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Merck & Co Inc

MRK
Healthcare|Drug Manufacturers - General|USA
$120.85
+0.00 (+0.00%)
DCF (FCF)
$75.40
Tangible Book
$1.76
Graham Number
$18.83
Earnings Power
$41.17

Clinical Trials (731)

TrialConditionsPhaseStatusEnrollmentDesignDrug
NCT05823844
Efficacy of Suvorexant on Post-operative Sleep Disturbance
Postoperative Insomnia, Postoperative Delirium
P4
Recruiting92RCT, Double-blindSuvorexant, Placebo
NCT05992480
REVIVE (Response to the Ebola Virus Vaccine)
Ebola Virus Disease
P4
Recruiting40Open-labelrVSVDG-ZEBOV-GP Ebola Virus Vaccine (ERVEBO)
NCT05911295
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
Urothelial Carcinoma
P3
Active412RCT, Open-labeldisitamab vedotin, pembrolizumab, gemcitabine, cisplatin, carboplatin
NCT03682536
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
Myelodysplastic Syndromes
P3
Active363RCT, Open-labelLuspatercept, Epoetin alfa
NCT06623422
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Carcinoma, Non-Small-Cell Lung
P3
Recruiting680RCT, Double-blindPembrolizumab, Cisplatin, Carboplatin, Pemetrexed, Gemcitabine, Paclitaxel, Intismeran autogene
NCT03924895
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
Urinary Bladder Cancer, Muscle-invasive
P3
Active595RCT, Open-labelPembrolizumab, Enfortumab Vedotin
NCT05224141
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
Small Cell Lung Carcinoma
P3
Active460RCT, Double-blindPembrolizumab/Vibostolimab Co-Formulation, Saline placebo, Etoposide, Cisplatin, Atezolizumab, Carboplatin
NCT04895358
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Breast Neoplasms
P3
Active340RCT, Double-blindpembrolizumab, paclitaxel, nab-paclitaxel, liposomal doxorubicin, capecitabine, normal saline, dextrose
NCT06422143
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Non-small Cell Lung Cancer, NSCLC
P3
Recruiting851RCT, Open-labelPembrolizumab, sac-TMT, Carboplatin, Paclitaxel, Nab-paclitaxel
NCT01874353
Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy
Platinum Sensitive, BRCA Mutated
P3
Active327RCT, Double-blindOlaparib 300mg tablets, Placebo to match olaparib 300mg
NCT02362594
Study of Pembrolizumab (MK-3475) Versus Placebo After Complete Resection of High-Risk Stage III Melanoma (MK-3475-054/1325-MG/KEYNOTE-054)
Melanoma
P3
Active1,019RCT, Double-blindpembrolizumab, placebo
NCT06824467
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Ovarian Cancer, Fallopian Tube Cancer
P3
Recruiting770RCT, Open-labelSacituzumab tirumotecan, Bevacizumab, H1 receptor antagonist, H2 receptor antagonist, Acetaminophen (or equivalent), Dexamethasone (or equivalent), Steroid mouthwash (dexamethasone or equivalent)
NCT05714085
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Heart Failure, Left Ventricular Systolic Dysfunction
P2P3
Recruiting342RCT, Double-blindVericiguat tablet, Vericiguat suspension, Placebo tablet, Placebo suspension
NCT06492291
Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
Hypercholesterolemia
P3
Active3,000Open-labelEnlicitide Decanoate
NCT07355218
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
Systematic Lupus Erythematosus, Cutaneous Lupus Erythematosus
P3
Recruiting202RCT, Double-blindEnpatoran, Placebo, Standard of care (SoC)
NCT06074588
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
Non-small Cell Lung Cancer (NSCLC)
P3
Recruiting556RCT, Open-labelSacituzumab tirumotecan, Docetaxel, Pemetrexed
NCT03725059
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
Breast Cancer
P3
Active1,240RCT, Double-blindPembrolizumab (K), Placebo (P), Paclitaxel (X), Doxorubicin (A), Epirubicin (E), Cyclophosphamide (C), Endocrine therapy
NCT05450705
V503 in Chinese Girls 9-14 Years Old Versus Chinese Women 20-26 Years Old (V503-071)
Papillomavirus Infections
P3
Active1,500RCT, Open-label9vHPV vaccine
NCT04945460
A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)
Hypertension, Pulmonary
P2
Active164RCT, Double-blindSotatercept 0.3 mg/kg, Placebo, Sotatercept 0.3 mg/kg escalating to 0.7 mg/kg
NCT04143724
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia
Beta-Thalassemia
P2
Recruiting99Open-labelACE-536
NCT03634540
A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
Renal Cell Carcinoma (RCC), Clear Cell Renal Cell Carcinoma (ccRCC)
P2
Active118Open-labelBelzutifan, Cabozantinib
NCT03401788
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation
P2
Active50Open-labelBelzutifan
NCT04471727
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
Small-Cell Lung Cancer, Neuroendocrine Carcinoma
P1P2
Active232Open-labelGocatamig, Atezolizumab, Ifinatamab Deruxtecan (I-DXd)
NCT04262141
IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV)
Essential Thrombocythemia, Polycythemia Vera
P2
Active4Open-labelIMG-7289
NCT04081220
Hematology, IMG-7289, LSD1 (Lysine-Specific Demethylase 1) Inhibitor, Essential Thrombocythemia (ET), Ph 2
Thrombocythemia, Essential
P2
Active9Open-labelIMG-7289
NCT05270668
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease
P2
Active154RCT, Double-blindTulisokibart, Placebo
NCT03162536
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
Lymphoma, B-Cell, Small Lymphocytic Lymphoma
P1P2
Active190Open-labelNemtabrutinib
NCT06814145
Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)
Hypertension, Pulmonary
P2
Recruiting130RCT, Double-blindSotatercept
NCT02886585
Pembrolizumab In Central Nervous System Metastases
Brain Metastases
P2
Active101Open-labelPembrolizumab
NCT06979596
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Malignant Neoplasm
P2
Recruiting250RCT, Single-blindOpevesostat, Fludrocortisone/ Fludrocortisone acetate, Dexamethasone/Dexamethasone acetate, Rescue Medications, Fulvestrant, Exemestane, Megestrol acetate/Medroxyprogesterone acetate, Tamoxifen, Letrozole
NCT05286619
A Study of Pembrolizumab (MK-3475) Plus Platinum and Gemcitabine as First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (PIPER)
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
P2
Recruiting63Open-labelPembrolizumab, Cisplatin, Carboplatin, Gemcitabine
NCT05309421
A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma
Melanoma Stage IV, Unresectable Melanoma
P2
Active17Open-labelEVX-01, Pembrolizumab 25 MG/ML
NCT04875585
Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC
Non Small Cell Lung Cancer
P2
Recruiting33Open-labelneoadjuvant therapy with Pembrolizumab/Lenvatinib, Adjuvant Treatment Phase
NCT06266338
Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)
Cervix Cancer, Cervical Cancer
P2
Recruiting30Open-labelPembrolizumab, Lenvatinib
NCT02734290
Standard of Care Chemotherapy Plus Pembrolizumab for Breast Cancer
Triple Negative Breast Cancer
P1P2
Active29Open-labelPembrolizumab, Paclitaxel, Capecitabine
NCT05558982
BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Metastatic Pancreatic Ductal Adenocarcinoma
P2
Active22Open-labelBXCL701, Pembrolizumab
NCT06207656
Study to Evaluate the Efficacy and Safety of Cetuximab in Combination with Encorafenib Plus Binimetinib As Induction Treatment in BRAF V600E Mutated MSS Initially Resectable or Potentially Resectable Advanced Colorectal Cancer
Colorectal Cancer
P2
Recruiting70Open-labelEBC
NCT07089992
A Study of Pembrolizumab in People With Ultra-Rare Sarcomas
Sarcoma
P2
Recruiting32Open-labelPembrolizumab
NCT04701476
TATE and Pembrolizumab (MK3475) in mCRC and NSCLC
Colorectal Cancer; Lung Cancer
P2
Recruiting110RCT, Open-labelTATE and pembrolizumab, TAS-102 pill, Regorafenib Pill
NCT03272334
Her2-BATS and Pembrolizumab in Metastatic Breast Cancer
Metastatic Breast Cancer
P1P2
Active22Open-labelHER2 BATs with Pembrolizumab
NCT05296512
Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer
Ovarian Clear Cell Carcinoma, Gynecologic Cancer
P2
Active30Open-labelLenvatinib, Pembrolizumab
NCT06433219
Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)
Ovarian Cancer
P2
Active63RCT, Open-labelTuvusertib (M1774), Niraparib, Lartesertib (M4076)
NCT06493019
Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer
Anal Cancer
P2
Recruiting23Open-labelPembrolizumab, Paclitaxel, Carboplatin, Pembrolizumab
NCT06660654
A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)
Advanced Solid Tumor, Metastatic Solid Tumors
P2
Recruiting200Open-labelRaludotatug deruxtecan
NCT03813836
Phase II Trial of Pembrolizumab in Recurrent or Metastatic HNSCC
Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
P2
Active63Open-labelPembrolizumab
NCT02422381
MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small-Cell Lung
P1P2
Active16Open-labelMK-3475, Gemcitabine
NCT04712851
Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia, Cervical Squamous Cell Carcinoma In Situ
P2
Recruiting25Open-labelPembrolizumab
NCT04585035
Study to Evaluate D-1553 in Subjects With Solid Tumors
Solid Tumor, Adult, NSCLC
P1P2
Active180Open-labelD-1553, D-1553 in combination with Drug: pembrolizumab, Drug:KEYTRUDA® , Drug: cetuximab, Drug: other
NCT04666740
A Study of Pembrolizumab and Olaparib for People With Metastatic Pancreatic Ductal Adenocarcinoma and Homologous Recombination Deficiency or Exceptional Treatment Response to Platinum-Based Therapy
Metastatic Pancreatic Ductal Adenocarcinoma, Homologous Recombination Deficiency (HRD)
P2
Active63Open-labelPembrolizumab, Olaparib
NCT05446298
ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary
P2
Active58RCT, Open-labelONC-392, Pembrolizumab
NCT04225117
A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)
Locally Advanced or Metastatic Malignant Solid Tumors
P2
Active329Open-labelenfortumab vedotin, pembrolizumab
NCT03519997
A Study of Pembrolizumab and Bavituximab in Patients With Advanced Hepatocellular Carcinoma
Hepatocellular Carcinoma
P2
Active35Open-labelPembrolizumab, Bavituximab
NCT04745988
An Open Label Phase 2 Study to Evaluate the Safety and Efficacy of Lenvatinib with Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the Neoadjuvant / Adjuvant Treatment for Patients with Gastric Cancer
Gastric Cancer
P2
Active43Open-labelLenvatinib 20mg, Pembrolizumab, Lenvatinib 8mg, Docetaxel, Oxaliplatin, Levofolinate, Fluorouracil
NCT04430699
Cisplatin+Pembrolizumab+RT in Vulvar Cancer
Vulvar Cancer, Vulvar Squamous Cell Carcinoma
P2
Active24Open-labelCisplatin, Pembrolizumab
NCT05524935
Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma
Uveal Melanoma, Ocular Melanoma
P2
Recruiting37Open-labelPembrolizumab, Olaparib
NCT04971499
A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma
Melanoma
P1P2
Active26Open-labelDapansutrile, Pembrolizumab
NCT05623319
Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC)
SCLC,Extensive Stage
P2
Recruiting60Open-labelPembrolizumab/Olaparib
NCT05077709
IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC
Lung Cancer Non Small Cell, Head and Neck Squamous Cell Carcinoma
P2
Active63Open-labelIO102-IO103 in combination with pembrolizumab
NCT06123338
A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
Esophageal Cancer, Gastric Adenocarcinoma
P2
Recruiting49Open-labelPembrolizumab, Trastuzumab, Oxaliplatin, Capecitabine, 5-Fluorouracil, Docetaxel
NCT04184050
Study of HPN217 in Participants With Relapsed/Refractory Multiple Myeloma MK-4002 (MK-4002-001)
Multiple Myeloma in Relapse, Multiple Myeloma
P1
Active100Open-labelMK-4002
NCT02293980
A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)
ccRCC, RCC
P1
Active110Open-labelMK-3795, Nivolumab, Cabozantinib, Bezlutifan
NCT02974738
A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)
Advanced Solid Tumors, Solid Tumor
P1
Active120Open-labelBelzutifan
NCT05597306
Venetoclax and Bomedemstat in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
P1
Recruiting18Open-labelBomedemstat, Venetoclax
NCT07199465
A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)
Cytomegalovirus Prophylaxis
P1
Recruiting40Open-labelLetermovir
NCT03932409
Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer
Endometrial Cancer
P1
Active45Open-labelPembrolizumab, Paclitaxel, Carboplatin
NCT02998567
Combination Study of Guadecitabine/ASTX727 and Pembrolizumab
Non Small Cell Lung Cancer
P1
Recruiting60Open-labelGuadecitabine, Pembrolizumab, ASTX727
NCT06580587
A Study of MK-8527 in Healthy Lactating Female Participants (MK-8527-009)
Healthy, HIV Pre-exposure Prophylaxis
P1
Active12Open-labelMK-8527
NCT04846920
A Study of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)
Carcinoma, Renal Cell
P1
Active52Open-labelBelzutifan
NCT06475235
Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
Lymphoma, Primary Central Nervous System Lymphoma
P1
Recruiting15Open-labelPembrolizumab, Methotrexate, Temozolomide, Rituximab
NCT06641908
Anti-GD2 ADC M3554 in Advanced Solid Tumors
Advanced Solid Tumor
P1
Recruiting52Open-labelM3554
NCT05081180
Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors
Central Nervous System Tumors
P1
Active17Open-labelAvelumab, Lenvatinib
NCT03260491
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer (NSCLC)
P1
Active312Open-labelHER3-DXd (FL-DP), HER3-DXd (CTM-1 Lyo-DP), HER3-DXd (CTM-3 Lyo-DP)
NCT00404989
Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People.
HIV Infections, Hepatitis B
Recruiting24,258
NCT05421806
A Cohort Study of Use of Doravirine (DOR) Based Regimens in Clinical Practice in Europe DoRavirine Europe Real World/
HIV I Infection
Active500
NCT07348250
Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease
Parkinson's Disease (PD), Parkinson's Disease
Early P1
Recruiting22Open-label[18F]MK-0947
NCT05266664
Preterm Immune System Development and Response to Immunization
Immune System Disorder, Preterm
Recruiting145
NCT04165798
KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)
Carcinoma, Non-Small-Cell Lung
Recruiting1,065
NCT06036810
Spanish Decision Tool for Ovarian Cancer Maintenance Therapy
Ovarian Cancer
N/A
Recruiting70Open-label
NCT06068582
Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis
Multiple Sclerosis
N/A
Recruiting270RCT, Double-blind
NCT06053749
An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden
Multiple Sclerosis (MS)
Active4Avonex (IFNβ-1-a, Biogen Netherlands B.V), Rebif (IFNβ-1-a, Merck Europe B.V.), Extavia (IFNβ-1-b, Novartis Europharm Limited), Betaseron (IFN-β-1-b, BAY86-5046, Bayer AG), Plegridy (Peg IFNβ-1-a, Biogen Netherlands B.V), MS disease modifying drugs (MSDMDs)
NCT04471493
Pediatric and Ambulatory Research in Infectious Diseases
Otitis, Bronchiolitis
Recruiting400,000
NCT01133600
Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens
Diabetic Foot
P4
Terminated6RCT, Open-labelCubicin, Vancomycin
NCT01196169
Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty
Staphylococcal Infections, Methicillin-resistant Staphylococcus Aureus
P4
Terminated28RCT, Open-labelDaptomycin, Vancomycin
NCT02355938
Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury
Clostridium Difficile, Spinal Cord Injury
P4
Terminated12RCT, Double-blindFidaxomicin 200 mg, Placebo, Vancomycin
NCT02421120
Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients
Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
P4
Completed21Open-labelCeftolozane/Tazobactam
NCT00638157
Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)
Infective Endocarditis
P4
Terminated24RCT, Double-blinddaptomycin, daptomycin and gentamicin
NCT00572260
A Pilot Study of Daptomycin for Antimicrobial Prophylaxis
Antimicrobial Prophylaxis
P4
Terminated11Open-labeldaptomycin 6 mg/kg IV
NCT00711802
Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections
Skin Diseases, Infectious
P4
Completed396RCT, Single-blindDaptomycin, Standard of Care (SOC)
NCT00295178
Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas
Cellulitis
P4
Completed80RCT, Single-blindDaptomycin, Vancomycin
NCT01175707
Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting
Complicated Skin or Skin Structure Infection
P4
Terminated80RCT, Open-labelDaptomycin, Vancomycin
NCT01419184
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA
Staphylococcal Skin Infections
P4
Completed250RCT, Open-labelDaptomycin, Vancomycin
NCT00651131
Cubicin(R) for Complicated Post-surgical Wound Infections
Wound Infections
P4
Terminated69RCT, Open-labeldaptomycin
NCT01728376
Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)
Bacteremia
P4
Completed82RCT, Open-labelDaptomycin, Comparator
NCT01775397
A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System
Clostridium Difficile
P4
Terminated12RCT, Double-blindFidaxomicin, Vancomycin, Placebo
NCT00708201
A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy
Postoperative Ileus
P4
Completed280RCT, Double-blindAlvimopan, Placebo
NCT00102947
Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections
Soft Tissue Infections
P4
Terminated72RCT, Open-labeldaptomycin (up to 14 days)
NCT01287832
Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs)
Bacteremia
P4
Terminated11RCT, Open-labelVancomycin, Daptomycin
NCT01104662
Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment
Complicated Skin and Skin Structure Infections, S. Aureus Bacteremia
P4
Terminated92RCT, Single-blindVancomycin, Daptomycin, Semi-Synthetic Penicillin
NCT00663403
Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)
Critically Ill, Hemodialysis
P4
Completed8Open-labelDaptomycin
NCT01818141
Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin
Clostridium Difficile Infection
P4
Completed34RCT, Open-labelVancomycin, Fidaxomicin
NCT03010423
Efficacy Study of Oral Nicorandil on Improving Microvascular Function in Female Non-obstructive Coronary Artery Disease (CAD) Participants
Non-obstructive Coronary Artery Disease
P4
Terminated8Open-labelNicorandil
NCT00407771
The Effects of Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention
Coronary Artery Disease
P4
Unknown44RCT, Open-labelTirofiban
NCT01057160
Rizatriptan 10 MG RPD in the Treatment of Acute Migraine
Migraine
P4
Completed195RCT, Open-labelRizatriptan
NCT02342418
Single Dose PK of IV Tedizolid Phosphate in Morbidly Obese and Non-Obese Adults
Obesity
P4
Completed19Open-labelTedizolid phosphate
NCT01245101
Addition of Raltegravir to Established Antiretroviral Suppressive Therapy
HIV
P4
Terminated15RCT, Open-labelRaltegravir, Raltegravir
NCT00406094
Singulair Use in Non-Allergic Rhinitis Eosinophil Syndrome (NARES)
Rhinitis
P4
Unknown6RCT, Double-blindmontelukast, placebo
NCT02724111
Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery
Neuromuscular Blockade, Surgery
P4
Completed90RCT, Double-blindsufficient dose of rocuronium, sugammadex 10 min after position change
NCT05562999
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Neuromuscular Blockade, Innate Inflammatory Response
P4
Completed100RCT, Double-blindRocuronium Bromide, Rocuronium Bromide
NCT01396395
Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina
Stable Angina, Coronary Disease
P4
Completed402RCT, Open-labelNicorandil, Standard Treatment
NCT01756079
A Study to Evaluate the Efficacy and Safety of Boceprevir Added to Standard of Care Therapy in Previously Treated Participants With Chronic Hepatitis C Genotype 1 and Cirrhosis (MK-3034-105)
Hepatitis C
P4
Completed58Open-labelboceprevir, PegIFN-2b, RBV
NCT01587118
An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder
Posttraumatic Stress Disorder
P4
Completed18Open-labelAdjunctive asenapine
NCT00752622
Treatment With Infliximab in a Medical Setting (Study P05587)
Crohn's Disease
P4
Terminated100RCT, Open-labelInfliximab 5 mg/kg, Infliximab 5 mg/kg every 6 weeks, Infliximab 7 mg/kg every 8 weeks
NCT04689737
Removal of Doravirine by Hemodialysis in HIV-Infected Patients With End-stage Renal Disease (ESRD)
HIV-infected Participants With ESRD Undergoing Routine Hemodialysis
P4
Completed8Open-labelDoravirine
NCT04274153
HPV Vaccination Study in Postpartum Women
HPV, Immunization
P4
Completed225Open-labelGardasil9
NCT00910689
Drug and Non-Drug Treatment Of Severe Migraine
Migraine Headache
P4
Completed232RCT, Double-blindPropranolol or nadolol, Placebo control, Optimal Acute Therapy
NCT03087513
A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo
Posterior Cervical Decompression and Fusion
P4
Completed40RCT, Double-blindSugammadex Injection [Bridion], Placebo
NCT00222664
Qidong Hepatitis B Intervention Study
Hepatitis B, Liver Neoplasms
P4
Completed80,000RCT, Open-labelHep-V Vax
NCT00307307
Carotid Atherosclerosis Regression at Magnetic Resonance Assessment.
Established Carotid Atherosclerosis
P4
Completed69RCT, Double-blindNiacin/simvastatin compared to simvastatin alone at 2 doses
NCT01210144
EXpression PRofile Endometrium Samples Study
In Vitro Fertilization
P4
Terminated27RCT, Open-labelGonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist, Gonadotropin-releasing hormone (GnRH) Antagonist
NCT00686725
Standard Temodal (Temozolomide) Regimen Versus Standard Regimen Plus Early Postsurgery Temodal for Newly Diagnosed Glioblastoma Multiforme (Study P05572)
Glioblastoma
P4
Completed99RCT, Open-labelTemozolomide
NCT01027806
Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children
Obstructive Sleep Apnea
P4
Terminated64RCT, Double-blindMontelukast
NCT00781768
Odansetron and Dexamethasone Alone vs. Odansetron, Dexamethason and Apreptant to Prevent Nausea
Nausea, Vomiting
P4
Completed181RCT, Double-blindStandard PO (Zofran + Dexamethason), Aprepitant (MK-869) + Standard PO
NCT00650663
Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377)
Hypercholesterolemia, Atherosclerosis
P4
Completed247RCT, Double-blindEzetimibe + Simvastatin, Simvastatin
NCT02294084
Sitagliptin and Brown Adipose Tissue
Neoplasms, Adipose Tissue
P4
Completed30RCT, Double-blindSitagliptin, placebo
NCT00934713
The Effect of Montelukast Treatment in Wheezy Infants
Lung Disease, Obstructive, Signs and Symptoms, Respiratory
P4
Completed112RCT, Double-blindmontelukast
NCT01066039
Phase 4 Study to Assess the Effect of Bisoprolol on Glycemic Level in Type II Diabetic Subjects With Suboptimal Blood Pressure Control
Hypertension, Diabetes Mellitus, Type II
P4
Completed202Open-labelBisoprolol
NCT01384331
New Treatments for Troublesome Bleeding in Implanon Users
Menstrual Problem
P4
Unknown200RCT, Double-blindMarvelon
NCT05289271
Safety, Tolerability, and Immunogenicity of Vaxelis™ in Children Previously Vaccinated With Vaxelis™ or Hexyon™ (V419-016)
Vaccines, Combined, Hexavalent Vaccine
P4
Completed168Open-labelVaxelis™
NCT01616160
An Open-label Study to Identify Molecular Markers of Steroid Resistance
Nasal Polyps
P4
Terminated11Open-labelmometasone furoate
NCT01960725
An Alternate Dosing Schedule for Pentavalent Rotavirus Vaccine (RotaTeq)
Diarrhea, Gastroenteritis
P4
Completed66Open-labelRV5 (Pentavalent Rotavirus Vaccine)
NCT03098121
Efficacy and Tolerability of Grazoprevir and Elbasvir in Patients With Chronic Genotype 1 HCV and HIV Co-infection
Chronic Hepatitis C
P4
Completed40Open-labelgrazoprevir and elbasvir
NCT01928199
Efficacy Study of Sitagliptin to Prevent New-onset Diabetes After Kidney Transplant
Posttransplant Diabetes Mellitus
P4
Completed61RCT, Double-blindSitagliptin, Placebo
NCT05435209
Effectiveness of the Q-HPV Vaccine 9-years Post Vaccination Among HIV Positive Adolescents
HPV Infection, HPV Vaccination
P4
Completed158Open-labelQuadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine
NCT01364298
Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management
Diabetic Peripheral Neuropathic Pain
P4
Completed353RCT, Open-labelGabapentin/B-complex, Pregabalin
NCT03350698
Occupational Exposure to Human Papilloma Virus (HPV) and Prophylactic Vaccination
Papillomavirus Vaccines
P4
Unknown100Open-labelGardasil-9
NCT01448291
Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers
Vaginosis, Bacterial
P4
Unknown30Open-labelEtonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
NCT00289913
Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068)
Hepatitis A Virus
P4
Completed1,274RCT, Open-labelComparator: VAQTA™, Comparator: Infanrix™, Comparator: PedvaxHIB™
NCT01448486
A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIV
Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND)
P4
Terminated6RCT, Open-labelRaltegravir
NCT00444379
Anti-Retrovirals for Kaposi's Sarcoma
Kaposi's Sarcoma, HIV Infections
P4
Completed224RCT, Single-blindLopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
NCT03378479
Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients
Aspergillosis; Pulmonary, Invasive (Etiology)
P4
Completed88RCT, Open-labelSOC +Posaconazole 18 MG/ML (milligram/milliliter)
NCT01379157
Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia
Ventilator Associated Pneumonia
P4
Completed8RCT, Open-labelImipenem, Imipenem
NCT01606800
Efficacy and Safety of Short Course Therapy With Peginterferon Alpha-2b (PEG-IFN Alfa-2b) and Ribavirin (RBV) for Chronic Hepatitis C (Genotype 4) Participants Achieving a Rapid Virological Response at Week 4 of Treatment (MK-8908B-059)
Hepatitis C, Chronic
P4
Terminated45RCT, Open-labelPEG-IFN alfa-2b, ribavirin
NCT01922011
Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)
Acute Hematogenous Osteomyelitis
P3
Completed149RCT, Double-blindDaptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent)
NCT00328692
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
Heart Failure, Congestive
P3
Completed932RCT, Double-blindrolofylline, Comparator: Placebo (unspecified)
NCT01170221
TR-701 FA vs. Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections.
Skin and Subcutaneous Tissue Bacterial Infections
P3
Completed667RCT, Double-blindTR-701 FA, Linezolid
NCT00388401
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
Ileus
P3
Completed510RCT, Double-blindAlvimopan
NCT01696643
Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Opioid-Induced Constipation
P3
Terminated1,407RCT, Double-blindCB-5945, Placebo
NCT00241722
Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Bowel Dysfunction, Constipation
P3
Completed805RCT, Double-blindAlvimopan, Placebo
NCT01853982
Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia
Ventilator-Associated Pneumonia (VAP)
P3
Terminated4RCT, Open-labelCeftolozane/Tazobactam, Piperacillin/Tazobactam
NCT03520959
A Phase 3, Randomized, Double-blind, Placebo-controlled Study For Subjects With Locally-advanced Unresectable or Metastatic Synovial Sarcoma (V943-003, IMDZ-04-1702)
Synovial Sarcoma, Cancer
P3
Terminated1RCT, Double-blindLV305, G305
NCT01901302
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Opioid-Induced Constipation
P3
Terminated61RCT, Double-blindCB-5945, Placebo
NCT02604433
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia
Erythrocyte Transfusion, Beta-Thalassemia
P3
Completed336RCT, Double-blindLuspatercept
NCT00314951
Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018)
Clostridium Infections, Diarrhea
P3
Completed629RCT, Double-blindFidaxomicin, Vancomycin, Matching Placebo to Fidaxomicin
NCT00540072
Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae
Pneumonia, Bacterial
P3
CompletedRCT, Double-blinddaptomycin
NCT01216241
Daptomycin Versus Placebo in Patients With Neutropenia and Fever
Febrile Neutropenia
P3
Terminated36RCT, Double-blindDaptomycin, Daptomycin
NCT00055198
Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria
Gram-Positive Bacterial Infections
P3
Terminated75Open-labeldaptomycin
NCT00448422
Safety and Efficacy of Prulifloxacin vs Placebo in Treatment of Acute Gastroenteritis in Adult Travelers
Acute Bacterial Gastroenteritis
P3
Completed268RCT, Double-blindprulifloxacin
NCT01691248
Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (MK-5119-001)
Clostridium Difficile-Associated Diarrhea (CDAD)
P3
Completed611RCT, Double-blindfidaxomicin, Placebo
NCT01421511
TR-701 FA vs Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections
Skin and Subcutaneous Tissue Bacterial Infections
P3
Completed666RCT, Double-blindTR-701 FA, Linezolid
NCT00388258
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
Ileus
P3
Completed451RCT, Double-blindAlvimopan
NCT00354458
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
Heart Failure, Congestive
P3
Completed1,102RCT, Double-blindrolofylline, Comparator: Placebo (unspecified)
NCT00259922
Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Bowel Dysfunction, Constipation
P3
Completed485RCT, Double-blindPlacebo, Alvimopan, Alviompan
NCT04317040
Efprezimod Alfa (CD24Fc, MK-7110) as a Non-antiviral Immunomodulator in COVID-19 Treatment (MK-7110-007)
Coronavirus Disease 2019 (COVID-19)
P3
Completed234RCT, Double-blindEfprezimod alfa, Placebo
NCT01597505
Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005)
Clostridium Difficile Infection
P3
Completed606RCT, Double-blindSurotomycin, Vancomycin, Placebo
NCT02070757
Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008)
Healthcare-Associated Pneumonia, Ventilator-Associated Pneumonia
P3
Completed726RCT, Double-blindCeftolozane/tazobactam, Meropenem
NCT00256932
Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Bowel Dysfunction, Constipation
P3
Completed518RCT, Double-blindalvimopan, Placebo
NCT02631070
A Study of Luspatercept (ACE-536) to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes
Myelodysplastic Syndromes
P3
Completed229RCT, Double-blindLuspatercept
NCT04811092
Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13)
Pulmonary Arterial Hypertension
P3
Completed321RCT, Double-blindSotatercept
NCT00538694
Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia
Pneumonia, Bacterial
P3
CompletedRCT, Double-blinddaptomycin
NCT01755767
Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy
Hepatocellular Carcinoma
P3
Completed383RCT, Double-blindTivantinib, Placebo
NCT04576988
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)
Pulmonary Arterial Hypertension
P3
Completed324RCT, Double-blindSotatercept, Placebo, Background PAH Therapy
NCT01244191
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer
Non Squamous, Non-small-cell Lung Cancer
P3
Terminated1,048RCT, Double-blindTivantinib, Placebo, Erlotinib
NCT01901341
The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Opioid-Induced Constipation
P3
Terminated44RCT, Double-blindCB-5945, Placebo
NCT01704651
Accelerating Gastrointestinal Recovery
Ovarian Cancer, Fallopian Tube Cancer
P3
Completed146RCT, Double-blindAlvimopan, Placebo
NCT00205842
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
Ileus
P3
Completed660RCT, Double-blindalvimopan
NCT00468728
PAR-101/OPT-80 Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD)
Clostridium Infections, Diarrhea
P3
Completed535RCT, Double-blindPAR-101/OPT-80, Vancomycin
NCT02276482
Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012)
Skin Diseases, Infectious, Skin Diseases, Bacterial
P3
Completed120RCT, Single-blindTedizolid Phophate, Antibiotic comparator, Aztreonam, Metronidazole
NCT00388479
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus
Ileus
P3
Completed666RCT, Double-blindAlvimopan
NCT02019420
Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002)
Pneumonia
P3
Completed726RCT, Double-blindTedizolid phosphate, Linezolid
NCT01345929
Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis
Complicated Urinary Tract Infection, Pyelonephritis
P3
Completed558RCT, Double-blindCXA-201, Levofloxacin
NCT01901328
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
Opioid-Induced Constipation
P3
Terminated49RCT, Double-blindCB-5945, Placebo
NCT00701636
Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery
Late Effects of Surgery, Staphylococcus Aureus
P3
Completed30Open-labeldaptomycin
NCT04095858
Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005)
Hematopoietic Stem Cell Transplantation, Acute Graft Versus Host Disease
P3
Terminated11RCT, Double-blindEfprezimod alfa, Placebo, Methotrexate, Tacrolimus
NCT00093067
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
Bacterial Endocarditis, Bacteremia
P3
CompletedRCT, Open-labeldaptomycin
NCT04896008
A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH)
Pulmonary Arterial Hypertension
P3
Completed173RCT, Double-blindSotatercept
NCT01598311
A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006)
Clostridium Difficile Infection
P3
Completed608RCT, Double-blindCB-183,315, Vancomycin, Placebo
NCT00443690
Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy
Heart Failure, Congestive
P3
Completed480RCT, Double-blindrolofylline, Comparator: Placebo (unspecified)
NCT01445678
Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Meropenem in Complicated Intraabdominal Infections
Complicated Intra-abdominal Infection
P3
Completed494RCT, Double-blindCXA-201 and metronidazole, Meropenem
NCT07365319
A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.
Non Small Cell Lung Cancer (Squamous or Non Squamous), Stage 4 NSCLC
P2P3
Not Yet Recruiting750RCT, Double-blindEIK1001, Pembrolizumab (KEYTRUDA®), Placebo, Paclitaxel + Carboplatin, Nab-paclitaxel + Carboplatin, Pemetrexed + Cisplatin /Carboplatin
NCT03480802
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults Infected With Human Immunodeficiency Virus (HIV) (V114-018)
Pneumococcal Infections
P3
Completed302RCT, Double-blindV114, Prevnar 13™, PNEUMOVAX™23
NCT00686881
Efficacy of Peginterferon Alfa-2b (SCH 054031) vs Glycyrrhizin in Interferon (IFN)-Treated Patients With Chronic Hepatitis C and F2/F3 Liver Fibrosis (P04773)
Hepatitis C, Chronic
P3
Terminated261RCT, Open-labelPeginterferon alfa-2b (PegIFN-2b), Comparator: Stronger neo minophagen C (SNMC)
NCT00325130
Concomitant Use of Gardasil (V501) (Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diphtheria, Tetanus, Pertussis Vaccine and Meningococcal Conjugate Vaccine in Adolescents (V501-025)
Neoplasms, Glandular and Epithelial, Diphtheria
P3
Completed1,042RCT, Open-labelComparator: Quadrivalent Human Papillomavirus (HPV) vaccine, Comparator: Menactra™ (Concomitant), Comparator: Adacel™ (Concomitant), Comparator: Menactra™ (Non-concomitant), Comparator: Adacel™
NCT01089647
Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)
Obstructive Sleep Apnea
P3
Completed34RCT, Double-blindbudesonide and montelukast, Placebo
NCT04676412
Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study
Non-small Cell Lung Cancer
P3
Completed107RCT, Double-blindPembrolizumab, Lenvatinib, Placebo for lenvatinib
NCT03635567
Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826)
Cervical Cancer
P3
Completed617RCT, Double-blindPembrolizumab, Paclitaxel, Cisplatin, Carboplatin, Bevacizumab, Placebo to pembrolizumab
NCT01937247
Redesigned Process in the Operating Room
Non-operative Time, General Surgery, Above 18 Years of Age
P2P3
Completed120RCT, Double-blindpatient will be reversed with sugammadex 4mg/kg IV
NCT00686790
Efficacy of Peginterferon Alfa-2b in Previously Untreated Subjects With Chronic Hepatitis B and D Co-infection (Study P04603)
Hepatitis D, Chronic, Hepatitis B, Chronic
P3
Completed68Open-labelPeginterferon alfa-2b (PegIntron, SCH 54031)
NCT01299376
MK-0954E Phase III Long-Term Study in Participants With Hypertension (MK-0954E-356)
Hypertension
P3
Completed286RCT, Double-blindL50/H12.5/A5, L50/H12.5, Placebo to L50/H12.5/A5, Placebo to L50/H12.5
NCT00534248
Study to Evaluate the Safety and Effectiveness of Zostavax™ in Subjects 50 - 59 Years of Age (V211-022)
Shingles
P3
Completed22,439RCT, Double-blindZoster Vaccine, Live (Zostavax™), Comparator: Placebo
NCT01302691
MK-0954E Study in Participants With Hypertension (MK-0954E-357)
Hypertension
P3
Completed327RCT, Double-blindlosartan potassium + hydrochlorothiazide + amlodipine besylate (MK-0954E), Losartan potassium, Amlodipine besylate, Placebo to MK-0954E, Placebo to losartan potassium, Placebo to amlodipine besylate
NCT00552097
Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)
Atherosclerosis, Hypercholesterolemia
P3
Completed720RCT, Double-blindezetimibe (plus simvastatin), placebo (plus simvastatin)
NCT00954265
Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)
Embryonic Development, Pregnancy
P3
Unknown130RCT, Single-blind10000 IU urinary HCG, 250 mcg recombinant HCG
NCT00833053
Dose Optimization of Infliximab in Moderate to Severe Plaque Psoriasis (Study P05315)
Psoriasis
P3
Terminated39RCT, Open-labelInfliximab, Infliximab and methotrexate
NCT01534351
Comparison of Finasteride and Tamsulosin for Treatment of Benign Prostatic Hyperplasia (BPH) (MK-0906A-149 AM2)
Benign Prostatic Hyperplasia
P3
Terminated1RCT, Double-blindFinasteride, Tamsulosin, Finasteride-matching placebo, Tamsulosin-matching placebo
NCT03969901
Safety, Tolerability, Efficacy and Pharmacokinetics of Imipenem/Cilastatin/Relebactam (MK-7655A) in Pediatric Participants With Gram-negative Bacterial Infection (MK-7655A-021)
Suspected or Documented Gram-negative Bacterial Infection
P2P3
Completed115RCT, Open-labelIMI/REL, Active Control, Oral Switch
NCT00035295
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061)
Major Depressive Disorder
P3
Completed584RCT, Double-blindMK0869, aprepitant, Comparator: placebo
NCT00080444
Study of Aprepitant (MK-0869) for Chemotherapy-Induced Nausea and Vomiting (CINV) in Adolescent Participants (MK-0869-097)
Vomiting
P3
Completed50RCT, Double-blindaprepitant, ondansetron, dexamethasone, placebo to aprepitant, placebo to dexamethasone, rescue medication
NCT02784171
Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma
Mesothelioma
P2P3
Completed520RCT, Open-labelCisplatin, Pemetrexed, Pembrolizumab
NCT00536263
PegIntron Treatment of Chronic Hepatitis B e Antigen-Positive Patients (P05170/MK-4031-327)
Hepatitis B, Chronic
P3
Completed671RCT, Open-labelpegylated interferon alpha-2b, pegylated interferon alpha-2b, pegylated interferon alpha-2b
NCT00237484
Effect of Infliximab on the Efficacy of Peg-Intron/Ribavirin in Patients With Hepatitis C (Study P04257AM4)(COMPLETED)
Hepatitis C, Chronic
P3
Completed89RCT, Open-labelInduction dose of (a) infliximab followed by combination of (b) pegylated interferon alfa-2b and (c) ribavirin, Combination of (a) pegylated interferon alfa-2b and (b) ribavirin
NCT04193176
Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)
Chronic Cough
P3
Completed376RCT, Double-blindGefapixant, Placebo
NCT00750919
Twenty-six Week Extension Trial of Org 50081 (Esmirtazapine) in Outpatients With Chronic Primary Insomnia (176003/P05721/MK-8265-007)
Sleep Initiation and Maintenance Disorders, Mental Disorders
P3
Terminated184Open-labelesmirtazapine
NCT00984152
Trial of TDF/FTC + Raltegravir Versus TDF/FTC + Efavirenz in HIV-1-Infected Women
HIV-1 Infections
P3
WithdrawnRCT, Open-labelTDF/FTC Once-Daily + Raltegravir 400 mg Orally Twice-Daily, TDF/FTC + Efavirenz (Atripla) Once-Daily
NCT00759109
Pegylated Alfa-2b Interferon Therapy of Patients With Hepatitis C-related Cirrhosis and High Liver Cell Proliferation (P02733/MK-4031-085)
Carcinoma, Hepatocellular
P3
Completed150RCT, Open-labelPeginterferon alfa-2b
NCT00433927
5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC)
Neoplasm Metastasis, Colorectal Cancer
P3
Unknown568RCT, Open-label5-FU, folinic acid, irinotecan, cetuximab, bevacizumab
NCT00251641
The Effects of Infliximab Versus Methotrexate in the Treatment of Moderate to Severe Psoriasis (Study P04271AM2)(COMPLETED)
Psoriasis
P3
Completed868RCT, Open-labelinfliximab, methotrexate
NCT03950856
Lot-to-Lot Consistency of V114 in Healthy Adults (V114-020)
Pneumococcal Infections, Pneumonia, Pneumococcal
P3
Completed2,340RCT, Double-blindV114, Prevnar 13™
NCT01945294
Short Duration Versus Standard Response-Guided Therapy With Boceprevir Combined With PegIntron and Ribavirin in Previously Untreated Non-Cirrhotic Asian Participants With Chronic HCV Genotype 1 (MK-3034-107)
Hepatitis C, Chronic
P3
Completed257RCT, Open-labelBoceprevir, Peg-interferon alfa-2b, Ribavirin
NCT01761266
A Multicenter, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-line Treatment of Participants With Unresectable Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC)
P3
Completed954RCT, Open-labelLenvatinib, Sorafenib
NCT01457937
Boceprevir/PegIFN α-2b/Riba in HCV+ Gt1 Menopausal Women, Nonresponders to PegIFN/Riba or Treatment-naives (MEN_BOC)
Chronic Hepatitis C, Menopause
P3
Unknown240RCT, Open-labelPegylated Interferon, Ribavirin, Boceprevir
NCT01841697
Study to Evaluate the Safety and Efficacy of the Addition of Omarigliptin (MK-3102) Compared With the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-026)
Type 2 Diabetes
P3
Completed642RCT, Double-blindOmarigliptin, Sitagliptin, Placebo to omarigliptin, Placebo to Sitagliptin, Open-label Metformin, Open-label Glimepiride
NCT00381017
Effects of Low-dose Maintenance Peg Interferon Alfa-2b Therapy Versus Supportive Care in Patients With Cirrhotic Hepatitis C With HIV (Study P04371)
Hepatitis C, Liver Cirrhosis
P3
WithdrawnRCT, Open-labelPeg interferon alpha-2b
NCT00564460
On Label, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Finasteride in Patients Undergoing Transurethral Resection of the Prostate (TURP)
Benign Prostatic Hyperplasia
P3
WithdrawnRCT, Double-blindFinasteride, Placebo
NCT00092196
Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED)
Nausea, Vomiting
P3
Completed820RCT, Open-labelMK0869, aprepitant / Duration of Treatment: 3 days
NCT06450366
A Study to Evaluate the Efficacy and Safety of Enlicitide (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018/CORALreef AddOn)
Hypercholesterolemia
P3
Completed301RCT, Double-blindEnlicitide, Ezetimibe, Bempedoic Acid
NCT01860729
A Study of the Safety and Efficacy of Anacetrapib (MK-0859) Among Participants With Hypercholesterolemia When Added to Ongoing Statin Therapy (MK-0859-022)
Hypercholesterolemia
P3
Completed589RCT, Double-blindAnacetrapib, Placebo
NCT00131430
An Eighteen Month Efficacy and Safety Study in Obese Patients (0364-020)(COMPLETED)
Obesity and Obesity-related Medical Conditions
P2P3
Completed500RCT, Double-blindtaranabant
NCT00708500
Boceprevir in Subjects With Chronic Hepatitis C Genotype 1 Who Failed Prior Treatment With Peginterferon/Ribavirin (Study P05101AM3)(COMPLETED)
Hepatitis C, Chronic
P3
Completed404RCT, Double-blindBoceprevir (SCH 503034), Pegylated interferon alfa-2b (SCH 54031), Ribavirin (SCH 18908), Boceprevir placebo
NCT01803607
Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Oral Bisphosphonate (MK-0822-076)
Osteoporosis
P3
Terminated135RCT, Double-blindodanacatib
NCT00039871
PEG-Intron Plus Rebetol Treatment of Chronic Hepatitis C Subjects Who Failed Response to Alpha-Interferon Plus Ribavirin (Study P02370)
Hepatitis, Hepatitis C, Chronic
P3
Completed2,333Open-labelPegIntron (peginterferon alfa-2b; SCH 54031), REBETOL (ribavirin; SCH 18908)
NCT01228734
A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC) in Chinese Rat Sarcoma Viral Oncogene Homolog (RAS) Wild-type Patients
Metastatic Colorectal Cancer
P3
Completed553RCT, Open-labelCetuximab, Oxaliplatin, Folinic Acid, 5Fluorouracil
NCT01114425
Safety Study of Isentress® + Truvada® in Post-exposure Treatment of HIV Infection
HIV Infections
P3
Completed149Open-labelraltegravir (Isentress), Truvada®
NCT04066491
Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTC
Biliary Tract Cancer, Cholangiocarcinoma
P2P3
Terminated309RCT, Double-blindM7824, Placebo, Gemcitabine, Cisplatin
NCT00002393
A Study of Indinavir Taken With or Without DMP 266
HIV Infections
P3
Completed300Indinavir sulfate, Efavirenz
NCT00689390
Three-year Follow-up of Participants After Administration of Boceprevir or Narlaprevir for the Treatment of Chronic Hepatitis C (P05063)
Hepatitis C, Chronic, Hepacivirus
P2P3
Terminated1,954Open-labelBoceprevir, Narlaprevir, Peginterferon alfa-2b, Ribavirin
NCT01485614
Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083)
Diabetes Mellitus, Type 2 Diabetes
P3
Completed200RCT, Double-blindSitagliptin, Metformin, Placebo to sitagliptin, Placebo to metformin, Glycemic Rescue 1, Glycemic Rescue 2
NCT01241552
A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)
Clostridium Difficile Infection
P3
Completed1,452RCT, Double-blindMK-3415, MK-6072, MK-3415A, Placebo, SOC
NCT00034632
Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)
Mycoses
P3
CompletedOpen-labelPosaconazole oral suspension
NCT00835380
A Study of 2 Doses of VAQTA™ in Healthy Children 12 to 23 Months of Age (V251-069)
Hepatitis A Virus Infection
P3
Completed80Open-labelHepatitis A Vaccine, Purified Inactivated (VAQTA™)
NCT01839188
Spanish Mixed HEXA/PENTA/HEXA Schedule (V419-010)
Neisseria Meningitidis, Bacterial Infections
P3
Completed385Open-labelPR5I, Pediacel®, NeisVac-C®, RotaTeq®, Prevenar 13®
NCT01076088
Safety and Efficacy of Co-Administration of Sitagliptin and Metformin in China (MK-0431-121)
Type 2 Diabetes Mellitus
P3
Completed744RCT, Double-blindSitagliptin 50 mg, Metformin 500 mg, Sitagliptin 100 mg, Placebo, Metformin 850 mg
NCT00092079
A Study of MK0217A and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227)
Osteoporosis, Vitamin D Deficiency
P3
Completed652RCT, Double-blindMK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 24 weeks
NCT00298831
Use of Sugammadex at the End of Case in Routine Anesthesia (MK-8616-023)
Anesthesia, General
P3
Completed224Open-labelSugammadex, Rocuronium
NCT01294683
A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118)
Primary Hypercholesterolemia, Dyslipidemia
P3
Terminated977RCT, Double-blindSimvastatin, Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM), Extended Release (ER) niacin/laropiprant (N/LRPT), Placebo
NCT01012258
Cetuximab With Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck in Chinese Subjects
Squamous Cell Carcinoma of the Head and Neck
P3
Completed70Open-labelCetuximab + concomitant boost radiotherapy
NCT01465178
Improving the Understanding of the Response to Vitamin D Supplementation
Vitamin D Deficiency
P3
Completed62RCT, Double-blind
NCT05119855
Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076)
Papillomavirus Infections, Coronavirus Disease (COVID-19)
P3
Completed165RCT, Open-label9vHPV Vaccine, mRNA-1273 Vaccine
NCT00421148
Dose-Finding Pediatric and Adult Trial With Sugammadex (Org 25969, MK-8616, SCH 900616) (19.4.306) (MK-8616-034) (P05961)
Anesthesia
P3
Completed94RCT, Double-blindSugammadex 0.5 mg/kg, Sugammadex 1 mg/kg, Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Placebo, Rocuronium bromide
NCT05464420
A Study to Evaluate the Safety, Tolerability, Immunogenicity, and Lot Consistency of V116 in Adults 18 to 49 Years of Age (V116-004, STRIDE-4)
Pneumococcal Disease
P3
Completed2,162RCT, Double-blindV116, PPSV23
NCT00393523
Hepatitis B Vaccine Booster Study (V232-058)(COMPLETED)
Hepatitis B
P3
Completed1,478RCT, Single-blindComparator: Modified Process Hepatitis B Vaccine, Comparator: Comparator: ENGERIX-B
NCT00820755
Trial With Cetuximab in Maintenance Therapy After Platinum Based Chemotherapy in First Line Treatment of Non-small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
P3
Completed583RCT, Open-labelCetuximab plus Platinum-based Doublet Chemotherapy, Cetuximab 500 mg/m^2, Cetuximab 250 mg/m^2
NCT00116324
Predicting the Response to Montelukast by Genetic Variation in Asthmatics
Asthma
P3
Completed150RCT, Double-blindMontelukast
NCT00003880
Paclitaxel Plus Carboplatin With or Without SCH-58500 in Treating Patients With Newly Diagnosed Stage III Ovarian or Stage III Primary Peritoneal Cancer
Ovarian Cancer, Primary Peritoneal Cavity Cancer
P2P3
Terminated132RCTrecombinant adenovirus-p53 SCH-58500, carboplatin, paclitaxel
NCT03507413
Metformin Therapy in Non-diabetic AAA Patients
Abdominal Aortic Aneurysm
P2P3
Unknown170RCT, Double-blindMetformin Glucophage 500mg (IR) tablets M90, Placebo Oral Tablet
NCT04223791
Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018)
HIV Infection
P3
Completed643RCT, Double-blindDOR/ISL, BIC/FTC/TAF, Placebo to BIC/FTC/TAF, Placebo to FDC DOR/ISL
NCT03845140
L-PZQ ODT in Schistosoma Infected Children
Schistosomiasis
P3
Completed288RCT, Open-labelL-PZQ ODT 50 mg/kg, Biltricide®, L-PZQ ODT 60 mg/kg
NCT00935480
IntensVIH: Impact Of Therapy Intensification By An Integrase Inhibitor +/- CCR5 Inhibitor On The Lymphoid Reservoir For Hiv-1 In Chronically Infected Patients
HIV Infections
P3
Completed17RCT, Open-labelIsentress®, Celsentri®
NCT03260894
Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)
Renal Cell Carcinoma (RCC)
P3
Completed129RCT, Open-labelPembrolizumab, Epacadostat, Sunitinib, Pazopanib
NCT00985166
A Study of ProQuad in Healthy 4 to 6 Year Old Children (V221-014)
Measles, Mumps
P3
Completed801RCT, Double-blindProQuad (Measles, Mumps, Rubella and Varicella (Oka-Merck) Virus Vaccine Live), Comparator: M-M-R II, Comparator: Varivax, Comparator: Placebo
NCT00403715
Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease
Dry Eye Disease
P3
Completed500RCT, Double-blinddiquafosol tetrasodium (INS365) Ophthalmic Solution
NCT00559468
Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)
Anesthesia, General
P3
Completed52RCT, Single-blindSugammadex, Rocuronium, Sevoflurane, Propofol
NCT02382900
Two-dose Schedule of Quadrivalent HPV Recombinant Vaccine in 11-year-old Boys in Mexico City
Human Papilloma Virus
P3
Unknown500Open-labelquadrivalent human papillomavirus (types 6, 11, 16,18) recombinant vaccine
NCT00404352
REbif FLEXible Dosing in Early Multiple Sclerosis (MS)
Multiple Sclerosis
P3
Completed517RCT, Double-blindRNF, RNF, Placebo
NCT00716833
Etoricoxibe - Preemptive and Postoperative Analgesia for Abdominal and Thoracic Surgery
Pain, Abdominal Surgery
P3
Terminated87RCT, Double-blindEtoricoxibe, Placebo
NCT01432730
A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)
Chronic Cough
P2
Completed24RCT, Double-blindGefapixant, Placebo
NCT03136185
Bomedemstat (IMG-7289/MK-3543) in Participants With Myelofibrosis (IMG-7289-CTP-102/MK-3543-002)
Myelofibrosis, Post-polycythemia Vera Myelofibrosis (PPV-MF)
P1P2
Completed90Open-labelBomedemstat
NCT02476890
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)
Refractory Chronic Cough
P2
Completed36RCT, Double-blindGefapixant 100 mg, Placebo
NCT02296476
A Dose-finding Study of Birabresib (MK-8628) in Participants With Recurrent Glioblastoma Multiforme (MK-8628-002)
Glioblastoma Multiforme
P2
Terminated12Open-labelBirabresib
NCT00626275
Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
P2
Completed46RCT, Double-blindADL5859, Naproxen, Placebo, ADL5859, Placebo
NCT05569538
Bomedemstat (IMG-7289) Plus Ruxolitinib for Myelofibrosis
Myelofibrosis
P2
Unknown40Open-labelBomedemstat
NCT01146574
A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.
Anemia
P2
Completed50RCT, Single-blindSotatercept, Placebo
NCT05191797
Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer
Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma
P1P2
Terminated3Open-labelBomedemstat, Atezolizumab
NCT00993863
Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction
Acute Pain
P2
Completed201RCT, Double-blindPlacebo, ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg, ibuprofen 400 mg
NCT04254978
Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)
Essential Thrombocythemia
P2
Completed73Open-labelBomedemstat
NCT00102700
ARQ 501 in Combination With Gemcitabine in Subjects With Pancreatic Cancer
Pancreatic Cancer, Adenocarcinoma
P2
Completed66Open-labelARQ 501 in combination with gemcitabine
NCT02349425
A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010)
Refractory Chronic Cough
P2
Completed59RCT, Double-blindGefapixant, Placebo (for gefapixant)
NCT04552704
CD24Fc for the Treatment of Immune Related Adverse Events in Patients With Advanced Solid Tumors, TIRAEC Study
Advanced Malignant Solid Neoplasm
P1P2
Terminated3RCT, Double-blindCD24 Extracellular Domain-IgG1 Fc Domain Recombinant Fusion Protein CD24Fc, Placebo Administration
NCT01239758
Extension Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy
P2
Terminated11Open-labelACE-031 (Extension of cohort 1 from core study, A031-03), ACE-031 (Extension of cohort 2 from core study, A031-03), ACE-031 (Extension of cohort 3 from core study, A031-03)
NCT05558696
A Study of Bomedemstat (MK-3543) in Participants With Polycythemia Vera (MK-3543-004)
Polycythemia Vera
P2
Completed20Open-labelBomedemstat
NCT05223920
An Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005)
Thrombocythemia, Essential, Primary Myelofibrosis
P2
Completed81Open-labelBomedemstat
NCT01749540
Study to Evaluate the Safety and Efficacy of Luspatercept (ACE-536) in Participants With Beta-thalassemia (A536-04/MK-6143-002)
B-Thalassemia
P2
Completed64Open-labelluspatercept
NCT00988741
Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapy
Unresectable Hepatocellular Carcinoma
P2
Completed107RCT, Double-blindARQ 197, Placebo
NCT00159627
Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).
Heart Failure, Congestive
P2
Completed52RCT, Double-blindKW-3902IV
NCT01554579
A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee
Osteoarthritis of the Knee
P2
Completed171RCT, Double-blindGefapixant, Sugar Pill
NCT01178411
An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) Protocols
Advanced Solid Tumors
P1P2
Completed60Open-labelTivantinib, Anti-Cancer Combination Therapy
NCT03577028
Study of HPN424 in Patients With Advanced Prostate Cancer
Advanced Prostate Cancer
P1P2
Terminated104Open-labelHPN424 Fixed IV 1.3 to 150 ng/kg, HPN424 Prime Step IV 36 ng/kg Target, HPN424 1 Prime Step IV 225-300 ng/kg Target, HPN424 2 Prime Step IV 300 ng/kg Target, HPN424 2 Prime Step IV 450 ng/kg Target, HPN424 Fixed SC
NCT01519778
A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study
Major Cutaneous Abscess, Cellulitis
P2
Completed200Open-labelTR701 FA
NCT04504916
A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)
Triple-negative Breast Cancer, Non-squamous Non-small-cell Lung Cancer
P2
Terminated102Open-labelZilovertamab vedotin
NCT00558207
A Randomized Phase 2 Study of ARQ 197 Versus Gemcitabine in Treatment-Naïve Patients With Unresectable Locally Advanced or Metastatic Pancreatic Adenocarcinoma
Pancreatic Neoplasms
P2
Completed43RCT, Open-labelARQ 197, gemcitabine
NCT00467272
Catheter Related - Gram Positive Bloodstream Infections
Bloodstream Infection
P2
Completed30Open-labelDaptomycin
NCT01070290
A Study of ARQ 197 Versus Investigator's Choice of Second-Line Chemotherapy in Patients With Locally Advanced or Metastatic Gastric Cancer Who Have Progressive Neoplastic Disease Following Treatment With One Prior Chemotherapy Regimen
Gastric Cancer
P2
WithdrawnRCT, Open-labelARQ 197, Oxaliplatin, capecitabine or irinotecan
NCT02397460
Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)
Refractory Chronic Cough
P2
Completed50RCT, Double-blindGefapixant, Placebo
NCT02842827
A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001)
Acute Myeloid Leukemia, Myelodysplastic Syndrome
P1P2
Completed45Open-labelbomedemstat, tretinoin
NCT03094832
Study of Miransertib (MK-7075) in Participants With PIK3CA-related Overgrowth Spectrum and Proteus Syndrome (MOSAIC) (MK-7075-002)
PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome
P1P2
Terminated50Open-labelMiransertib
NCT02024087
Study of Dalantercept and Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Advanced Adult Hepatocellular Carcinoma
P1P2
Completed21Open-labelDalantercept plus sorafenib
NCT02268409
Extension Study to Evaluate the Safety and Efficacy of Luspatercept in Participants With β-Thalassemia Previously Enrolled in A536-04 (A536-06/MK-6143-004)
β-Thalassemia
P2
Completed51Open-labelluspatercept
NCT00358930
A Study of ARQ 501 in Patients With Squamous Cell Carcinoma of the Head and Neck
Head and Neck Neoplasms, Carcinoma, Squamous Cell
P2
Completed60Open-labelARQ 501
NCT01085591
Study of CB-183,315 in Participants With Clostridium Difficile Infection
Clostridium Difficile Infection, Diarrhea
P2
Completed210RCT, Double-blindCB-183,315, Placebo, Vancomycin
NCT01993329
A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009)
Asthma
P2
Completed20RCT, Double-blindGefapixant 50 mg, Gefapixant 300 mg, Placebo to mimic 50 mg tablets, Placebo to mimic 300 mg tablets
NCT02927080
Study of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD)
Facioscapulohumeral Muscular Dystrophy
P2
Terminated95RCT, Double-blindACE-083, ACE-083 or placebo
NCT03342404
A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia
Thalassemia
P2
Completed145RCT, Double-blindLuspatercept
NCT01752920
Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations
Solid Tumor
P1P2
Completed119Open-labelDerazantinib low dose range, Derazantinib middle dose range, Derazantinib high dose range, Derazantinib at recommended phase 2 dose (RP2D)
NCT03738150
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension
P2
Completed21Open-labelSotatercept
NCT00979953
Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee
Osteoarthritis of the Knee
P2
Completed408RCT, Double-blindADL5859, ADL5747, Oxycodone CR, Placebo
NCT01569438
The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005)
Bladder Pain Syndrome
P2
Terminated107RCT, Double-blindGefapixant, Placebo
NCT03960541
Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003)
HIV Infections, Dyslipidemias
P2
Terminated8RCT, Double-blindEfprezimod alfa (human CD24 extracellular domain and human IgG1 Fc fusion protein), Saline Solution
NCT00761215
Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections
Skin Diseases, Infectious, Skin Diseases, Bacterial
P2
Completed192RCT, Double-blindTR-701 200 mg, TR-701 300 mg, TR-701 400 mg
NCT00652782
Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients
Congestive Heart Failure, Renal Impairment
P2
Completed160RCT, Double-blindrolofyline, Comparator Placebo (unspecified)
NCT01207427
Evaluation of the Efficacy and Safety of ADL5945 for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain
Opioid Induced Constipation
P2
Completed131RCT, Double-blindPlacebo, ADL5945 0.1 mg, ADL5945 0.25 mg
NCT03496207
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension
P2
Completed106RCT, Double-blindPlacebo, Sotatercept
NCT02303782
A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in Patients With Newly-diagnosed Acute Myeloid Leukemia (AML) Not Candidate for Standard Intensive Induction Therapy (SIIT)
Acute Myeloid Leukemia
P1P2
WithdrawnRCT, Open-labelOTX015, Vidaza (azacitidine)
NCT01727336
Study of Dalantercept and Axitinib in Patients With Advanced Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
P2
Terminated160RCT, Double-blindDalantercept and axitinib, Placebo and axitinib
NCT00695903
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia
Endocarditis, Bacterial, Infective Endocarditis
P2
Terminated38RCT, Double-blinddaptomycin, vancomycin
NCT01749514
Study of Luspatercept for the Treatment of Anemia in Patients With Myelodysplastic Syndrome (MDS) (MK-6143-001)
Anemia
P2
Completed116Open-labelLuspatercept
NCT02663622
Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-002)
Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation
P2
Completed44RCT, Double-blindEfprezimod alfa, Methotrexate, Tacrolimus, Placebo
NCT00310518
Safety and Efficacy Study of ARQ 501 in Adult Patients With Leiomyosarcoma
Cancer
P2
Completed30Open-labelARQ 501
NCT01275755
Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain
Constipation
P2
Completed81RCT, Double-blindPlacebo, ADL5945 0.25 mg
NCT00777309
A Randomized Phase 2 Study of Erlotinib + ARQ 197 Versus Erlotinib + Placebo in Previously Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Non Small Cell Lung Cancer
P2
Completed167RCT, Double-blindARQ 197, Erlotinib, Placebo
NCT02609984
Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab Alone in Participants With Sarcoma (IMDZ-C232/V943A-002)
Sarcoma, Myxoid/Round Cell Liposarcoma
P2
Terminated89RCT, Open-labelCMB305, atezolizumab
NCT00228592
HepeX-B in Post Hepatic Allografts for Treatment of End Stage Liver Disease Due to Hepatitis B Infection
Hepatitis B, Liver Transplantation
P2
TerminatedRCT, Open-labelHepeX-B, Hepatitis B Immune Globulin (HBIg)
NCT01058642
Study to Assess the Efficacy, Safety, and Tolerability of ADL5747 in Participants With Postherpetic Neuralgia
Postherpetic Neuralgia
P2
Terminated41RCT, Double-blindADL5747, Placebo, Pregabalin
NCT03108066
MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003)
VHL Gene Mutation, VHL
P2
Completed4Open-labelMK-3795
NCT00101998
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
Constipation, Bowel Dysfunction
P2
Completed233RCT, Double-blindalvimopan, placebo
NCT02612610
A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)
Refractory Chronic Cough
P2
Completed253RCT, Double-blindGefapixant, Placebo (for gefapixant)
NCT01458392
Study of Dalantercept in Patients With Squamous Cell Carcinoma of the Head and Neck
Squamous Cell Carcinoma of the Head and Neck
P2
Completed46Open-labelDalantercept
NCT00557609
Phase 2 Study in Patients With MiT Tumors
Renal Cell Carcinoma (RCC), Alveolar Soft Part Sarcoma (ASPS)
P2
Completed47Open-labelARQ 197
NCT02268383
Extension Study to Evaluate Long-Term Effects of Luspatercept in Patients With Myelodysplastic Syndromes (MDS) (A536-05/MK-6143-003)
Myelodysplastic Syndromes
P2
Completed75Open-labelLuspatercept
NCT00331045
Clinical Evaluation Of Alvimopan (SB767905) On Constipation And Related Symptoms Associated With Opioid
Cancer, Constipation
P2
Terminated21RCT, Double-blindalvimopan, Placebo, Alvimopan 0.5 mg/day, Alvimopan 1 mg/day
NCT02502097
A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016)
Idiopathic Pulmonary Fibrosis, Cough
P2
Completed51RCT, Double-blindGefapixant
NCT03124459
Study of ACE-083 in Patients With Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease
P2
Terminated63RCT, Double-blindACE-083, Placebo
NCT00448864
Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement
Blood Loss, Surgical
P2
Terminated75RCT, Double-blindEcallantide, Placebo
NCT01591863
Safety, Tolerability, and Pharmacokinetics of Fidaxomicin in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
Clostridium Difficile-associated Diarrhea
P2
Completed38Open-labelfidaxomicin
NCT00428844
Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci
Osteomyelitis
P2
Completed75RCT, Open-labeldaptomycin, daptomycin, vancomycin, teicoplanin, nafcillin, oxacillin, flucloxacillin
NCT02501473
Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Participants With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142)
Follicular Low Grade Non-Hodgkin's Lymphoma
P1P2
Terminated52RCT, Open-labelG100, Pembrolizumab, Rituximab
NCT01099761
Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy
P2
Terminated24RCT, Double-blindACE-031 0.5 mg/kg q4wk, ACE-031 1.0 mg/kg q2wk
NCT03216499
HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma
Recurrent Glioblastoma
P2
Completed24Open-labelHIF-2alpha Inhibitor PT2385
NCT00622063
An Extension Study for Patients Previously Treated With ARQ 501
Cancer
P1P2
Completed1Open-labelARQ 501
NCT00816023
A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume
Bloodloss, Surgical Procedures, Operative
P2
Completed276RCT, Double-blindecallantide, placebo
NCT00507247
Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus
Staphylococcus Aureus
P2
Completed11Open-labelDaptomycin
NCT02612623
An 8-Week Refractory Chronic Cough Study (MK-7264-021)
Refractory Chronic Cough
P2
Completed24RCT, Double-blindGefapixant, Placebo (for gefapixant)
NCT00135577
Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects
Cancer, Bowel Dysfunction
P2
Completed67Double-blindalvimopan, placebo
NCT01147640
Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections
Complicated Intra-abdominal Infection
P2
Completed122RCT, Double-blindCXA-101/ tazobactam and metronidazole, meropenem plus saline placebo
NCT00888940
Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery
Bloodloss, Surgical Procedures, Operative
P2
Completed243RCT, Double-blindEcallantide, Cyklokapron(R)
NCT00097422
OPT-80 in Clostridium Difficile-Associated Diarrhea (CDAD)
Diarrhea
P2
CompletedRCT, Open-labelOPT-80
NCT01258569
Entereg Laparoscopic Colon Resection Study
Laparoscopic Colonic Resection
P2
Completed135RCT, Double-blindEntereg, Entereg, placebo
NCT00159614
Effect of KW-3902IV in Combination With IV Furosemide on Renal Function in Subjects With CHF and Renal Impairment
Heart Failure, Congestive, Renal Insufficiency
P2
Completed30RCT, Double-blindKW-3902IV
NCT00426933
Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections
Soft Tissue Infections
P2
Completed100RCT, Open-labelDaptomycin, Vancomycin
NCT00603265
Safety and Efficacy Study of ADL5859 in Participants With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Peripheral Neuropathy, Neuropathic Pain
P2
Completed226RCT, Double-blindADL5859, Duloxetine, Placebo
NCT02406781
Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial
Sarcoma
P2
Completed129Open-labelCombination of MK3475 with Metronomic CP, Combination of MK3475 with Metronomic CP and G100
NCT00921024
Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections
Complicated Urinary Tract Infection
P2
Completed129RCT, Double-blindCXA-101, Ceftazidime
NCT02477709
A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic Pulmonary Fibrosis
P2
Completed6Open-labelGefapixant
NCT01395758
Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Metastatic Non-Small Cell Lung Cancer
P2
Completed96RCT, Open-labelARQ 197 plus erlotinib, Pemetrexed, docetaxel or gemcitabine
NCT04060407
CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI)
Metastatic Melanoma
P1P2
WithdrawnOpen-labelCD24Fc, Ipilimumab, Nivolumab
NCT04996797
A Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Moderately to Severely Active Ulcerative Colitis (MK-7240-005)
Ulcerative Colitis
P2
Completed178RCT, Double-blindTulisokibart
NCT03943290
Extension Study to Evaluate the Long-Term Effects of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD) and Charcot-Marie Tooth (CMT) Disease Types 1 and X (CMT1 and CMTX)
Facioscapulohumeral Muscular Dystrophy, Charcot-Marie-Tooth Disease
P2
Terminated62RCT, Open-labelACE-083
NCT05013905
A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease
Crohn Disease
P2
Completed55Open-labelPRA023 IV
NCT00451113
Sitagliptin in the Elderly
Type 2 Diabetes
P2
Completed12RCT, Single-blindSitagliptin 100 mg
NCT03160079
Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts
B-Cell Acute Lymphoblastic Leukemia, Adult
P1P2
Completed16Open-labelblinatumomab, pembrolizumab
NCT01234857
A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)
Breast Cancer
P2
Completed115RCT, Open-labelridaforolimus + dalotuzumab, exemestane, ridaforolimus, dalotuzumab
NCT04704219
Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61)
Renal Cell Carcinoma
P2
Completed160Open-labelPembrolizumab, Lenvatinib
NCT01269658
A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Vehicle in Subjects With Blepharitis (P08636)
Blepharitis
P2
Terminated40RCT, Double-blindAzithromycin ophthalmic solution, 1%, Vehicle
NCT03840915
M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small-Cell Lung
P1P2
Completed70Open-labelCisplatin, Carboplatin, Pemetrexed, Nab-paclitaxel, Gemcitabine, Docetaxel, M7824, Carboplatin, Carboplatin, Bintrafusp alfa, Paclitaxel
NCT02975336
A Phase II Study of M2951 in SLE
Systemic Lupus Erythematosus
P2
Terminated469RCT, Double-blindPlacebo, M2951, M2951, M2951, M2951
NCT03258398
A Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer
Microsatellite Stable Relapsed or Refractory Colorectal Cancer
P2
Completed56RCT, Open-labeleFT508, Avelumab
NCT03325166
Pembrolizumab and Magnetic Resonance Imaging With Ferumoxytol in Treating Patients With Non-small Cell Lung Cancer and Brain Metastases
Lung Carcinoma Metastatic in the Brain, Stage IV Lung Non-Small Cell Cancer AJCC v7
P2
Terminated2Open-labelFerumoxytol, Pembrolizumab
NCT03523702
The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial
Non-small Cell Lung Cancer, NSCLC
P2
Completed25Open-labelPembroRT
NCT00711555
Emend for Multiple-day Emetogenic Chemotherapy
Nausea, Vomiting
P2
Completed22Open-labelaprepitant, ondansetron, dexamethasone
NCT00239655
A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI)(0812-003)(COMPLETED)
Relapsing-Remitting Multiple Sclerosis
P2
Terminated120RCT, Double-blindMK0812
NCT00481663
A Study of Different Doses of Sitagliptin (MK-0431) in Participants With Type 2 Diabetes Mellitus (MK-0431-014)
Type II Diabetes Mellitus
P2
Completed555RCT, Double-blindSitagliptin, Placebo to sitagliptin, Metformin, Rescue
NCT04447755
A Study of Lenvatinib (MK-7902) in Pediatric Participants With Relapsed or Refractory Solid Malignancies (MK-7902-013/E7080)
Relapsed or Refractory Solid Tumors
P2
Completed127Open-labelLenvatinib
NCT00645333
Phase I/II Study of MK-0752 Followed by Docetaxel in Advanced or Metastatic Breast Cancer
Metastatic Breast Cancer
P1P2
Completed30Open-labelMK-0752, Docetaxel, Pegfilgrastim
NCT01192087
Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
Adenoid Cystic Carcinoma
P1P2
Unknown49Open-labelCetuximab
NCT03430700
Trial of Pembrolizumab Following Weekly Paclitaxel for Platinum-resistant Ovarian, Fallopian Tube or Peritoneal Cancer
Ovarian Cancer, Fallopian Tube Cancer
P2
Unknown28Open-labelPembrolizumab
NCT05998447
GEN-001 Plus Pembrolizumab for Patients With Advanced Refractory Biliary Tract Cancer
Biliary Tract Cancer
P2
Terminated10Open-labelGEN-001, Pembrolizumab, mFOLFOX
NCT05493618
Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.
Multiple Myeloma, Refractory
P1P2
WithdrawnOpen-labelPembrolizumab, Belantamab mafodotin, Dexamethasone
NCT00231790
A Placebo-Controlled Study of MK0634 in Patients With Overactive Bladder (0634-007)
Urinary Incontinence
P2
Completed848RCT, Double-blindMK-0634 50 mg, MK-0634 125 mg, Placebo for MK-0634
NCT03568097
Immunotherapy in Combination With Chemotherapy in Small-cell Lung Cancer
Small Cell Lung Carcinoma
P2
Unknown55Open-labelAvelumab
NCT00703690
MK0767 in Metabolic Syndrome-Dyslipidemia (0767-016)
Metabolic X Syndrome Dyslipidemia
P2
Terminated436RCT, Double-blindMK0767, Comparator: fenofibrate, Comparator: Placebo (unspecified)
NCT02892201
Pembrolizumab in HNSCC With Residual Disease After Radiation
Head and Neck Squamous Cell Carcinoma
P2
Terminated9Open-labelPembrolizumab
NCT00797667
MK0974 (Telcagepant) for Migraine Prophylaxis in Patients With Episodic Migraine (0974-049)
Migraine
P2
Terminated660RCT, Double-blindTelcagepant 140 mg, Telcagepant 280 mg, 140 mg telcagepant placebo, 280 mg telcagepant placebo
NCT03051672
Phase II PEMBROLIZUMAB + PALLIATIVE RADIOTHERAPY IN BC
Metastatic Breast Cancer
P2
Terminated8Open-labelPembrolizumab
NCT00504530
r-hLIF for Improving Embryo Implantation in IVF
Infertility Implantation Failure
P1P2
Completed50RCT, Double-blindEmfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
NCT02105454
Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) + Ribavirin in Participants With Chronic Hepatitis C Who Failed Prior Direct-Acting Antiviral Therapy (MK-5172-048)
Hepatitis C Virus
P2
Completed79Open-labelGrazoprevir (GZR), Elbasvir (EBR), Ribavirin (RBV)
NCT04361851
Study of Dara-Pembro for Multiple Myeloma Patients
Multiple Myeloma
P2
WithdrawnOpen-labelPembrolizumab
NCT00254553
A Study to Test a Measure of Symptoms of Older Men With Low Testosterone On and Off Testosterone Replacement Treatment (P05815)
Hypogonadism
P2
Terminated150RCT, Double-blindTestim 1% (testosterone gel), Placebo
NCT01651936
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Trial to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 in Participants With Rheumatoid Arthritis (MK-8457-010)
Rheumatoid Arthritis
P2
Terminated56RCT, Double-blindMK-8457 100 mg, Methotrexate, Dose-match placebo
NCT04483544
Pembrolizumab and Olaparib in Cervical Cancer Patients
Cervical Cancer, Cervical Carcinoma
P2
Terminated8Open-labelpembrolizumab, olaparib
NCT01045798
Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067)
Invasive Candidiasis
P2
Terminated15RCT, Double-blindCaspofungin acetate, Placebo
NCT00610441
Dose Finding Study in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)(174007/P05805/MK-8777-003)
Attention Deficit Hyperactivity Disorder
P2
Completed67RCT, Double-blindMK-8777, Placebo
NCT00486044
Evaluating Simvastatin's Potential Role in Therapy
Alzheimer Disease
P2
Completed103RCT, Double-blindSimvastatin, Placebo
NCT00003760
Irofulvene in Treating Patients With Stage III or Stage IV Pancreatic Cancer
Pancreatic Cancer
P2
Completed3Open-labelirofulven
NCT00242476
A Study to Assess the Effectiveness of an Investigational Drug in Elderly Subjects With Low Vitamin D Levels (0822A-009)
Vitamin D Deficiency
P2
Completed216RCT, Double-blindMK0822A
NCT00725725
Org 25935 Versus Placebo as Augmentation to Cognitive-behavioral Therapy to Treat Panic Disorder (P05705)
Panic Disorder
P2
Terminated46RCT, Double-blindOrg 25935, Org 25935, Placebo
NCT03609359
Lenvatinib and Pembrolizumab Simultaneous Combination Study
Advanced Gastric Cancer
P2
Completed29Open-labelLenvatinib, Pembrolizumab
NCT00679718
A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease
Dry Eye Disease
P2
Completed150RCT, Double-blinddiquafosol tetrasodium (INS365) ophthalmic solution
NCT00482898
A Study of MK0359 in Patients With Chronic Asthma (0359-013)
Asthma
P2
Completed56RCT, Double-blindMK0359
NCT04944992
A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
P2
Completed145RCT, Open-labelEfinopegdutide 20 mg/mL, Semaglutide 1.34 mg/mL
NCT00832377
COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED)
Glaucoma
P2
Completed37Open-labeltimolol/dorzolamide combination
NCT00546819
ZOSTAVAX™ in Patients on Chronic/Maintenance Corticosteroids (V211-017) (COMPLETED)
Herpes Zoster
P2
Completed309RCT, Double-blindZoster Vaccine, Live, Comparator: Placebo
NCT03637803
Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors
Oncology, Solid Tumor
P1P2
Terminated63Open-labelMRx0518, Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA]
NCT02971956
Pembrolizumab in Refractory Advanced Esophageal Cancer
Esophageal Cancer, Squamous Cell Esophagus Cancer
P2
Completed49Open-labelPembrolizumab
NCT00266812
Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED)
Carcinoma, Non-Small-Cell Lung
P2
Terminated35RCT, Open-labelTemozolomide and radiotherapy
NCT01710501
A Study of Different Doses of Grazoprevir (MK-5172) Given With Pegylated Interferon Alfa-2b and Ribavirin to Treatment-Naïve Participants With Chronic Hepatitis C (MK-5172-038)
Chronic Hepatitis C (CHC)
P2
Completed87RCT, Double-blindGrazoprevir, pegylated interferon alfa-2b, Ribavirin, Placebo
NCT05597839
Study of DF9001 in Patients With Advanced Solid Tumors
Solid Tumor, Adult
P1P2
Completed24Open-labelDF9001, KEYTRUDA® (pembrolizumab)
NCT00736970
Oral Deforolimus With Trastuzumab for Patients With HER2-positive Trastuzumab-Refractory Metastatic Breast Cancer (8669-009)
Breast Cancer, Breast Neoplasms
P2
Completed34Open-labelridaforolimus, trastuzumab
NCT00551018
Efficacy and Safety of VICRIVIROC in HIV-Infected Treatment-Naïve Subjects (Study P04875)
HIV Infections
P2
Completed218RCT, Open-labelVicriviroc, emtricitabine and tenofovir disoproxil fumarate
NCT04815720
Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC)
P1P2
Completed49Open-labelpepinemab + pembrolizumab
NCT01432574
Study of Gardasil in Mid-Adult Males (MAM)
Human Papillomavirus
P2
Completed150Open-labelGardasil
NCT02332720
Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Virus (HCV) Genotype (GT) 3, GT4, GT5, and GT6 Infection (MK-3682-012)
Hepatitis C
P2
Completed413RCT, Open-labelGrazoprevir, Uprifosbuvir, Elbasvir, Ruzasvir, MK-3682B, Ribavirin (RBV)
NCT00673062
Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED)
Seasonal Allergic Rhinitis
P2
Completed265RCT, Double-blindSCH 900538, Pseudoephedrine, Placebo Capsules
NCT03004183
SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC
Metastatic Non-small Cell Lung Cancer, Metastatic Triple-negative Breast Cancer
P2
Completed57Open-labelADV/HSV-tk, Valacyclovir, Pembrolizumab
NCT00092170
An Investigational Agent for the Treatment of Complicated Intra-Abdominal Infections or Acute Pelvic Infections (0826-038)
Infections, Pelvic Infections
P2
Completed100RCT, Open-labelMK0826, ertapenem sodium, Comparator: Ticarcillin/Clavulanate
NCT04811027
Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC
HNSCC
P2
Completed171RCT, Open-labeleftilagimod alpha, pembrolizumab (KEYTRUDA®)
NCT03184571
Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
Lung Cancer Metastatic, NSCLC Stage IV
P2
Completed99Open-labelPembrolizumab, Bemcentinib
NCT00739830
Clinical Trial of Ridaforolimus Compared to Progestin or Chemotherapy for Advanced Endometrial Carcinoma (MK-8669-007 AM6)
Endometrial Cancer
P2
Completed130RCT, Open-labelridaforolimus, medroxyprogesterone acetate tablets OR megestrol acetate, chemotherapy
NCT00311857
Safety Study of Cetuximab, Radiotherapy and Temozolomide in Primary Glioblastoma Multiforme(GERT)
Glioblastoma Multiforme
P1P2
Unknown46Open-labelCetuximab, Temozolomide
NCT00230230
Comparison of SCH 486757 to Codeine and Placebo in Subjects With Persistent Postviral Cough (Study P03069AM2)(COMPLETED)
Cough
P2
Completed91RCT, Double-blindSCH 486757
NCT00988728
Efficacy & Safety of SCH 900435 in Schizophrenia (Study P06079)(WITHDRAWN)
Schizophrenia
P2
WithdrawnRCT, Double-blindSCH 900435 (Org 25935), Placebo, Olanzapine
NCT00725075
Adjuvant Treatment With a Glycine Uptake Inhibitor in Participants With Negative Symptoms of Schizophrenia (P05695) (MK-8435-001)
Schizophrenia
P2
Completed215RCT, Double-blindMK-8435 (Org 25935) 4-8 mg, Placebo, MK-8435 (Org 25935) 12-16 mg
NCT02097108
Changes in Lipids and Lipoproteins in HIV Infected Women After Switch From Protease Inhibitor to Raltegravir
HIV Infections
P2
Completed11Open-labelRaltegravir
NCT06361810
PSMA Therapy and Immunotherapy in Kidney Cancer
Metastatic Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma
P1P2
WithdrawnOpen-labelPembrolizumab, 177Lu-PNT2002, (F-18)-DCFPyL
NCT03598608
Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)
Hodgkin Disease, Lymphoma, Non-Hodgkin
P1P2
Completed137Open-labelpembrolizumab, Favezelimab
NCT00083343
Caspofungin for the Treatment of Non-blood Candida Infections (0991-045)
Candidiasis
P2
Completed48Open-labelMK0991, caspofungin acetate/Duration of Treatment: variable
NCT01748240
Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine Failure
Myelodysplastic Syndrome
P2
Terminated21Open-labelAzacitidine and oral vorinostat
NCT05599789
Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004)
Non Small Cell Lung Cancer Metastatic
P2
Unknown47Open-labelPembrolizumab in Combination with Plinabulin and Docetaxel
NCT01717287
A Study of the Safety, Tolerability, and Antiretroviral Activity of Raltegravir (MK-0518) in Combination With Other Antiretroviral Therapies in Russian Children and Adolescents Infected With Human Immunodeficiency Virus (HIV-1) (MK-0518-248)
HIV Infection
P2
Completed32Open-labelRaltegravir Film-coated Tablet, Raltegravir Chewable Tablet, Other Anti-Retroviral Therapy
NCT00321802
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
Atrial Fibrillation
P2
Completed40RCT, Double-blindSimvastatin, Placebo
NCT03278379
Avelumab in G2-3 NET
Neuroendocrine Tumors
P2
Completed17Open-labelAvelumab
NCT00853762
Atacicept in Multiple Sclerosis Extension Study, Phase II
Relapsing Multiple Sclerosis
P2
Terminated74RCT, Double-blindAtacicept 25 mg, Atacicept 75 mg, Atacicept 150 mg, Atacicept 150 mg
NCT03349450
DPX-Survivac and Checkpoint Inhibitor in DLBCL
Adult Diffuse Large Cell Lymphoma, Recurrent
P2
Completed25Open-labelDPX-Survivac, Pembrolizumab, Cyclophosphamide 50mg
NCT00362024
MK0952 in Patients With Mild-to-Moderate Alzheimer's Disease (0952-004)(COMPLETED)
Alzheimer's Disease
P2
Terminated24RCT, Double-blindMK0952, Comparator: Placebo
NCT04099641
An Open Label Study of Bavituximab and Pembrolizumab in Advanced Gastric and GEJ Cancer Patients
Gastric Cancer, GastroEsophageal Cancer
P2
Completed80Open-labelBavituximab, Pembrolizumab Injection
NCT00609154
Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates
Type 2 Diabetes
P1P2
Terminated20RCT, Open-labelglucagon like peptide-1
NCT03342937
KeyLargo: Pembrolizumab + Oxaliplatin + Capecitabine in Gastric Cancer
Gastric Cancer, Esophagus Cancer
P2
Completed36Open-labelOxaliplatin+Capecitabine+Pembrolizumab
NCT05162586
The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW)
Systemic Lupus Erythematosus
P2
Completed456RCT, Double-blindEnpatoran low dose, Enpatoran medium dose, Enpatoran high dose, Placebo
NCT05545969
Neoadjuvant Pembrolizumab and Lenvatinib for Mucosal Melanoma
Mucosal Melanoma
P2
WithdrawnOpen-labelPembrolizumab, Lenvatinib
NCT00397683
A 52-Week Study to Assess the Effects of MK0822 on Knee Osteoarthritis (MK-0822-011)
Osteoarthritis
P2
Terminated2RCT, Double-blindMK0822
NCT04655183
Study of M4344 in Combination With Niraparib
Advanced Solid Tumor, Breast Cancer
P1P2
WithdrawnRCT, Open-labelNiraparib, M4344, Niraparib, M4344, Niraparib, Niraparib
NCT01186705
Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type, PIK3CA-Mutated, Colorectal Cancer
Colon Cancer, Rectal Cancer
P2
Terminated1Open-labelMK-2206
NCT02064920
Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318)
Alzheimer's Disease
P2
Completed36RCT, Double-blindPlacebo, Donepezil, Donepezil
NCT04729348
Pembrolizumab And Lenvatinib In Leptomeningeal Metastases
Solid Tumor, Solid Tumor, Adult
P2
Terminated10Open-labelPembrolizumab, Lenvatinib
NCT01260974
Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients
Fungemia, Mycoses
P2
Unknown38Open-labelCaspofungin
NCT00082524
Documented Candida or Aspergillus Infections in Pediatric Patients (0991-043)
Aspergillosis, Candidiasis
P2
Completed50Open-labelcaspofungin acetate
NCT00543868
MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001)
Stomach Ulcer, Duodenal Ulcer
P2
Completed462RCT, Double-blindMK0782
NCT00130182
A Study in Pediatric Patients With Cystic Fibrosis Lung Disease
Cystic Fibrosis
P2
Completed13RCT, Double-blinddenufosol tetrasodium (INS37217)
NCT03173560
Trial to Assess Safety and Efficacy of Lenvatinib (18 mg vs. 14 mg) in Combination With Everolimus in Participants With Renal Cell Carcinoma
Renal Cell Carcinoma
P2
Completed343RCT, Open-labellenvatinib, everolimus
NCT03029598
Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
P1P2
Completed29Open-labelCarboplatin, Pembrolizumab
NCT01012336
Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin
Chemotherapy-Induced Nausea and Vomiting, Ovarian Cancer
P2
Completed89Open-labelAprepitant/Ramosetron/Dexamethasone
NCT00420511
Beta-Cell Function and Sitagliptin Trial (BEST)
Type 2 Diabetes Mellitus
P2
Completed21RCT, Double-blindSitagliptin, Placebo, metformin
NCT00684593
A Study to Assess the Clinical Effects of Navarixin in Participants With Psoriasis (MK-7123-009)
Psoriasis
P2
Completed31RCT, Double-blindNavarixin 10 mg
NCT05986071
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers
Breast Cancer
P1P2
Not Yet Recruiting57Open-labelM1774, Fulvestrant injection
NCT00508664
Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA)
Squamous Cell Carcinoma of the Hypopharynx, Larynx Carcinoma
P2
Completed180RCT, Open-labelCetuximab, Docetaxel, Cisplatin (TP), 5-Fluorouracil (TPF) (only until Feb 2009)
NCT00539721
A Randomized Controlled Study of Rolapitant for the Prevention of Nausea and Vomiting Following Surgery (Study P04937AM1)(COMPLETED)
Postoperative Nausea and Vomiting
P2
Completed619RCT, Double-blindRolapitant Dose 1, Rolapitant Dose 2, Rolapitant Dose 3, Rolapitant Dose 4, Ondansetron, Placebo
NCT02886624
Short Duration Therapy of Acute Hepatitis C Genotypes 1 or 4
Acute Hepatitis C, HIV
P2
Completed30Open-labelGrazoprevir/Elbasvir
NCT07511023
Phase 2 Trial Of Sacituzumab Tirumotecan For Treatment Of Refractory Metastatic Or Unresectable Squamous Cell Carcinoma Of The Anus/Rectum
Phase 2, Sacituzumab Tirumotecan
P2
Not Yet Recruiting20Open-labelSacituzumab Tirumotecan
NCT03514017
Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
P2
Terminated5Open-labelPembrolizumab, Ibrutinib
NCT03990961
Pembrolizumab for Patients With PD-L1 Diffuse Large B Cell Lymphoma (DLBCL)
Diffuse Large B Cell Lymphoma, Lymphoma
P2
Terminated5Open-labelPembrolizumab
NCT02599779
A Proof of Principle Study of Pembrolizumab With SBRT in TKI mRCC Patients
Stage IV Renal Cell Cancer AJCC V7
P2
Completed4Open-labelPembrolizumab
NCT04931979
SRT in Combination With Pembrolizumab in Patients With Recurrent Prostate Cancer After Radical Prostatectomy
Urologic Cancer, Biochemical Recurrence of Malignant Neoplasm of Prostate
P2
Unknown49Open-labelPembrolizumab Injection [Keytruda]
NCT04358237
Lurbinectedin (PM01183) Combined With Pembrolizumab in Small Cell Lung Cancer.
Small Cell Lung Carcinoma
P1P2
Completed28Open-labelLurbinectedin, Pembrolizumab
NCT01134627
Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS]
Multiple Sclerosis, Relapsing-Remitting
P2
Terminated305RCT, Double-blindMinocycline, Placebo
NCT03331562
A SU2C Catalyst® Trial of a PD1 Inhibitor With or Without a Vitamin D Analog for the Maintenance of Pancreatic Cancer
Pancreatic Cancer, Pancreas Adenocarcinoma
P2
Completed24RCT, Double-blindPembrolizumab, paricalcitol, placebo
NCT03149822
Study of Pembrolizumab and Cabozantinib in Patients With Metastatic Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
P1P2
Completed45Open-labelCabozantinib, Pembrolizumab
NCT03025035
Pembrolizumab in Combination With Olaparib in Advanced BRCA-mutated or HDR-defect Breast Cancer
Breast Cancer
P2
Completed14Open-labelPembrolizumab, Olaparib
NCT00387140
A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005)
Pain, Postoperative, Tooth Extraction
P2
Completed89RCT, Double-blindMK2295
NCT02630368
A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX)
Solid Tumors, Soft-tissue Sarcoma
P1P2
Unknown197RCT, Open-labelCyclophosphamide and JX-594 dose escalation, Cyclophosphamide and JX-594, Cyclophosphamide, Avelumab and JX-594 and Cyclophosphamide
NCT03674567
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination with Pembrolizumab
Advanced Cancer
P1P2
Completed323Open-labelFLX475, pembrolizumab (KEYTRUDA®)
NCT00555399
Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)
Glioblastoma Multiforme, Anaplastic Glioma
P1P2
Terminated55RCT, Open-labelVorinostat, Isotretinoin, Temozolomide
NCT00783601
MK0524 Asthma POC Study (0524-008)(COMPLETED)
Asthma
P2
Completed130RCT, Double-blindComparator: MK0524 + placebo, Comparator: MK0524 + montelukast, Comparator: placebo + montelukast, Comparator: Placebo
NCT03077828
Pembrolizumab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Lymphocyte-Rich Classical Hodgkin Lymphoma, Recurrent Lymphocyte-Depleted Classical Hodgkin Lymphoma
P2
Unknown43Open-labelCarboplatin, Etoposide, Ifosfamide, Pembrolizumab
NCT03379506
Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079)
HCV Infection
P2
Completed57Open-labelEBR/GZR FDC Tablet, Placebo, Grazoprevir Oral Granules, Elbasvir Oral Granules
NCT00910000
Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive Ovarian Cancer
Ovarian Cancer, Fallopian Tube Cancer
P1P2
Terminated15Open-labelVorinostat, Carboplatin, Gemcitabine
NCT03654326
A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)
Endometriosis-related Pain
P2
Completed187RCT, Double-blindGefapixant, Placebo, Naproxen
NCT07368985
Pembrolizumab and Lenvatinib in Patients With High Risk Locally Advanced Cervix Cancer
Cervical Cancer by FIGO Stage 2018, Squamous Cell Carcinoma FIGO 2018 Stage IIIA, IIIB, IIIC1-IIIC2
P2
Not Yet Recruiting87Open-labelpembrolizumab and lenvatinib
NCT02255110
A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Soft Tissue Sarcoma
P2
Terminated6Open-labelTH-302, Doxorubicin
NCT00825487
Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies
Metastatic Solid Tumors, Refractory/Relapsed Hematologic Malignancies
P1
Completed50Open-labelARQ 621
NCT02387125
Phase 1b Safety Study of CMB305 in Patients With Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1
Sarcoma, Melanoma
P1
Terminated79Open-labelCMB305, G100, Metronomic CPA
NCT03006926
A Trial of Lenvatinib Plus Pembrolizumab in Participants With Hepatocellular Carcinoma
Hepatocellular Carcinoma
P1
Completed104Open-labellenvatinib, pembrolizumab (200 mg)
NCT00075933
ARQ 501 in Subjects With Cancer
Cancer
P1
Completed80Open-labelARQ 501
NCT02553356
PT2385-102 Food Effect Study of PT2385 in Healthy Volunteers
Healthy
P1
Completed16RCT, Open-labelPT2385
NCT03478319
A Study of ACE-2494 in Healthy Subjects
Healthy Volunteers
P1
Completed48RCT, Double-blindACE-2494 or placebo
NCT05603182
A Study of PRA052 in Healthy Volunteers
Healthy
P1
Completed96RCT, Double-blindPRA052
NCT02508740
Single Oral Dose of Bevenopran in Patients With Varying Degrees of Renal Impairment
Renal Impairment
P1
Terminated31RCT, Open-labelbevenopran
NCT03445169
A Food Effect Study in Healthy Volunteers With Belzutifan (PT2977, MK-6482) Tablets
Healthy
P1
Completed16RCT, Open-labelBelzutifan
NCT02257489
Phase 1 Study of ACE-083 in Healthy Subjects
Musculoskeletal Diseases
P1
Completed58RCT, Double-blindACE-083
NCT00658554
Bioequivalence Study of ARQ 197 Amorphous and Crystalline Polymorphs A and B in Normal Healthy Volunteers
Healthy
P1
Completed24RCT, Open-labelARQ 197
NCT00398840
A Study of ARQ 171 in Patients With Advanced Solid Tumors
Cancer
P1
Terminated14Open-labelARQ 171
NCT01397604
The Effects of GLA on Human Volunteers
Healthy Volunteers
P1
Completed32RCT, Double-blindGLA-AF, GLA-SE
NCT02083627
A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects
Drug-Drug Interaction (DDI), Intestinal Absorption
P1
Completed25RCT, Open-labelrosuvastatin, fidaxomicin
NCT01156077
Pharmacokinetic (PK) Study of Oral and IV TR-701 FA in Adolescent Patients
Bacterial Infection
P1
Completed20Open-labelTR-701 FA, TR-701 FA
NCT02035657
A Proof-of-Concept Trial of GLA-SE in Patients With Merkel Cell Carcinoma
Merkel Cell Carcinoma
P1
Completed10Open-labelGLA-SE
NCT01019395
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics
Gram Positive Bacterial Infection
P1
Completed23Open-labelDaptomycin
NCT04676178
A Study of PRA023 in Healthy Volunteers
Healthy
P1
Completed69RCT, Double-blindPRA023
NCT00709540
A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women
Osteoporosis
P1
Completed40RCT, Double-blindACE-011 or placebo
NCT01496677
Pharmacokinetics, Safety, and Tolerability of TR-701 Free Acid (FA) in Elderly Subjects
Healthy Subjects
P1
Completed28RCT, Open-labelTR-701 FA 200 mg, TR-701 FA 200 mg
NCT01225536
Dose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS Mutations
Solid Tumor
P1
Completed24Open-labelARQ 736
NCT00490737
Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)
End-Stage Renal Disease
P1
Completed12Open-labeldaptomycin
NCT01724320
A Phase I, First-in-man Study of OTX008 Given Subcutaneously as a Single Agent to Patients With Advanced Solid Tumors
Solid Tumors
P1
Unknown20Open-labelOTX008
NCT02508753
Safety Study Designed to Study the Effects of Two Different Doses of CXA-101/Tazobactam, a Low Dose and a High Dose, on the QT/QTc Intervals in Healthy Subjects
Healthy
P1
Completed52RCT, Double-blindCXA-101/tazobactam, CXA-101/tazobactam, Moxifloxacin, placebo
NCT05354349
Bioavailability of SC Formulation and Japanese Ethnobridging Study for PRA023
Healthy
P1
Completed49RCT, Double-blindPRA023 IV Low Dose, PRA023 SC, Placebo IV, Placebo SC, PRA023 IV High Dose
NCT02492776
A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations
Healthy
P1
Completed14Open-labelOmeprazole, Gefapixant, Gefapixant
NCT04948554
A Study of MK-2225 / ACE-1334 in Participants With Systemic Sclerosis With and Without Interstitial Lung Disease (MK-2225-002)
Systemic Sclerosis With and Without Interstitial Lung Disease
P1
Terminated5RCT, Double-blindMK-2225, Placebo
NCT00679835
PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections
Gram Positive Infection, Concurrent Antibiotic Treatment
P1
Completed24Open-labeldaptomycin
NCT00876655
Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid Phosphate
Healthy
P1
Completed12RCT, Open-labelTR-701 di-sodium phosphate salt, TR-701 free acid phosphate
NCT03872206
Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression
Advanced Cancers Associated With Mesothelin Expression
P1
Completed95Open-labelHPN536 Fixed IV 6 to 560 ng/kg, HPN536 1 Prime Step IV 600-1200 ng/kg Target, 2 Prime Step IV 900-14000 ng/kg Target
NCT00802555
Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
Cirrhosis, Hepatocellular Carcinoma
P1
Completed21Open-labelARQ 197
NCT00827177
Dose Escalation Study of ARQ 197 in Combination With Sorafenib in Adult Patients With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed87Open-labelTreatment with ARQ 197 in combination with sorafenib
NCT01149720
Determination of the Relative Bioavailability of ARQ 197 Tablet Formulation With Capsule C Formulation as a Reference in Subjects With Advanced Solid Tumors
Solid Tumors
P1
Completed24RCT, Open-labelTivantinib (ARQ 197) Capsule, Tivantinib (ARQ 197) Tablet, Tivantinib (ARQ 197) Capsule D, oral
NCT00671814
Single and Multiple Ascending Dose Pharmacokinetic Study of TR701 in Healthy Adults
Healthy Subjects
P1
Completed80RCT, Double-blindTR-701, linezolid, placebo
NCT02015416
A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer
Melanoma, Ovarian Cancer
P1
Completed13Open-labelIDC-G305
NCT01431833
A PK and Safety Study in Subjects With Hepatic Impairment
Hepatic Impairment
P1
Completed32Open-labelTR-701 FA
NCT03833180
A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)
Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma
P1
Completed91Open-labelZilovertamab vedotin
NCT01432717
Study of ACE-536 in Healthy Postmenopausal Women
Anemia
P1
Completed40RCT, Double-blindACE-536
NCT01473095
Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma
Solid Tumor, Malignant Lymphoma
P1
Completed120Open-labelARQ 092
NCT01713582
A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001)
Acute Myeloid Leukemia, Diffuse Large B-cell Lymphoma
P1
Completed141Open-labelOTX015/Birabresib
NCT01577459
A Phase 1 Crossover Study of Blood Pressure and Heart Rate Response
Healthy Subjects
P1
Completed18RCT, Double-blindTR-701 FA with PSE
NCT00651638
A Study of ARQ 197 in Healthy Volunteers to Assess the Pharmacokinetic (PK) Profile in Extensive and Poor Metabolizers as Defined by Cytochrome P450 2C19 (CYP 2C19) Genotype
Healthy
P1
Completed17Open-labelTreatment with ARQ 197
NCT01461460
A Thorough QT Study of TR-701free Acid (FA) in Healthy Subjects
Healthy Volunteer
P1
Completed48RCT, Double-blindTR-701 FA 1200 mg, Moxifloxacin 400 mg, TR-701 FA 200 mg plus Placebo, Placebo
NCT00882557
Study to Evaluate Daptomycin Given During Dialysis and After Dialysis
End-stage Renal Disease, Renal Failure Chronic Requiring Hemodialysis
P1
Completed16RCT, Open-labeldaptomycin, daptomycin
NCT00671359
Food Effects of Single Oral Dose of 600mg TR-701
Healthy
P1
Completed12RCT, Open-labelTR-701 600mg
NCT02790840
A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations
Healthy
P1
Completed32Open-labelOmeprazole, Omeprazole, Gefapixant, Gefapixant
NCT01813448
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Fidaxomicin in Healthy Male Japanese and Caucasian Subjects
Pharmacokinetics of Fidaxomicin, Healthy Subjects
P1
Completed36RCT, Double-blindFidaxomicin, Placebo
NCT02229877
A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264)
Healthy Volunteers
P1
Completed18Single-blindOmeprazole, Gefapixant, Gefapixant, Gefapixant
NCT01271998
Pulmonary Disposition of TR-700 Following Once-Daily Oral 200 mg
Bacterial Infection
P1
Completed20Open-labelTR-701 FA
NCT01539473
A Phase 1 TR-701 FA Study of Blood Pressure Response Post Tyramine Challenge
Healthy Volunteers
P1
Completed30RCT, Double-blindTR-701 FA with Tyramine, Placebo-controlled withTyramine
NCT01502800
Clinical Trial of ARQ 761 in Advanced Solid Tumors
Solid Tumors
P1
Completed91RCT, Open-labelARQ 761, ARQ 761 Weekly Administration, Bi-Weekly Administration of ARQ 761, Two Consecutive Weeks Administration of ARQ 761 with one week of rest
NCT01442831
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
Healthy
P1
Completed6Open-labelHuman ADME
NCT02259114
A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)
NUT Midline Carcinoma, Triple Negative Breast Cancer
P1
Completed47Open-labelBirabresib
NCT00755638
A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 (ActRIIB-IgG1)in Healthy Postmenopausal Volunteers
Muscle Loss
P1
Completed48RCT, Double-blindACE-031
NCT02650895
Safety Study of Efprezimod Alfa (CD24Fc, MK-7110) When Administered Intravenously in Healthy Adult Subjects (MK-7110-001)
Healthy Volunteers
P1
Completed40RCT, Double-blindEfprezimod alfa, Saline
NCT00952887
A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women
Muscular Atrophy
P1
Completed70RCT, Double-blindACE-031, Placebo
NCT04222985
Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2
Genital Herpes
P1
Terminated24RCT, Double-blindHSV 2 Formulation 1, HSV 2 Formulation 2, HSV 2 Formulation 3, HSV 2 Formulation 4, HSV 2 Formulation 5, HSV 2 Formulation 6, Sodium Chloride 0.9%
NCT02266706
Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)
Proven or Suspected Gram-negative Bacterial Infection, Peri-operative Prophylaxis
P1
Completed43Open-labelCeftolozane/Tazobactam 1000/500 mg, Ceftolozane/Tazobactam 30/15 mg/kg, Ceftolozane/Tazobactam 20/10 mg/kg, Ceftolozane/Tazobactam 18/9 mg/kg, Ceftolozane/Tazobactam 12/6 mg/kg
NCT00136292
Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics
Gram-positive Bacterial Infections
P1
Completed33Open-labeldaptomycin
NCT00612703
A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors
Cancer
P1
Completed32Open-labelARQ 197
NCT01452828
A Pharmacokinetics and Safety Study in Subjects With Renal Impairment
Renal Impairment
P1
Completed24Open-labelTR-701 FA single infusion, TR-701 FA, TR-701 FA
NCT00666601
Microdialysis and Pharmacokinetic Study of TR-701
Healthy
P1
Completed15Open-labelTR-700 (active moiety), TR-701 (pro-drug)
NCT03006887
Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors
Solid Tumors
P1
Completed6Open-labellenvatinib, pembrolizumab
NCT02476955
Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole
Solid Tumors, Ovarian Cancer
P1
Terminated41Open-labelARQ 092 + carboplatin + paclitaxel (Closed), ARQ 092 + paclitaxel (Closed), ARQ 092 + anastrozole
NCT00983255
Ascending Dose Pharmacokinetic (PK) and Absolute Bioavailability (BA)
Bacterial Infections
P1
Completed90RCT, Double-blindTR-701 FA for injection, 200 mg/vial, TR-701 FA tablets
NCT02761694
Vevorisertib (ARQ 751) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations (MK-4440-001)
Cancer, Solid Tumors
P1
Terminated78Open-labelVevorisertib, Fulvestrant, Paclitaxel
NCT02387372
Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)
Critically Ill, Pneumonia
P1
Completed37Open-labelCeftolozane/Tazobactam - Multiple Doses, Ceftolozane/Tazobactam - Single Dose
NCT01623401
A Phase 1, Open-Label, 10 Day Safety Study
Healthy Subjects
P1
Completed72Open-labelTR-701 FA
NCT00302172
ARQ 197 in Subjects With Metastatic Solid Tumors
Cancer, Tumor
P1
Completed78Open-labelARQ 197
NCT00524524
An Exploratory Biomarker Study of ARQ 501 in Patients With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed9Open-labelARQ 501
NCT00612209
A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors
Cancer, Advanced Solid Tumors
P1
Completed51Open-labelARQ 197
NCT02652936
A Pharmacokinetics Study of AF-130 in Healthy Subjects
Healthy Volunteers
P1
Completed80RCT, Double-blindAF-130, Placebo comparator
NCT02341599
Study of Pharmacokinetics of a Single IV Dose of CB-238,618 in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Subjects (MK-6183-001)
Healthy Volunteers, Renal Impairment
P1
Completed40Open-labelMK-6183
NCT00874042
Dose Escalation Study of ARQ 197 in Combination With Gemcitabine in Adult Patients With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed74Open-labelTreatment with ARQ 197 in combination with gemcitabine
NCT02122861
Phase 1 Study of Intradermal LV305 in Patients With Locally Advanced, Relapsed or Metastatic Cancer Expressing NY-ESO-1
Melanoma - Currently Enrolling, Non-small Cell Lung Cancer - Enrollment Completed
P1
Completed47Open-labelID-LV305
NCT00996957
Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma
Advanced Solid Tumors, Multiple Myeloma
P1
Completed37Open-labelACE-041
NCT00099190
ARQ 501 in Combination With Docetaxel in Patients With Cancer
Carcinoma
P1
Completed50Open-labelARQ 501
NCT00851643
Broad Spectrum HPV Vaccine Dose Escalation Study (V502-002)
Human Papilloma Virus, Cervical Cancer
P1
Completed158RCT, Double-blindOctavalent HPV with 15 mcg IMX / AAHS, Octavalent HPV with 30 mcg IMX / AAHS, Octavalent HPV with 60 mcg IMX / AAHS, Octavalent HPV with 120 mcg IMX / AAHS, Comparator: Quadrivalent HPV Vaccine (qHPV), (GARDASIL™)
NCT01288417
Pharmacokinetic Study of the HCV Protease Inhibitor Boceprevir and the HIV Integrase Inhibitor Raltegravir
HIV Infections, HCV Infections
P1
Completed24RCT, Open-labelboceprevir, raltegravir
NCT00111813
Phase 1 Study of Vorinostat and Bortezomib in Multiple Myeloma (MK-0683-015 EXT 1 (AM1))
Multiple Myeloma
P1
Completed34Open-labelvorinostat, bortezomib
NCT02835105
A Study of Ascending Single Doses of Surotomycin in Healthy Participants (MK-4261-008)
Clostridium Difficile Associated Diarrhea (CDAD)
P1
Completed40RCT, Double-blindSurotomycin, Placebo
NCT06615869
A Study to Evaluate Molnupiravir Tablet Formulation Compared to the Molnupiravir Capsule Formulation in Healthy Adult Participants (MK-4482-011)
Healthy
P1
Completed64RCT, Open-labelMolnupiravir
NCT06688045
A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)
Healthy
P1
Completed15Open-labelNemtabrutinib, Itraconazole
NCT00302471
MK0429 Study in Prostate Cancer Patients With Metastatic Bone Disease (0429-011)
Prostatic Neoplasms
P1
Completed29RCT, Double-blindComparator: MK0429, Comparator: MK0429, Comparator: MK0429, Comparator: MK0429
NCT01174199
Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer
Prostate Cancer, Adenocarcinoma of the Prostate
P1
Terminated13Open-labelvorinostat, temsirolimus
NCT00871871
Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)
Hypertension
P1
Completed64RCT, Double-blindHydrochlorothiazide (HCTZ), Comparator: Placebo to HCTZ, Isosorbide mononitrate (ISMN), Comparator: Placebo to ISMN
NCT06626464
A Study of MK-8189 Human Absorption, Metabolism, and Excretion in Healthy Male Participants (MK-8189-010)
Healthy
P1
Completed6Open-label[14C]MK-8189
NCT01934647
Acute Dosing of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-003)
Pulmonary Arterial Hypertension
P1
Terminated7Open-labelMK-8892
NCT06619665
A Study of MK-6552 in Sleep Deprived Healthy Participants (MK-6552-003)
Healthy, Narcolepsy
P1
Completed18RCT, Double-blindMK-6552, MK-6552 placebo, Modafinil, Modafinil placebo
NCT01630616
A Study of Odanacatib When Administered to Adolescents and Young Adults Treated With Glucocorticoids (MK-0822-066)
Osteoporosis
P1
Terminated19RCT, Double-blindOdanacatib, Placebo
NCT06658652
The Effect of Food and Water Volume in Healthy Adult Participants Administered Enlicitide Decanoate (MK-0616) (MK-0616-022)
Healthy
P1
Completed34RCT, Open-labelEnlicitide decanoate
NCT01014936
First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors
Patients With Solid Tumors, Either Refractory to Standard Therapy or for Which no Effective Standard Therapy is Available
P1
Completed149Open-labelMSC2156119J
NCT01919125
Pharmacokinetics of IDX719 in Participants With Normal and Impaired Hepatic Function (MK-1894-008)
Hepatitis C, Chronic
P1
Completed36Open-labelIDX719
NCT00518297
DDI HV (ATV - Merck)
HIV Infections
P1
Completed22Open-labelRaltegravir, Atazanavir, Atazanavir + Raltegravir
NCT00935259
Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED)
Hypercholesterolemia, Dyslipidemia
P1
Completed31RCT, Double-blindSimvastatin, Placebo
NCT06575595
Pharmacokinetic (PK) Characterization of Subcutaneous Tulisokibart (MK-7240-010)
Healthy
P1
Completed60RCT, Open-labelTulisokibart
NCT01640873
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8655 in Participants With Type 2 Diabetes (MK-8655-002)
Type 2 Diabetes
P1
Completed33RCT, Double-blindMK-8655, Placebo
NCT05277402
ADG116 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
P1
Completed6Open-labelADG116
NCT01713036
Oral Bioavailability and Mass Balance Trial With Pimasertib
Locally Advanced or Metastatic Solid Tumors
P1
Completed6Open-labelPimasertib
NCT00694356
Study of Dalotuzumab (MK-0646) in Adults With Solid Tumors (MK-0646-009)
Neoplasm
P1
Completed15Open-labelDalotuzumab
NCT01012102
EMD 640 744 in Montanide ISA 51 VG Administered in Subjects With Advanced Solid Tumors
Advanced Solid Tumors
P1
Completed104RCT, Open-labelEMD 640744, EMD 640744, EMD 640744
NCT02313272
Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas
Malignant Glioma
P1
Completed32Open-labelPembrolizumab, Bevacizumab
NCT00767364
Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome
Short Bowel Syndrome
P1
Completed8Open-labelOral, live, pentavalent rotavirus vaccine; RotaTeq(R)
NCT01451437
Study of MK-8242 Alone and in Combination With Cytarabine in Participants With Acute Myelogenous Leukemia (P07649)
Acute Myelogenous Leukemia (AML)
P1
Terminated26Open-labelMK-8242
NCT01323855
A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)
Parkinson Disease
P1
Completed46Open-labelPreladenant
NCT01294735
Study of the Safety and Efficacy of MK-4827 Given With Temozolomide in Participants With Advanced Cancer (MK-4827-014 AM1)
Recurrence of Solid Tumor, Glioblastoma Multiforme
P1
Completed19Open-labelMK-4827, Temozolomide
NCT02269423
Vaccine Treatment for Ebola Virus in Healthy Adults (V920-001)
Ebola Virus
P1
Completed39RCT, Double-blindV920
NCT00559182
A Study of MK-8033 in Patients With Advanced Solid Tumors (MK-8033-001)
Advanced Cancer
P1
Completed47Open-labelComparator: MK-8033, Comparator: MK-8033 +/- omeprazole
NCT00954993
Pharmacokinetics of Vaniprevir (MK-7009) and Hepatitis C Virus RNA Levels After Vaniprevir Treatment (MK-7009-029)
Chronic Hepatitis C Infection
P1
Terminated3Open-labelVaniprevir
NCT00894114
A Study of Safety, Tolerability and Immunogenicity of a 1-Dose Regimen of MRKAd5 HIV-1 Gag Vaccine Versus the ALVAC_HIV Vaccine (V520-019)
HIV-1 Infection
P1
Completed250RCT, Double-blindV520, Comparator: ALVAC-HIV vaccine
NCT00849732
A Worldwide, Phase I, Dose-Escalating Study of a 3-Dose Regimen of the MRKAd5 (Clade B) Vaccine in Healthy Adults (V520-018)
HIV-1, HIV Infections
P1
Completed360RCT, Double-blindV520, Comparator: V520 (1x10^9 vp/d), Comparator: V520 (1x10^10 vp/d), Comparator: Placebo
NCT02364609
Pembrolizumab and Afatinib in Patients With Non-small Cell Lung Cancer With Resistance to Erlotinib
Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer
P1
Completed11Open-labelAfatinib Dimaleate, Pembrolizumab
NCT00838929
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases
Brain Metastases
P1
Completed17Open-labelVorinostat
NCT00944645
MK0524A Bioequivalence Study (0524A-059)
Dyslipidemia
P1
Completed188RCT, Open-labelniacin (+) laropiprant (Source 1), Comparator: niacin (+) laropiprant (Source 2)
NCT00694083
Study of Ridaforolimus (MK-8669) in Participants With Solid Tumors (MK-8669-003)(COMPLETED)
Neoplasm
P1
Completed13Open-labelRidaforolimus
NCT00851266
A Study of a Bivalent Influenza Peptide Conjugate Vaccine in Healthy Adults
Influenza
P1
Completed187RCT, Double-blindV512, Comparator: Placebo to V512
NCT01023737
Hydroxychloroquine + Vorinostat in Advanced Solid Tumors
Malignant Solid Tumour
P1
Completed72Open-labelHydroxychloroquine, Vorinostat
NCT01470690
Pharmacokinetic Study of the HCV Protease Inhibitor Bo-cePRevir and the Proton Pump Inhibitor OMeprazOle (PROMO)
HCV Infections, Gastric Acid-related Disorders
P1
Completed24RCT, Open-labelboceprevir, Omeprazole
NCT03374254
Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651)
Metastatic Colorectal Cancer
P1
Completed116Open-labelPembrolizumab, Binimetinib, Oxaliplatin, Leucovorin, 5-Fluorouracil [5-FU], Irinotecan
NCT05466422
A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)
Alzheimer Disease
P1
Completed34RCT, Double-blindMK-2214, Placebo
NCT02530502
Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma
Adult Glioblastoma
P1
Terminated4Open-labelPembrolizumab, Temozolomide
NCT02112942
Study Assessing Single and Multiple Doses of IDX21459 in Healthy and HCV-Infected Subjects
Chronic Hepatitis C
P1
Terminated48RCT, Double-blindIDX21459, Matching Placebo
NCT01215175
Safety and Tolerability Study for the Pneumococcal Conjugate Vaccine V114 Versus Prevnar™ (V114-001)
Pneumococcal Infections
P1
Completed150RCT, Double-blindPrevnar™, V114, Aluminum Adjuvanted, V114, Aluminum Nonadjuvanted
NCT00109109
A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004)
Multiple Myeloma
P1
Terminated60Open-labelMK0683, vorinostat, Suberoylanilide Hydroxamic Acid (SAHA) / Duration of Treatment - Up to 8 Cycles or 6 months
NCT00106145
A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014)
Advanced Breast Cancer, Other Solid Tumors
P1
Completed103Open-labelComparator: MK0752, Notch Inhibitor, Comparator: MK0752, Notch Inhibitor - 450 mg, Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off, Comparator: MK0752, Notch Inhibitor - 1 day on, 6 off, Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off 350 mg
NCT06633419
A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012)
Healthy
P1
Completed14Open-labelOpevesostat, Prednisone, Fludrocortisone acetate, Carbamazepine
NCT02621398
Pembrolizumab, Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-IIIB Non-Small Cell Lung Cancer
Stage II Non-Small Cell Lung Cancer, Stage IIIA Non-Small Cell Lung Cancer
P1
Completed23Open-labelCarboplatin, Paclitaxel, Pembrolizumab
NCT02910739
An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016)
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
P1
Completed16Open-labelMK-8931
NCT01343407
A Two-part Study of the Effects of MK-1029 in Allergen-Challenged Asthmatics (MK-1029-003)
Asthma
P1
Completed16RCT, Double-blindMK-1029 10 mg, MK-1029 100 mg, Placebo for MK-1029 10 mg, Placebo for MK-1029 100 mg
NCT01324440
Safety, Tolerability, and Immunogenicity of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine With or Without Merck Aluminum Adjuvant (V710-002)
Staphylococcal Infections
P1
Completed64RCT, Double-blindV710 (30 µg) with MAA, V710 (30 µg) without MAA
NCT07063238
A Clinical Study of MK-8527 in Healthy Adult Participants (MK-8527-014)
Healthy
P1
Completed42RCT, Double-blindMK-8527, Moxifloxacin, Placebo
NCT04665050
Safety, Tolerability, and Immunogenicity of a Polyvalent Pneumococcal Conjugate Vaccine (V116) in Japanese Adults (V116-002)
Pneumococcal Infection
P1
Completed102RCT, Double-blindV116, PNEUMOVAX™23
NCT02835690
Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Pembrolizumab (MK-3475) in Chinese Participants With Non-Small-Cell Lung Cancer (MK-3475-032/KEYNOTE-032)
Non-Small-Cell Lung Cancer
P1
Completed44RCT, Open-labelPembrolizumab
NCT01798849
A Rising Single Dose Study of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics of MK-8892 (MK-8892-001)
Pulmonary Arterial Hypertension
P1
Completed25RCT, Double-blindMK-8892, Placebo for MK-8892
NCT02699515
MSB0011359C (M7824) in Participants With Metastatic or Locally Advanced Solid Tumors
Solid Tumors
P1
Completed114Open-labelMSB0011359C
NCT01656408
A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8150 (MK-8150-002)
Hypertension, Isolated Systolic Hypertension
P1
Completed103RCT, Double-blindMK-8150, Placebo for MK-8150
NCT00990821
A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012)
Chemotherapy-Induced Nausea and Vomiting, Postoperative Nausea and Vomiting
P1
Completed188RCT, Double-blind90 mg MK-0517 (PS80), 100 mg MK-0517 (PS80), 100 MK-0517 (PS80) + 2 mg midazolam, 115 mg MK-0517 (PS80), 150 mg MK-0517 (PS80), 40 mg MK-0517 (non-PS80), 100 mg MK-0517 (non-PS80), 150 mg MK-0517 (Non-PS80), Placebo, 40 mg Aprepitant, 125 mg Aprepitant, 2 mg Midazolam
NCT03514719
PD-L1 Imaging in Non Small Cell Lung Cancer' (PINNACLE)
Non Small Cell Lung Cancer
P1
Completed24Open-labelAvelumab
NCT03745144
Effects of Cladribine Tablets on the PK of Microgynon®
Relapsing Multiple Sclerosis (RMS)
P1
Completed28RCT, Double-blindCladribine, Placebo, Microgynon®
NCT01840579
Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011)
Solid Tumor, Non-small Cell Lung Cancer
P1
Completed57Open-labelPembrolizumab 2 mg/kg, Pembrolizumab 10 mg/kg, Pembrolizumab 200 mg, Cisplatin 75 mg/m^2, Pemetrexed 500 mg/m^2, Carboplatin AUC 5 mg/mL/min, Carboplatin AUC 6 mg/mL/min, Paclitaxel 200 mg/m^2, Nab-paclitaxel 100 mg/m^2, Ipilimumab 1 mg/kg, Etoposide 100 mg/m^2, G-CSF (pegfilgrastim) 3.6 mg
NCT01537120
Evaluation of Continuous Glucose Monitoring in Participants With Type 2 Diabetes Mellitus (MK-0000-258 AM2)
Type 2 Diabetes Mellitus
P1
Completed25Single-blindVildagliptin, Placebo
NCT00759785
A Study of Dalotuzumab (MK-0646) in Breast Cancer Patients (MK-0646-013)
Breast Cancer
P1
Completed48RCT, Open-labeldalotuzumab (MK0646)
NCT00886613
A Study to Evaluate Immunity to Varicella Zoster Virus After Immunization With V212 Vaccine or Zostavax (V212-003)
Herpes Zoster
P1
Completed120RCT, Double-blindV212, Comparator: Zostavax™, Comparator: Placebo
NCT03871959
Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Colon
P1
Completed54Open-labelPembrolizumab, DEBIO1143
NCT06880874
A Clinical Study to Evaluate Enlicitide (MK-0616) Formulations in Healthy Adult Participants (MK-0616-035)
Healthy
P1
Completed40RCT, Open-labelEnlicitide
NCT05213481
Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants
Healthy
P1
Completed18Open-labelTepotinib, Carbamazepine
NCT00917696
Study to Evaluate ATP-induced Pain and ATP-induced Dermal Vasodilation by Iontophoresis (0000-118)(COMPLETED)
Osteoarthritis Pain
P1
Completed44RCT, Double-blind
NCT00667433
Raltegravir as Early Therapy in African-Americans Living With HIV Study
HIV Infections
P1
Completed38Open-labelRaltegravir + Truvada
NCT00888238
A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)
Type 2 Diabetes Mellitus
P1
Completed12RCT, Double-blindsitagliptin, Comparator: Placebo
NCT01500382
A Study of the Pharmacokinetics and Pharmacodynamics of Vibegron (MK-4618) in Women With Overactive Bladder (MK-4618-004)
Overactive Bladder, Overactive Urinary Bladder
P1
Terminated4RCT, Double-blindVibegron, Tolterodine ER, Prophylactic Antibiotic
NCT06843460
A Clinical Study of MK-7962 in Healthy Chinese Participants (MK-7962-021)
Healthy
P1
Completed24RCT, Double-blindSotatercept
NCT03979274
A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers
Healthy
P1
Completed44RCT, Open-labelReference Eutirox®, Test Eutirox®
NCT02339324
Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b
Melanoma
P1
Completed31Open-labelPembrolizumab and high dose interferon alfa-2b (HDI)
NCT03552536
MK-8583 Single Dose Study in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8583-002)
HIV-1 Infection
P1
Completed5Open-labelMK-8583
NCT04075721
First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in Combination With Dexamethasone
Multiple Myeloma
P1
Terminated10Open-labelM3258, M3258 20 mg
NCT03347292
Regorafenib Plus Pembrolizumab in First Line Systemic Treatment of HCC
Carcinoma, Hepatocellular
P1
Completed58Open-labelRegorafenib(Stivarga, BAY73-4506), Pembrolizumab
NCT02549040
Bioavailability of Doravirine (MK-1439) Experimental Nano Formulations in Healthy Adults (MK-1439-046)
Human Immunodeficiency Virus-1 (HIV-1)
P1
Completed16Open-labelTreatment A: Doravirine 100 mg film coated tablet, Treatment B: Doravirine 150 mg tablet (40% drug loaded granule), Treatment C: Doravirine 150 mg tablet (30% drug loaded granule), Treatment D: Doravirine 150 mg tablet (50% drug loaded granule), Treatment E: Doravirine 100 mg tablet (30% drug loaded granule)
NCT03724890
Study of Avelumab-M3814 Combinations
Oncology, Solid Tumors
P1
Completed57Open-labelM3814, M3814, Avelumab
NCT00907517
Study of SCH 900776 (MK-8776) With and Without Cytarabine in Participants With Acute Leukemias (P05247)
Myelogenous Leukemia, Acute, Leukemia, Lymphocytic, Acute
P1
Terminated24Open-labelMK-8776, Cytarabine
NCT05311618
Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors
Pancreatic Cancer, Breast Cancer
P1
Unknown71Open-labelNGM438, Pembrolizumab (KEYTRUDA ®)
NCT04994522
A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021)
End Stage Renal Disease, Renal Impairment
P1
Completed14Open-labelBelzutifan
NCT02437370
Pembrolizumab and Docetaxel or Gemcitabine Hydrochloride in Treating Patients Urothelial Cancer
Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter, Recurrent Bladder Carcinoma
P1
Completed32Open-labelPembrolizumab, Docetaxel, Gemcitabine Hydrochloride
NCT06836037
A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011)
Healthy
P1
Completed56RCT, Double-blindEfinopegdutide, Placebo
NCT00772967
A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
Osteoarthritis
P1
Completed22RCT, Double-blindNaproxen, Placebo, Ultracet
NCT03188523
Activity of MK-8504 in Anti-retroviral-naïve, Human Immunodeficiency Virus 1 (HIV-1) Infected Participants (MK-8504-002)
HIV-1 Infection
P1
Completed12Open-labelMK-8504
NCT07086079
A Study of Doravirine/Islatravir in Healthy Lactating Females (MK-8591A-061)
Healthy
P1
Completed12Open-labelDOR/ISL
NCT04515641
Single-Dose Islatravir in Moderate Hepatic Impairment (MK-8591-030)
Human Immunodeficiency Virus (HIV) Infection
P1
Completed12Open-labelIslatravir
NCT05519540
PK Study of Xevinapant (Debio 1143) in Healthy East Asian Participants
Healthy
P1
Completed24Open-labelXevinapant (Debio 1143)
NCT00424775
A Study of Carboplatin + Paclitaxel and MK0683 in Patients With Chemotherapy-naive Non-Small Cell Lung Cancer (NSCLC)(0683-066)
Neoplasms
P1
Terminated3Open-labelMK0683, vorinostat
NCT00963547
A Study of MK-2206 in Combination With Trastuzumab and Lapatinib for the Treatment of HER2+ Solid Tumors (MK-2206-015)
Advanced Solid Tumors, Breast Cancer
P1
Terminated33Open-labelMK-2206, Trastuzumab, Lapatinib
NCT01379300
A Study to Investigate Biomarkers After Single Doses of Anticoagulants in Healthy Young Male and Healthy Elderly Participants (MK-0000-216 AM1)
Thrombosis
P1
Completed42RCT, Open-labeldabigatran etexilate, rivaroxaban
NCT01557504
A Study to Assess the Pharmacokinetics and the Ability for Pediatric Participants With Type 2 Diabetes to Swallow MK-0431A XR Tablets (MK-0431A-296)
Type 2 Diabetes Mellitus
P1
Completed25RCT, Open-labelSitagliptin/metformin XR, Placebo, Metformin, Thyroid hormone
NCT03982004
Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer
Metastatic Breast Cancer
P1
Terminated1Open-labelTopical imiquimod, Pembrolizumab, Intra-lesional GM-CSF
NCT03317366
Expanded Access to Provide ARQ 092 for the Treatment of Overgrowth Diseases and/or Vascular Anomalies
Proteus Syndrome, PIK3CA-Related Overgrowth Spectrum (PROS)
NO_LONGER_AVAILABLEARQ 092
NCT01025271
Cerebrospinal Fluid Pharmacokinetics of Daptomycin
Meningitis
N/A
Terminated2Open-labelDaptomycin
NCT01216540
Vancomycin-Associated Nephrotoxicity
Nephrotoxicity
Completed398
NCT01012089
Study of the Pharmacokinetics of Daptomycin in Children With Renal Disease
Chronic Kidney Disease, Bacterial Infection
N/A
Completed6Open-labelDaptomycin
NCT00492193
Early Post-Op Recovery After Partial Large Bowel Resection
Diverticulitis, Colon Polyps
Completed139
NCT02762721
Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples
Intrahepatic Cholangiocarcinoma, Mixed Hepatocellular Cholangiocarcinoma
Completed131
NCT01075451
Antimicrobial Drug Use and Resistant Staphylococcus Aureus
Staphylococcus Aureus
Completed41
NCT01813500
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
Crohn's Disease, Ulcerative Colitis
Completed400
NCT01150760
Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database
Ileus
Completed7,050Alvimopan
NCT01143259
Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use
Ileus
N/A
Completed274RCT, Double-blindAlvimopam, 300 mg Polyethylene
NCT02097953
Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin
Drug Interactions, Pharmacokinetics
Early P1
Completed12Open-labelDaptomycin, Rifampin
NCT00261807
Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections
Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections
N/A
Completed25Open-labelDaptomycin 6mg/kg/day
NCT07487441
Reverse Remodeling of the Pulmonary Vasculature: a Longitudinal, Investigational Study of the Effects of Sotatercept.
Pulmonary Arterial Hypertension (PAH), Pulmonary Hypertension
Not Yet Recruiting30
NCT04291040
Use of an Educational Multimedia Tool Versus Routine Care for the Uptake of Postpartum LARC in High-Risk Pregnancies
Pregnancy, High Risk, Contraception
N/A
Unknown380RCT, Open-label
NCT03213730
Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery
Brain Concussion, Post-Concussion Symptoms
N/A
Completed63RCT, Single-blind
NCT00724295
Safety and Efficacy of PegIntron and Rebetol Combination Therapy in Patients With Chronic Hepatitis C in Japan (Study P04505)
Hepatitis C, Chronic, Hepatitis C
Completed1,077peginterferon alfa-2b, ribavirin
NCT00709228
Study of Patients With Chronic Hepatitis C Infected With HCV LVL G1 and Effect of Peg-Intron Plus Rebetol Treatment (Study P04793)
Hepatitis C
Completed496PegIntron, Rebetol
NCT00724672
A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521)
Rheumatoid Arthritis
Withdrawnetanercept, infliximab, adalimumab
NCT04025502
Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects
Schizophrenia
Completed161
NCT03503565
Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
Thoracic Surgery, One-lung Ventilation
Completed118
NCT00908011
Addition of Ezetimibe (Ezetrol®) to Ongoing Therapy With Rosuvastatin (Crestor®) in HIV Positive Patients Not Reaching Cholesterol Targets
Hypercholesterolemia, HIV Infections
N/A
Completed43RCT, Open-labelEzetimibe, Rosuvastatin (standard care)
NCT00699855
Long Term Follow up Study of Predictive Markers in GHD and TS Children
Growth Hormon Deficiency, Turner Syndrome in Pre-pubertal Children
Completed182
NCT02657148
Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
Opiate Addiction, Pregnancy
Completed200Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care
NCT01422395
Effect of Oocyte Vitrification on Fertilization Rate, Embryo Quality and Development
Fertility
Early P1
Completed40RCT, Single-blind
NCT00723892
Adherence in Patients Receiving PegIntron/Rebetol for Hepatitis C in Conjunction With a Psychotherapy Support Program (Study P04252)
Hepatitis C, Chronic, Hepacivirus
Completed614Peginterferon alfa-2b (PegIntron), Rebetol (Ribavirin)
NCT02823457
VBMI to Increase Treatment Completion With MK-MK-5172/MK-8742 Among Veterans With Active Substance Use Disorders Genotype 1 Chronic Hepatitis C
Patient Adherence, Chronic Hepatitis C, Alcohol-related Disorders
N/A
Completed20Open-label
NCT02037919
Nexplanon Application Post-Abortion (NAPA)
Contraception, Abortion, Therapeutic
N/A
Completed148RCT, Open-label
NCT04923035
Paediatric Pneumococcal Pneumonia in Malaysia Prior to and During Pneumococcal Conjugate Vaccine (PCV) Implementation
Pneumonia, Pneumococcal, Pneumonia Childhood
Unknown1,010
NCT03153410
Pilot Study With CY, Pembrolizumab, GVAX, and IMC-CS4 (LY3022855) in Patients With Borderline Resectable Adenocarcinoma of the Pancreas
Pancreatic Cancer
Early P1
Completed11Open-labelCyclophosphamide, GVAX Pancreas Vaccine (GVAX), Pembrolizumab, IMC-CS4
NCT02218320
Comparison of Virologic and Immunologic Responses to Raltegravir and Dolutegravir in the Gastrointestinal Tract of HIV-Positive Adults
Human Immunodeficiency Virus
Completed20Raltegravir, Dolutegravir
NCT04024020
Chronic Insomnia and CSF Markers of Dementia
Insomnia Chronic
Completed30
NCT00748930
The Canadian Follow-up Program for the ATTRACT Study (P04868)(TERMINATED)
Arthritis, Rheumatoid
Terminated13
NCT00727311
Real-life Surveillance Study of Patients With Chronic Hepatitis C Treated With PegIntron Injector and Rebetol (Study P04538)(COMPLETED)
Hepatitis C, Chronic, Hepatitis C
Completed2,302PegIntron (peginterferon alfa-2b; SCH 54031) injector, Rebetol (ribavirin; SCH 18908)
NCT01814722
Quality of Life of HIV-infected Participants Switched to Raltegravir Versus Other Antiretroviral Regimens (MK-0518-266)
Human Immunodeficiency Virus
Terminated63
NCT00418405
Hanyang University Medical Center Arthritis Network
Arthritis, Rheumatoid
Unknown1,500
NCT01645241
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
INFERTILITY, Fertility Preservation
N/A
Completed15Open-labelgonadotropins plus GnRH antagonists, ganirelix
NCT01207856
Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis
Multiple Sclerosis, Cognitive Rehabilitation
N/A
Completed65RCT, Single-blind
NCT00125060
Transesophageal Magnetic Resonance Imaging (MRI) in Conjunction With Lipid Lowering Measures
Heart Diseases
N/A
Completed72RCT, Double-blindSimvastatin (20mg versus 80mg/day)
NCT00641641
The Effect of Raltegravir on HIV Decay During Primary and Chronic Infection
HIV Infection
N/A
Completed16Open-labelTenofovir + emtricitabine + raltegravir.
NCT01164605
Pilot Study of Raltegravir Lipodystrophy IISP
HIV Infection
N/A
Unknown30Open-labelRaltegravir
NCT01632254
Study to Investigate the Sensitivity and Specificity of 3.0 Tesla MRI for Carotid Artery Plaque
Atherosclerosis
Unknown30
NCT04758351
Prospective Study on the Evaluation, Patient Reported Outcomes and Effectiveness of Treatment for Chronic Cough
Chronic Cough
Completed100
NCT01110577
Study of Magnetic Resonance Imaging (MRI) to Quantify Liver Fat in Diabetic and Pre-Diabetic Patients (0000-171)
Non-alcoholic Fatty Liver Disease (NAFLD)
Completed10
NCT00005232
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other Variables
Cardiovascular Diseases, Heart Diseases
Completed
NCT01582334
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Argentina
Growth Disorders
Completed68
NCT00962819
Measles, Mumps, and Rubella (MMR) Immunity in College Students
Measles, Mumps
Completed74MMR vaccine
NCT02256995
uChek Pilot Study for Urinalysis in the Antenatal Care Setting
Preeclampsia, Eclampsia
Unknown375
NCT03123575
Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy
HIV
Unknown1,000
NCT01363674
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Greece
Growth Disorders
Completed180
NCT00738725
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
Plaque, Atherosclerotic Disease
Completed7,687
NCT06374134
The Impact of Community and Patient Engagement Practices on Vaccine Confidence in the United States
Vaccine Hesitancy
Not Yet Recruiting30
NCT00726609
Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641)
Mycoses
Completed214Posaconazole
NCT02596984
Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients
Shock
N/A
Completed50Open-labelCaspofungin
NCT01400984
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Slovakia
Growth Disorders
Completed92
NCT01706003
The Utility of Telemedicine in the Management of Migraine
Migraine Headaches
Completed45
NCT04196608
In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients
Ceftolozane/Tazobactam, Imipenem/Relebactam
Unknown1,005Ceftolozane/tazobactam, imipenem- relebactam
NCT06229353
Developing and Evaluating a Novel Approach to Improve HPV Vaccination Coverage Among High-risk, Under-immunized Adults Via the Emergency Department
Human Papilloma Virus
Terminated34Gardasil 9
NCT02545270
Validation of a Subjective Rating Scale for Assessment of the Surgical Workspace in Laparoscopy
Hernia, Inguinal
N/A
Completed16RCT, Double-blind
NCT00774683
A Pilot Study to Characterize the Pharmacokinetics of Raltegravir in the Cervicovaginal Fluids of HIV-infected Women
HIV, AIDS
Completed1Raltegravir (Isentress®)
NCT01787838
Improving Pneumococcal Vaccination Rates in an Ambulatory Pre-surgical Testing Setting
Community Acquired Pneumonia
N/A
Completed2,509Open-label
NCT01374282
Post Marketing Surveillance Study of Cuprimine
Scleroderma
NO_LONGER_AVAILABLECuprimine (penicillamine)
NCT01035060
Blood Flow, Muscle Regeneration and Sarcopenia
Sarcopenia
Completed68
NCT01446718
A Cohort Study to Assess Sustained Immunogenicity to qHPV Vaccine Among HIV-infected Girls and Boys Age 9-14 Years
Human Papillomavirus, HIV-1 Infection
Completed179Gardasil vaccine
NCT00402818
RESTORE: Raptiva® (Efalizumab) Evaluation of Safety and Treatment Optimization
Plaque Psoriasis
Terminated294
NCT00736333
A Study to Evaluate Safety and Tolerability in Patients With Metastatic Breast Cancer Receiving Treatment With Caelyx (Study P04878)(COMPLETED)
Breast Neoplasm
Completed167Pegylated Liposomal Doxorubicin
NCT01376921
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Spain
Growth Disorders
Completed300
NCT01299714
Community Awareness, Resources and Education (CARE II): Project 3
Uterine Cervical Cancer
Completed191
NCT00514878
Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV)
Nausea, Postoperative Nausea and Vomiting
Completed2,000
NCT01936376
A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving First Cycle of Cisplatin Chemotherapy for Head and Neck Cancers
Head and Neck Cancer
Unknown150
NCT00735826
A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer
Aerodigestive Tract Cancer, Lung Cancer
N/A
Completed10Open-labelVorinostat
NCT01109550
Biliary Candidiasis - Optimization of Diagnostics and Therapy
Secondary Cholangitis, Bile Duct Strictures of Unknown Origin
Completed123
NCT00669929
Cost-Effectiveness Analysis of Rotavirus Vaccination for Children in Korea
Gastroenteritis, Rotavirus Vaccines
Unknown200
NCT01119703
Vaccine Hyporesponse in Healthy Elderly Participants (MK-0000-131 AM2)
Vaccine Response Impaired
Completed174Tetanus & Diphtheria booster vaccine (Td), TwinrixTM [Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine], Dukoral® Traveler's Diarrhea Vaccine (WC/rBS)
NCT03655223
Early Check: Expanded Screening in Newborns
Spinal Muscular Atrophy, Fragile X Syndrome
By Invite30,000
NCT01196273
Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up
Coronary Heart Disease, Heart Failure
Completed1,424
NCT01082315
A Korean Post-marketing Surveillance Study on Erbitux® in Patients With Metastatic Colorectal Cancer Refractory to Irinotecan-containing Treatment
Colorectal Neoplasms
Completed730Erbitux (Cetuximab)
NCT01015625
Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer
Synchronous Metastasized Breast Cancer, Circulating Tumor Cells
N/A
Completed90RCT, Open-label
NCT01284374
Parent-son-provider Decision-making About HPV Vaccination
Human Papillomavirus Vaccination
Completed62
NCT01213264
Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556)
Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
Completed659Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice
NCT00652509
Journey for Control of Diabetes Study (0431-111)
Type 2 Diabetes Mellitus
N/A
Completed621RCT, Open-label
NCT02909348
Immunophenotyping of Melanoma Patients on Treatment With Pembrolizumab
Neoplasms, Melanoma
Completed25Pembrolizumab
NCT03308357
Comparison of the Performance of SB2-Infliximab With Originator Infliximab in the Measure of Serum Concentrations in Serum
Inflammatory Bowel Diseases
Unknown6
NCT02607293
A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation
Polycystic Ovary Syndrome
Completed1,064Gonal-f®, Long GnRH agonist, GnRH antagonist