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ALX Oncology Holdings Inc.

ALXO
Healthcare|Biotechnology|US
$1.16
+0.01 (+0.43%)
DCF Value
$0.13
Tangible Book / Share
$1.00
Cash / Share
$1.02

About

ALX Oncology Holdings Inc., a clinical-stage immuno-oncology company, focuses on developing therapies for cancer patients in the United States. The company’s lead product candidate is Evorpacept, a CD47 blocking therapeutic biologic development as a combination therapy with other anti-cancer agents, including ASPEN-06, under phase 2 clinical study for treating Gastric/GEJ cancer. It has collaboration agreement for Evorpacept combination programs comprising Jazz Pharmaceuticals plc for zanidatamab, under phase 1b/2 trial for the treatment of breast cancer and other solid tumors; HER2 with an ADC, fam-trastuzumab deruxtecan-nxki, under phase 1 trial for the treatment of patients with breast cancer; ALX2004, under phase 1 clinical trial for treating solid tumors; MD Anderson Cancer Center with rituximab and lenalidomide for the treatment of patients with indolent and aggressive NHL; and Sanofi with isatuximab and dexamethasone, under phase 1/2 trial for the treatment of patients with relapsed or refractory multiple myeloma. It has license agreements with Board of Trustees of Leland Stanford Junior University. The company was incorporated in 2015 and is headquartered in South San Francisco, California.

Stock Price

-1.7%(1Y)
1M
-2.1%
3M
-45.0%
6M
-44.5%
YTD
+2.2%
1Y
-9.1%
3Y
-87.2%
5Y
-97.8%

Pipeline Summary

13 total trials
7
Phase 1
8
Phase 2
1
Phase 3
0
Phase 4
Completed: 4Recruiting: 3Terminated: 3Active: 3

Active Trials (6)

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
NCT07085091NSCLC (Advanced Non-small Cell Lung Cancer)
Phase 1Recruiting
Enrollment: 170 participants
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
NCT07007559Breast Cancer, Metastatic
Phase 2Recruiting
Enrollment: 120 participants
PRE-ISPY Phase I/II Oncology Platform Program
NCT05868226HER2-positive Breast Cancer
Phase 1Phase 2Recruiting
Enrollment: 280 participants
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
NCT04675333Head and Neck Cancer
Phase 2Active
Enrollment: 172 participants
Safety and Efficacy of Anti-CD47, ALX148 in Combination With Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer
NCT05467670Ovarian Cancer
Phase 2Active
Enrollment: 16 participants

Key Facts

Market Cap$159.7M
Employees43 (-46% YoY)
CEOJason Lettmann
IPO DateJul 17, 2020
Beta0.40
52-Week Range$0.8617 – $2.66
Avg Volume1,148,595
ExchangeNASDAQ

Ownership

Float68.7%
Shares Outstanding138.3M

Recent Insider Trades

Lettmann JasonSELL
Aug 17, 20262,230 shares @ $1.93
Wong ShellySELL
Aug 17, 2026573 shares @ $1.93
Wong ShellySELL
Jul 1, 20261,404 shares @ $2.04
Knight Jeff E.AWARD
Apr 16, 2026800,000 shares @ $1.68
Klencke BarbaraAWARD
Apr 16, 2026100,000 shares @ $1.68

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Data last updated: Nov 9, 2026, 03:54 AM