Opus Genetics, Inc.
IRDHealthcare|Biotechnology|US
$4.18
+0.17 (+4.37%)
Cash / Share
$0.93
Clinical Trials (17)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT07140783 OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity | Vision Loss Night, Vision Disorders | P3 | Recruiting | 580 | RCT, Double-blind | 0.75% Phentolamine Ophthalmic Solution, Placebo |
| NCT05616793 Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients | LCA5 | P1P2 | Recruiting | 22 | Open-label | AAV8.hLCA5 |
| NCT07185256 Safety and Tolerability of Subretinally Injected OPGx-BEST1 in Patients With Best Vitelliform Macular Dystrophy (BVMD) or Autosomal-Recessive Bestrophinopathy (ARB) | ARB, BVMD | P1P2 | Recruiting | 10 | Open-label | — |
| NCT07681778 Safety and Tolerability of Subretinal OPGx-RDH12-1001 for LCA-Associated Inherited Retinal Degeneration (LCA-IRD) | Leber Congenital Amaurosis, Leber Congenital Amaurosis (LCA) | P1P2 | Recruiting | 10 | Open-label | OPGx-RDH12 |
| NCT04638660 Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances | Dim Light Vision Disturbances | P3 | Completed | 144 | RCT, Double-blind | Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle (Placebo) |
| NCT05134974 Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3) | Mydriasis, Dilation | P3 | Completed | 368 | RCT, Double-blind | Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle |
| NCT06542497 Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia | Presbyopia | P3 | Completed | 569 | RCT, Double-blind | 0.75% phentolamine ophthalmic solution, Placebo |
| NCT05646719 Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia | Presbyopia | P3 | Completed | 333 | RCT, Double-blind | Phentolamine Opthalmic Solution 0.75%, Low dose pilocarpine |
| NCT06349759 Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances | Mesopic Vision, Night Vision Loss | P3 | Completed | 200 | RCT, Double-blind | phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist, Placebo |
| NCT04620213 Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis | Mydriasis, Dilation | P3 | Completed | 185 | RCT, Double-blind | Phentolamine Ophthalmic Solution 0.75% |
| NCT05223478 Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects | Mydriasis, Dilation | P3 | Completed | 23 | RCT, Double-blind | Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle |
| NCT04024891 Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis | Mydriasis, Dilation | P2 | Completed | 32 | RCT, Double-blind | Phentolamine Mesylate Ophthalmic Solution 1% |
| NCT03960866 Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma | Open Angle Glaucoma, Ocular Hypertension | P2 | Completed | 39 | RCT, Double-blind | Phentolamine Mesylate Ophthalmic Solution 1% |
| NCT04675151 Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia | Presbyopia | P2 | Completed | 150 | RCT, Double-blind | Phentolamine Ophthalmic Solution 0.75%, Pilocarpine |
| NCT01703559 The Safety and Efficacy of Phentolamine Mesylate Ophthalmic Solution in Subjects With Severe Night Vision Disturbances | Night Vision Complaints, Decrease in Night Vision | P2 | Completed | 60 | RCT, Double-blind | Phentolamine Mesylate Ophthalmic Solution 1.0%, Phentolamine Mesylate Ophthalmic Solution 0.5% |
| NCT04004507 Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances | Decrease in Night Vision, Disturbance; Vision, Loss | P2 | Completed | 24 | RCT, Double-blind | Phentolamine Mesylate Ophthalmic Solution 1% |
| NCT04692688 Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy | Diabetic Retinopathy, Diabetic Macular Edema | P2 | Completed | 103 | RCT, Double-blind | APX3330, Placebo |