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Aclaris Therapeutics, Inc.

ACRS
Healthcare|Biotechnology|US
$3.90
+0.29 (+8.03%)
Tangible Book / Share
$1.12
Cash / Share
$0.76

About

Aclaris Therapeutics, Inc., a biopharmaceutical firm operating in the United States, is currently in the clinical development phase, focused on creating novel therapeutic agents for various immune-inflammatory conditions. The company's operations are divided into two primary divisions: the Therapeutics segment, dedicated to discovering and progressing innovative treatments to address crucial unmet needs in immuno-inflammatory disorders; and the Contract Research segment, which delivers specialized laboratory services. The company's pipeline features several investigational compounds. Among these is Zunsemetinib, an MK2 inhibitor, being developed to treat moderate to severe cases of rheumatoid arthritis, psoriatic arthritis, and hidradenitis suppurativa. Another significant candidate is ATI-1777, a soft JAK 1/3 inhibitor, intended for the management of moderate to severe atopic dermatitis. Additionally, Aclaris is advancing ATI-2138, an ITK/TXK/JAK3 inhibitor, as a potential intervention for T cell-mediated autoimmune diseases; a Gut-Biased Program targeting inflammatory bowel disease; and ATI-2231, an MK2 inhibitor, for the treatment of pancreatic and metastatic breast cancer. Established in 2012, Aclaris Therapeutics, Inc. has its corporate headquarters situated in Wayne, Pennsylvania.

Stock Price

+71.8%(1Y)
1M
+2.9%
3M
-34.0%
6M
-20.9%
YTD
+29.6%
1Y
+83.1%
3Y
-28.4%
5Y
-76.6%

Pipeline Summary

36 total trials
4
Phase 1
26
Phase 2
6
Phase 3
2
Phase 4
Completed: 28Withdrawn: 1Terminated: 4Recruiting: 2Active: 1

Active Trials (3)

Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis
NCT06374459Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer
Phase 1Phase 2Recruiting
Enrollment: 152 participants
MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma
NCT06648434Metastatic Pancreatic Ductal Adenocarcinoma
Phase 1Recruiting
Enrollment: 51 participants
ATI-045 Versus Placebo in Patients With Moderate-to-Severe Atopic Dermatitis
NCT07011706Atopic Dermatitis
Phase 2Active
Enrollment: 110 participants

Key Facts

Market Cap$574.1M
Employees69 (+13% YoY)
CEONeal S. Walker
IPO DateOct 6, 2015
Beta0.80
52-Week Range$2.1 – $6.6
Avg Volume2,602,716
ExchangeNASDAQ

Ownership

Float75.4%
Shares Outstanding147.2M

Recent Insider Trades

Kolbeck Roland WilhelmOPTION EX.
Aug 1, 202636,375 shares
Kolbeck Roland WilhelmOPTION EX.
Aug 1, 202636,375 shares
Kolbeck Roland WilhelmTAX W/H
Aug 1, 202612,385 shares @ $5.20
Mehra AnandOPTION EX.
Jun 5, 202611,580 shares
SCHIFF ANDREW NAWARD
Jun 4, 202642,350 shares @ $4.71

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Data last updated: Nov 9, 2026, 03:52 AM