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Amgen Inc

AMGN
Healthcare|Drug Manufacturers - General|USA
$342.57
-5.37 (-1.54%)
DCF (FCF)
$219.78
Earnings Power
$83.10

Clinical Trials (540)

TrialConditionsPhaseStatusEnrollmentDesignDrug
NCT06072482
A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
Antineutrophil Cytoplasmic Antibody-associated Vasculitis
P4
Recruiting300RCT, Double-blindAvacopan, Placebo, Standard of Care
NCT06588153
A Study for the Evaluation of Efficacy and Safety of Prolia® in Participants With Glucocorticoid-induced Osteoporosis in Mainland China
Glucocorticoid-induced Osteoporosis
P4
Recruiting100Open-labelProlia®
NCT07037459
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction
P3
Recruiting5,056RCT, Double-blindMaridebart cafraglutide, Placebo
NCT04934475
MInimal Residual Disease Adapted Strategy
Multiple Myeloma
P3
Active791RCT, Open-labelIsatuximab
NCT05565560
A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis
Plaque Psoriasis
P3
Active17Open-labelApremilast
NCT04528082
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
Behçet Disease
P3
Recruiting60RCT, Double-blindApremilast, Placebo
NCT05111626
Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
P3
Active515RCT, Double-blindBemarituzumab, Nivolumab, Chemotherapy
NCT05882877
A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)
Atopic Dermatitis
P3
Active2,621RCT, Double-blindRocatinlimab
NCT06117774
Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
Limited Stage Small Cell Lung Cancer, Small Cell Lung Cancer
P3
Recruiting400RCT, Double-blindTarlatamab, Placebo
NCT04307576
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Leukemia, Acute Lymphoblastic
P3
Recruiting6,430RCT, Open-labelOmitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy, Imatinib, 6-tioguanine+Standard Maintenance Therapy, Blinatumomab
NCT04483739
Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)
Multiple Myeloma
P3
Active302RCT, Open-labelCarfilzomib Lenalidomide Dexamethasone, Isatuximab Carfilzomib Lenalidomide Dexamethasone
NCT04303780
Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).
KRAS p, G12c Mutated /Advanced Metastatic NSCLC
P3
Active345RCT, Open-labelAMG 510, Docetaxel
NCT04804553
Apremilast Pediatric Study in Children With Active Juvenile Psoriatic Arthritis
Active Juvenile Psoriatic Arthritis
P3
Recruiting60RCT, Double-blindApremilast, Placebo
NCT06883305
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
Chronic Obstructive Pulmonary Disease (COPD)
P3
Recruiting990RCT, Double-blindTezepelumab
NCT07226765
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
Obstructive Sleep Apnea
P3
Recruiting250RCT, Double-blindMaridebart cafraglutide, Placebo
NCT05583227
Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis
Eosinophilic Esophagitis
P3
Active368RCT, Double-blindTezepelumab, Tezepelumab
NCT05920356
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Non-Small Cell Lung Cancer (NSCLC)
P3
Recruiting750RCT, Open-labelSotorasib, Pembrolizumab
NCT07388498
A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout
Uncontrolled Gout
P3
Recruiting270RCT, Double-blindPegloticase, Methotrexate
NCT07213674
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
Metastatic Castration-resistant Prostate Cancer
P3
Recruiting750RCT, Open-labelXaluritamig, Abiraterone acetate, Docetaxel, Cabazitaxel
NCT03836040
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
Migraine
P3
Active457RCT, Double-blindErenumab Dose 1, Erenumab Dose 2, Erenumab Dose 3
NCT06104124
A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity
Sjogren's Syndrome
P3
Active651RCT, Double-blindDazodalibep, Placebo
NCT05767047
A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis
Behçet's Disease, Juvenile Psoriatic Arthritis
P3
Recruiting48Open-labelApremilast
NCT07037433
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Atherosclerotic Cardiovascular Disease, Overweight
P3
Recruiting12,800RCT, Double-blindMaridebart Cafraglutide, Placebo
NCT07005128
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
Small-cell Lung Cancer, Extensive Stage Small-cell Lung Cancer
P3
Recruiting330RCT, Open-labelTarlatamab, Durvalumab, Carboplatin, Etoposide
NCT03937154
Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Non-small Cell Lung Cancer (NSCLC), Ovarian Cancer, or Breast Cancer
Chemotherapy-induced Thrombocytopenia
P3
Active145RCT, Double-blindRomiplostim, Placebo
NCT03289299
Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant
Smoldering Multiple Myeloma
P2
Active87Open-labelCarfilzomib, Lenalidomide, Daratumumab, Dexamethasone
NCT05848687
TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
Lymphoblastic Leukemia
P1P2
Recruiting90Open-labelDexamethasone, Mitoxantrone, PEG asparaginase, Bortezomib, Vorinostat, Mercaptopurine, Methotrexate, Blinatumomab, Ziftomenib
NCT02925234
The Drug Rediscovery Protocol (DRUP Trial)
Cancer, Tumors
P2
Recruiting1,550Open-labelPanitumumab, Olaparib, Dabrafenib, Nilotinib, Trametinib, Erlotinib, Trastuzumab and Pertuzumab (combination treatment), Vemurafenib and Cobimetinib (combination treatment), Vismodegib, Regorafenib, Nivolumab, Afatinib, Dabrafenib and trametinib, Ribociclib, Lenvatinib, Pembrolizumab, Durvalumab, Rucaparib, Axitinib, Palbociclib, Crizotinib, Sunitinib, Cabozantinib, Abemaciclib, Alectinib, Atezolizumab and Bevacizumab, Ipilimumab and nivolumab, Entrectinib, Talazoparib, Dacomitinib, Lorlatinib, Erdafitinib, Alpelisib, Niraparib, Pemigatinib, Selpercatinib, Tepotinib
NCT05074810
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Non Small Cell Lung Cancer, KRAS Activating Mutation
P1P2
Active153Open-labelavutometinib and sotorasib, avutometinib and sotorasib and defactinib
NCT06054113
Study of Blinatumomab Administration in Chinese Pediatric Participants With Relapsed/Refractory B Precursor Acute Lymphoblastic Leukemia (R/R B-ALL)
B Precursor Acute Lymphoblastic Leukemia, Relapsed/Refractory B Precursor Acute Lymphoblastic Leukemia
P2
Active18Open-labelBlinatumomab
NCT06788938
Tarlatamab in Advanced Delta-like 3 (DLL3)-Expressing Tumors Including Neuroendocrine Neoplasms
DLL3-expressing Tumors, Advanced Tumors
P2
Recruiting29Open-labelTarlatamab treatment
NCT06401044
A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease
Thyroid Eye Disease
P1P2
Recruiting88RCT, Double-blindAMG 732
NCT00863460
Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients
Primary Central Nervous System Lymphoma
P2
Active140RCT, Open-labelintensive chemotherapy and hematopoietic stem cell rescue, MTX based chemotherapy
NCT04430894
KRDI in Transplant-Eligible MM
Multiple Myeloma
P2
Active50Single-blindCarfilzomib, Isatuximab, Lenalidomide, Dexamethasone
NCT05094336
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
Advanced MTAP-null Solid Tumors
P1P2
Active329Open-labelAnvumetostat, Docetaxel, Comparator Anvumetostat Test Tablet
NCT07134088
A Study of Subcutaneous Blinatumomab in Children With R/R and and MRD+ B-Cell Precursor Acute Lymphoblastic Leukemia
Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia, Minimal Residual Disease + B-Cell Acute Lymphoblastic Leukemia
P1P2
Recruiting104Open-labelBlinatumomab
NCT06502977
Study Evaluating Tarlatamab in Chinese Participants With Advanced Small Cell Lung Cancer After Two or More Prior Lines of Treatment
Extensive Stage Small Cell Lung Cancer
P2
Active32Open-labelTarlatamab
NCT06593522
A Phase 2 Study of AMG 193 in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
MTAP-deleted NSCLC
P2
Recruiting200RCT, Open-labelAMG 193
NCT05322577
A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.
Gastric Cancer, Gastroesophageal Junction Cancer
P1P2
Active72Open-labelBemarituzumab, CAPOX, SOX, Nivolumab
NCT05060016
A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)
Relapsed/Refractory Small Cell Lung Cancer
P2
Active222RCT, Open-labelTarlatamab
NCT06745323
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC
Small Cell Lung Cancer (SCLC)
P2
Active252RCT, Open-labelTarlatamab
NCT06570798
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis
P2
Recruiting220Open-labelInebilizumab, Blinatumomab
NCT06660810
Neoadjuvant Intralesional Injection of Talimogene Laherparepvec
Soft Tissue Sarcoma, Sarcoma,Soft Tissue
P2
Active2Open-labelTalimogene Laherparepvec
NCT04329325
Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia, Philadelphia Chromosome-Positive
P2
Active17Open-labelBlinatumomab, dasatinib, dexamethasone, methotrexate
NCT07222579
Subcutaneous Blinatumomab for Treatment of Adult Patients With CD19-Positive Mixed Phenotype Acute Leukemia (MPAL)
CD19 Positive, Mixed Phenotype Acute Leukemia (MPAL)
P2
Recruiting78Open-labelSubcutaneous Blinatumomab
NCT04800367
Romosozumab/Denosumab Study for Premenopausal IOP
Premenopausal Idiopathic Osteoporosis
P2
Active30Open-labelRomosozumab Prefilled Syringe [Evenity], Denosumab 60 MG/ML Prefilled Syringe [Prolia]
NCT07153796
A Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab in Combination With Low Intensity Chemotherapy in Older Patients With Newly Diagnosed B-cell Acute Lymphoblastic Leukemia
B-cell Acute Lymphoblastic Leukemia
P2
Recruiting60Open-labelBlinatumomab, Mini-CVD, MTX/ARA-C
NCT06312020
A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome
Sjogren's Syndrome
P2
Active209RCT, Double-blindHZN-1116, Placebo
NCT07037758
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
Extensive Stage Small Cell Lung Cancer
P1
Recruiting380Open-labelTarlatamab, AB248
NCT02332850
Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P1
Active83RCT, Open-labelIsatuximab, Carfilzomib, Dexamethasone
NCT06555796
Evaluation of Xaluritamig in High-Risk, Biochemically Recurrent, Non-metastatic Castrate-sensitive Prostate Cancer
Prostate Cancer, High-risk Biochemical Recurrence
P1
Active50Open-labelXaluritamig
NCT06637371
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
Asthma
P1
Recruiting124RCT, Double-blindAMG 691, Placebo
NCT06807619
A Study of Sotorasib in People With Brain Tumors
Brain Tumor
P1
Recruiting16Open-labelSotorasib
NCT06613100
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
Prostate Cancer
P1
Recruiting40Open-labelXaluritamig, GnRH Antagonist
NCT06131398
A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors
Advanced Solid Tumors
P1
Active77Open-labelAMG 355, Pembrolizumab
NCT06898957
Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer
P1
Recruiting200Open-labelYL201, Tarlatamab, Atezolizumab, Durvalumab
NCT01959698
Carfilzomib, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Stage I-IV Diffuse Large B-cell Lymphoma
CD20 Positive, Recurrent Diffuse Large B-Cell Lymphoma
P1
Active29Open-labelCarboplatin, Carfilzomib, Etoposide, Ifosfamide, Rituximab
NCT07297979
Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)
Ewing Sarcoma
P1
Recruiting50Open-labelXaluritamig
NCT06333951
AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Thoracic Tumors, Non-small Cell Lung Cancer
P1
Recruiting500Open-labelAMG 193, Carboplatin, Paclitaxel, Pembrolizumab, Pemetrexed, Sotorasib
NCT07013578
TIDHI Mental Health in IBD Patients Study
Crohn Disease (CD), Ulcerative Colitis (UC)
N/A
Recruiting100RCT, Open-label
NCT01848028
PsoBest - The German Psoriasis Registry
Psoriasis, Psoriatic-arthritis
Recruiting3,500
NCT01277419
German Spondyloarthritis Inception Cohort
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
Recruiting1,000
NCT02009345
Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
Familial Hypercholesterolemia, Lipid Disorder
Recruiting6,000
NCT04151342
CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)
Cancer, Malignancies Multiple
Recruiting5,500Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents.
NCT06576050
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
Heart Failure, Obesity
Active21
NCT02208869
Russian Familial Hypercholesterolemia Registry
Familial Hypercholesterolemia
Recruiting1,000
NCT03851263
Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion
Coronary Artery Disease
P4
WithdrawnOpen-labelEvolocumab
NCT00640393
Safety and Efficacy of Combining nbUVB to Etanercept in Patients
Psoriasis Vulgaris
P4
Completed99RCT, Single-blindEtanercept
NCT00967538
Safety and Efficacy of Etanercept in Patients With Psoriasis Who Failed to Respond to Other Biologic Treatments
Psoriasis
P4
Completed89Open-labeletanercept 50 mg
NCT03168529
Trial Assessing the Effectiveness of Ivabradine Started at Discharge From the Observation Unit
Heart Failure
P4
Terminated19RCT, Double-blindIvabradine, Placebo
NCT01313208
Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel)
Rheumatoid Arthritis
P4
Completed210RCT, Double-blindetanercept, Placebo, DMARD Therapy
NCT00094341
Preference of Rheumatoid Arthritis (RA) Patients of Enbrel® (Etanercept) Auto-Injector Versus Enbrel® Pre-Filled Syringes
Rheumatoid Arthritis
P4
Completed215RCT, Open-labelEtanercept
NCT00443430
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis
P4
Completed85RCT, Double-blindmethotrexate, methotrexate - etanercept - prednisolone arm
NCT00368901
STAAR-2 Clinical Study
Chronic Kidney Disease, Chronic Renal Insufficiency
P4
Completed618Open-labelDarbepoetin alfa
NCT03774875
A Study of the Impact of Apremilast (CC-10004) on Quality of Life, Efficacy, and Safety in Adults With Manifestations of Plaque Psoriasis and Impaired Quality of Life
Psoriasis
P4
Completed277RCT, Double-blindApremilast, Placebo
NCT02246218
A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders
Urea Cycle Disorder
P4
Completed27Open-labelRAVICTI
NCT02576652
Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement
Osteoporosis
P4
Completed6Open-label
NCT00037518
A Study of an Investigational Medication for Severe Primary Hyperparathyroidism or Parathyroid Cancer
Hyperparathyroidism, Parathyroid Neoplasms
P4
Completed46Open-labelAMG 073
NCT03636373
Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout
Gout Attack
P4
Terminated5RCT, Double-blindEtanercept, Triamcinolone Acetonide
NCT00907478
Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP)
Thrombocytopenia, Idiopathic Thrombocytopenic Purpura
P4
Completed169Open-labelromiplostim
NCT00654368
CAMEO: Canadian Methotrexate and Etanercept Outcome Study
Rheumatoid Arthritis
P4
Completed258RCT, Open-labelEtanercept, Methotrexate
NCT02749370
Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast
Plaque Psoriasis
P4
Completed80Open-labelEtanercept
NCT01250405
Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
Chronic Kidney Disease
P4
Completed23RCT, Double-blindCinacalcet, Placebo
NCT00117104
Evaluating Aranesp® in Subjects With End Stage Renal Disease onChronic Hemodialysis
End Stage Renal Disease
P4
CompletedOpen-labelAranesp®
NCT00121043
Evaluating Kineret® (Anakinra) in Rheumatoid Arthritis (RA) Subjects Using aSelf-Reported Questionnaire
Rheumatoid Arthritis
P4
CompletedRCT, Open-labelKineret® (Anakinra)
NCT03335488
Study of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders (UCDs)
Urea Cycle Disorder
P4
Completed16RCT, Open-labelRAVICTI, NaPBA
NCT05135312
Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging
Psoriasis, Psoriatic Arthritis
P4
Unknown10Open-labelEtanercept
NCT04265755
Biomarker and Genetic Predictors of Erenumab Treatment Response
Migraine
P4
Completed1,406Open-labelErenumab
NCT01053819
Can We Miss Pigmented Lesions in Psoriasis Patients?
Psoriasis, Melanoma
P4
Completed6Open-labeletanercept
NCT03912337
Effect of Erenumab-aooe on Disability and Work Productivity in Employed Subjects With Episodic Migraine
Migraine
P4
Terminated29RCT, Double-blindPlacebo, Erenumab
NCT03096288
Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivity
Atherosclerotic Cardiovascular Disease
P4
Completed259RCT, Double-blindEvolocumab
NCT03971071
A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache
Migraine Headache
P4
Completed620RCT, Double-blindErenumab 70 mg, Erenumab 140 mg, Placebo
NCT00259610
Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)
Rheumatoid Arthritis
P4
Completed755RCT, Double-blindmethotrexate, sulfasalazine, hydroxychloroquine, etanercept
NCT00369733
STAAR-3 Clinical Study
Chronic Kidney Disease, Chronic Renal Insufficiency
P4
Completed443Open-labelDarbepoetin alfa
NCT03783026
A Study to Evaluate the Impact of Apremilast on Magnetic Resonance Imaging (MRI) Outcomes in Adults With Psoriatic Arthritis
Psoriatic Arthritis
P4
Completed123Open-labelApremilast
NCT00127842
REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®)
Psoriatic Arthritis
P4
Completed110Open-labelEtanercept
NCT03927144
Study of Sustained Benefit of AMG334 in Adult Episodic Migraine Patients
Episodic Migraine
P4
Completed621RCT, Open-labelAMG334, Oral Prophylactic
NCT01901146
Efficacy and Safety Study of ABP 980 Compared With Trastuzumab in Women With HER2-positive Early Breast Cancer
Breast Cancer
P3
Completed725RCT, Double-blindABP 980, Trastuzumab, Paclitaxel
NCT03029234
Carfilzomib in Combination With Dexamethasone (Kd) in Chinese Patients With Relapsed & Refractory Multiple Myeloma
Relapsed and Refractory Multiple Myeloma
P3
Completed126Open-labelDexamethasone, Carfilzomib
NCT01966003
Efficacy and Safety Study of ABP 215 Compared With Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer
Non-small Cell Lung Cancer Metastatic
P3
Completed642RCT, Double-blindCarboplatin, Paclitaxel, ABP 215, Bevacizumab
NCT00353119
A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis
Palmoplantaris Pustulosis
P3
Completed15RCT, Double-blindPlacebo comparator, Etanercept
NCT02126449
DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer
Fasting Mimicking Diet, Breast Cancer
P2P3
Completed131RCT, Open-label
NCT00116181
Study to Help Understand the Action of the Drug Etanercept for the Adult Patient With Psoriasis
Psoriasis
P3
Completed30RCT, Open-labelEtanercept
NCT03433755
Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Participants With Primary Hypercholesterolemia and Mixed Dyslipidemia
Primary Hypercholesterolemia, Mixed Dyslipidemia
P3
Terminated259RCT, Double-blindevolocumab, placebo
NCT00415532
Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
P3
Completed234RCT, Open-labelMedical Standard of Care for ITP, Romiplostim
NCT03287609
EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)
Acute Coronary Syndrome
P3
Completed308RCT, Double-blindEvolocumab 140 mg/mL, Placebo
NCT01901185
Study to Evaluate the Ability of Subjects With Rheumatoid Arthritis or Psoriatic Arthritis to Effectively Use a Reusable Autoinjector to Self-inject Etanercept
Rheumatoid Arthritis, Psoriatic Arthritis
P3
Completed77Open-labelEtanercept / Autoinjector A
NCT01419717
Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer
Bone Metastases in Men With Hormone-Refractory Prostate Cancer, Bone Metastases in Subjects With Advanced Breast Cancer
P3
Completed129Open-labelDenosumab
NCT03638128
Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI)
P3
Terminated75Open-labelDenosumab, Alternative osteoporosis medications
NCT00117052
SENSOR: Study to Investigate Cinacalcet Treatment in Haemodialysis Patients With Secondary Hyperparathyroidism
Secondary Hyperparathyroidism, End Stage Renal Disease
P3
Completed673RCT, Open-labelcinacalcet
NCT00119613
A Study of Subjects With Previously Untreated Extensive-Stage Small-Cell Lung Cancer (SCLC) Treated With Platinum Plus Etoposide Chemotherapy With or Without Darbepoetin Alfa
Small Cell Lung Cancer
P3
Completed600RCT, Double-blindplacebo, darbepoetin alfa
NCT01099436
Neo-Adjuvant Chemotherapy (TAC) With or Without Zoledronic Acid in Treating HER2-negative Breast Cancer Patients
Breast Cancer
P3
Completed250RCT, Open-labelcyclophosphamide, docetaxel, doxorubicin hydrochloride, zoledronic acid
NCT00119587
Darbepoetin Alfa Treatment of Anemia in Hemodialysis Subjects
Anemia
P3
CompletedRCT, Double-blinddarbepoetin alfa
NCT02125344
A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto)
Tubular Breast Cancer Stage II, Tubular Breast Cancer Stage III
P3
Completed961RCT, Open-labelnon-pegylated liposomal doxorubicin, Carboplatin, Paclitaxel, Epirubicin, Cyclophosphamide, Pertuzumab, Trastuzumab, Ferric carboxymaltose
NCT03300609
5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab
Colorectal Adenocarcinoma, RAS Wild Type
P3
Terminated4RCT, Open-labelPanitumumab, Oxaliplatin, Leucovorin Calcium, Fluorouracil, Capecitabine
NCT03701763
Efficacy and Safety Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis
Psoriasis
P3
Completed245RCT, Double-blindApremilast (CC-10004)
NCT00339183
Comparison of Treatment Effect of Chemotherapy With Panitumumab to Chemotherapy Alone
Metastatic Colorectal Cancer
P3
Completed1,186RCT, Open-labelPanitumumab, FOLFIRI
NCT00356356
16.0040 Ankylosing Spondylitis Study
Ankylosing Spondylitis
P3
Completed257Open-labelEtanercept
NCT01412957
Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
P3
Completed377RCT, Open-labelPanitumumab
NCT00523341
Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis
Osteopenia, Osteoporosis
P3
Completed4,550Open-labelDenosumab
NCT04175613
A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis
Psoriasis
P3
Completed160Open-labelApremilast
NCT03570697
Imaging of Coronary Plaques in Participants Treated With Evolocumab
Coronary Artery Disease (CAD)
P3
Completed164RCT, Double-blindEvolocumab, Placebo, Statin therapy
NCT00041665
Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy
Stomatitis
P3
CompletedRCT, Double-blindRecombinant Human Keratinocyte Growth Factor
NCT00089674
AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Androgen-Deprivation Therapy for Non-metastatic Prostate Cancer
Prostate Cancer
P3
Completed1,468RCT, Double-blindAMG 162, Placebo
NCT01444417
Safety and Efficacy Study of Romiplostim to Treat Immune Thrombocytopenia (ITP) in Pediatric Patients
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
P3
Completed62RCT, Double-blindRomiplostim, Placebo
NCT01270347
Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients
Cystic Fibrosis
P3
Completed282RCT, Open-labelMP-376 (Levofloxacin Solution for Inhalation), TIS (Tobramycin Inhalation Solution)
NCT02341417
Extension Study of Cinacalcet for Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Patients With Chronic Kidney Disease on Dialysis
Secondary Hyperparathyroidism, Chronic Kidney Disease
P3
Completed28Open-labelCinacalcet
NCT00358215
RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial
Heart Failure, Anemia
P3
Completed2,278RCT, Double-blindDarbepoetin alfa, Placebo
NCT03689946
Effect of Evolocumab on Coronary Atherosclerosis
Cardiovascular Disease, Hyperlipidemia
P3
Completed55Open-labelEvolocumab, Omnipaque, Metoprolol, Nitroglycerin
NCT03461211
Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study
Thyroid Eye Disease
P3
Completed51Open-labelTeprotumumab
NCT01733316
Open-Label, Safety and Superior Effectiveness Study of Cysteamine Bitartrate Delayed-Release Capsules (RP103) in Cystinosis
Cystinosis
P3
Completed41Open-labelRP103, Cystagon®
NCT00169104
Effects of Granulocyte Colony-stimulating Factor (G-CSF), Trastuzumab, and Vinorelbine on Immune Cell Function
Metastatic Breast Cancer
P2P3
Terminated23RCT, Double-blindG-CSF, trastuzumab, vinorelbine, G-CSF, saline placebo
NCT00111449
Evaluating the Safety of Etanercept 50 mg Twice Weekly in Subjects With Psoriasis
Psoriasis
P3
Completed600RCT, Double-blindEtanercept
NCT07223190
A Study Evaluating Subcutaneous Versus Intravenous Blinatumomab in Newly Diagnosed Adults With B-cell Precursor Acute Lymphoblastic Leukaemia
Philadelphia Chromosome Negative B-cell Precursor Acute Lymphoblastic Leukemia
P3
Not Yet Recruiting560RCT, Open-labelBlinatumomab, Blinatumomab, HyperCVAD
NCT00785421
Chemotherapy With or Without Enoxaparin in Pancreatic Cancer
Pancreatic Cancer
P2P3
Completed312RCT, Open-labelenoxaparin, chemotherapy with LMWH - enoxaparin, only chemotherapy
NCT00091793
Study to Evaluate AMG 162 in the Prevention of Postmenopausal Osteoporosis
Postmenopausal Osteoporosis
P3
Completed332RCT, Double-blindAMG 162, Placebo
NCT05724199
A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD)
Atopic Dermatitis
P3
Completed746RCT, Double-blindRocatinlimab
NCT01984424
Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-3
Hyperlipidemia
P3
Completed511RCT, Double-blindAtorvastatin, Placebo to Atorvastatin, Ezetimibe, Evolocumab
NCT02376790
Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis
Psoriatic Arthritis
P3
Completed851RCT, Double-blindEtanercept, Methotrexate, Placebo to Etanercept, Placebo to Methotrexate
NCT03347279
Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma
Asthma
P3
Completed1,061RCT, Double-blindExperimental: Tezepelumab
NCT00117091
Anakinra (Kineret®) in Combination With Disease Modifying Anti-Rheumatic Drugs (DMARDS) in Subjects With Active Rheumatoid Arthritis (RA)
Rheumatoid Arthritis
P3
CompletedOpen-labelAnakinra (Kineret®)
NCT01197378
Long-Term Safety Follow-up Study of Cysteamine Bitartrate Delayed-release Capsules (RP103)
Cystinosis
P3
Completed60Open-labelCysteamine Bitartrate Delayed-release Capsules
NCT00094484
Cinacalcet HCl in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism Not Receiving Dialysis
Kidney Disease, Chronic Kidney Disease
P3
Completed400RCT, Double-blindCinacalcet HCl
NCT01631214
Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
Postmenopausal Women With Osteoporosis
P3
Completed4,093RCT, Double-blindRomosozumab, Alendronate, Placebo to Romosozumab, Placebo to Alendronate
NCT00450216
Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment
Ulcer
P3
Completed906RCT, Double-blindIbuprofen/famotidine, Ibuprofen
NCT01879319
Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pen
Primary Hypercholesterolemia, Mixed Dyslipidemia
P3
Completed164RCT, Open-labelEvolocumab AMD, Evolocumab AI/pen
NCT00116688
Open Label Extension Study of Romiplostim (AMG 531) in Thrombocytopenic Patients With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Thrombocytopenia, Idiopathic Thrombocytopenic Purpura
P3
Completed313RCT, Open-labelRomiplostim
NCT00450658
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
Peptic Ulcer
P3
Completed627RCT, Double-blindHZT-501, Ibuprofen
NCT03859427
A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Relapsed or Refractory Multiple Myeloma
P3
Completed454RCT, Open-labelCarfilzomib, Carfilzomib, Lenalidomide, Dexamethasone
NCT00527267
Safety and Efficacy Study of AMG 073 in Hemodialysis Subjects
Hyperparathyroidism
P3
Completed320RCT, Double-blindPlacebo, AMG 073
NCT01568866
Phase 3 Study With Carfilzomib and Dexamethasone Versus Bortezomib and Dexamethasone for Relapsed Multiple Myeloma Patients
Multiple Myeloma
P3
Completed929RCT, Open-labelCarfilzomib, Bortezomib, Dexamethasone
NCT01281254
AMG 386 (Trebananib) in Ovarian Cancer (TRINOVA-2)
Fallopian Tube Cancer, Ovarian Cancer
P3
Terminated223RCT, Double-blindAMG386 plus PLD, Placebo plus PLD
NCT03811418
A Study to Compare Pertuzumab + Trastuzumab + Vinorelbine vs. Placebo + Trastuzumab + Docetaxel in Previously Untreated HER2-positive Metastatic Breast Cancer
Advanced Breast Cancer, HER2-positive Breast Cancer
P3
WithdrawnRCT, Open-labelTrastuzumab, Pertuzumab, Vinorelbine, Docetaxel
NCT05398263
Tezepelumab Efficacy and Safety in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma
Asthma
P3
Terminated125RCT, Double-blindTezepelumab
NCT00115167
A Study of Darbepoetin Alfa in Anemic Subjects Not Receiving Chemotherapy Who Have Completed the 20010103 Study
Anemia, Cancer
P3
Completed371RCT, Double-blindPlacebo, Darbepoetin alfa
NCT02585895
Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study Enrollment
Hypercholesterolemia
P3
Completed39RCT, Open-labelEvolocumab
NCT01302392
A Study of Carfilzomib vs Best Supportive Care in Subjects With Relapsed and Refractory Multiple Myeloma
Multiple Myeloma
P3
Completed315RCT, Open-labelCarfilzomib, Best Supportive Care
NCT01624142
Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders
Severe Familial Hypercholesterolemia
P2P3
Completed300Open-labelEvolocumab
NCT03930186
A Phase 3B, Open-label, Single-arm Study of the Efficacy and Safety of Apremilast, in Subjects With Plaque Psoriasis That is Not Adequately Controlled by Topical Therapy
Plaque Psoriasis
P3
Completed152Open-labelApremilast, Topical Therapy
NCT00115765
PACCE: Panitumumab Advanced Colorectal Cancer Evaluation Study
Colorectal Cancer
P3
Completed1,053RCT, Open-labelOxaliplatin Based Chemotherapy, Panitumumab, Irinotecan Based Chemotherapy, Bevacizumab
NCT00925600
Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss
Cancer, Cataract
P3
Completed769RCT, Double-blindDenosumab, Placebo
NCT04851964
Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis With Nasal Polyps
P3
Completed416RCT, Double-blindExperimental: Tezepelumab, Mometasone furoate or equivalent intranasal corticosteroid
NCT00557817
Erythropoietin (Epo) and Venofer Trial After Autologous Hematopoietic Stem Cell Transplantation (HSCT)
Hematological Malignancies
P2P3
Completed125RCT, Open-labelDarbepoetin alpha (Aranesp), Iron saccharate (Venofer)
NCT02797080
Long-Term Safety Extension Study of ACTIMMUNE® (Interferon γ-1b) in Children and Young Adults With Friedreich's Ataxia
Friedreich's Ataxia
P3
Completed38Open-labelinterferon γ-1b
NCT00117910
Treatment for Elderly Patients With High Risk Breast Cancer
Breast Cancer
P3
CompletedRCT, Open-labelpegfilgrastim
NCT03406078
Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma
Asthma
P3
Completed150RCT, Double-blindTezepelumab
NCT01180634
MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis
Cystic Fibrosis
P3
Completed330RCT, Double-blindAeroquin, Placebo
NCT02791516
A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis
Postmenopausal Osteoporosis
P3
Completed67RCT, Double-blindRomosozumab, Placebo
NCT00093015
Trial to Reduce Cardiovascular Events With Aranesp® Therapy (TREAT)
Kidney Disease, Diabetes Mellitus
P3
Completed4,038RCT, Double-blindPlacebo, darbepoetin alfa
NCT03080935
Fourier Open-label Extension Study in Subjects With Clinically Evident Cardiovascular Disease in Selected European Countries
Dyslipidemia
P3
Terminated1,600Open-labelEvolocumab
NCT00984282
Nexavar® Versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Thyroid Neoplasms
P3
Completed417RCT, Double-blindSorafenib (Nexavar, BAY43-9006), Placebo
NCT00111007
A Treatment Combination for Patients With Unresectable Stage III or Stage IV Melanoma
Melanoma
P3
Completed270RCT, Double-blindSorafenib (Nexavar, BAY43-9006), Carboplatin/Paclitaxel, Placebo
NCT00544232
Preoperative Epirubicin Paclitaxel Aranesp Study (PREPARE)
Breast Cancer
P3
Completed720RCT, Open-labelEpirubicin, paclitaxel, cyclophosphamide, Methotrexate, 5 FU, darbepoetin alfa, Epirubicin, Cyclophosphamide, Paclitaxel, dabepoetin alfa
NCT02986139
Study to Assess the Injection Site Pain Associated With a New Etanercept Formulation in Adults With Rheumatoid Arthritis or Psoriatic Arthritis
Arthritis, Rheumatoid; Arthritis, Psoriatic
P3
Completed111RCT, Double-blindCommercial Formulation Etanercept, New Formulation Etanercept
NCT00345839
E.V.O.L.V.E. Trial™: EValuation Of Cinacalcet Hydrochloride (HCl) Therapy to Lower CardioVascular Events
Secondary Hyperparathyroidism, Chronic Kidney Disease
P3
Completed3,883RCT, Double-blindCinacalcet, Placebo
NCT01854918
Open-label Extension Study of Evolocumab (AMG 145) in Adults With Hyperlipidemia and Mixed Dyslipidemia
Hyperlipidemia and Mixed Dyslipidemia
P3
Completed3,681RCT, Open-labelEvolocumab, Standard of Care
NCT00364013
PRIME: Panitumumab Randomized Trial In Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy
Metastatic Colorectal Cancer
P3
Completed1,183RCT, Open-labelPanitumumab, FOLFOX regimen
NCT00436748
Study to Assess Darbepoetin Alfa Dosing for the Correction of Anemia in Pediatric Patients With Chronic Kidney Disease
Anemia, Chronic Kidney Disease
P3
Terminated116RCT, Double-blindDarbepoetin Alfa, Placebo
NCT01764633
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
Dyslipidemia
P3
Completed27,564RCT, Double-blindEvolocumab, Placebo
NCT00838201
Extension Study to Evaluate Long Term Safety of Denosumab in Subjects Undergoing ADT for Non-Metastatic Prostate Cancer
Cancer, Carcinoma
P3
Completed384Open-labelDenosumab
NCT02994927
A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis
ANCA-Associated Vasculitis
P3
Completed331RCT, Double-blindAvacopan, Prednisone, Cyclophosphamide, Rituximab, Azathioprine
NCT02393859
Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)
Leukemia, Acute Lymphoblastic
P3
Completed111RCT, Open-labelBlinatumomab, Dexamethasone, Vincrisitne, Daunorubicin, Methotrexate, Ifosfamide, PEG-asparaginase, Erwinia-asparaginase
NCT00534456
An Exploratory Sub-study for the RED-HF™ (Reduction of Events With Darbepoetin Alfa in Heart Failure) Trial
Anemia, Cardiovascular Disease
P3
Terminated12RCT, Double-blindPlacebo, Darbepoetin alfa
NCT00377819
Study of Transitioning From Alendronate to Denosumab
Postmenopausal Osteoporosis
P3
Completed504RCT, Double-blindalendronate, Denosumab (AMG 162)
NCT00984815
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
Osteoarthritis, Rheumatoid Arthritis
P3
Completed86Open-labelHZT-501
NCT00110903
Treatment for Subjects With Active Rheumatoid Arthritis (RA)
Rheumatoid Arthritis
P3
CompletedOpen-labelEtanercept Liquid
NCT02729025
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflammation in Patients With Elevated Lipoprotein(a) (Lp(a))
Subjects With Hyperlipidemia, Dyslipidemia
P3
Completed129RCT, Double-blindEvolocumab, Placebo
NCT00286091
Study on Prolonging Bone Metastasis-Free Survival in Men With Hormone Refractory Prostate Cancer
Hormone Refractory Prostate Cancer
P3
Completed1,435RCT, Double-blindDenosumab, Placebo
NCT00556374
Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy
Breast Cancer
P3
Completed3,420RCT, Double-blindPlacebo, Denosumab, Non-steroidal aromatase inhibitor therapy, Zoledronic Acid
NCT02138838
Efficacy and Safety of Cinacalcet in Pediatric Patients With Secondary Hyperparathyroidism (SHPT) and Chronic Kidney Disease (CKD) on Dialysis
Chronic Kidney Disease, Secondary Hyperparathyroidism
P3
Terminated55RCT, Open-labelCinacalcet HCl
NCT03780959
Safety and Efficacy of Etanercept (Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein [TNFR:Fc]) in Children With Juvenile Rheumatoid Arthritis (JRA)
Juvenile Rheumatoid Arthritis
P2P3
Completed69RCT, Double-blindEtanercept, Placebo
NCT02373813
Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission
Rheumatoid Arthritis
P3
Completed371RCT, Double-blindetanercept pre-filled syringe subcutaneous injection, Oral methotrexate, Placebo for etanercept subcutaneous injection, Placebo for methotrexate
NCT01362140
Darbepoetin Alfa in Patients With Anemic Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
MDS
P3
Completed147RCT, Double-blindDarbepoetin alfa, Placebo
NCT03476239
Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)
Acute Lymphoblastic Leukemia
P3
Completed121Open-labelBlinatumomab, Dexamthasone
NCT01970475
Efficacy and Safety Study of ABP 501 Compared to Adalimumab in Subjects With Moderate to Severe Rheumatoid Arthritis
Arthritis, Rheumatoid
P3
Completed526RCT, Double-blindABP 501, Adalimumab
NCT01763866
LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2
Hyperlipidemia
P3
Completed2,067RCT, Double-blindEvolocumab, Ezetimibe, Placebo to Evolocumab, Placebo to Ezetimibe, Atorvastatin, Rosuvastatin, Simvastatin
NCT01277510
Pediatric Chronic Kidney Disease Safety and Efficacy
Chronic Kidney Disease, Hyperparathyroidism
P3
Terminated43RCT, Double-blindcinacalcet capsule, placebo, Standard of Care
NCT01583374
Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis
Ankylosing Spondyloarthritis
P3
Completed490RCT, Double-blindApremilast tablet 20 mg, Apremilast tablet 30 mg BID, Placebo
NCT01818752
Phase 3 Study of Carfilzomib, Melphalan, Prednisone vs Bortezomib, Melphalan, Prednisone in Newly Diagnosed Multiple Myeloma
Multiple Myeloma
P3
Completed955RCT, Open-labelCarfilzomib, Bortezomib, Melphalan, Prednisone
NCT01313221
Efficacy and Safety of Etanercept 50 mg Once Weekly Plus As Needed Topical Agent in Moderate to Severe Plaque Psoriasis
Psoriasis
P3
Completed310RCT, Single-blindetanercept, Topical agents
NCT01763918
Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2
Hyperlipidemia
P3
Completed331RCT, Double-blindEvolocumab, Placebo
NCT00975000
Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients
Chronic Allograft Nephropathy, Chronic Kidney Disease
P3
Completed114RCT, Double-blindCinacalcet, Placebo
NCT00657644
Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction
Erectile Dysfunction
P3
Completed130Open-labelLevitra (Vardenafil, BAY38-9456)
NCT00911170
PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study
Cancer, Colon Cancer
P3
Completed847RCT, Double-blindPegfilgrastim, Placebo, Bevacizumab, Standard Chemotherapy
NCT02593773
Safety, Tolerability and Efficacy of ACTIMMUNE® Dose Escalation in Friedreich's Ataxia Study
Friedreich's Ataxia
P3
Completed86Open-labelInterferon γ-1b
NCT00111111
An Evaluation of Etanercept in the Treatment of Subjects With Psoriasis
Psoriasis
P3
CompletedRCT, Open-labelEtanercept
NCT00101582
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
Mucositis, Solid Tumors
P3
Completed188RCT, Double-blindPlacebo, palifermin, cisplatin chemotherapy
NCT02456740
Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention
Migraine
P3
Completed955RCT, Double-blindErenumab, Placebo
NCT04169347
FOLFOXIRI Plus Panitumumab in Metastatic RAS Wild-type, Left-sided Colorectal Cancer
Colorectal Cancer Metastatic
P2
Unknown27Open-labelOxaliplatin
NCT00346099
Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With Capecitabine and Radiation of the Pelvis for Treatment of Patients With Rectal Cancers That May or May Not Have Spread Beyond the Rectum
Rectal Cancer, Neoplasm Metastasis
P2
WithdrawnOpen-labelPanitumumab with capecitabine and oxaliplatin (CAPOX) followed by, Panitumumab with capecitabine and radiation
NCT05180422
A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis
Non Small Cell Lung Cancer
P1P2
WithdrawnOpen-labelAMG 510, MVASI
NCT00591851
Phase II Study of Dose-Dense Doxurubicin and Cyclophosphamide (AC) Followed By Paclitaxel With Trastuzumab in HER2/ NEU-Amplified Breast Cancer: Feasibility
Breast Cancer
P2
Completed70Open-labelAC [Adriamycin (A) (also known as doxorubicin) and Cyclophosphamide (C)] Followed By Paclitaxel (P)
NCT06068153
AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC
Metastatic Non Small Cell Lung Cancer, KRAS G12C
P2
WithdrawnOpen-labelSotorasib, Lenvatinib
NCT00632541
A Phase II Study of Bevacizumab + Sorafenib in Metastatic Breast Cancer
Metastatic Breast Cancer
P2
Terminated18Open-labelSorafenib, Bevacizumab
NCT07178912
Phase II Study of the Combination of Subcutaneous Blinatumomab and Olverembatinib in Patients With Philadelphia Chromosome (ph)-Positive and/or BCR::ABL1 Positive Acute Lymphoblastic Leukemia (ALL)
Phase II Clinical Trial, Blinatumomab
P2
Not Yet Recruiting60Open-labelBlinatumomab, olverembatinib
NCT00193479
Combination Chemotherapy and Rituximab With Pegfilgrastim Followed by Rituximab, in Large B-Cell Non-Hodgkin's Lymphoma
Non-Hodgkins Lymphoma
P2
Completed51Open-labelCyclophosphamide, Mitoxantrone, Vincristine, Prednisone, Rituximab
NCT00940316
Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer
Colorectal Cancer
P2
Completed28RCT, Open-labelpanitumumab, erlotinib hydrochloride, irinotecan hydrochloride
NCT00400764
A Study of Dulanermin in Combination With Rituximab in Subjects With Follicular and Other Low Grade, CD20+, Non-Hodgkin's Lymphomas
Non-Hodgkin's Lymphoma
P1P2
Terminated72RCT, Open-labelDulanermin, Rituximab
NCT04448834
Blincyto Amgen Acrotech BioPharma PH2 Blincyto Marqibo R/R Philadelphi CD19+ ALL
B-cell Acute Lymphoblastic Leukemia
P2
WithdrawnOpen-labelBlinatumomab
NCT03301467
Controlled Trial Evaluating Avacopan in C3 Glomerulopathy
C3 Glomerulopathy (C3G)
P2
Completed57RCT, Double-blindAvacopan, Avacopan Matching Placebo
NCT04338581
Evaluation of AMG 714 for Vitiligo
Vitiligo
P2
Completed60RCT, Double-blindAMG 714, Placebo
NCT01464034
A Safety and Efficacy Study of Carfilzomib and Pomalidomide With Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P1P2
Terminated136Open-labelCarfilzomib, Pomalidomide, Dexamethasone
NCT00508625
A Study of AMG 951 [rhApo2L/TRAIL] in Subjects With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) Treated With Chemotherapy +/- Bevacizumab
Non-Small Cell Lung Cancer
P2
Completed213RCT, Open-labelAMG 951 (rhApo2L/TRAIL), Bevacizumab, Carboplatin, Paclitaxel
NCT00293202
Safety and Efficacy Study of the Effect of Etanercept in Hemodialysis Patients
End Stage Renal Disease
P2
Terminated10RCT, Double-blindEtanercept, Placebo
NCT05054725
Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies
Non-Small Cell Lung Cancer
P2
Completed47Open-labelRMC-4630, Sotorasib
NCT03160079
Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts
B-Cell Acute Lymphoblastic Leukemia, Adult
P1P2
Completed16Open-labelblinatumomab, pembrolizumab
NCT04129164
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
Sjögren's Syndrome
P2
Completed183RCT, Double-blindVIB4920, Placebo
NCT00597909
Efficacy and Safety Study of Ammonul® in Patients With Grade 3 or 4 Hepatic Encephalopathy
Hepatic Encephalopathy
P2
Terminated1RCT, Double-blindsodium phenylacetate and sodium benzoate injection 10% / 10%, sodium phenylacetate and sodium benzoate injection 10% / 10%, placebo solution (10% dextrose)
NCT07301424
Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL+ B-ALL
Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+), BCR-ABL Positive Acute Lymphoblastic Leukemia
P2
Not Yet Recruiting80Open-labelTreatment with blinatumomab given subcutaneously.
NCT03795558
A Study to Investigate the Influence of PTH-lowering by Etelcalcetide (Parsabiv®) on the Calcification Propensity of Serum in Dialysis Patients
End Stage Renal Disease
P2
Completed37Open-labelEtelcalcetide
NCT02453191
TVEC and Preop Radiation for Sarcoma (4 ml Dose)
Soft Tissue Sarcoma
P1P2
Completed30Open-labelTalimogene Laherparepvec
NCT00841789
A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki Disease
Mucocutaneous Lymph Node Syndrome, Kawasaki Disease
P2
Completed205RCT, Double-blindEtanercept, Placebo
NCT00526929
Fixed Dose NESP Study in Subjects With CRI
Pre-Dialysis
P2
Completed75Open-labeldarbepoetin alfa
NCT00037700
Evaluation of the Efficacy of Combination Treatment With Anakinra and Pegsunercept in Improving Rheumatoid Arthritis
Rheumatoid Arthritis
P2
CompletedRCT, Double-blindanakinra, pegsunercept
NCT00079612
Study of Nexavar (Sorafenib, BAY 43-9006) in Patients With Advanced Refractory Cancer
Carcinoma, Renal Cell
P2
Completed501RCT, Double-blindSorafenib (Nexavar, BAY43-9006), Placebo
NCT00095264
A Study of Darbepoetin Alfa in Anemic Subjects With Low Risk Myelodysplastic Syndrome
Myelodysplastic Syndromes
P2
Completed209Open-labelDarbepoetin Alfa
NCT00000626
Phase II Study of Filgrastim (G-CSF) Plus ABVD in the Treatment of HIV-Associated Hodgkin's Disease
HIV Infections, Hodgkin's Disease
P2
Completed27Vinblastine sulfate, Dacarbazine, Filgrastim, Bleomycin sulfate, Doxorubicin hydrochloride
NCT00639717
Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant
Graft Versus Host Disease
P2
Completed48Open-labeltacrolimus (standard GVHD prophylaxis), mycophenolate (standard GVHD prophylaxis), etanercept, methoxsalen
NCT02087943
Efficacy and Safety Study of Apremilast in Subjects With Moderate to Severe Atopic Dermatitis
Dermatitis, Atopic Dermatitis
P2
Completed191RCT, Double-blindApremilast, Apremilast, Placebo, Placebo
NCT01466179
Clinical Study With Blinatumomab in Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)
Acute Lymphoblastic Leukemia
P2
Completed225Open-labelBlinatumomab
NCT01379807
Efficacy and Safety of Panitumumab Combined With Docetaxel and Cisplatin as a First-line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
P2
Unknown55Open-labelpanitumumab + docetaxel + cisplatino
NCT04330430
Neo-adjuvant T-VEC + Nivolumab Combination Therapy for Resectable Early Metastatic (stage IIIB/C/D-IV M1a) Melanoma with Injectable Disease
Melanoma Stage III, Melanoma Stage IV
P2
Completed24Open-labelT-VEC
NCT03137537
Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy.
Lymphoma, Autonomic Imbalance
P2
Terminated23RCT, Double-blindIvabradine, Placebo Oral Tablet
NCT02429882
Study of Efficacy and Safety of Brodalumab Compared With Placebo in Subjects With Axial Spondyloarthritis
Axial Spondyloarthritis
P2
WithdrawnRCT, Double-blindBrodalumab 210 mg, Placebo
NCT00594620
Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy
Prostate Cancer
P2
Terminated11RCT, Double-blindPlacebo
NCT03809663
A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic Dermatitis
Atopic Dermatitis
P2
Terminated251RCT, Double-blindTezepelumab
NCT02464891
Complement Inhibition in aHUS Dialysis Patients
Atypical Hemolytic Uremic Syndrome
P2
Terminated6Open-labelCCX168
NCT02412306
Study of Blinatumomab in Japanese Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Relapsed Refractory B Precursor Acute Lymphoblastic Leukemia
P1P2
Completed66Open-labelBlinatumomab
NCT02833610
A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency
Multiple Myeloma
P2
Completed55Open-labelDenosumab Q4W
NCT04231682
A Study to Evaluate Efficacy and Safety of Denosumab for Prevention and Treatment of Osteoporosis in 1st Time Liver Transplant Recipients.
Osteoporosis
P2
WithdrawnRCT, Double-blindDenosumab Injection, Placebos
NCT01234324
ECX + Panitumumab vs. ECX Alone in Locally Advanced Gastric Cancer or Cancer of the Gastroesophageal Junction
Stomach Neoplasms, Gastroesophageal Junction Neoplasms
P2
Completed171RCT, Open-labelEpirubicin, Cisplatin, Capecitabine, Panitumumab, Epirubicin, Cisplatin, Capecitabine
NCT01987232
Phase 1b/2 Study of Carfilzomib, Carboplatin, and Etoposide in Patients With Previously Untreated Extensive Stage Small-cell Lung Cancer
Extensive-Stage Small-Cell Lung Cancer
P1P2
Completed32Open-labelCarfilzomib, Carboplatin, Etoposide
NCT00113958
Cinacalcet Study to Reach Kidney Disease Outcomes Quality Initiative (K/DOQI) Levels
End Stage Renal Disease
P2
CompletedOpen-labelCinacalcet
NCT06333678
A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer
P2
Completed10RCT, Open-labelDurvalumab, Sotorasib
NCT02289417
Efficacy and Safety Study of Apremilast to Treat Active Ulcerative Colitis
Ulcerative Colitis
P2
Completed170RCT, Double-blindApremilast, Placebo
NCT01150890
Brodalumab (AMG 827) in Adults With Moderate to Severe Crohn's Disease
Crohn's Disease
P2
Terminated130RCT, Double-blindBrodalumab, Placebo
NCT04478123
Using Romiplostim to Treat Low Platelet Counts Following Chemotherapy and Autologous Hematopoietic Cell Transplantation in People With Blood Cancer
Multiple Myeloma, Hodgkin Lymphoma
P2
Completed62Open-labelRomiplostim
NCT01351623
Infusional Carfilzomib in Patients With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P2
Completed44Open-labelCarfilzomib
NCT04039113
Tezepelumab COPD Exacerbation Study
Chronic Obstructive Pulmonary Disease (COPD)
P2
Completed337RCT, Double-blindTezepelumab
NCT00321711
Determination of Safe and Effective Dose of Romiplostim (AMG 531) in Subjects With Myelodysplastic Syndrome (MDS)Receiving Hypomethylating Agents
MDS, Myelodysplastic Syndromes
P2
Completed69RCT, Double-blindPlacebo, AMG 531 (Romiplostim), Azacitidine, Decitabine
NCT02227914
Phase 1b/2 Study of Oprozomib in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma
P1P2
WithdrawnRCT, Open-labelOprozomib, Sorafenib
NCT00936650
A Study to Assess the Efficacy and Safety of Twice-Daily Dose Regimens of an Oral Calcimimetic Agent AMG 073 (Cinacalcet) in Primary Hyperparathyroidism (PHPT)
Hyperparathyroidism, Primary
P2
Completed78RCT, Double-blindplacebo, cinacalcet
NCT00661141
Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism
Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
P2
Completed32RCT, Double-blindAntizol, Placebo
NCT00050674
Docetaxel and Gemcitabine With Filgrastim-SD/01 Support in Patients With Advanced Non-Small Cell Lung Carcinoma
Non-small Cell Lung Cancer
P2
Completed40Open-labelFilgrastim-SD/01
NCT00756444
A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck
Squamous Cell Carcinoma of Head and Neck
P2
Completed67RCT, Open-labelPanitumumab, Cisplatin, 5FU
NCT03238781
Study to Evaluate the Efficacy and Safety of AMG 301 in Migraine Prevention
Chronic Migraine or Episodic Migraine
P2
Completed343RCT, Double-blindPlacebo, AMG 301
NCT01568216
20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms
Schizophrenia
P2
Terminated121RCT, Double-blindAMG 747, Placebo
NCT04270760
Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study
Cardiovascular Disease
P2
Completed281RCT, Double-blindOlpasiran, Placebo
NCT01907308
Trebananib (AMG 386) in Combination With Docetaxel for Advanced Urothelial Carcinoma
Urothelial Carcinoma
P2
WithdrawnOpen-labelAMG 386, Docetaxel
NCT01285310
Study of Apremilast to Evaluate the Safety and Effectiveness for Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
P2
Terminated237RCT, Double-blindApremilast 30 mg, Apremilast 20 mg, Placebo
NCT00035620
Pegfilgrastim as Support to Pediatric Sarcoma Patients Receiving Chemotherapy
Sarcoma, Neutropenia
P2
Completed44RCT, Open-labelpegfilgrastim, filgrastim
NCT01701076
Bendamustine, Lenalidomide (Revlimid®) and Dexamethasone (BRd) as 2nd-line Therapy for Patients With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P2
Completed50Open-labelBendamustine
NCT00411450
Panitumumab Regimen Evaluation in Colorectal Cancer to Estimate Primary Response to Treatment
Colon Cancer, Colorectal Cancer
P2
Completed116Open-labelPanitumumab, FOLFIRI
NCT01902290
Study of Efficacy and Safety of Brodalumab Compared With Placebo in Adults With Inadequately Controlled Asthma With High Bronchodilator Reversibility
Asthma
P2
Terminated421RCT, Double-blindPlacebo, Brodalumab
NCT00117455
A Study of Peripheral Blood Progenitor Cell (PBPC) Mobilisation by Chemotherapy With Pegfilgrastim or Filgrastim in Subjects With Non-Hodgkin's Lymphoma
Non-Hodgkin's Lymphoma
P2
CompletedRCT, Double-blindpegfilgrastim, filgrastim
NCT00049985
Heart Failure and Anemia
Heart Failure, Anemia
P2
Completed300RCT, Double-blindDarbepoetin Alfa
NCT02779855
Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
Breast Cancer, Ductal Carcinoma
P1P2
Completed50Open-labelTalimogene laherparepvec, Paclitaxel
NCT01143038
Interventional Study in Adults With Immune Thrombocytopenia Purpura (ITP) Receiving Romiplostim
Idiopathic Thrombocytopenic Purpura
P2
Completed75Open-labelRomiplostim
NCT02000427
Blinatumomab in Adults With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia
Relapsed/Refractory Philadelphia Positive B-precursor ALL
P2
Completed45Open-labelBlinatumomab
NCT00120705
Treatment for Anemic Subjects With Non-Myeloid Malignancies Receiving Chemotherapy
Neoplasms, Anemia
P2
Completed204RCT, Open-labeldarbepoetin alfa
NCT03298412
Effect of Blinatumomab on Minimal Residual Disease (MRD) in Diffuse Large B-Cell Lymphoma (DLBCL) Subjects Post Autologous Hematopoietic Stem Cell Transplantation (aHSCT)
High-risk Diffuse Large B-cell Lymphoma
P2
Terminated10Open-labelBlinatumomab
NCT00751894
Pegfilgrastim for Stem Cell Mobilization in Children (Meg-5)
Solid Malignancies
P2
Unknown30Open-labelPegfilgrastim (Neulasta, Amgen)
NCT00189488
Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation
Graft Versus Host Disease, Hematologic Malignancies
P2
Completed155RCT, Double-blindPalifermin, Placebo, Methotrexate
NCT05591222
Study of Daxdilimab (HZN-7734) in Participants With Moderate-to-Severe Primary Discoid Lupus Erythematosus
Discoid Lupus Erythematosus
P2
Terminated72RCT, Double-blindPlacebo, Daxdilimab
NCT00231582
High-dose Chemotherapy With Autologous Stem Cell Transplantation in Poor Prognosis Germ-cell Tumors: TAXIF II
Testicular Neoplasms
P2
Completed50Open-labelepirubicin, paclitaxel, etoposide, ifosfamide, carboplatin
NCT01172717
Study of Panitumumab in the Treatment of Carcinoid Syndrome
Carcinoid Syndrome
P2
WithdrawnOpen-labelPanitumumab
NCT01017653
Panitumumab and Irinotecan for Malignant Gliomas
Malignant Glioma of Brain
P2
Terminated16Open-labelIrinotecan, Panitumumab
NCT00500760
Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer
Head and Neck Cancer, Squamous Cell Carcinoma
P2
Completed153RCT, Open-labelCisplatin, Panitumumab
NCT02215200
ATG-GCSF in New Onset Type 1 Diabetes
Diabetes Mellitus, Type 1
P2
Completed89RCT, Double-blindAnti-Thymocyte Globulin (ATG), Granulocyte colony stimulating factor (GCSF), Placebo (for ATG), Placebo (for GCSF)
NCT03512353
A Study of Carfilzomib Plus Dexamethasone in Adults With Relapsed or Refractory Multiple Myeloma at US Community Oncology Centers
Relapsed or Refractory Multiple Myeloma
P2
Terminated7Open-labelDexamethasone, Carfilzomib
NCT00005960
Combination Chemotherapy in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
Pain, Prostate Cancer
P2
Unknownfilgrastim, cyclophosphamide, docetaxel, doxorubicin hydrochloride
NCT01568229
20110165: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms (Study 165)
Schizophrenia
P2
Terminated111RCT, Double-blindAMG 747, Placebo
NCT01128387
Trial of Panitumumab/Cisplatin/Fluorouracil Combined With Radiation in Esophageal Cancer
Cancer
P1P2
Terminated11Open-labelPanitumumab
NCT00865709
Study of Modified FOLFOX6 Plus or Minus Sorafenib in Stage IV Metastatic Colorectal Carcinoma (mCRC) Subjects
Metastatic Colorectal Cancer
P2
Completed198RCT, Double-blindSorafenib (Nexavar, BAY43-9006) + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin), Matching placebo + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin)
NCT00038298
A Rheumatoid Arthritis (RA) Study Treating Signs and Symptoms of RA in People With RA & Receiving Methotrexate
Rheumatoid Arthritis
P2
Completed53RCT, Double-blindPlacebo, AMG 719, AGM 719, AMG 719, placebo to AMG 719
NCT04987307
Safety and Efficacy of Efavaleukin Alfa in Participants With Moderately to Severely Active Ulcerative Colitis
Ulcerative Colitis
P2
Terminated221RCT, Double-blindEfavaleukin alfa, Placebo
NCT01792102
Safety, Efficacy, and Pharmacodynamics of a 60-Minute Infusion of Carfilzomib for Progressive Multiple Myeloma
Multiple Myeloma
P1P2
Unknown38Open-labelCarfilzomib and Dexamethasone
NCT01016795
Stem Cell Factor (SCF) Priming of Haematopoietic Stem Cell Grafts in Malignant Lymphoma
Malignant Lymphoma
P2
Terminated32RCT, Double-blindr-metHuSCF and Filgrastim, r-metHuSCF and Filgrastim, Chemotherapy plus Filgrastim
NCT00401544
Darbepoetin Alfa With or Without Intravenous (IV) Iron
Anemia, Non-Myeloid Malignancies
P2
Completed243RCT, Double-blinddarbepoetin alfa, IV iron dextran
NCT04082442
Evolocumab in Patients With Acute MI
Acute Coronary Syndrome
P2
Completed100RCT, Double-blindEvolocumab, Placebos
NCT00757172
Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
P2
Completed70Open-labelpanitumumab, cisplatin, docetaxel
NCT00585650
Study of Tumor Necrosis Factor Receptor Fusion Protein Etanercept (Enbrel) in Psoriasis of the Hands and/or Feet
Psoriasis
P1P2
Completed20RCT, Double-blindEtanercept
NCT01313884
Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma
Bone Cancer, Ewing's Sarcoma
P2
Terminated3Open-labelIrinotecan, Vincristine, Temozolomide, Doxorubicin, Cytoxan, Pegfilgrastim
NCT04785547
ALL SCTped 2012 FORUM Add-on Study Blina Post HSCT
ALL, Childhood, Minimal Residual Disease
P2
Terminated3Open-labelBlinatumomab
NCT01328171
FOLFOXIRI With or Without Panitumumab in Metastatic Colorectal Cancer (VOLFI)
Metastatic Colorectal Cancer
P2
Completed93RCT, Open-labelFOLFOXIRI + Panitumumab, FOLFOXIRI
NCT01375764
Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects
Hyperlipidemia
P2
Completed160RCT, Double-blindEvolocumab, Ezetimibe
NCT03620019
Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma
Melanoma Stage Iii, Melanoma Stage Iv
P2
Completed25Open-labelDenosumab, Pembrolizumab, Nivolumab
NCT00360867
An Open Label Treatment Extension Study of AMG 706
Solid Tumors
P2
Terminated94Open-labelAMG 706
NCT01175733
Chemoradiation With Gemcitabine in Combination With Panitumumab for Patients With Locally Advanced Pancreatic Cancer
Pancreatic Cancer
P1P2
Completed18Open-labelPanitumumab
NCT03852472
Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA)
Hidradenitis Suppurativa, Acne Inversa
P2
Completed435RCT, Double-blindAvacopan
NCT00884312
A Study of Extended Carfilzomib Therapy for Patients Previously Enrolled in Carfilzomib Treatment Protocols
Multiple Myeloma, Solid Tumors
P2
Completed101Open-labelCarfilzomib
NCT00936988
A Multicenter, Open-label Extension Study to Assess the Long-term Safety and Efficacy of an Oral Calcimimetic Agent AMG 073 (Cinacalcet) in Primary Hyperparathyroidism
Hyperparathyroidism, Primary
P2
Completed45Open-labelcinacalcet
NCT01207388
Confirmatory Phase II Study of Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL)
B-cell Acute Lymphoblastic Leukemia
P2
Completed116Open-labelBlinatumomab
NCT00095277
Darbepoetin Alfa Administered Once Every 4 Weeks in the Treatment of Subjects With Anemia of Cancer
Anemia
P2
Completed220RCT, Double-blindDarbepoetin Alfa
NCT00283439
A Dose and Schedule Finding Trial With AMG 531 for Chemotherapy Induced Thrombocytopenia (CIT) in Adults With Lymphoma
Chemotherapy-Induced Thrombocytopenia, Hodgkin's Lymphoma
P1P2
Completed39Open-labelAMG 531
NCT03280667
Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Clear Cell, Metastatic Kidney Cancer
P2
Unknown59Open-labelPembrolizumab plus denosumab
NCT00511238
Phase 2 Study of Carfilzomib in Relapsed and Refractory Multiple Myeloma
Multiple Myeloma
P2
Completed312Open-labelcarfilzomib, carfilzomib
NCT00037648
Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis
P2
Completed86RCT, Double-blindAnakinra, Placebo
NCT00661921
A Randomized Double Blind, Placebo Controlled Trial With AMG 108 in Patients With Type 2 Diabetes Mellitus
Diabetes Mellitus
P2
WithdrawnRCT, Double-blindAMG 108, Placebo
NCT01290263
Amgen 386 for Recurrent Glioblastoma
Glioblastoma Multiforme
P1P2
Completed48Open-labelAmgen 386, Bevacizumab
NCT00682383
Combined Modality Therapy With Growth Factor Support in Locally Advanced Non-small Cell Lung Cancer (NSCLC)
Unresectable Locally Advanced NSCLC
P2
Completed26Open-labelCisplatin; Etoposide; Radiation therapy; Docetaxel; Neulasta
NCT02597062
High-Dose Weekly Carfilzomib Plus Cyclophosphamide and Dexamethasone in the Treatment of Relapsed Multiple Myeloma
Multiple Myeloma
P2
Completed76Open-labelCarfilzomib, Cyclophosphamide, Dexamethasone
NCT01288339
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
P2
Completed78Open-labelPanitumumab + FOLFOX (DP), Panitumumab + FOLFOX (no-DP)
NCT00113945
Research Study Evaluating Cinacalcet for Patients With End Stage Renal Disease (ESRD)
End Stage Renal Disease
P2
Completed360Open-labelCinacalcet
NCT03070002
Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells
Breast Carcinoma Metastatic in the Bone, Circulating Tumor Cell Count
P2
Terminated1Open-labelDenosumab
NCT00001059
Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS
Sarcoma, Kaposi, HIV Infections
P2
Completed120Doxorubicin hydrochloride (liposomal), Filgrastim, Bleomycin sulfate, Vincristine sulfate
NCT04556084
Blinatumomab Bridging Therapy for BALL
B-cell Acute Lymphoblastic Leukemia, Refractory B Acute Lymphoblastic Leukemia
P2
Terminated2Open-labelBlinatumomab
NCT04427306
Neoadjuvant T-VEC in High Risk Early Melanoma
Melanoma
P2
SUSPENDED6Open-labelT-Vec
NCT00356681
A Study of AMG 706 or Bevacizumab, in Combination With Paclitaxel Chemotherapy, as Treatment for Breast Cancer
Breast Neoplasms, Breast Tumors
P2
Terminated282RCT, Double-blindAMG 706 placebo, Bevacizumab, AMG 706, Paclitaxel
NCT00730392
Etanercept in New Onset Type 1 Diabetes
Type 1 Diabetes
P1P2
Completed18RCT, Double-blindEtanercept, Placebo
NCT00067639
Pegfilgrastim (Neulasta) for Stem Cell Mobilization in Patients With Multiple Myeloma
Multiple Myeloma
P2
Completed50Open-labelPegfilgrastim (Neulasta)
NCT02335268
Validation of a Predictive Model of Response to Romiplostim in Patients With IPSS Low or Intermediate-1 Risk MDS and Thrombocytopenia
Myelodysplastic Syndromes
P2
Completed77Open-labelN-Plate / romiplostim
NCT01194869
Preoperative Trial of Sorafenib in Combination With Cisplatin Followed by Paclitaxel for Early Stage Breast Cancer
Breast Cancer
P2
Terminated25Open-labelSorafenib, Cisplatin, Paclitaxel
NCT01296035
Panitumumab and Gemcitabine in Relapsed Ovarian Cancer
Ovarian Cancer, Fallopian Tube Cancer
P2
Terminated8Open-labelPanitumumab
NCT01349088
Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer
Breast Cancer, Metastatic Breast Cancer
P1P2
WithdrawnOpen-labelIxabepilone, Capecitabine, Motesanib
NCT01199289
A Study to Evaluate the Dosing of AMG 827 for Subjects With Inadequately Controlled Asthma
Asthma
P2
Completed315RCT, Double-blindAMG 827, Placebo
NCT00113789
Evaluating Pegfilgrastim and a Multi-Day Topotecan Regimen in Subjects With Relapsed or Refractory Ovarian Cancer
Ovarian Cancer
P2
Completed21RCT, Double-blind
NCT01696396
Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's Disease
Crohn's Disease
P2
Completed254RCT, Double-blindAbrilumab, Placebo
NCT03688074
Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)
Asthma, Bronchial Diseases
P2
Completed116RCT, Double-blindTezepelumab
NCT00770848
AMG 102 in Combination With Mitoxantrone and Prednisone in Subjects With Previously Treated Castrate Resistant Prostate Cancer
Cancer, Castrate-Resistant Prostate Cancer
P1P2
Completed162RCT, Double-blindAMG 102, AMG 102, Mitoxantrone, Placebo, Prednisone
NCT00094835
Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Lung Cancer, Non-Small Cell Lung Cancer
P1P2
Completed51Open-labelPanitumumab, Motesanib diphosphate, Paclitaxel, Carboplatin
NCT02983097
Therapy of Non-Hodgkin-Lymphoma by Combination of Lenalidomide + Rituximab, Dexa, High-dose ARA-C and CisP
Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma Grade III (FL III°)
P1P2
Terminated34Open-labelRituximab, Cisplatin, Carboplatin, Dexamethasone, Cytarabine, Lenalidomide, PegFilgrastim
NCT02420587
AMG 208 Tumor Microenvironment in Metastatic Castration Resistant Prostate Cancer (mCRPC)
Prostate Cancer
P2
WithdrawnOpen-labelAMG 208
NCT00083616
Evaluating Panitumumab (ABX-EGF) Monotherapy in Patients With Metastatic Colorectal Cancer Following Treatment With Fluoropyrimidine, Irinotecan, and Oxaliplatin Chemotherapy
Colorectal Cancer, Metastatic Cancer
P2
Completed185Open-labelPanitumumab
NCT00885885
Safety and Efficacy Study of FOLFOX4+Panitumumab vs.FOLFIRI+Panitumumab in Subjects WT KRAS Colorectal Cancer and Liver-only Metastases
Colorectal Cancer
P2
Completed80RCT, Open-labelPanitumumab+FOLFOX-4, Panitumumab+FOLFIRI
NCT00117143
Amgen Megakaryopoiesis Protein 2 (AMG 531) in Thrombocytopenic Subjects With Immune Thrombocytopenic Purpura (ITP)
Thrombocytopenic Purpura
P1P2
Completed16Open-labelRomiplostim
NCT00306189
A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects
Osteoporosis
P2
Completed212RCT, Double-blind100 mg AMG 162, 60 mg AMG 162, 14 mg AMG 162, Placebo
NCT03656666
The AP-GELP Study: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus
Lichen Planus of Vulva, Female Genital Disease
P2
Unknown42RCT, Double-blindApremilast, Placebo
NCT04057937
A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Japanese Subjects With Palmoplantar Pustulosis
Palmoplantaris Pustulosis
P2
Completed90RCT, Double-blindApremilast, Placebo
NCT00540384
Dose-finding Study of Novel Erythropoiesis Stimulating Protein (NESP) for the Treatment of Anaemia in Subjects With Solid Tumours Receiving Multicycle Chemotherapy
Anemia, Solid Tumors
P1P2
Completed405RCT, Double-blindPlacebo, Novel Erythropoiesis Stimulating Protein (NESP) (darbepoetin alfa)
NCT03773107
LCI-HEM-MYE-CRD-004 (MMRC-073 CARJAK): Study of CRD for Carfilzomib-Refractory Multiple Myeloma
Multiple Myeloma
P1P2
Completed12Open-labelCarfilzomib, Ruxolitinib, Dexamethasone
NCT01024387
AMG 479 in Advanced Carcinoid and Pancreatic Neuroendocrine Tumors
Neuroendocrine Tumor, Carcinoid Tumor
P2
Completed60Open-labelAMG 479
NCT01325194
CHemoImmunotherapy With Early Central Nervous System (CNS) Prophylaxis
Primary Disease
P2
Completed143Open-labelliposomal cytarabine
NCT03605199
Denosumab in Subjects With Giant Cell Rich Tumors of Bone
Aneurysmal Bone Cysts, Giant Cell Granuloma
P2
Unknown60Open-labelDenosumab
NCT03155100
Carfilzomib + Elotuzumab + Dexamethasone for Relapsed Multiple Myeloma After 1-3 Prior Treatment Lines
Multiple Myeloma in Relapse
P2
Completed15Open-labelCarfilzomib for Inj 60 milligram (MG), Elotuzumab 400 MG, Dexamethasone
NCT01470196
Carfilzomib, Rituximab and Dexamethasone in Waldenstrom's Macroglobulinemia
Waldenstrom's Macroglobulinemia
P2
Completed31Open-labelDexamethasone, Carfilzomib, Rituximab
NCT00293813
A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density
Postmenopausal Osteoporosis
P2
Completed247RCT, Double-blindAlendronate, Denosumab, Placebo
NCT03410056
Safety and Efficacy of Efavaleukin Alfa in Subjects With Active Rheumatoid Arthritis
Rheumatoid Arthritis RA
P1P2
Terminated36RCT, Double-blindEfavaleukin alfa, Placebo
NCT00101413
BAY43-9006 - Phase II Study in Non-Small Cell Lung Carcinoma (NSCLC)
Cancer, Carcinoma, Non-Small Cell Lung
P2
Completed52Open-labelSorafenib (Nexavar, BAY43-9006)
NCT00094861
Study to Evaluate Palifermin in the Reduction of Dysphagia in Patients With Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Dysphagia, Non-Small Cell Lung Cancer
P2
Completed100RCT, Double-blindPalifermin, Placebo, Paclitaxel, Carboplatin
NCT00866359
A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Behçet Disease
Behcet Syndrome
P2
Completed111RCT, Double-blindApremilast (CC-10004), Placebo
NCT00043186
Determine the Efficacy, Safety and Tolerability of Denosumab (AMG 162) in the Treatment of Postmenopausal Women With Low Bone Mineral Density
Low Bone Mineral Density
P2
Completed412RCT, Double-blindPlacebo, Denosumab, Alendronate
NCT00586443
BEP Study Phase I (Bevacizumab, Everolimus, Panitumumab)
Solid Tumors
P1
Completed56Open-labelbevacizumab, everolimus, panitumumab
NCT01789242
A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis
Amyloidosis, Systemic Light Chain Amyloidosis
P1
Completed32Open-labelCarfilzomib, Dexamethasone
NCT05480865
SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation
Solid Tumor, Adult, Metastatic Solid Tumor
P1
Terminated28RCT, Open-labelBBP-398, sotorasib
NCT01549431
Study of the Combination of Panobinostat & Carfilzomib in Patients With Relapsed &/or Refractory Multiple Myeloma
Multiple Myeloma
P1
Completed32Open-labelPanobinostat, Carfilzomib, Dexamethasone
NCT00986895
A Study of Glyceryl Tri-(4-phenylbutyrate) Administered Orally as a Single Dose, and Twice Daily for Seven Consecutive Days to Subjects With Hepatic Impairment With Cirrhosis and to a Control Group
Hepatic Encephalopathy, Urea Cycle Disorders
P1
Completed32Open-labelHPN-100
NCT00007813
Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
P1
Completed21Open-labelfilgrastim, carboplatin, cyclophosphamide, etoposide
NCT00879385
KRAS Wild-type Metastatic Colorectal Cancer Trial
Colorectal Cancer
P1
Completed21Open-labelDacogen™ (decitabine), Vectibix® (panitumumab)
NCT04293094
Study of AMG 650 in Adult Participants With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed66Open-labelAMG 650
NCT03797261
A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies
Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma
P1
Terminated9Open-labelVenetoclax, AMG 176
NCT00977600
A Study of Glyceryl Tri-(4-phenylbutyrate) (GT4P)
Healthy
P1
Completed24RCT, Open-labelHPN-100, Ammonul, Buphenyl
NCT01660750
A Safety Study of Carfilzomib, Cyclophosphamide & Dexamethasone Prior to ASCT in Patients With Newly Diagnosed Myeloma
Multiple Myeloma
P1
Completed29Open-labelCarfilzomib, Cyclophosphamide, Dexamethasone
NCT01124279
Single-dose, Pharmacokinetics of AMG 853 in Healthy Adult Subjects
Healthy Volunteers
P1
Completed43RCT, Open-labelAMG 853
NCT03276728
Study to Evaluate the Safety and Tolerability of AMG 986 in Healthy Volunteers and Heart Failure Patients
Heart Failure, Healthy Volunteer
P1
Terminated182RCT, Double-blindAMG 986 IV, AMG 986 PO, Placebo PO, Placebo IV
NCT01101048
An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density
Osteopenia
P1
Completed74RCT, Double-blindPlacebo, AMG 167
NCT04524455
Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALL
Acute Lymphoblastic Leukemia
P1
Completed17Open-labelBlinatumomab, AMG 404, Dexamethasone Premedication
NCT03541369
Safety, Tolerability, PK, PD, and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia
Relapsed/Refractory Acute Myeloid Leukemia (AML)
P1
Terminated64Open-labelAMG 427
NCT02244112
A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction With Midazolam, and Safety and Tolerability in Patients With Advanced Malignancies
Advanced Non-Central Nervous System (CNS) Malignancies
P1
Terminated43Open-labelOprozomib, Midazolam
NCT01331941
A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal Function
Advanced Solid Tumors, Kidney Disease
P1
Completed35Open-labelAMG 386 + Paclitaxel, AMG 386
NCT06389578
A Study of TEPEZZA® Treatment in Participants With Thyroid Eye Disease
Thyroid Eye Disease
P1
Completed16RCT, Open-labelTeprotumumab
NCT06352892
A Study to Evaluate AMG 133 in Chinese Participants With Obesity or Overweight
Obesity
P1
Completed20RCT, Open-labelMaridebart Cafraglutide
NCT02291614
A Phase 1 Study of AMG 211 in Participants With Advanced Gastrointestinal Cancer
GI Adenocarcinoma
P1
Terminated45Open-labelAMG 211
NCT00757042
Safety Study of Tezepelumab (AMG 157) in Healthy Adults and Adults With Atopic Dermatitis
Atopic Dermatitis, Healthy Volunteers
P1
Completed78RCT, Double-blindTezepelumab, Placebo
NCT00040651
Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients
Scleroderma, Systemic Sclerosis
P1
Terminated15Open-labelFludarabine, Cyclophosphamide, Thymoglobulin
NCT01135680
Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100
Drug Toxicity
P1
Completed98RCT, Double-blindHPN-100, HPN-100 or Placebo, Placebo, Moxifloxacin, HPN-100, HPN-100
NCT02053753
Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product
Healthy Volunteer
P1
Completed146RCT, Double-blindDenosumab CP4, Denosumab CP2
NCT01290029
Study to Evaluate Cinacalcet in Children With Chronic Kidney Disease
Chronic Kidney Disease, Hyperparathyroidism, Secondary
P1
Completed14Open-labelCinacalcet
NCT04727554
Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed11Open-labelAMG 994, AMG 404
NCT05988034
A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants
Electrocardiography
P1
Completed58RCT, Double-blindAvacopan, Moxifloxacin, Placebo for avacopan, Placebo for moxifloxacin
NCT02641353
Study to Evaluate Bioavailability of Apremilast Oral Suspension Relative to Tablet and to Assess Effect of Food on the Pharmacokinetics (PK) of the Oral Suspension
Healthy Volunteers
P1
Completed34RCT, Open-labelApremilast Tablet, Apremilast Oral Suspension
NCT03822078
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Denosumab (AMG 162) in Japanese Postmenopausal Women
Osteoporosis
P1
Completed45RCT, Double-blindPlacebo, Denosumab
NCT07283640
A Phase IB Trial of Subcutaneous Blinatumomab in Combination With Revumenib for Patients With KMT2A-rearranged Acute Lymphoblastic Leukemia
Blinatumomab, Revumenib
P1
Not Yet Recruiting20Open-labelRevumenib, Blinatumomab
NCT03626662
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a)
Cardiovascular Disease
P1
Completed79RCT, Double-blindAMG 890, Placebo
NCT05578859
A Study of the Absorption, Metabolism, and Excretion of [14C]-AMG 510 Following a Single Oral Dose in Healthy Male Subjects
Healthy Subjects
P1
Completed8Open-labelAMG 510
NCT02269085
Trial of PCI-32765 (BTK Inhibitor) in Combination With Carfilzomib in Relapse/Refractory Mantle Cell Lymphoma
Lymphoma
P1
Terminated8Open-labelIbrutinib, Carfilzomib
NCT06004960
A Study to Assess the Mass Balance Recovery (Absorption, Distribution, Metabolism and Excretion) of [14C]CCX168 in Healthy Participants
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
P1
Completed6Open-label[14C]CCX168
NCT01059435
A First-in-human Study Evaluating Romosozumab (AMG 785) in Healthy Men and Postmenopausal Women
Osteopenia
P1
Completed74RCT, Double-blindRomosozumab, Placebo
NCT01428154
Study to Evaluate Darbepoetin Alfa in Pediatric Subjects With Anemia Due to Chronic Kidney Disease
Anemia, Chronic Kidney Disease
P1
WithdrawnOpen-labelDarbepoetin alfa
NCT00150462
Safety Study of the Proteasome Inhibitor PR-171 (Carfilzomib for Injection) in Patients With Hematological Malignancies
Waldenstrom's Macroglobulinemia, Non-Hodgkin's Lymphoma
P1
Completed48Open-labelCarfilzomib, Dexamethasone
NCT02561962
A Phase 1 Study in Subjects With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P1
Completed42Open-labelAMG 224
NCT04857606
Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
P1
Completed47RCT, Double-blindAMG 609, Placebo
NCT02512926
Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children
Relapsed Solid Tumors, Refractory Solid Tumors
P1
Completed4Open-labelCarfilzomib, Cyclophosphamide, Etoposide
NCT02780674
A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases
Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc
P1
Completed36RCT, Double-blindMEDI7734, Placebo
NCT01791374
Phase 1/1b Study of Rilotumumab in Japanese Subjects With Advanced Solid Tumors or Advanced or Metastatic Gastric or GEJ
Part 1- Advanced Solid Tumors, Part 2- Advanced or Metastatic Gastric Cancer
P1
Completed21Open-labelRilotumumab, Rilotumumab
NCT00950950
A Study to Evaluate the Effect of Romosozumab (AMG 785) on Bone Quality of the Forearm in Postmenopausal Women With Low Bone Mass
Osteopenia
P1
Completed24RCT, Double-blindRomosozumab, Placebo
NCT02103283
A Phase 1, Open-Label Study of Teprotumumab in Patients With Diabetic Macular Edema (DME)
Diabetic Macular Edema
P1
Completed5Open-labelTeprotumumab
NCT05317078
A Phase 1 Safety, Tolerability, and Pharmacokinetics Study of AMG 794 With Claudin 6-positive Non-small Cell Lung Cancer, Epithelial Ovarian Cancer, and Other Malignant Solid Tumor Indications
Non-squamous Non-small Cell Lung Cancer, Epithelial Ovarian Cancer
P1
Terminated3Open-labelAMG 794
NCT03554044
T-VEC With Chemotherapy or Endocrine Therapy in Treating Participants With HER2- Negative Breast Cancer
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
P1
Completed20Open-labelAnastrozole, Exemestane, Fulvestrant, Letrozole, Paclitaxel, Talimogene Laherparepvec, Tamoxifen, Nab paclitaxel, Gemcitabine, Carboplatin
NCT02802735
Study to Evaluate the Pharmacokinetics of Single and Multiple Doses of Apremilast in Healthy Adult Male Korean Subjects
Pharmacokinetics
P1
Completed28RCT, Open-labelApremilast, Placebo
NCT01555268
Trebananib With or Without Low-Dose Cytarabine in Treating Patients With Acute Myeloid Leukemia
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
P1
Completed24Open-labeltrebananib, cytarabine
NCT03156023
Multiple Ascending Doses of Rozibafusp Alfa (AMG 570) in Adults With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed34RCT, Double-blindRozibafusp Alfa, Placebo
NCT03088176
Combining Talimogene Laherparepvec With BRAF and MEK Inhibitors in BRAF Mutated Advanced Melanoma
Melanoma, BRAF Gene Mutation
P1
Unknown4Open-labelTalimogene Laherparepvec 1 Million Pfu/Ml Inj,Susp,1Ml,Vil, Talimogene Laherparep 100 Mil Pfu/Ml 1Ml, Dabrafenib, Trametinib
NCT01493518
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Effects of AMG 557 in Adults With Psoriasis
Psoriasis
P1
Terminated6RCT, Double-blindAMG 557 or PLACEBO
NCT02777554
A Study to Evaluate the Pharmacokinetic Exposure of 2 Formulations of Apremilast in Healthy Adults
Healthy Volunteers
P1
Completed144RCT, Open-labelApremilast IR, Apremilast XL
NCT06563856
A Study of TEPEZZA Subcutaneous Administration in Healthy Adults
Bioavailability, Bioequivalence
P1
Completed37Open-labelTEPEZZA, EDP
NCT00997022
Trial of Sorafenib in Hepatocellular Cancer (HCC) Transplant Patients
Hepatocellular Cancer
P1
Completed14Open-labelSorafenib
NCT00448786
Effect of Different Doses of AMG 706 on the Gallbladder in Advanced Solid Tumors
Solid Tumors
P1
Completed49RCT, Open-labelAMG 706, AMG 706, AMG 706
NCT06468826
A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)
End-Stage Renal Disease (ESRD)
P1
Completed13Open-labelAvacopan
NCT02391259
A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of AMG 557 in Subjects With Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
P1
Completed57RCT, Double-blindAMG 557, Placebo
NCT05550129
Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants
Healthy Volunteers
P1
Completed13Open-labelAMG 510, Metformin
NCT03751709
Blinatumomab Plus HLA-Mismatched Cellular Therapy for Relapsed/Refractory CD19+ ALL
B-Cell Acute Lymphoblastic Leukaemia, ALL, Adult
P1
Completed22Open-labelBlinatumomab
NCT02437916
Safety Study of AMG 228 to Treat Solid Tumors
Advanced Malignancy, Advanced Solid Tumors
P1
Terminated30Open-labelAMG 228
NCT01755442
Investigate Effect of AMG 151 on 24-hour Ambulatory Blood Pressure & Glucose Levels in Type 2 Diabetes Mellitus Subjects
Diabetes Mellitus
P1
Terminated5RCT, Double-blindAMG 151
NCT01380756
Study Evaluating Orally Administered AMG 900 in Adult Subjects With Acute Myeloid Leukemia
Cancer, Hematologic Malignancies
P1
Completed35Open-labelArm 1- Dose Escalation, Arm 2- Dose Expansion
NCT05045638
Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants
Healthy Participants
P1
Completed13Open-labelRosuvastatin, Sotorasib
NCT05327491
A Study in Healthy Volunteers to Compare the Pharmacokinetics of Sotorasib Administered as 1 or 2 Tablets
Healthy Participants
P1
Completed146RCT, Open-labelSotorasib
NCT07428525
A Study to Evaluate AMG 133 in Participants With Varying Degrees of Hepatic Impairment or Normal Hepatic Function
Hepatic Impairment
P1
Completed36Open-labelAMG 133
NCT00563316
Effect of Panitumumab on the Pharmacokinetics of Irinotecan
Metastatic Colorectal Cancer
P1
Completed28Open-labelPanitumumab, Irinotecan
NCT06004947
A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
P1
Completed32Open-labelCCX168, Midazolam, Celecoxib, Itraconazole, Rifampicin
NCT02499315
Study to Evaluate the Safety, Tolerability, and Action of AMG 357 in Females With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Terminated32RCT, Double-blindAMG 357, Placebo
NCT03989544
A Study to Evaluate the Pharmacokinetics of Tezepelumab After Being Delivered by an Accessorized Pre Filled Syringe or Autoinjector Compared With Vial and Syringe in Healthy Adult Subjects
Asthma
P1
Completed315RCT, Open-labelTezepelumab
NCT05481411
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment
Hepatic Impairment
P1
Completed25Open-labelOlpasiran
NCT02741310
Study to Evaluate the Effect of Erenumab on Blood Pressure When Given Concomitantly With Subcutaneous Sumatriptan
Healthy Subjects
P1
Completed34RCT, Double-blindPlacebo, Sumatriptan, Erenumab
NCT06207682
Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin
Healthy Volunteers
P1
Completed32RCT, Open-labelAvacopan, Simvastatin
NCT01688739
Ascending Single Doses of Erenumab (AMG 334) in Healthy Adults and Migraine Patients
Migraine
P1
Completed61RCT, Double-blindErenumab, Placebo
NCT04998747
A Study of Subcutaneous (SC) AMG 701 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Relapsed/Refractory Multiple Myeloma
P1
WithdrawnOpen-labelAMG 701, AMG 701
NCT00274742
Safety Study of the Bispecific T-cell Engager Blinatumomab (MT103) in Patients With Relapsed NHL
Non-Hodgkin's Lymphoma, Relapsed
P1
Completed76Open-labelBlinatumomab (MT103)
NCT04702737
A Study of AMG 757 in Participants With Neuroendocrine Prostate Cancer
Neuroendocrine Prostate Cancer
P1
Completed41Open-labelTarlatamab
NCT05599828
A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
Healthy Participants
P1
Completed14Open-labelAMG 510, Omeprazole, Famotidine
NCT00503490
Safety, Pharmacokinetic and Pharmacodynamic Study of MP-376 in Patients With Cystic Fibrosis
Cystic Fibrosis
P1
Completed40RCT, Single-blindMP-376 (Levofloxacin solution for Inhalation), placebo
NCT01497821
AMG 172 First in Human Study in Patients With Kidney Cancer
Renal Cell Adenocarcinoma, Clear Cell Renal Carcinoma
P1
Completed37Open-labelAMG 172
NCT02833857
A Single-dose Study in Paediatric Patients Aged 2 to Less Than 18 Years With Secondary Hyperparathyroidism (sHPT) Receiving Haemodialysis
Chronic Kidney Disease, Secondary Hyperparathyroidism
P1
Completed11Open-labelEtelcalcetide
NCT05267470
A Study of Bemarituzumab Monotherapy and Combination With Other Anti-cancer Therapy in SqNSCLC With FGFR2b Overexpression (FORTITUDE-201)
Squamous-Cell Non-Small-Cell Lung Cancer
P1
Terminated74Open-labelBemarituzumab, Docetaxel, Pembrolizumab, Carboplatin, Paclitaxel, Nab-paclitaxel
NCT01999335
A Study of Oprozomib, Pomalidomide, and Dexamethasone in Adults With Primary Refractory or Relapsed and Refractory Multiple Myeloma
Multiple Myeloma
P1
Terminated33Open-labelOprozomib, Pomalidomide, Dexamethasone
NCT00562380
AMG-479 in Treating Patients With Advanced Solid Tumors or Non-Hodgkin Lymphoma
Lymphoma, Prostate Cancer
P1
Completed64RCT, Open-labelganitumab
NCT00752414
A Phase 1b Study to Evaluate the Safety and PK of MP-376 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic Obstructive Pulmonary Disease
P1
Completed21RCT, Single-blindMP-376 (Levofloxacin solution for Inhalation), Placebo
NCT05577624
A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants
Healthy Participants
P1
Completed14Open-labelAMG 510, Rifampin
NCT03451422
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efavaleukin Alfa in Participants With Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
P1
Completed35RCT, Double-blindEfavaleukin Alfa, Placebo
NCT04740034
A Study of AMG 340 in Subjects With Metastatic Castrate-Resistant Prostate Carcinoma
Metastatic Castration-resistant Prostate Cancer
P1
Terminated42Open-labelAMG 340
NCT03170193
AMG 529 First in Human Study
Cardiovascular
P1
Completed48RCT, Double-blindAMG 529, Placebo
NCT00858377
A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors
Advanced Malignancy, Advanced Solid Tumors
P1
Completed95Open-labelArm 1- Dose Escalation, Arm 1- Dose Expansion
NCT01389895
Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus
Cutaneous Lupus, Lupus
P1
Terminated1RCT, Double-blindAMG 557, AMG 557 Placebo
NCT01738594
Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell Lymphoma
Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome
P1
Terminated7RCT, Open-labelcarfilzomib, romidepsin
NCT00361634
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed14Open-labelEtanercept
NCT01869686
Study to Evaluate the Concentration of Denosumab in Seminal Fluid in Healthy Men After a Single Subcutaneous Dose
Healthy Volunteer
P1
Completed12Open-labelDenosumab
NCT04822298
Study of AMG 160 in Subjects With Non-Small Cell Lung Cancer
Non-small Cell Lung Cancer, NSCLC
P1
Terminated3Open-labelAMG 160
NCT02132429
Phase I, Double-Blind,Placebo, MAD Study to Evaluate the Safety, Tolerability, PK, and PD of AMG 333 in Healthy Subjects and Migraine Subjects
Migraine
P1
Terminated16RCT, Double-blindAMG 333, Placebo
NCT04478994
A Study With TEPEZZA in Patients With Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Diffuse Cutaneous Systemic Sclerosis
P1
Terminated3RCT, Double-blindTEPEZZA
NCT00101894
Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer
Rectal Cancer, Colon Cancer
P1
Completed119Open-labelFOLFOX-4, AMG 706, Panitumumab (Part 1a only), FOLFIRI
NCT02504476
Multiple Ascending Dose Study on Safety, Tolerability, and Pharmacokinetics of AMG 581 in Healthy Subjects or Subjects With Schizophrenia or Schizoaffective
Schizophrenia or Schizoaffective Disorder
P1
Completed52RCT, Double-blindAMG 581, Placebo, Midazolam
NCT03904069
Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AML
Relapsed/Refractory Acute Myeloid Leukemia
P1
WithdrawnOpen-labelAMG 553
NCT01212380
Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL)
B-cell Chronic Lymphocytic Leukemia, Hematopoietic/Lymphoid Cancer
P1
Completed21Open-labelcarfilzomib
NCT05245851
Clinical Deployment and Validation of Rho
Low Bone Density
N/A
Completed1,146Open-label
NCT01139918
Exploratory Study on Quality of Life in Patient With Moderate Psoriasis and Moderate Psoriatic Arthritis
Psoriatic Arthritis, Psoriasis
Completed105
NCT05347745
Therascreen® KRAS RGQ PCR Kit
Colo-rectal Cancer
N/A
Completed219Open-label
NCT02520362
Denosumab Safety Assessment in Multiple Observational Databases
Osteoporosis
Completed517,991denosumab, bisphosphonate
NCT05826756
Project PEER: Understanding the Lung Cancer Patient ExperiEnce in the Real-World Setting
Lung Cancer Patients, Caregivers
Unknown1,300
NCT06607393
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS3]
Metastatic Nonsmall Cell Lung Cancer
Completed851Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin
NCT02922179
Descriptive Analysis of Long- and Intermediate-Acting Insulin in Adult Diabetics
Diabetes
Completed103,951Long- and intermediate- acting insulins
NCT05348187
Clinical Performance Study Protocol for Therascreen® KRAS RGQ PCR Kit
Non-Small Cell Lung Cancer, Colorectal Cancer
N/A
Completed309Open-label
NCT05347797
Clinical Study Testing DNA Extracted From Tumour Tissue Biopsy Samples, Using the Therascreen® KRAS RGQ PCR Kit
Non-small Cell Lung Cancer
N/A
Completed495Open-label
NCT06585189
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS4]
Metastatic Non Small Cell Lung Cancer
Completed304Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin
NCT06607601
CARE Initiative: Real-world Emulation of the PALOMA-2 Trial
Metastatic Breast Cancer
Completed724Palbociclib, Letrozole
NCT05360225
Testing of DNA Extracted From Tumor Tissue Biopsy Samples Using Therascreen KRAS RGQ PCR Kit
Non Small Cell Lung Cancer
Completed5,000
NCT00186602
Does a Peer Navigator Improve Quality of Life at Diagnosis for Women With Breast Cancer?
Breast Cancer
Completed
NCT02922192
Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis
Rheumatoid Arthritis, Inflammatory Bowel Disease
Completed90,360TNF-α antagonists, non-TNFs, DMARD non-biologics
NCT02921191
Descriptive Analysis of G-CSF Use in Patients With Breast Cancer, Lung Cancer, or Lymphoma Treated
Breast Cancer, Lung Cancer
Completed57,725filgrastim, TBO-filgrastim or pegfilgrastim
NCT02185911
Observational Study of Correction of Anaemia With Darbepoetin Alfa at QM Dosing Interval in Patients With CKD Not on Dialysis
Anaemia, Chronic Kidney Disease (CKD)
Completed308
NCT00418743
Second-line Treatment in Patients With Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer
Unknown138
NCT02537535
Guidelines Oriented Approach to Lipid Lowering (GOAL) in Canada
Dyslipidemia
Completed2,027
NCT00322439
Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis
Psoriasis
Completed2,511Etanercept
NCT03398954
a Prospective Pilot Study of Screening Out Rate and Clinical Management of Familial Hypercholesterolemia
Familial Hypercholesterolemia
Unknown1,128
NCT01668589
Observational Study of Denosumab (Prolia®) in Postmenopausal Women With Osteoporosis
Postmenopausal Osteoporosis
Completed1,501
NCT02178475
Prospective Observational Study of Febrile Neutropenia (FN) and Pegfilgrastim Primary Prophylaxis in Breast Cancer and Non-Hodgkin's Lymphoma Patients Receiving High (>20%) FN-risk Chemotherapy
Chemotherapy-induced Febrile Neutropenia
Completed943
NCT02875184
A Study of Apremilast Use and Effectiveness in Patients With Psoriatic Arthritis in The Netherlands
Arthritis, Psoriatic
Completed200
NCT02740218
A Study of Real-World Experience of Psoriasis Patients Treated With Apremilast in Clinical Dermatology Practice
Psoriasis
Completed610
NCT01997892
TRANSFORM - Observational Cohort Study of Darbepoetin Alfa Use in European Union (EU) Hemodialysis Patients Switched From PEG Epoetin Beta
Anemia
Completed1,027
NCT02287610
A Non-Interventional Study of RAYOS in Adult Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
Completed75RAYOS (delayed-release prednisone)
NCT03780504
Apremilast in Psoriatic Arthritis in Real-life Clinical Practice in Greece
Psoriatic Arthritis
Unknown170
NCT02976818
Lp(a) and Aortic Valve Calcification
Heterozygous Familial Hypercholesterolemia
Completed173
NCT01936376
A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving First Cycle of Cisplatin Chemotherapy for Head and Neck Cancers
Head and Neck Cancer
Unknown150
NCT00094822
Pegfilgrastim Given Same Day As or Day After Carboplatin and Docetaxel in Advanced Metastatic Non-Small Cell Lung Cancer (NSCLC)
Lung Cancer, Non-Small Cell Lung Cancer
Completed90
NCT03117621
Observational Study of Blinatumomab
Blincyto Use in Routine Clinical Practice
Completed279
NCT01015625
Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer
Synchronous Metastasized Breast Cancer, Circulating Tumor Cells
N/A
Completed90RCT, Open-label
NCT03812367
Activity of Pre-Osteoclasts and Osteoclasts Over Time in Postmenopausal Women Treated With Denosumab or Zoledronic Acid
Osteoporosis, Postmenopausal
Withdrawn
NCT03139630
COPANA - A09 PCSK 9 Substudy: Impact of Protease Inhibitors on PCSK9 Levels in Naive HIV-Infected Patients
HIV Seropositivity, Dyslipidemias
Completed193
NCT00501228
Tissue Repair in Stem Cell Transplant Recipients
Graft-Versus-Host Disease
N/A
Terminated2Open-labelFilgrastim
NCT01710722
The Effect of Leptin A-200, Caffeine/Ephedrine and Their Combination Upon Weight Loss and Body Composition in Man
Obesity
N/A
Completed45RCT, Double-blindcaffeine and ephedrine, Leptin A, caffeine, ephedrine, and leptin A
NCT00949546
Treatment of Hidradenitis Suppurativa Using Etanercept
Hidradenitis Suppurativa
Completed20etanercept
NCT01948427
Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)
Urea Cycle Disorder
Terminated203
NCT00116727
Rheumatoid Arthritis DMARD Intervention and UtilizationStudy
Rheumatoid Arthritis
Completed5,103ENBREL®
NCT03469661
Differential Diagnostic of Immune ThrombocytoPenia (ITP) and Myelodysplastic Syndrome (MDS)
Immune Thrombocytopenia, Myelodysplastic Syndromes
Completed63
NCT00454857
Retrospective & Prospective Observational Study of Patients With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
Completed326
NCT01791361
Medical Records Review to Describe the Patterns of KRAS Testing and Vectibix Use in Europe
Metastatic Colorectal Cancer
Completed439
NCT00617370
Dose-Dense Epirubicin and Cyclophosphamide (EC) Followed by Paclitaxel in Breast Cancer: Feasibility
Breast Cancer, Adenocarcinoma of the Breast
N/A
Completed38Open-labelepirubicin, cyclophosphamide, Paclitaxel,
NCT00300001
Home-Based Symptom Monitoring: Its Impact on Cancer Care Team Behaviors and Patient Outcomes
Cancer, Solid Tumor
Unknown300
NCT00838097
European Union Registry in Paediatric Chronic Kidney Disease Patients Looking at Safety and Usage Patterns of Darbepoetin Alfa
Chronic Kidney Disease
Completed321
NCT01967160
Osteonecrosis of the Jaw (ONJ) and Infection Among Nordic Cancer Patients Treated With XGEVA™ or Zoledronic Acid
Osteonecrosis of the Jaw, Infection Leading to Hospitalization
Completed2,560
NCT01998607
Survey of XGEVA® Presrcibers in Europe to Evaluate Their Knowledge of the Summary of Product Characteristics Pertaining to Osteonecrosis of the Jaw
Solid Tumours, Bone Metastasis
Completed420
NCT02173171
Registry Study for Talimogene Laherparepvec
Any Tumor Type Eligible for Treatment With Talimogene Laherparepvec in Amgen or BioVEX-sponsored Clinical Trial
Completed185
NCT02957604
Evolocumab Pregnancy Exposure Registry
Hypercholesterolemia; ASCVD; Pregnancy
Terminated140evolocumab
NCT03970902
Quality of Life in Postmenopausal Women With Osteoporosis
Postmenopausal Osteoporosis
Completed239
NCT05378529
A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)
Atherosclerotic Cardiovascular Disease
N/A
Completed39,480Open-label
NCT01813721
Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy.
Chemotherapy-induced Febrile Neutropenia
Completed1,007
NCT03620188
Treatment Goals in Psoriatic Arthritis
Psoriatic Arthritis
Completed250
NCT00355407
Darbepoetin Alfa (Aranesp) Following Allogeneic Stem Cell Transplantation
Hematologic Malignancies
N/A
Completed31Open-labelDarbepoetin alfa
NCT02085993
Study of Patients With ITP Estimating the Proportion Administering Romiplostim Correctly After Receiving Home Administration Training
Immune Thrombocytopenic Purpura
Completed41
NCT02808403
Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in Japan
Hypercholesterolemia, Familial Hypercholesterolemia
Completed6,000
NCT00903812
IMPACT Non Hodgkins Lymphoma (NHL) Study
Non-Hodgkin's Lymphoma
Completed1,837
NCT04197453
The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)
ASCVD
Terminated752
NCT02770131
Chart Review of Repatha® in Subjects With Hyperlipidaemia
Hypercholesterolaemia
Completed1,986
NCT03751072
Efficacy and Toxicity of Blinatumomab in the French ATU for Adult BCP-ALL R/R, or With MRD+ (FRENCH-CYTO)
Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission
Completed92
NCT00189501
A Multi-Center, Observational Registry of Subjects With Secondary Hyperparathyroidism (HPT) and Chronic Kidney Disease (CKD)
Nephrology
Completed1,000Sensipar®
NCT06081153
Mechanistic Clinical Trial of PCSK9 Inhibition for AAA
Abdominal Aortic Aneurysm
Early P1
Not Yet Recruiting44RCT, Double-blindEvolocumab, Placebo
NCT06590051
AMG 335 Expanded Access Program for IgG4-Related Disease
AVAILABLEUPLIZNA
NCT03224819
Study of Emerfetamab (AMG 673) in Adults With Relapsed/Refractory Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia
Early P1
Terminated46Open-labelEmerfetamab
NCT05885607
Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
By Invite40
NCT02322736
Prospective Observational Study of 1st and 2nd Line Vectibix® Use in RAS-wt mCRC Pts to Evaluate Pattern of Use and ORR
Metastatic Colorectal Cancer
Completed218
NCT00283621
Aranesp and Neulasta in Patients With Sarcoma Receiving Adriamycin and Ifosfamide
Sarcoma
N/A
Completed51Open-labelAranesp (darbepoetin alfa), Neulasta (pegfilgrastim), Adriamycin, Ifosfamide
NCT04386629
Health Economy Register
Breast Neoplasms
Completed219
NCT07085117
Real World Study to Describe the Effectiveness and Safety of Teprotumumab Among Thyroid Eye Disease Patients
Thyroid Eye Disease
Completed5Teprotumumab
NCT02993120
Getting to an Improved Understanding of Low-Density Lipoprotein Cholesterol and Dyslipidemia Management (GOULD) a Registry of High Cardiovascular Risk Subjects in the United States
Medical Conditions to be Studied, Dyslipidemia
Completed5,006
NCT00704652
Evaluation of Retinal Changes in Systemic Darbepoetin Alpha Treatment in Patients With Diabetes Mellitus
Diabetic Retinopathy
Terminated5
NCT06064500
Tarlatamab (AMG 757) Expanded Access Protocol for Advanced Small Cell Lung Cancer
Small Cell Lung Cancer
APPROVED_FOR_MARKETINGTarlatamab
NCT02273570
Optimal Anemia Treatment in End Stage Renal Disease (ERSD)
Hyperparathyroidism, Secondary
N/A
Unknown50RCT, Open-labelstandard care, Optimal (I. iPTH control: Zemplar®,Mimpara®; phosphorous control: Renvela®, Phoslo®, Osvaren®, Foznol®,Maalox®; calcium control: calcium and vitamin D
NCT00116714
Rheumatoid Arthritis (DMARD) Intervention and UtilizationStudy
Rheumatoid Arthritis
Completed4,968DMARD
NCT02066805
Estimation of Off-Label Use of XGEVA® (Denosumab) Using Population-Based Databases in Denmark
XGEVA Off-label Use
Completed142Database assessment of off-label XGEVA use
NCT03106051
Study of Apremilast Use in Patients With Psoriatic Arthritic in Practice Conditions
Arthritis, Psoriatic
Completed526
NCT06761703
A Study to Determine the Feasibility of Online Recruitment of People Using an Anti-Obesity Medication for Weight Loss
Obesity
Completed200