glaucoma | P3 | Completed | 74 | Open-label | — |
| NCT05316233 A Study to Assess Adverse Events and Change in Disease Activity of JUVÉDERM® VOLITE™ XC Injectable Gel for Change in Neck Appearance in Adult Participants | Neck Lines | P3 | Completed | 159 | RCT, Single-blind | — |
| NCT01833533 A Study to Evaluate Chronic Hepatitis C Infection in Adults With Genotype 1a Infection | Chronic Hepatitis C Infection | P3 | Completed | 305 | RCT, Double-blind | ABT-450/r/ABT-267, ABT-333, Ribavirin, Placebo for Ribavirin |
| NCT04435600 A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease Symptoms | Psoriasis | P3 | Completed | 139 | RCT, Single-blind | Risankizumab, Ustekinumab |
| NCT02470585 Veliparib With Carboplatin and Paclitaxel and as Continuation Maintenance Therapy in Adults With Newly Diagnosed Stage III or IV, High-grade Serous, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Ovarian Cancer, Ovarian Neoplasm | P3 | Terminated | 1,140 | RCT, Double-blind | Veliparib, Paclitaxel, Carboplatin |
| NCT02185014 Open Label Study to Evaluate Long Term Efficacy, Safety and Tolerability of Repeated Dosing in Subjects With Crohn's Disease and Who Participated and Successfully Completed M14-115 | Crohn's Disease | P3 | Completed | 252 | Open-label | Adalimumab |
| NCT02243293 A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-Administration of ABT-493 and ABT-530 With and Without RBV in Subjects With Chronic Hepatitis C Virus (HCV) Genotypes 2, 3, 4, 5 or 6 Infection | Chronic Hepatitis C, Hepatitis C Virus | P2P3 | Completed | 694 | RCT, Open-label | ABT-493, ABT-530, ribavirin (RBV), ABT-493/ABT-530 |
| NCT02723084 A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Japanese Adults With Genotype 2 Chronic Hepatitis C Virus Infection | Chronic Hepatitis C Virus, Hepatitis C Virus | P3 | Completed | 136 | RCT, Open-label | ABT-493/ABT-530, sofosbuvir (SOF), ribavirin (RBV) |
| NCT05248880 A Study to Assess Adverse Events and Change in Disease Activity of Intramuscular AGN-151586 Injection in Toxin-Naïve Adult Participants With Glabellar Lines | Glabellar Lines | P3 | Completed | 309 | RCT, Double-blind | AGN-151586, Placebo |
| NCT07365241 A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer | Small Cell Lung Cancer | P3 | Not Yet Recruiting | 531 | RCT, Open-label | ABBV-706, Topotecan, Topotecan, Lurbinectedin, Amrubicin |
| NCT03732703 Myeloma-Developing Regimens Using Genomics (MyDRUG) | Relapsed Refractory Multiple Myeloma | P1P2 | Completed | 103 | Open-label | Abemaciclib, dexamethasone, ixazomib, pomalidomide, Enasidenib, dexamethasone, ixazomib, pomalidomide, Cobimetinib, dexamethasone, ixazomib, pomalidomide, Erdafitinib, dexamethasone, ixazomib, pomalidomide, Venetoclax, dexamethasone, ixazomib, pomalidomide, Daratumumab, dexamethasone, ixazomib, pomalidomide, Belantamab mafodotin, dexamethasone, ixazomib, pomalidomide, Selinexor, dexamethasone, ixazomib, pomalidomide |
| NCT00645177 Phase 2 Study of ABT-869 in Combination With Paclitaxel Versus Paclitaxel Alone to Treat Metastatic Breast Cancer | Metastatic Breast Cancer | P2 | Completed | 10 | RCT, Double-blind | ABT-869, paclitaxel, Placebo for ABT-869 |
| NCT05744401 A Long-term Extension Study to Evaluate Safety, Tolerability, and Efficacy of AL002 in Alzheimer's Disease | Alzheimer's Disease | P2 | Terminated | 197 | RCT, Double-blind | AL002 |
| NCT04720976 JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors | Solid Tumor, NSCLC | P1P2 | Completed | 58 | Open-label | JAB-3312, Binimetinib, Pembrolizumab, Sotorasib, Osimertinib |
| NCT01794520 Study Evaluating ABT-199 in Participants With Relapsed or Refractory Multiple Myeloma | Relapsed/Refractory Multiple Myeloma | P1P2 | Completed | 117 | Open-label | Venetoclax, Dexamethasone |
| NCT05760313 A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide | Functional Constipation | P2 | Completed | 19 | RCT, Double-blind | Linaclotide, Placebo |
| NCT00707889 Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer | Advanced Colorectal Cancer, Adenocarcinoma of the Colon | P2 | Completed | 159 | RCT, Open-label | ABT-869, bevacizumab, oxaliplatin, folinic acid, fluorouracil, ABT-869 |
| NCT00486538 Study of ABT-869 in Subjects With Advanced Renal Cell Carcinoma Who Have Previously Received Treatment With Sunitinib | Advanced Renal Cell Carcinoma | P2 | Completed | 53 | Open-label | ABT-869 |
| NCT02265731 Study Evaluating Venetoclax in Subjects With Hematological Malignancies | Non-Hodgkin Lymphoma (NHL), Multiple Myeloma (MM) | P1P2 | Completed | 38 | Open-label | azacitadine, venetoclax, rituximab / IDEC-C2B8, rituximab / IDEC-C2B8 |
| NCT07197307 Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL) | Aggressive Diffuse Large B-cell Lymphoma, High-grade B-cell Lymphoma (HGBL) | P2 | Not Yet Recruiting | 120 | Open-label | Loncastuximab Tesirine and Epcoritamab |
| NCT00481091 A Study of ABT-263 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | P1P2 | Completed | 60 | Open-label | ABT-263 |
| NCT02287233 A Study Evaluating Venetoclax in Combination With Low-Dose Cytarabine in Treatment-Naïve Participants With Acute Myelogenous Leukemia | Acute Myelogenous Leukemia, AML | P1P2 | Completed | 94 | Open-label | Venetoclax, Cytarabine |
| NCT00716534 Study of Carboplatin/Paclitaxel in Combination With ABT-869 in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) | Advanced or Metastatic Non-Small Cell Lung Cancer | P2 | Completed | 145 | RCT, Double-blind | ABT-869, Placebo for ABT-869, ABT-869, Carboplatin, Paclitaxel |
| NCT06119217 Phase 2 Study of TTX-030 and Chemotherapy With or Without Budigalimab for 1L mPDAC Patients | Pancreatic Cancer | P2 | Completed | 194 | RCT, Open-label | — |
| NCT01423539 A Study of Navitoclax in Addition to Bendamustine and Rituximab in Patients With Relapsed Diffuse Large B-Cell Lymphoma (NAVIGATE) | Diffuse Large B-Cell Lymphoma | P2 | Withdrawn | — | RCT, Open-label | bendamustine, navitoclax, rituximab |
| NCT00517920 Phase 2 Study of ABT-869 in Advanced Hepatocellular Carcinoma (HCC) | Advanced Hepatocellular Carcinoma | P2 | Completed | 44 | Open-label | ABT-869 |
| NCT00445198 A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies | Small Cell Lung Cancer, Small Cell Lung Carcinoma | P1P2 | Completed | 86 | Open-label | ABT-263 |
| NCT01994837 A Phase 2 Study of ABT-199 in Subjects With Acute Myelogenous Leukemia (AML) | Acute Myelogenous Leukemia, AML | P2 | Completed | 32 | Open-label | ABT-199 |
| NCT01889186 A Study of the Efficacy of ABT-199 in Subjects With Relapsed/Refractory or Previously Untreated Chronic Lymphocytic Leukemia With the 17p Deletion | Chronic Lymphocytic Leukemia, 17p Deletion | P2 | Completed | 158 | Open-label | ABT-199 (Main Cohort), ABT-199 (Safety Expansion Cohort) |
| NCT03785184 A Study of Venetoclax Plus Lenalidomide and Dexamethasone for the Treatment of Newly Diagnosed t(11;14)-Positive Multiple Myeloma in Subjects Who Are Ineligible for High-Dose Therapy | Multiple Myeloma | P2 | Withdrawn | — | Open-label | venetoclax, lenalidomide, dexamethasone |
| NCT00517790 Study of ABT-869 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer (NSCLC) | P2 | Completed | 140 | RCT, Open-label | ABT-869 .25 mg/kg, ABT-869 0.10 mg/kg |
| NCT01087151 A Study of ABT-263 in Combination With Dose-Intensive Rituximab, or Dose-Intensive Rituximab Alone, in Previously Untreated Patients With B-Cell, Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P2 | Completed | 118 | RCT, Open-label | ABT-263, rituximab |
| NCT05041257 Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers | Ovarian Cancer, Peritoneal Cancer | P2 | Completed | 79 | Open-label | Mirvetuximab soravtansine |
| NCT01911845 An Open-label, Single Arm, Phase 2 Study to Evaluate ABT-450/r/ABT-267 and ABT-333 With Ribavirin (RBV) in Adults With Genotype 1 HCV Infection Taking Methadone or Buprenorphine | Chronic Hepatitis C Infection, Chronic Hepatitis C | P2 | Completed | 38 | Open-label | ABT-450/r/ABT-267, ABT-333, Ribavirin (RBV) |
| NCT00406809 A Study of ABT-263 in Subjects With Relapsed or Refractory Lymphoid Malignancies | Chronic Lymphoid Leukemia, Lymphoid Malignancies | P1P2 | Completed | 81 | Open-label | ABT-263 |
| NCT02556736 AGN-151597 (Formerly RST-001) Phase I/II Trial for Advanced Retinitis Pigmentosa | Advanced Retinitis Pigmentosa | P1P2 | Completed | 14 | Open-label | AGN-151597 |
| NCT00935311 Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction | Pain | P2 | Completed | 122 | RCT, Double-blind | ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release, Placebo |
| NCT02068222 A Study to Evaluate the Safety and Antiviral Effect of ABT-450/Ritonavir and ABT-530 Coadministered With and Without Ribavirin in Adults With Genotype 3 Hepatitis C (HCV) Infection | Chronic Hepatitis C, Hepatitis C Virus | P2 | Completed | 10 | Open-label | ABT-450/ritonavir (r), ABT-530, Ribavirin (RBV) |
| NCT05227703 A Trial of 15 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia | Schizophrenia | P2 | Completed | 391 | RCT, Double-blind | Emraclidine 15 mg, Emraclidine 30 mg, Placebo |
| NCT05630885 A Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV | HIV-1-infection, Elevated Cardiovascular Risk | P2 | Completed | 110 | RCT, Double-blind | CVC 150 mg, CVC 300 mg |
| NCT01051349 Safety and Efficacy Extension Study of Daclizumab High Yield Process (DAC HYP) (BIIB019) in Participants Who Have Completed Study 205MS202 (NCT00870740) to Treat Relapsing Remitting Multiple Sclerosis | Relapsing-Remitting Multiple Sclerosis | P2 | Completed | 410 | Open-label | BIIB019 (Daclizumab), trivalent seasonal influenza vaccine |
| NCT02493855 Ombitasvir/ABT-450/Ritonavir and Dasabuvir Therapy With Low Dose Ribavirin (RBV), Full Dose RBV or RBV Add-On in Treatment Naive Genotype 1a Hepatitis C Virus Infected Adults | Chronic Hepatitis C, Hepatitis C (HCV) | P2 | Completed | 46 | RCT, Open-label | Ombitasvir/ABT-450/Ritonavir, Dasabuvir, Ribavirin (RBV) |
| NCT00920764 A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors | Chronic Kidney Disease, Diabetic Nephropathy | P2 | Completed | 92 | RCT, Double-blind | Placebo for Atrasentan 0.2 mg/mL solution, 0.25 mg Atrasentan QD, 0.75 mg Atrasentan QD, 1.75 mg Atrasentan QD |
| NCT02118714 Atrasentan Spermatogenesis and Testicular Function | Nephropathy, Diabetes | P2 | Completed | 20 | Open-label | Atrasentan |
| NCT01777165 A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Cardiac Surgery | Acute Kidney Injury | P2 | Completed | 240 | RCT, Double-blind | ABT-719, Placebo |
| NCT03567616 A Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | P2 | Terminated | 8 | Open-label | Venetoclax, Pomalidomide, Dexamethasone |
| NCT02677324 Study of ABT-199 (GDC-199) In Patients With Relapsed Or Refractory Waldenström Macroglobulinemia | Waldenstrom Macroglobulinemia | P2 | Completed | 33 | Open-label | ABT199 |
| NCT01549834 Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors | Alzheimer's Disease | P2 | Completed | 434 | RCT, Double-blind | ABT-126, ABT-126, placebo |
| NCT05291234 A Study to Assess Safety of ABBV-916 and How Intravenous ABBV-916 Moves Through Body and Affects Brain Amyloid Plaque Clearance in Adult Participants (Aged 50-90 Years) With Early Alzheimer's Disease | Alzheimer's Disease (AD) | P2 | Completed | 106 | RCT, Double-blind | ABBV-916, Placebo |
| NCT00507936 Safety and Efficacy Study in Subjects With Diabetic Neuropathic Pain | Diabetic Neuralgia, Diabetic Neuropathies | P2 | Completed | 280 | RCT, Double-blind | ABT-894, ABT-894, ABT-894, placebo, Duloxetine |
| NCT05513703 A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) | Non Small Cell Lung Cancer | P2 | Terminated | 9 | Open-label | Telisotuzumab Vedotin |
| NCT00619866 An Efficacy and Safety Study of Elagolix (NBI-56418) in Women With Endometriosis | Endometriosis, Pain | P2 | Completed | 155 | RCT, Double-blind | Elagolix, placebo |
| NCT04965272 A Study To Assess Adverse Events and Change in Disease Activity With Oral Cariprazine When Added to Antidepressant Therapies (ADTs) Compared to Placebo in Adult Participants With Generalized Anxiety Disorder (GAD) Who Have Had an Inadequate Response to ADTs Alone | Generalized Anxiety Disorder | P2 | Withdrawn | — | RCT, Double-blind | Cariprazine 0.75 mg/day, Cariprazine 1.5 mg/day, Cariprazine 3.0 mg/day |
| NCT01113957 A Trial of ABT-888 in Combination With Temozolomide Versus Pegylated Liposomal Doxorubicin Alone in Ovarian Cancer | Ovarian Cancer | P2 | Completed | 168 | RCT, Open-label | ABT-888, pegylated liposomal doxorubicin, temozolomide |
| NCT03368859 A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab | Cancer | P2 | Terminated | 70 | RCT, Open-label | Leucovorin, Fluorouracil - bolus, Bevacizumab, Fluorouracil - infusion, ABT-165, Irinotecan |
| NCT01685203 A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection | Hepatitis C, Chronic | P2 | Completed | 316 | RCT, Open-label | ABT-450/r, ABT-267, Ribavirin (RBV) |
| NCT05217472 An Efficacy and Safety Study of Injectable Ravagalimab to Assess Change in EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) in Adult Participants With Moderately to Severely Active Primary Sjogren's Syndrome (pSS) | Sjogren's Syndrome (SS) | P2 | Withdrawn | — | RCT, Double-blind | Ravaglimab, Ravagalimab, Placebo, Placebo |
| NCT00726882 A Follow-up Assessment of Resistance to ABT-333 in Hepatitis C Virus (HCV)-Infected Subjects Who Have Received ABT-333 in ABT-333 Studies | HCV Infection | P2 | Completed | 35 | Open-label | ABT-333 |
| NCT01441635 Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids | Heavy Uterine Bleeding, Uterine Fibroids | P2 | Completed | 271 | RCT, Double-blind | Elagolix, Placebo, Estradiol/Norethindrone acetate (E2/NETA), Estradiol, Progesterone |
| NCT03026166 A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer | Small Cell Lung Cancer | P1P2 | Terminated | 42 | Open-label | Ipilimumab, Nivolumab, Rovalpituzumab tesirine |
| NCT02880956 A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's Disease | Alzheimer's Disease | P2 | Completed | 453 | RCT, Double-blind | ABBV-8E12, placebo for ABBV-8E12 |
| NCT01817530 Safety and Efficacy in Premenopausal Women With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF) | Heavy Uterine Bleeding, Uterine Fibroids | P2 | Completed | 571 | RCT, Double-blind | Elagolix, 0.5 mg estradiol / 0.1 mg norethindrone acetate, 1 mg estradiol / 0.5 mg norethindrone acetate, E2/NETA placebo |
| NCT05771428 Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-552 Capsules Moves Through the Body of Participants Aged 50 to 90 Years With Mild Alzheimer's Disease | Alzheimer's Disease (AD) | P2 | Completed | 263 | RCT, Double-blind | ABBV-552, Placebo for ABBV-552 |
| NCT02478320 Phase II Study of Ilorasertib (ABT348) in Patients With CDKN2A Deficient Solid Tumors | Advanced Cancers | P2 | Terminated | 12 | Open-label | Ilorasertib |
| NCT02471118 Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab (OKINADA) | Osteoarthritis, Knee | P2 | Completed | 62 | RCT, Double-blind | Adalimumab 40 mg, Placebo |
| NCT05227690 A Trial of 10 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia | Schizophrenia | P2 | Completed | 385 | RCT, Double-blind | Placebo, Emraclidine 10 mg, Emraclidine 30 mg |
| NCT00804908 A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanoma | Melanoma, Metastatic Melanoma | P2 | Completed | 346 | RCT, Double-blind | temozolomide, ABT-888 |
| NCT02412371 A Study Evaluating the Efficacy and Tolerability of Veliparib in Combination With Paclitaxel/Carboplatin-Based Chemoradiotherapy Followed by Veliparib and Paclitaxel/Carboplatin Consolidation in Adults With Stage III Non-Small Cell Lung Cancer (NSCLC) | Non-small Cell Lung Cancer Stage III | P1P2 | Terminated | 48 | Open-label | Paclitaxel, Placebo for Veliparib, Carboplatin, Veliparib |
| NCT02047110 BI 655066 (Risankizumab) Proof of Concept Dose Finding Study in Ankylosing Spondylitis (AS) | Ankylosing Spondylitis (AS) | P2 | Completed | 159 | RCT, Double-blind | placebo for risankizumab, risankizumab |
| NCT02015793 Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Two Treatment Modules in Chinese Subjects With Moderate to Severe Crohn's Disease | Crohn's Disease | P2 | Completed | 30 | RCT, Double-blind | Adalimumab, Placebo for adalimumab |
| NCT01077700 Efficacy and Safety Study for Cognitive Deficits in Adult Subjects With Schizophrenia | Cognitive Deficits in Schizophrenia | P2 | Completed | 214 | RCT, Double-blind | ABT-288 Low Dose, Placebo, ABT-288 High Dose |
| NCT02031276 Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease. | Crohn Disease | P2 | Completed | 121 | RCT, Double-blind | risankizumab IV, risankizumab SC, Placebo |
| NCT05216250 Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor | Upper Limb Essential Tremor (UL ET) | P2 | Completed | 174 | RCT, Double-blind | BOTOX, Placebo for BOTOX |
| NCT04042740 Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection | Hepatitis C Infection, HIV Infection | P2 | Completed | 45 | Open-label | Glecaprevir/Pibrentasvir (G/P) |
| NCT03148756 Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis | Endocarditis, Bacteremia | P2 | Terminated | 2 | RCT, Single-blind | Dalbavancin, Standard of Care |
| NCT04958031 A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy | Apathy in Dementia | P2 | Terminated | 41 | RCT, Double-blind | CVL-871 1.0 mg, CVL-871 3.0 mg, Placebo |
| NCT06247540 Venetoclax, Rituximab and Nivolumab in Combination for the Treatment of Richter's Transformation Arising From Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Recurrent Transformed Chronic Lymphocytic Leukemia, Refractory Transformed Chronic Lymphocytic Leukemia | P2 | Withdrawn | — | Open-label | Nivolumab, Rituximab, Venetoclax |
| NCT02415959 Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis | Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis | P2 | Completed | 70 | RCT, Double-blind | Creon IR, Creon® (DR/GR) |
| NCT02305758 Study Comparing Veliparib Plus FOLFIRI Versus Placebo Plus FOLFIRI With or Without Bevacizumab in Previously Untreated Metastatic Colorectal Cancer | Untreated Metastatic Colorectal Cancer | P2 | Completed | 130 | RCT, Double-blind | Veliparib, Placebo, Modified FOLFIRI, FOLFIRI, Bevacizumab, Fluorouracil infusion |
| NCT01095562 Safety and Efficacy Study for Cognitive Deficits in Adult Subjects With Schizophrenia | Cognitive Deficits in Schizophrenia | P2 | Completed | 207 | RCT, Double-blind | ABT-126, Placebo |
| NCT00401570 A Study of Volociximab in Combination With Gemcitabine in Metastatic Pancreatic Cancer | Pancreatic Cancer | P2 | Completed | 40 | Open-label | Volociximab, Gemcitabine |
| NCT05606757 A Study to Evaluate Adverse Events and Effectiveness of OnabotulinumtoxinA in Participants Undergoing Open Abdominal Ventral Hernia Repair for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique | Ventral Hernia, Abdominal Hernia | P2 | Withdrawn | — | RCT, Double-blind | BOTOX Dose A, Placebo for BOTOX, BOTOX Dose B, BOTOX Dose C |
| NCT01897519 A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery | Cardiothoracic Surgery, Vascular Surgery | P2 | Terminated | 56 | RCT, Double-blind | Placebo, ABT-719 |
| NCT04244175 A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures | Seizures | P2 | Completed | 154 | RCT, Double-blind | Placebo, CVL-865 |
| NCT03044795 Response to PARP Inhibitor Predicted by the RAD51 Assay | Cancer | P2 | Withdrawn | — | Open-label | Veliparib |
| NCT02292719 A Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir With Sofosbuvir With or Without Ribavirin in Adults With Chronic Hepatitis C Virus Infection | Chronic Hepatitis C Virus Infection | P2 | Completed | 70 | RCT, Open-label | OBV/PTV/r, Sofosbuvir, Ribavirin (RBV) |
| NCT02141282 A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy | Chronic Lymphocytic Leukemia | P2 | Completed | 127 | Open-label | Venetoclax |
| NCT06032546 A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion or Subcutaneous (SC) Injection of Budigalimab and/or ABBV-382 | Human Immuno-deficiency Virus (HIV) Disease | P2 | Terminated | 163 | RCT, Double-blind | Budigalimab, Placebo for Budigalimab, ABBV-382, Placebo for ABBV-382, Budigalimab |
| NCT04309474 A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke | Acute Ischemic Stroke | P2 | Completed | 121 | RCT, Double-blind | Elezanumab, Placebo |
| NCT00297089 A Phase 1/2 Study Evaluating ABT-751 in Combination With Alimta in Advanced Non-Small Cell Lung Cancer | Lung Cancer, NSCLC | P1P2 | Completed | 165 | RCT, Double-blind | ABT-751, pemetrexed, placebo |
| NCT02925117 A Study to Evaluate ABT-494 (Upadacitinib) in Adults With Moderate to Severe Atopic Dermatitis | Atopic Dermatitis | P2 | Completed | 167 | RCT, Double-blind | Upadacitinib, Placebo |
| NCT02066389 A Study Investigating the Efficacy and Safety of Upadacitinib (ABT-494) Given With Methotrexate (MTX) in Adults With Rheumatoid Arthritis Who Have Had an Inadequate Response to MTX Alone | Rheumatoid Arthritis | P2 | Completed | 300 | RCT, Double-blind | Placebo, Upadacitinib |
| NCT03873493 A Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Participants With T-cell Prolymphocytic Leukemia | Leukemia, T-cell Prolymphocytic Leukemia (T-PLL) | P2 | Completed | 14 | Open-label | Venetoclax, Ibrutinib |
| NCT04295538 Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI) | Spinal Cord Injury (SCI) | P2 | Completed | 60 | RCT, Double-blind | Elezanumab, Placebo |
| NCT01527916 Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease | Alzheimer's Disease | P2 | Completed | 438 | RCT, Double-blind | placebo, donepezil, ABT-126 |
| NCT02213289 PANGEA-IMBBP: Personalized Antibodies for Gastro-Esophageal Adenocarcinoma - A 1st Pilot Metastatic Trial of Biologics Beyond Progression | Adenocarcinoma | P2 | Completed | 80 | Open-label | Trastuzumab, ABT-806, Bemarituzumab, Ramucirumab, Nivolumab, Standard cytotherapy |
| NCT05443724 A Study to Evaluate Safety and Tolerability of CVL-231 (Emraclidine) in Adult Participants With Schizophrenia | Schizophrenia | P2 | Completed | 700 | Open-label | CVL-231 30 mg |
| NCT02142959 RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE | Breast Cancer | P2 | Completed | 187 | RCT, Double-blind | Omaveloxolone Lotion 0.5%, Omaveloxolone Lotion 3%, Vehicle Lotion |
| NCT05105841 Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax in Combination With Intravenous (IV) Obinutuzumab or Oral Ibrutinib in Adult Participants With Untreated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) | Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) | P2 | Completed | 20 | RCT, Open-label | Venetoclax, Ibrutinib, Obinutuzumab |
| NCT02719613 Continuing Treatment for Participants Who Have Participated in a Prior Protocol Investigating Elotuzumab | Multiple Myeloma | P2 | Completed | 67 | Open-label | Elotuzumab, Dexamethasone, Dexamethasone, Lenalidomide, Bortezomib, Pomalidomide, Nivolumab |
| NCT01579279 A Study Comparing the Efficacy and Safety of ABT-652 to Placebo in Subjects With Diabetic Neuropathic Pain | Diabetic Neuropathic Pain | P2 | Terminated | 1 | RCT, Double-blind | ABT-652 6 mg, ABT-652 12 mg, ABT-652 12 mg - 18 mg, Placebo, Duloxetine |
| NCT04372628 Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 | COVID-19 | P2 | Completed | 452 | RCT, Double-blind | Lopinavir/Ritonavir 400 mg/100 mg |
| NCT02674568 Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer | Small Cell Lung Cancer | P2 | Completed | 342 | Open-label | Rovalpituzumab tesirine |
| NCT06605599 Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipolar I or II Disorder | Bipolar I Disorder, Bipolar II Disorder | P2 | Completed | 161 | RCT, Double-blind | ABBV-932, Placebo for ABBV-932 |
| NCT00948909 Efficacy and Safety Study for Subjects With Mild-to-Moderate Alzheimer's Disease | Alzheimer's Disease | P2 | Completed | 274 | RCT, Double-blind | Placebo, ABT-126, donepezil |
| NCT01163617 The Usability and Injection Time of the Physiolis Syringe and Autoinjector in Rheumatoid Arthritis Patients | Rheumatoid Arthritis | P2 | Completed | 85 | RCT, Open-label | — |
| NCT02055820 A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax Combined With Chemotherapy in Participants With B-Cell Non-Hodgkin's Lymphoma (NHL) and DLBCL | Lymphoma, Non-Hodgkin | P1P2 | Completed | 267 | RCT, Open-label | Venetoclax, Cyclophosphamide, Obinutuzumab, Rituximab, Doxorubicin, Vincristine, Prednisone |
| NCT03567876 Rituximab, Bendamustine and Cytarabine Followed by Venetoclax in High Risk Elderly Patients With MCL | Lymphoma, Mantle-Cell | P2 | Completed | 141 | Open-label | Venetoclax |
| NCT05025423 Phase II Trial of Venetoclax and Rituximab as Initial Therapy in Older Patients With Mantle Cell Lymphoma | Mantle Cell Lymphoma | P2 | Terminated | 7 | Open-label | Venetoclax Oral Tablet [Venclexta] |
| NCT01479127 Study of Safety, Tolerability, Pharmacokinetics, and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease | Advanced Parkinson's Disease | P2 | Completed | 8 | Open-label | ABT-SLV187, Oral Levodopa/Carbidopa |
| NCT01671904 A Study of Venetoclax in Combination With Bendamustine + Rituximab or Bendamustine + Obinutuzumab in Participants With Relapsed/Refractory or Previously Untreated Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P1 | Completed | 84 | Open-label | Bendamustine, Obinutuzumab, Rituximab, Venetoclax |
| NCT04196283 A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 Plus Tilsotolimod and Other Therapy Combinations in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma | Advanced Solid Tumors Cancer | P1 | Completed | 30 | Open-label | ABBV-368, Tilsotolimod, Nab-paclitaxel, ABBV-181 |
| NCT03955783 Venetoclax and Selinexor in Treating Patients with Relapsed or Refractory High Risk Hematologic Malignancies | Diffuse Large B-cell Lymphoma, Acute Myeloid Leukemia | P1 | Completed | 78 | Open-label | Venetoclax, Selinexor |
| NCT00733187 Pharmacokinetic Study To Evaluate Effect of Food and Diurnal Variation on ABT-869 | Advanced Solid Tumors | P1 | Completed | 34 | Open-label | ABT-869 |
| NCT01328626 A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma | Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma | P1 | Completed | 222 | Open-label | ABT-199 |
| NCT01682616 A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma | Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia | P1 | Completed | 49 | Open-label | ABT-199, Rituximab |
| NCT00868413 Study of ABT-263 When Administered in Combination With Either Fludarabine/Cyclophosphamide/Rituximab or Bendamustine/Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | P1 | Completed | 32 | Open-label | ABT-263, FCR, BR |
| NCT02640833 A Study of Duvelisib and Venetoclax in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Indolent or Aggressive Non-Hodgkin Lymphoma, Who Have Not Previously Received a Bcl-2 or PI3K Inhibitor | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | P1 | Withdrawn | — | Open-label | Duvelisib, Venetoclax |
| NCT04306900 TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers | Solid Tumor, Adult | P1 | Completed | 185 | Open-label | — |
| NCT01969695 An Extension Study of ABT-199 in Subjects With Advanced Non-Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | P1 | Completed | 11 | Open-label | ABT-199 |
| NCT00891605 Safety Study of ABT-263 in Combination With Paclitaxel in Subjects With Solid Tumors | Solid Tumors | P1 | Completed | 19 | Open-label | ABT-263, paclitaxel |
| NCT00878449 A Study Evaluating the Safety of ABT-263 in Combination With Etoposide/Cisplatin in Subjects With Cancer | Solid Tumors | P1 | Completed | 12 | Open-label | ABT-263, etoposide/cisplatin |
| NCT02203773 Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML) | Acute Myelogenous Leukemia, Myelogenous Leukemia | P1 | Terminated | 212 | Open-label | Posaconazole, ABT-199, Decitabine, Azacitidine |
| NCT03441555 A Study of Venetoclax and Alvocidib in Patients With Relapsed/Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia (AML) | P1 | Completed | 36 | Open-label | Venetoclax, Alvocidib |
| NCT03625505 A Study to Assess Safety and Efficacy of Venetoclax in Combination With Gilteritinib in Participants With Relapsed/Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia (AML) | P1 | Completed | 61 | Open-label | Venetoclax, Gilteritinib |
| NCT02095574 A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma | Relapsed/Refractory Non-Hodgkin's Lymphoma | P1 | Withdrawn | — | Open-label | [14C]ABT-199 (GDC-0199) |
| NCT01594229 A Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Combination With Bendamustine/Rituximab (BR) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | P1 | Completed | 60 | Open-label | ABT-199, Rituximab, Bendamustine |
| NCT00788684 Safety Study of ABT-263 in Combination With Rituximab in Lymphoid Cancers | CD20-Positive Lymphoid Malignancies, Chronic Lymphoid Leukemia | P1 | Completed | 29 | Open-label | rituximab, ABT-263 |
| NCT03797261 A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies | Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma | P1 | Terminated | 9 | Open-label | Venetoclax, AMG 176 |
| NCT01794507 A Study Evaluating ABT-199 in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy | Relapsed/Refractory Multiple Myeloma | P1 | Completed | 66 | Open-label | ABT-199, bortezomib, dexamethasone |
| NCT02598570 Study Evaluating Duvelisib in Japanese Subjects With Relapsed or Refractory Lymphoma | Lymphoma | P1 | Completed | 7 | Open-label | duvelisib |
| NCT01969682 A Study to Assess the Effect of Rifampin on the Metabolism of ABT-199 | Non-Hodgkin's Lymphoma | P1 | Withdrawn | — | Open-label | ABT-199, Rifampin |
| NCT01969669 A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-199 | Non-Hodgkin's Lymphoma | P1 | Completed | 12 | Open-label | ABT-199, Ketoconazole |
| NCT00887757 Safety Study of ABT-263 in Combination With Gemzar (Gemcitabine) in Subjects With Solid Tumors | Solid Tumors | P1 | Completed | 46 | Open-label | ABT-263, gemcitabine |
| NCT01685892 A Study of Venetoclax in Combination With Obinutuzumab in Participants With Chronic Lymphocytic Leukemia | Lymphocytic Leukemia, Chronic | P1 | Completed | 82 | Open-label | Obinutuzumab, Venetoclax |
| NCT00982566 Assess the Oral Bioavailability of a New ABT-263 Formulation in Subjects With Cancer | Lymphoid Malignancy, Solid Tumors | P1 | Completed | 37 | RCT, Open-label | ABT-263, ABT-263, ABT-263, ABT-263 |
| NCT02966782 A Study Evaluating Venetoclax Alone and in Combination With Azacitidine in Participants With Relapsed/Refractory Myelodysplastic Syndromes (MDS) | Myelodysplastic Syndromes (MDS) | P1 | Completed | 70 | Open-label | venetoclax, azacitidine |
| NCT01484990 A Pharmacokinetic Study of Levodopa and Carbidopa Intestinal Gel in Subjects With Advanced Parkinson's Disease | Parkinson Disease | P1 | Completed | 19 | Open-label | Levodopa-Carbidopa |
| NCT00986037 Assessment of the Safety of ABT-308 in Healthy Volunteers and Subjects With Asthma | Asthma | P1 | Completed | 47 | RCT, Double-blind | ABT-308, ABT-308, Placebo, Placebo |
| NCT05274087 Study to Evaluate the Effect of Different Warm-Up Times of Risankizumab Autoinjector (AI) on the Injection Pain Experiences in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 30 | RCT, Double-blind | Risankizumab |
| NCT06278766 A Study to Assess the Mass Balance of [14C] ABBV-552 in Healthy Male Participants Following Single Oral Dose Administration | Healthy Volunteer | P1 | Completed | 8 | Open-label | ABBV-552 |
| NCT02596217 Safety, Tolerability and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Healthy Asian and Caucasian Male Volunteers | Healthy | P1 | Completed | 80 | RCT, Double-blind | ABBV-066, ABBV-066, Placebo, Placebo |
| NCT05538585 A Study to Assess How Food Affects the Safety and Pharmacokinetics of Galicaftor and Navocaftor | Healthy Volunteers | P1 | Completed | 24 | RCT, Open-label | Galicaftor, Navocaftor |
| NCT01472016 Study of ABT-700 in Subjects With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 74 | Open-label | ABT-700, docetaxel, FOLFIRI, cetuximab, erlotinib, ABT-700 |
| NCT04480086 Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With Ruxolitinib Tablet or Navitoclax Tablet in Adult Participants With Myelofibrosis | Myelofibrosis (MF) | P1 | Terminated | 1 | Open-label | Mivebresib, Navitoclax, Ruxolitinib |
| NCT01403038 An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females | Folliculogenesis | P1 | Completed | 216 | RCT, Open-label | Elagolix, Elagolix, Elagolix, Elagolix, Elagolix, Elagolix, elagolix |
| NCT06151561 Study of AGN-151586 in Japanese Participants With Moderate to Severe Glabellar Lines | Moderate to Severe Glabellar Lines | P1 | Completed | 24 | RCT, Double-blind | AGN-151586, Placebo |
| NCT05836506 A Study to Assess the Relative Bioavailability of Immediate Release Formulations of ABBV-903 in Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 24 | RCT, Open-label | ABBV-903 Tablet Form 1, ABBV-903 Tablet Form 2 |
| NCT05644977 A Multiple Dose Trial of Emraclidine in Elderly Participants and in Participants With Dementia Due to Alzheimer's Disease | Healthy Participants, Alzheimer's Disease Dementia | P1 | Completed | 17 | RCT, Double-blind | Emraclidine, Placebo |
| NCT06024239 A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD) | Healthy Volunteers, Generalized Anxiety Disorder (GAD) | P1 | Completed | 72 | RCT, Double-blind | ABBV-932, Placebo for ABBV-932 |
| NCT03086239 A Study on the Safety and Tolerability of Rovalpituzumab Tesirine in Japanese Patients With Advanced, Recurrent Small Cell Lung Cancer | Small Cell Lung Cancer | P1 | Completed | 29 | Open-label | Rovalpituzumab tesirine |
| NCT01800695 Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme | Glioblastoma Multiforme | P1 | Completed | 202 | Open-label | ABT-414, Temozolomide |
| NCT07024797 Study to Assess the Adverse Events, Tolerability, and How Oral Doses of ABBV-932 Moves Through the Body in Healthy Adult Chinese Participants | Healthy Volunteer | P1 | Completed | 20 | RCT, Double-blind | ABBV-932, Placebo for ABBV-932 |
| NCT07219017 A Study to Assess the Mass Balance of Oral ABBV-1354 in Healthy Adult Male Participants | Healthy Volunteer | P1 | Completed | 8 | Open-label | ABBV-1354 |
| NCT06698926 A Study to Assess the Safety, Tolerability, and Interactions of ABBV-CLS-616 Oral Tablets in Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 110 | RCT, Double-blind | ABBV-CLS-616, Placebo, Itraconazole |
| NCT00888693 A Multiple Dose Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ABT-288 in Stable Subjects With Schizophrenia | Schizophrenia | P1 | Completed | 81 | RCT, Double-blind | ABT-288, Placebo |
| NCT06300580 Study of Oral ABBV-932 Capsules to Evaluate Dopamine D2 and D3 Receptor Occupancy in Brain in Adult Healthy Volunteers | Healthy Volunteers | P1 | Completed | 11 | Open-label | ABBV-932 |
| NCT06887010 A Study to Assess How Food Affects the Movement of Oral ABBV-101 Through the Body of Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 17 | RCT, Open-label | ABBV-101 |
| NCT02419560 Optimal Dose Finding Study ABT-199 and Ibrutinib in MCL | Lymphoma, Mantle-Cell, Recurrent Lymphoma, Mantle-Cell | P1 | Completed | 37 | Open-label | ABT-199 and Ibrutinib Combination |
| NCT06722417 A Single Dose Study to Assess Adverse Events and How Oral Icalcaprant Moves Through the Body in Healthy Adult Japanese and Han Chinese Participants | Healthy Volunteer | P1 | Completed | 16 | Open-label | Icalcaprant |
| NCT00850044 Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1 | HCV Infection | P1 | Completed | 87 | RCT, Double-blind | ABT-450, ritonavir, placebo for ABT-450, Placebo for ritonavir |
| NCT02750384 Bioavailability and Effect of Food on DSM265 Granules in Healthy Adult Subjects | Healthy Volunteers, Bioavailability | P1 | Terminated | 11 | RCT, Open-label | DSM265 50% SDD granules, DSM265 25% SDD powder for suspension |
| NCT04274933 A Study to Evaluate the Safety and Tolerability of Venetoclax Tablets in Combination With Capecitabine Tablets in Adult Participants With Hormone Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Who Had Disease Progression During or After CDK4/6 Inhibitor Therapy | Breast Cancer, Cancer | P1 | Terminated | 4 | Open-label | Venetoclax, Capecitabine |
| NCT06054425 A Study to Compare the Bioavailability of Intravenously Infused Risankizumab Manufactured by Two Different Processes in Healthy Adults | Healthy Volunteers | P1 | Completed | 48 | RCT, Open-label | Risankizumab |
| NCT02483104 Veliparib in Combination With Carboplatin And Weekly Paclitaxel in Japanese Subjects With Ovarian Cancer | Ovarian Cancer | P1 | Completed | 9 | Open-label | veliparib, carboplatin, paclitaxel |
| NCT03145909 A Study Evaluating the Safety, Pharmacokinetics and Anti-Tumor Activity of ABBV-176 in Subjects With Advanced Solid Tumors Likely to Express Prolactin Receptor (PRLR) | Advanced Solid Tumors Cancer | P1 | Terminated | 19 | Open-label | ABBV-176 |
| NCT04274907 A Safety Study of Oral Venetoclax in Combination With Intravenous Pembrolizumab in Adult Participants With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) With High Programmed Cell Death Ligand-1 (PD-L1) Expression | Non Small Cell Lung Cancer, Cancer | P1 | Terminated | 2 | RCT, Open-label | Venetoclax, Pembrolizumab |
| NCT00649207 A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases | Brain Diseases, Brain Neoplasms | P1 | Completed | 80 | Open-label | ABT-888 |
| NCT05763459 A Phase 1 Study of ABBV-CLS-7262, Rosuvastatin, and Digoxin in Healthy Subjects | Healthy | P1 | Completed | 12 | Open-label | ABBV-CLS-7262 |
| NCT03145948 A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ABBV-553 in Healthy Volunteers and in Subjects With Psoriasis and Efficacy of ABBV-553 in Subjects With Psoriasis | Psoriasis | P1 | Terminated | 12 | RCT, Double-blind | ABBV-553, Placebo |
| NCT02944396 Study of Veliparib in Combination With Nivolumab and Platinum Doublet Chemotherapy in Participants With Metastatic or Advanced Non-Small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer | P1 | Completed | 25 | RCT, Open-label | pemetrexed, nivolumab, paclitaxel, veliparib, carboplatin |
| NCT05686980 A Study to Assess the Adverse Events and How Oral ABBV-552 Capsules Moves Through the Body of Healthy Adult Japanese and Han Chinese Participants | Healthy Volunteers | P1 | Completed | 18 | Open-label | ABBV-552 |
| NCT01741493 A Study in Healthy Adults and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Doses of ABT-494 | Rheumatoid Arthritis | P1 | Completed | 67 | RCT, Double-blind | ABT-494, Placebo, Tofacitinib |
| NCT03400306 A Study Evaluating the Bioavailability and Food Effect of Veliparib Tablets Followed by an Extension in Subjects With Ovarian Cancer | Cancer - Ovarian | P1 | Withdrawn | — | RCT, Open-label | Veliparib, capsule, Veliparib, tablet, Carboplatin, Paclitaxel |
| NCT01133548 Pharmacokinetic and Comparative Bioavailability Study of Testosterone Absorption After Administration of Testosterone Gel 1.62% to the Upper Arms/Shoulders Using an Application Site Rotation or a Combination of Application Sites in Hypogonadal Males | Hypogonadism | P1 | Completed | 62 | RCT, Open-label | Testosterone Gel 1.62%, Testosterone Gel 1.62% |
| NCT05940402 A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function | Renal Impairment | P1 | Completed | 58 | Open-label | Emraclidine |
| NCT04417465 First In Human Study With ABBV-CLS-579 When Given Alone and In Combination In Participants With Locally Advanced Or Metastatic Tumors | Advanced Solid Tumors Cancer | P1 | Completed | 101 | Open-label | ABBV-CLS-579, PD-1 inhibitor, VEGFR TKI |
| NCT03311477 A Study to Evaluate the Safety and Pharmacokinetics ABBV-399 in Japanese Participants With Solid Tumors | Advanced Solid Tumors Cancer | P1 | Completed | 9 | Open-label | ABBV-399 |
| NCT03000257 A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 182 | Open-label | Venetoclax, Rovalpituzumab Tesirine, ABBV-181 |
| NCT03181126 A Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic Lymphoma | Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma | P1 | Completed | 69 | Open-label | Navitoclax, Chemotherapy, Venetoclax |
| NCT04807972 Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 is Administered in Combination With IV Modified FOLFIRINOX (mFFX) With or Without IV Budigalimab Compared to mFFX in Adult Participants With Untreated Pancreatic Cancer Metastasis | Pancreatic Cancer | P1 | Terminated | 40 | RCT, Open-label | ABBV-927, Budiglimab, modified FOLFIRINOX |
| NCT04070768 Study of the Safety and Efficacy of Gemtuzumab Ozogamicin (GO) and Venetoclax in Patients With Relapsed or Refractory CD33+ Acute Myeloid Leukemia:Big Ten Cancer Research Consortium BTCRC-AML17-113 | Acute Myeloid Leukemia | P1 | Completed | 18 | Open-label | Gemtuzumab Ozogamicin, Venetoclax |
| NCT01110473 ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies | Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | P1 | Completed | 52 | Open-label | ABT-348, ABT-348, ABT-348 and azacitidine, ABT-348 |
| NCT01225302 A Study of Linifanib (ABT-869) in Combination With Carboplatin/Paclitaxel in Japanese Subjects With Non-Small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer | P1 | Completed | 12 | Open-label | Linifanib, Linifanib, Carboplatin, Paclitaxel |
| NCT01617928 A Study of Veliparib in Combination With Carboplatin and Paclitaxel in Japanese Subjects With Solid Tumors | Solid Tumors | P1 | Completed | 12 | Open-label | veliparib (ABT-888), carboplatin, paclitaxel |
| NCT05376839 A Study to Assess Safety of Cedirogant and How Cedirogant Moves Through the Body in Adult Participants With Mild, Moderate and Severe Hepatic Impairment | Hepatic Impairment | P1 | Terminated | 6 | Open-label | Cedirogant |
| NCT03234712 A Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of ABBV-321 in Subjects With Advanced Solid Tumors Associated With Overexpression of the Epidermal Growth Factor Receptor (EGFR) | Advanced Solid Tumors Cancer | P1 | Completed | 62 | Open-label | ABBV-321 |
| NCT05564650 Navitoclax in Relapsed or Refractory High-Risk Myelodysplastic Syndrome | Myelodysplastic Syndrome, Recurrent Myelodysplastic Syndrome | P1 | Completed | 6 | Open-label | Navitoclax, Venetoclax, Decitabine |
| NCT01908478 Veliparib in Combination With Gemcitabine and Intensity Modulated Radiation Therapy in Patients With Pancreatic Cancer | Pancreatic Cancer | P1 | Completed | 34 | Open-label | Veliparib, Gemcitabine |
| NCT06937619 A Study to Assess the Relative Bioavailability of Risankizumab Following Subcutaneous Administration With On-Body Injector in Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 263 | RCT, Open-label | Risankizumab |
| NCT03922607 A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ABBV-157 in Healthy Volunteers and in Participants With Chronic Plaque Psoriasis | Psoriasis | P1 | Completed | 65 | RCT, Double-blind | ABBV-157, Placebo for ABBV-157 |
| NCT02365662 A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely to Exhibit Elevated Levels of Epidermal Growth Factor Receptor | Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer | P1 | Terminated | 46 | Open-label | ABBV-221 |
| NCT03374917 A Study in Subjects With Parkinson's Disease to Evaluate the Safety and Tolerability of Titration and Continuous Subcutaneous Infusion of ABBV-951 in an Outpatient Environment | Parkinson's Disease (PD) | P1 | Completed | 20 | Open-label | ABBV-951 |
| NCT05268068 A Study of Intravenously (IV) Infused or Subcutaneously (SC) Injected Risankizumab in Healthy Adult Participants in China | Healthy Volunteers | P1 | Completed | 30 | RCT, Open-label | Risankizumab, Risankizumab |
| NCT06477926 A Study to Assess Relative Bioavailability and Food Effect of ABBV-668 Extended-Release Formulations in Adult Participants | Healthy Volunteers | P1 | Completed | 25 | RCT, Open-label | ABBV-668 IR, ABBV-668 ER |
| NCT02029716 RTA 408 Lotion in Healthy Volunteers | Healthy | P1 | Completed | 109 | RCT, Double-blind | RTA 408 Lotion 0.5%, 1%, 3%, Lotion vehicle/placebo |
| NCT06571266 A Study to Assess the Relative Bioavailability of Two Formulations of Risankizumab Following Subcutaneous Administration With Prefilled Syringes in Healthy Adult Participants | Healthy Volunteers | P1 | Completed | 231 | RCT, Open-label | Risankizumab |
| NCT04262791 A Non-Drug Study Detecting And Quantifying Nocturnal Scratch Behaviors From Wrist Actigraphy Data In Adult Healthy Volunteers And Participants With Atopic Dermatitis (AD) | Atopic Dermatitis | P1 | Terminated | 16 | Open-label | — |
| NCT02601885 A Multiple Dose Study of ABT-555 in Subjects With Relapsing Forms of Multiple Sclerosis | Multiple Sclerosis | P1 | Completed | 20 | RCT, Double-blind | ABT-555 |
| NCT00696904 Study of ABT-333 in Both Healthy Volunteers and Hepatitis C Virus (HCV) + Genotype 1 Infected Subjects | HCV Infection | P1 | Completed | 133 | RCT, Double-blind | ABT-333, Placebo |
| NCT01063816 A Study of ABT-888 in Combination With Carboplatin and Gemcitabine in Subjects With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 79 | Open-label | veliparib (ABT-888), carboplatin, gemcitabine |
| NCT06402513 A Study in Healthy Adult Participants to Assess the Pharmacokinetics, Immunogenicity, Safety, and Tolerability of a Ravagalimab Subcutaneous Formulation in a Pre-Filled Syringe | Healthy Volunteers | P1 | Completed | 12 | Open-label | Ravagalimab |
| NCT05094050 Study to Assess How ABBV-951 is Absorbed When Administered at Different Subcutaneous Sites of Adult Participants With Parkinson's Disease | Parkinson's Disease | P1 | Completed | 16 | RCT, Open-label | ABBV-951 |
| NCT03138408 SC-004 Alone or With ABBV-181 in Subjects With Epithelial Ovarian, Fallopian Tube, Primary Peritoneal and Endometrial Cancers | Cancer | P1 | Terminated | 24 | Open-label | SC-004, ABBV-181 |
| NCT01121133 A Study to Assess the Effect of Rifampin on the Metabolism of Navitoclax | Lymphoma, Including Chronic Lymphocytic Leukemia, Solid Tumors | P1 | Completed | 12 | Open-label | navitoclax, Rifampin |
| NCT06487572 A Study to Assess Pharmacokinetic Exposures Following Intravenous and Subcutaneous Administration of Risankizumab in Healthy Participants | Healthy Volunteers | P1 | Completed | 60 | RCT, Open-label | Risankizumab, Risankizumab |
| NCT00718380 A Phase 1 Study of ABT-869 in Subjects With Solid Tumors | Solid Tumor | P1 | Completed | 18 | Open-label | ABT-869 |
| NCT02955251 A Study of ABBV-428, an Immunotherapy, in Subjects With Advanced Solid Tumors | Advanced Solid Tumors Cancer | P1 | Completed | 61 | Open-label | ABBV-428, Nivolumab |
| NCT01908010 Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors | Alzheimer's Disease | P1 | Completed | 20 | RCT, Double-blind | ABT-354, ABT-354, Placebo |
| NCT06607601 CARE Initiative: Real-world Emulation of the PALOMA-2 Trial | Metastatic Breast Cancer | Completed | 724 | — | Palbociclib, Letrozole | |
| NCT02305953 Cytokines and Vascular Inflammation in Psoriasis | Vascular Inflammation, Psoriasis | Completed | 96 | — | — | |
| NCT01078597 A Study on the Prevalence of the Modified Citrullinated Vimentin Anti-body (Anti-MCV) in an Irish Rheumatoid Arthritis (RA) Population and to Assess the Impact of Anti-MCV and the Anti-cyclic-citrullinated Peptide Antibody (Anti-CCP) Status on the Management of Irish Patients With Early RA | Rheumatoid Arthritis | Completed | 35 | — | — | |
| NCT01387802 Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Ankylosing Spondylitis | Ankylosing Spondylitis | Completed | 722 | — | — | |
| NCT01559038 Canadian Humira Post Marketing Observational Epidemiological Study Assessing Effectiveness in Psoriatic Arthritis | Psoriatic Arthritis | Completed | 483 | — | — | |
| NCT02922192 Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis | Rheumatoid Arthritis, Inflammatory Bowel Disease | Completed | 90,360 | — | TNF-α antagonists, non-TNFs, DMARD non-biologics | |
| NCT02922179 Descriptive Analysis of Long- and Intermediate-Acting Insulin in Adult Diabetics | Diabetes | Completed | 103,951 | — | Long- and intermediate- acting insulins | |
| NCT06607393 CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS3] | Metastatic Nonsmall Cell Lung Cancer | Completed | 851 | — | Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin | |
| NCT01387815 Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Psoriasis | Psoriasis | Completed | 662 | — | Adalimumab | |
| NCT06585189 CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS4] | Metastatic Non Small Cell Lung Cancer | Completed | 304 | — | Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin | |
| NCT01960881 Evaluation of Diet and Exercise in Prostate Cancer Patients | Prostate Cancer | Completed | 1,331 | — | — | |
| NCT01386684 Real Life Evaluation of Lupron in the Management of Prostate Cancer: A Canadian Post Marketing Observational Study | Prostate Cancer | Completed | 552 | — | — | |
| NCT01652157 Long-term Study in US Cystic Fibrosis Patients Receiving Digestive Enzyme Supplements to Assess Narrowing of the Large Intestine Causing Adverse Intestinal Symptoms (Fibrosing Colonopathy) | Fibrosing Colonopathy | Terminated | 17 | — | ULTRESA, PANCREAZE, CREON, ZENPEP, other non-sponsor pancreatic enzyme replacement therapy, PERTZYE | |
| NCT04721002 Study to Evaluate t(11;14) Status and BCL2 Expression in Adult Participants With Multiple Myeloma (MM) | Multiple Myeloma (MM) | Completed | 514 | — | — | |
| NCT02739828 Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients | Hidradenitis Suppurativa | Completed | 24 | — | Adalimumab | |
| NCT05394805 A Study of Subcutaneous HUMIRA (Adalimumab) Injection to Assess Adverse Events and Change in Disease Activity In Adult Participants With Moderate to Severe Active Crohn's Disease (CD) | Crohn's Disease | Completed | 156 | — | — | |
| NCT06503536 A Study to Assess Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization in Chinese Participants Receiving Upadacitinib for Atopic Dermatitis (AD) Through Chart Review | Atopic Dermatitis (AD) | Completed | 150 | — | — | |
| NCT04278235 Expanded Access to Elezanumab | Acute Spinal Cord Injury (SCI) | NO_LONGER_AVAILABLE | — | — | Elezanumab | |
| NCT05413785 Hepatitis C Treatment in Probation and Parole Office | Hepatitis C, HCV | N/A | Completed | 77 | Open-label | — |
| NCT01401452 Effectiveness of Adalimumab in Moderate to Severe Plaque Psoriasis Patients With Distinct Co-morbidities | Moderate to Severe Plaque Psoriasis | Completed | 246 | — | — | |
| NCT02158507 Pilot Study of Veliparib (ABT-888) and Lapatinib (Tykerb) in Patients With Metastatic, Triple Negative Breast Cancer | Metastatic Triple Negative Breast Cancer | N/A | Completed | 20 | Open-label | Combination of Veliparib + Lapatinib |
| NCT02028169 To Observe the Impacts of Anti-Tumor Necrosis Factor (TNF) Effectiveness on Improvement in Work Place and Household Productivity for Patients With Psoriatic Arthritis (PsA) | Psoriatic Arthritis, Work Productivity | Completed | 120 | — | — | |
| NCT04655261 Study of Oral Venetoclax Tablets in Combination With Intravenous Obinutuzumab Injection to Assess Achievement of Best Response in Adult Participants With Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia (CLL) | Terminated | 5 | — | — | |
| NCT02627924 Real-World Outcome of Rheumatoid Arthritis Patients in Korea on Adalimumab | Rheumatoid Arthritis | Completed | 91 | — | — | |
| NCT01356758 Cardiovascular Risk Assessment in Patients With Severe Psoriasis Treated With Biologic Agents | Psoriasis, Atopic Dermatitis | Completed | 126 | — | biological treatment | |
| NCT02640547 Real World Evidence of the Effectiveness of Paritaprevir/Ritonavir, Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C | Chronic Hepatitis C | Completed | 394 | — | — | |
| NCT04196647 Guideline for Hometitration With Duodopa for Parkinson Patients | Parkinson Disease | Completed | 10 | — | — | |
| NCT05210803 Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD | Neovascular Age-Related Macular Degeneration (nAMD), Gene Therapy | By Invite | 115 | — | — | |
| NCT05394792 An Observational Study of Upadacitinib to Assess Change in Disease Activity in Canadian Adult Participants With Moderate-to-Severe Atopic Dermatitis Who Are Inadequate Responders To or Discontinuing Dupilumab | Atopic Dermatitis | Completed | 111 | — | — | |
| NCT04253314 A Study of the Effectiveness of Venetoclax Tablets in Adult Acute Myeloid Leukemia Participants Ineligible for Standard Induction Therapy in Russian Federation | Acute Myeloid Leukemia (AML) | Completed | 51 | — | — | |
| NCT01316224 Prevalence and Incidence of Articular Symptoms and Signs Related to Psoriatic Arthritis in Patients With Psoriasis Severe or Moderate With Adalimumab Treatment | Psoriasis, Psoriatic Arthritis | Completed | 52 | — | — | |
| NCT07639632 Reduce Inefficiencies in Management of Spasticity | Stroke | N/A | Not Yet Recruiting | 80 | RCT, Open-label | — |
| NCT06439394 An Observational Study to Assess Optive MEGA-3 (OM3) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED) | Dry Eye | Completed | 52 | — | Optive MEGA-3 (OM3) | |
| NCT04140175 A Study of Women Receiving Standard of Care (SOC) for the Treatment of Pelvic Pain Due to Suspected or Confirmed Endometriosis and the Impact on the Disease or Symptom Progression. | Endometriosis, Chronic Pelvic Pain | Terminated | 291 | — | — | |
| NCT07604545 A Study to Assess the Use of Artificial Intellignce to Predict Eye Treatment Changes in Adult Participants With Diabetic Macular Edema | Diabetic Macular Edema | Not Yet Recruiting | 554 | — | — | |
| NCT02451839 An ObserVatIonal STudy of the Effectiveness of AdaLimumab on Health and Disability Outcomes in New Zealand Patients With Immune-Mediated InflammaTorY Diseases (VITALITY) | Crohn's Disease, Rheumatoid Arthritis | Completed | 168 | — | — | |
| NCT03740230 An Observational Study of Maviret (Glecaprevir/Pibrentasvir) for Korean Chronic Hepatitis C Genotypes 1 to 6 Patients According to the Standard for Re-examination of New Drugs | Hepatitis C | Completed | 3,134 | — | — | |
| NCT03099083 Real-World Outcome of Psoriasis Subjects in Korea on Adalimumab | Psoriasis | Completed | 97 | — | — | |
| NCT03498625 Crohn's Disease Endoscopic REmission Definition in an Objective Way | CD | N/A | Completed | 240 | Open-label | — |
| NCT02985658 Expanded Access With ABT-888 (Veliparib) to Treat Metastatic Breast Cancer | Metastatic Breast Cancer With BRCA 1 or BRCA 2 Genetic Mutation, Triple-Negative Breast Cancer | NO_LONGER_AVAILABLE | — | — | Veliparib, Cisplatin, Vinorelbine | |
| NCT04445025 Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis | Infertility, Endometriosis | Early P1 | Completed | 30 | RCT, Open-label | Elagolix 200 MG, Leuprolide Acetate 3.75 MG/ML |
| NCT03064815 The SpACE Study - Small Bowel Crohn's Disease and Spondyloarthropathies | Spondyloarthropathy, Crohn Disease | N/A | Completed | 67 | RCT, Open-label | — |
| NCT01073462 Study to Evaluate the Effect of Intravenous (IV) Paricalcitol (Zemplar) on Cardiac Morbidity in Patients With Chronic Kidney Disease (CKD) Stage 5 Over 2 Years | Secondary Hyperparathyroidism, Chronic Kidney Disease Stage V | Completed | 67 | — | — | |
| NCT01224782 Evaluation of Treatment With Zemplar Capsules in the Therapy of Secondary Hyperparathyroidism (SHPT) | Chronic Kidney Disease, Secondary Hyperparathyroidism | Completed | 994 | — | — | |
| NCT01346488 Special Investigation in Patients With Rheumatoid Arthritis (Working Productivity Activity Impairment) | Rheumatoid Arthritis | Completed | 2,088 | — | — | |
| NCT00799877 Chronic Plaque Psoriasis (Ps) Registry | Chronic Plaque Psoriasis | Completed | 6,065 | — | — | |
| NCT01117480 Real Life Evaluation of Rheumatoid Arthritis in Canadians Taking HUMIRA | Moderate-to-severe Rheumatoid Arthritis | Completed | 1,013 | — | — | |
| NCT02807402 Effectiveness of Paritaprevir/Ritonavir, Ombitasvir, + Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C in Romania | Chronic Hepatitis C | Completed | 522 | — | — | |
| NCT01474876 Multi-country Post-Marketing Observational Study on Maintenance of Effectiveness of Adalimumab (Humira®) in Patients With Ankylosing Spondylitis and Psoriatic Arthritis | Ankylosing Spondylitis, Psoriatic Arthritis | Completed | 566 | — | — | |
| NCT04577482 Study of Oral Glecaprevir/Pibrentasvir Tablets in Participants Aged 12 Years or Older With Chronic Hepatitis C to Assess Sustained Virological Response | Hepatitis C Virus (HCV) | Completed | 42 | — | — | |
| NCT05959070 An Observational Study to Validate the Cumulative Life Course Impairment (CLCI) Instrument (DermCLCI-p) in Adult Participants With Moderate to Severe Chronic Plaque Psoriasis (PsO) | Psoriasis | Completed | 154 | — | — | |
| NCT04198415 A Study of the Safety and Efficacy of Venetoclax in Japanese Participants With Relapsed and Refractory Chronic Lymphocytic Leukemia (Including Small Lymphocytic Leukemia) | Cancer, Chronic Lymphocytic Leukemia (CLL) | Completed | 4 | — | — | |
| NCT01169987 Evaluation of Humira Retention Rate in Psoriasis Patients in Daily Practice and Assessment of Work Productivity and Quality of Life | Psoriasis | Completed | 191 | — | — | |
| NCT02945228 Drug Use-Results Survey in Participants Infected With Hepatitis C Virus Genotype 2 | Chronic Hepatitis C Virus | Completed | 449 | — | — | |
| NCT03002818 Quality of Life Measurement in Treatment Naïve Patients With Hepatitis C Virus (HCV) Genotype 1 (GT1) Suffering From Fatigue and Receiving Ombitasvir, Paritaprevir, and Ritonavir and Dasabuvir (Viekirax®/Exviera®) | Chronic Hepatitis C Virus (HCV) | Completed | 41 | — | — | |
| NCT01412021 Special Investigation (All Case Survey) in Patients With Juvenile Idiopathic Arthritis | Arthritis, Juvenile Rheumatoid | Completed | 375 | — | — | |
| NCT04500106 Study to Assess Participant/Caregiver/Investigator Satisfaction of Video-Assisted Telenursing in Adult Participants With Parkinson's Disease Treated With Levodopa-Carbidopa Intestinal Gel | Parkinson's Disease | Completed | 41 | — | — | |
| NCT02750800 Post-marketing Observational Study to Evaluate the Incremental Impact of AbbVie's Patient Support Program on Patient Reported Outcomes and Health Resource Utilization in Inflammatory Arthritis, Psoriasis and Inflammatory Bowel Diseases in Hungary (VALUE) | Rheumatoid Arthritis, Ankylosing Spondylitis | Completed | 427 | — | Adalimumab | |
| NCT06362044 A Study to Assess Frequency of Undetectable Minimal Residual Disease (uMRD) in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Venetoclax Tablets ± Intravenously (IV) Infused Rituximab in Routine Clinical Practice in Japan | Chronic Lymphocytic Leukemia | Completed | 89 | — | — | |
| NCT00908544 New Era Study: Treatment With Multi Drug Class (MDC) HAART in HIV Infected Patients | HIV Infections | N/A | Completed | 47 | Open-label | — |
| NCT02506179 Impact of Adalimumab on Patient-reported Outcomes in Ulcerative Colitis | Ulcerative Colitis | Completed | 100 | — | — | |
| NCT01282086 Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Requiring General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on the Cardiovascular System in Common Clinical Practice | Anesthesia, General | Completed | 1,365 | — | — | |
| NCT05170646 An Observational Study to Assess the Real-World Effectiveness of Upadacitinib in Adult Participants With Rheumatoid Arthritis | Rheumatoid Arthritis | Completed | 97 | — | — | |
| NCT02713295 A Study to Provide Real-world Evidence on the Treatment Goal Achievement Rate, Adherence to and Utilization Patterns of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in Greece | Moderate to Severe Plaque Psoriasis | Completed | 273 | — | — | |
| NCT01155193 Prospective Study for the Use of Palivizumab (Synagis®) in High-risk Children in Germany | Respiratory Syncytial Virus Infections | Completed | 30,804 | — | — | |
| NCT01294371 Observational Program to Assess Routine Use of Add-back Therapy in Patients With Endometriosis in Russian Federation, Planned for 6-month Course of Lucrin Depot® (Leuprorelin) | Genital Endometriosis | Completed | 391 | — | — | |
| NCT01077258 Efficacy and Safety of Adalimumab in Patients With Rheumatoid Arthritis in Routine Clinical Practice | Rheumatoid Arthritis | Completed | 4,208 | — | — | |
| NCT02414633 Special Investigation in Patients With Psoriatic Arthritis (PsA) (Working Productivity and Activity Impairment [WPAI]) | Psoriatic Arthritis | Completed | 148 | — | — | |
| NCT03693586 Study to Determine the Hepatitis C Virus Infection Prevalence Among Patients Attended Primarily for Vasculitis | Chronic Hepatitis c, Vasculitis | Completed | 1,000 | — | — | |
| NCT01789151 99m-Technetium- Glucosamine in Arthritis | Rheumatoid Arthritis, Ankylosing Spondylitis | NO_LONGER_AVAILABLE | — | — | — | |
| NCT05029895 A Study to Evaluate Adverse Events and Change in Disease State of Oral Upadacitinib in Adolescent Participants Ages 12 to <18 Years Old Diagnosed With Atopic Dermatitis (AD) | Atopic Dermatitis | Completed | 167 | — | — | |
| NCT01383005 Treatment Perception of QD (Once a Day) Dosed Kaletra (Tablets) | Human Immunodeficiency Virus Infection | Completed | 97 | — | — | |
| NCT02526641 Macrophages, Portal Hypertension, and Liver Function During AbbVie Treatment of Chronic Hepatitis C | Hepatitis C | Completed | 16 | — | — | |
| NCT01401478 Observational Program of Zemplar in Patients With End Stage Chronic Kidney Disease and Parathyroid Disorder on Hemodialysis in the Russian Federation | Secondary Hyperparathyroidism | Completed | 86 | — | — | |
| NCT04630990 Study Of Oral Elagolix Tablets To Assess the Tolerability and Change in Disease Symptoms in Adult Female Participants With Moderate to Severe Endometriosis-associated Pain | Endometriosis | Completed | 117 | — | — | |
| NCT03894956 Observational Study Evaluating Long-Term Safety and Effectiveness of Humira in Patients With Hidradenitis Suppurativa | Hidradenitis Suppurativa (HS) | Completed | 46 | — | — | |
| NCT01662336 Real-life Effectiveness of the Kaletra Adherence Support Assistance (KASA) Program | Human Immunodeficiency Virus Infection | Completed | 173 | — | Lopinavir / ritonavir | |
| NCT05827887 An Observational Study to Assess Ubrogepant Tablets and Atogepant Tablets to Treat Migraine in Adult Participants | Migraine | Completed | 226 | — | — | |
| NCT01159743 A Comparison of Body Fat Distribution in HIV-1 Infected Patients Receiving, Since the Beginning and for at Least Two Years, an Antiretroviral Therapy Based on Efavirenz or Lopinavir/Ritonavir Combined With Tenofovir + Emtricitabine or Lamivudine | HIV Infection | Completed | 346 | — | — | |
| NCT04610762 HCV RNA Fingerstick Assay as Useful Point of Care of Diagnostic Tool for Drug Users in Brussels | Hepatitis C, Chronic | Completed | 103 | — | — | |
| NCT01282203 Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Required General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on Cardiovascular System in Common Clinical Practice | Anesthesia, General | Completed | 1,122 | — | — | |
| NCT01387789 A Study of Rheumatoid Arthritis Patients on Adalimumab to Evaluate Quality of Life Variables, Effects on Work Productivity and Functional Outcomes in Malaysia | Rheumatoid Arthritis | Completed | 71 | — | — | |
| NCT05894109 Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids | Adjuvant Zinc May Increase the Efficacy of Botulinum Toxin, Zinc Supplementation for Botulinum Toxin Treatment of the Forehead | N/A | Withdrawn | — | RCT, Double-blind | — |
| NCT03187873 Chamas for Change Validation | Pregnancy Related | N/A | Unknown | 3,040 | RCT, Open-label | — |
| NCT01754727 Impact of Adalimumab (Humira®) Therapy on Selected Health Care Resource Utilization and Sick Leave in Patients With Ankylosing Spondylitis in Clinical Practice | Ankylosing Spondylitis | Completed | 452 | — | — | |
| NCT06443775 An Observational Study to Assess Next Generation Emulsion Preservative Free Eye Drops (NGE-UD) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED) | Dry Eye | Completed | 47 | — | Next Generation Emulsion Preservative Free Eye Drops (NGE-UD) | |
| NCT02578238 Post-Marketing Surveillance of Humira in Korean Pediatric Crohn's Disease (CD) Patients Under the "New-Drug Re-examination" | Pediatric Crohn's Disease | Completed | 143 | — | — | |
| NCT05791526 An Observational Study to Assess Change in Disease Activity and Adverse Events of Rinvoq in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Japan | Ulcerative Colitis | Completed | 308 | — | — | |
| NCT03993847 CLassification of Axial SpondyloarthritiS Inception Cohort | Spondyloarthritis | Completed | 501 | — | — | |
| NCT01858519 Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy | Cystic Fibrosis | Completed | 1,310 | — | — | |
| NCT02582671 The Effectiveness of ABT-450/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C -An Observational Study in Ireland | Chronic Hepatitis C | Completed | 101 | — | Ombitasvir/paritaprevir/ritonavir, Dasabuvir, Ribavirin | |
| NCT03223012 Impact of AbbVie Care Patient Support Program on Clinical, Health Economic and Patient Reported Outcomes, in Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis and Axial Spondyloarthritis, in the Portuguese National Health Service | Crohn's Disease, Ulcerative Colitis (UC) | Completed | 116 | — | — | |
| NCT03053180 Real World Evidence of the Effectiveness of Paritaprevir/Ritonavir (r) - Ombitasvir, + Dasabuvir Without Ribavirin in Participants With Chronic Hepatitis C and Compensated Liver Cirrhosis in the Russian Federation | Chronic Hepatitis C | Completed | 60 | — | — | |
| NCT05938985 Croatian Version of the Ocular Surface Disease Index Questionnaire (OSDI) | Dry Eye, Ocular Surface Disease | Unknown | 150 | — | — | |
| NCT04541810 A Study of Oral Upadacitinib (RINVOQ) Tablets to Assess Adverse Events and Change in Disease Symptoms in Korean Participants With Moderate to Severe Active Rheumatoid Arthritis, Atopic Dermatitis, Ankylosing Spondylitis or Psoriatic Arthritis | Rheumatoid Arthritis (RA), Atopic Dermatitis (AD) | Completed | 2,369 | — | — | |
| NCT00783510 Juvenile Idiopathic Arthritis (JIA) Registry | Juvenile Idiopathic Arthritis, JIA | Completed | 849 | — | adalimumab, Methotrexate | |
| NCT01083173 Surveillance of Kaletra in Korean Patients | HIV-1 Infection | Completed | 595 | — | — | |
| NCT06362031 A Study to Explore Treatment Patterns, Treatment Outcomes, Healthcare Resource Utilization in Adult Participants With Acute Myeloid Leukemia (AML) Receiving Venetoclax Through Chart Review | Acute Myeloid Leukemia | Withdrawn | — | — | — | |
| NCT06594016 Expanded Access to Fosigotifator | Vanishing White Matter, Cree Leukoencephalopathy | NO_LONGER_AVAILABLE | — | — | Fosigotifator | |
| NCT02581020 The Durability of Response and Persistence of Resistance to AbbVie's 2 Direct-acting Antiviral Agent (2D) Therapy in Japanese Subjects | Hepatitis C Virus | Completed | 344 | — | — | |
| NCT02738125 Assessing Effectiveness of Adalimumab for Treating Ulcerative Colitis in Real Life Conditions | Ulcerative Colitis (UC) | Completed | 265 | — | — | |
| NCT03303599 Study of the Effectiveness and Clinical Practice Use of Glecaprevir Plus Pibrentasvir in Patients With Chronic Hepatitis C Genotypes 1 to 6 | Hepatitis C | Completed | 2,118 | — | — | |
| NCT02615145 Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C - An Observational Study in Germany (LIFE-C) | Chronic Hepatitis C | Completed | 472 | — | — | |
| NCT03592576 Expanded Access to Navitoclax | Myelofibrosis, Acute Lymphocytic Leukemia (ALL) | NO_LONGER_AVAILABLE | — | — | Navitoclax, Venetoclax | |
| NCT04818385 Study to Assess the Change in Disease State When Subcutaneous Risankizumab Injection is Given to Adult Participants With Psoriasis in Taiwan | Psoriasis | Completed | 240 | — | — | |
| NCT03310190 Study to Describe the Management and the Use of Healthcare Resources in Patients With Chronic Lymphocytic Leukemia (CLL) Initiating Venetoclax in Routine Clinical Practice | Chronic Lymphocytic Leukemia | Completed | 93 | — | — | |
| NCT01297504 A One-Year Observation of Palivizumab in Infants at Risk for Respiratory Syncytial Virus Infection in Latin America | Respiratory Syncytial Virus Infection | Completed | 464 | — | — | |
| NCT01163292 Special Investigation (Follow-up Survey of the Study of Adalimumab (D2E7) for Prevention of Joint Destruction in Patients With Rheumatoid Arthritis in Japan (M06-859 (NCT00870467)) | Rheumatoid Arthritis | Completed | 220 | — | — | |
| NCT03868163 Real World Evidence of the Effectiveness and Clinical Practice Use of Glecaprevir Plus Pibrentasvir in Patients With Chronic Hepatitis C in the Russian Federation | Chronic Hepatitis C (CHC) | Completed | 161 | — | — | |
| NCT02618928 The Effectiveness of Paritaprevir/Ritonavir - Ombitasvir, ± Dasabuvir, ± Ribavirin in France | Chronic Hepatitis C | Completed | 735 | — | — | |
| NCT02539849 Effect of Prebiotic FOS on Intestinal Abundance of Faecalibacterium Prausnitzii in Patients With Crohn´s Disease | Crohn Disease | N/A | Completed | 38 | Open-label | Adalimumab |
| NCT02856438 Early Patient Access Treatment Use Protocol CA204-220 | Multiple Myeloma | NO_LONGER_AVAILABLE | — | — | Elotuzumab, Lenalidomide, Dexamethasone | |
| NCT02016690 Synagis® Liquid 50mg, 100mg for Intramuscular Injection Special Investigation in Immunocompromised Children With Synagis® | Respiratory Syncytial Virus Infection | Completed | 312 | — | — | |
| NCT01744327 TL1A Expression in Psoriatic Skin | Psoriasis | Unknown | 20 | — | — | |
| NCT04178317 A Study of the Safety and Efficacy of Venetoclax for Participants With Chronic Lymphocytic Leukemia (CLL) Used in Routine Clinical Practice | Cancer, Chronic Lymphocytic Leukemia (CLL) | Completed | 14 | — | — | |
| NCT01076192 Study of Adalimumab (HUMIRA®) in Patients With Moderate to Severe Psoriasis (PS) in Spain (PROMISE) | Moderate-to-severe Chronic Plaque Psoriasis | Completed | 547 | — | — | |
| NCT02725866 Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Participants With Chronic Hepatitis C | Chronic Hepatitis C | Completed | 216 | — | Paritaprevir/ritonavir/ombitasvir, Dasabuvir, Ribavirin |