
Merck & Co Inc
MRKHealthcare|Drug Manufacturers - General|USA
$120.85
+0.00 (+0.00%)
DCF (FCF)
$75.40
Tangible Book
$1.76
Graham Number
$18.83
Earnings Power
$41.17
Clinical Trials (731)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT05823844 Efficacy of Suvorexant on Post-operative Sleep Disturbance | Postoperative Insomnia, Postoperative Delirium | P4 | Recruiting | 92 | RCT, Double-blind | Suvorexant, Placebo |
| NCT05992480 REVIVE (Response to the Ebola Virus Vaccine) | Ebola Virus Disease | P4 | Recruiting | 40 | Open-label | rVSVDG-ZEBOV-GP Ebola Virus Vaccine (ERVEBO) |
| NCT05911295 Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2 | Urothelial Carcinoma | P3 | Active | 412 | RCT, Open-label | disitamab vedotin, pembrolizumab, gemcitabine, cisplatin, carboplatin |
| NCT03682536 A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve | Myelodysplastic Syndromes | P3 | Active | 363 | RCT, Open-label | Luspatercept, Epoetin alfa |
| NCT06623422 A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009) | Carcinoma, Non-Small-Cell Lung | P3 | Recruiting | 680 | RCT, Double-blind | Pembrolizumab, Cisplatin, Carboplatin, Pemetrexed, Gemcitabine, Paclitaxel, Intismeran autogene |
| NCT03924895 Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303) | Urinary Bladder Cancer, Muscle-invasive | P3 | Active | 595 | RCT, Open-label | Pembrolizumab, Enfortumab Vedotin |
| NCT05224141 Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008) | Small Cell Lung Carcinoma | P3 | Active | 460 | RCT, Double-blind | Pembrolizumab/Vibostolimab Co-Formulation, Saline placebo, Etoposide, Cisplatin, Atezolizumab, Carboplatin |
| NCT04895358 Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49) | Breast Neoplasms | P3 | Active | 340 | RCT, Double-blind | pembrolizumab, paclitaxel, nab-paclitaxel, liposomal doxorubicin, capecitabine, normal saline, dextrose |
| NCT06422143 Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023] | Non-small Cell Lung Cancer, NSCLC | P3 | Recruiting | 851 | RCT, Open-label | Pembrolizumab, sac-TMT, Carboplatin, Paclitaxel, Nab-paclitaxel |
| NCT01874353 Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy | Platinum Sensitive, BRCA Mutated | P3 | Active | 327 | RCT, Double-blind | Olaparib 300mg tablets, Placebo to match olaparib 300mg |
| NCT02362594 Study of Pembrolizumab (MK-3475) Versus Placebo After Complete Resection of High-Risk Stage III Melanoma (MK-3475-054/1325-MG/KEYNOTE-054) | Melanoma | P3 | Active | 1,019 | RCT, Double-blind | pembrolizumab, placebo |
| NCT06824467 A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103) | Ovarian Cancer, Fallopian Tube Cancer | P3 | Recruiting | 770 | RCT, Open-label | Sacituzumab tirumotecan, Bevacizumab, H1 receptor antagonist, H2 receptor antagonist, Acetaminophen (or equivalent), Dexamethasone (or equivalent), Steroid mouthwash (dexamethasone or equivalent) |
| NCT05714085 Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036) | Heart Failure, Left Ventricular Systolic Dysfunction | P2P3 | Recruiting | 342 | RCT, Double-blind | Vericiguat tablet, Vericiguat suspension, Placebo tablet, Placebo suspension |
| NCT06492291 Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension | Hypercholesterolemia | P3 | Active | 3,000 | Open-label | Enlicitide Decanoate |
| NCT07355218 A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2) | Systematic Lupus Erythematosus, Cutaneous Lupus Erythematosus | P3 | Recruiting | 202 | RCT, Double-blind | Enpatoran, Placebo, Standard of care (SoC) |
| NCT06074588 Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004) | Non-small Cell Lung Cancer (NSCLC) | P3 | Recruiting | 556 | RCT, Open-label | Sacituzumab tirumotecan, Docetaxel, Pemetrexed |
| NCT03725059 Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756) | Breast Cancer | P3 | Active | 1,240 | RCT, Double-blind | Pembrolizumab (K), Placebo (P), Paclitaxel (X), Doxorubicin (A), Epirubicin (E), Cyclophosphamide (C), Endocrine therapy |
| NCT05450705 V503 in Chinese Girls 9-14 Years Old Versus Chinese Women 20-26 Years Old (V503-071) | Papillomavirus Infections | P3 | Active | 1,500 | RCT, Open-label | 9vHPV vaccine |
| NCT04945460 A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16) | Hypertension, Pulmonary | P2 | Active | 164 | RCT, Double-blind | Sotatercept 0.3 mg/kg, Placebo, Sotatercept 0.3 mg/kg escalating to 0.7 mg/kg |
| NCT04143724 Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia | Beta-Thalassemia | P2 | Recruiting | 99 | Open-label | ACE-536 |
| NCT03634540 A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003) | Renal Cell Carcinoma (RCC), Clear Cell Renal Cell Carcinoma (ccRCC) | P2 | Active | 118 | Open-label | Belzutifan, Cabozantinib |
| NCT03401788 A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004) | VHL - Von Hippel-Lindau Syndrome, VHL Gene Mutation | P2 | Active | 50 | Open-label | Belzutifan |
| NCT04471727 A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001) | Small-Cell Lung Cancer, Neuroendocrine Carcinoma | P1P2 | Active | 232 | Open-label | Gocatamig, Atezolizumab, Ifinatamab Deruxtecan (I-DXd) |
| NCT04262141 IMG-7289 in Patients With Essential Thrombocythemia (ET) or Polycythemia Vera (PV) | Essential Thrombocythemia, Polycythemia Vera | P2 | Active | 4 | Open-label | IMG-7289 |
| NCT04081220 Hematology, IMG-7289, LSD1 (Lysine-Specific Demethylase 1) Inhibitor, Essential Thrombocythemia (ET), Ph 2 | Thrombocythemia, Essential | P2 | Active | 9 | Open-label | IMG-7289 |
| NCT05270668 Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007) | Diffuse Cutaneous Systemic Sclerosis, Interstitial Lung Disease | P2 | Active | 154 | RCT, Double-blind | Tulisokibart, Placebo |
| NCT03162536 A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) | Lymphoma, B-Cell, Small Lymphocytic Lymphoma | P1P2 | Active | 190 | Open-label | Nemtabrutinib |
| NCT06814145 Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023) | Hypertension, Pulmonary | P2 | Recruiting | 130 | RCT, Double-blind | Sotatercept |
| NCT02886585 Pembrolizumab In Central Nervous System Metastases | Brain Metastases | P2 | Active | 101 | Open-label | Pembrolizumab |
| NCT06979596 A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) | Malignant Neoplasm | P2 | Recruiting | 250 | RCT, Single-blind | Opevesostat, Fludrocortisone/ Fludrocortisone acetate, Dexamethasone/Dexamethasone acetate, Rescue Medications, Fulvestrant, Exemestane, Megestrol acetate/Medroxyprogesterone acetate, Tamoxifen, Letrozole |
| NCT05286619 A Study of Pembrolizumab (MK-3475) Plus Platinum and Gemcitabine as First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (PIPER) | Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma | P2 | Recruiting | 63 | Open-label | Pembrolizumab, Cisplatin, Carboplatin, Gemcitabine |
| NCT05309421 A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma | Melanoma Stage IV, Unresectable Melanoma | P2 | Active | 17 | Open-label | EVX-01, Pembrolizumab 25 MG/ML |
| NCT04875585 Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC | Non Small Cell Lung Cancer | P2 | Recruiting | 33 | Open-label | neoadjuvant therapy with Pembrolizumab/Lenvatinib, Adjuvant Treatment Phase |
| NCT06266338 Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix) | Cervix Cancer, Cervical Cancer | P2 | Recruiting | 30 | Open-label | Pembrolizumab, Lenvatinib |
| NCT02734290 Standard of Care Chemotherapy Plus Pembrolizumab for Breast Cancer | Triple Negative Breast Cancer | P1P2 | Active | 29 | Open-label | Pembrolizumab, Paclitaxel, Capecitabine |
| NCT05558982 BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal Adenocarcinoma | Metastatic Pancreatic Ductal Adenocarcinoma | P2 | Active | 22 | Open-label | BXCL701, Pembrolizumab |
| NCT06207656 Study to Evaluate the Efficacy and Safety of Cetuximab in Combination with Encorafenib Plus Binimetinib As Induction Treatment in BRAF V600E Mutated MSS Initially Resectable or Potentially Resectable Advanced Colorectal Cancer | Colorectal Cancer | P2 | Recruiting | 70 | Open-label | EBC |
| NCT07089992 A Study of Pembrolizumab in People With Ultra-Rare Sarcomas | Sarcoma | P2 | Recruiting | 32 | Open-label | Pembrolizumab |
| NCT04701476 TATE and Pembrolizumab (MK3475) in mCRC and NSCLC | Colorectal Cancer; Lung Cancer | P2 | Recruiting | 110 | RCT, Open-label | TATE and pembrolizumab, TAS-102 pill, Regorafenib Pill |
| NCT03272334 Her2-BATS and Pembrolizumab in Metastatic Breast Cancer | Metastatic Breast Cancer | P1P2 | Active | 22 | Open-label | HER2 BATs with Pembrolizumab |
| NCT05296512 Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer | Ovarian Clear Cell Carcinoma, Gynecologic Cancer | P2 | Active | 30 | Open-label | Lenvatinib, Pembrolizumab |
| NCT06433219 Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302) | Ovarian Cancer | P2 | Active | 63 | RCT, Open-label | Tuvusertib (M1774), Niraparib, Lartesertib (M4076) |
| NCT06493019 Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer | Anal Cancer | P2 | Recruiting | 23 | Open-label | Pembrolizumab, Paclitaxel, Carboplatin, Pembrolizumab |
| NCT06660654 A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01) | Advanced Solid Tumor, Metastatic Solid Tumors | P2 | Recruiting | 200 | Open-label | Raludotatug deruxtecan |
| NCT03813836 Phase II Trial of Pembrolizumab in Recurrent or Metastatic HNSCC | Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | P2 | Active | 63 | Open-label | Pembrolizumab |
| NCT02422381 MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC) | Carcinoma, Non-Small-Cell Lung | P1P2 | Active | 16 | Open-label | MK-3475, Gemcitabine |
| NCT04712851 Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia | Cervical Intraepithelial Neoplasia, Cervical Squamous Cell Carcinoma In Situ | P2 | Recruiting | 25 | Open-label | Pembrolizumab |
| NCT04585035 Study to Evaluate D-1553 in Subjects With Solid Tumors | Solid Tumor, Adult, NSCLC | P1P2 | Active | 180 | Open-label | D-1553, D-1553 in combination with Drug: pembrolizumab, Drug:KEYTRUDA® , Drug: cetuximab, Drug: other |
| NCT04666740 A Study of Pembrolizumab and Olaparib for People With Metastatic Pancreatic Ductal Adenocarcinoma and Homologous Recombination Deficiency or Exceptional Treatment Response to Platinum-Based Therapy | Metastatic Pancreatic Ductal Adenocarcinoma, Homologous Recombination Deficiency (HRD) | P2 | Active | 63 | Open-label | Pembrolizumab, Olaparib |
| NCT05446298 ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer | Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary | P2 | Active | 58 | RCT, Open-label | ONC-392, Pembrolizumab |
| NCT04225117 A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) | Locally Advanced or Metastatic Malignant Solid Tumors | P2 | Active | 329 | Open-label | enfortumab vedotin, pembrolizumab |
| NCT03519997 A Study of Pembrolizumab and Bavituximab in Patients With Advanced Hepatocellular Carcinoma | Hepatocellular Carcinoma | P2 | Active | 35 | Open-label | Pembrolizumab, Bavituximab |
| NCT04745988 An Open Label Phase 2 Study to Evaluate the Safety and Efficacy of Lenvatinib with Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the Neoadjuvant / Adjuvant Treatment for Patients with Gastric Cancer | Gastric Cancer | P2 | Active | 43 | Open-label | Lenvatinib 20mg, Pembrolizumab, Lenvatinib 8mg, Docetaxel, Oxaliplatin, Levofolinate, Fluorouracil |
| NCT04430699 Cisplatin+Pembrolizumab+RT in Vulvar Cancer | Vulvar Cancer, Vulvar Squamous Cell Carcinoma | P2 | Active | 24 | Open-label | Cisplatin, Pembrolizumab |
| NCT05524935 Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma | Uveal Melanoma, Ocular Melanoma | P2 | Recruiting | 37 | Open-label | Pembrolizumab, Olaparib |
| NCT04971499 A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma | Melanoma | P1P2 | Active | 26 | Open-label | Dapansutrile, Pembrolizumab |
| NCT05623319 Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC) | SCLC,Extensive Stage | P2 | Recruiting | 60 | Open-label | Pembrolizumab/Olaparib |
| NCT05077709 IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC | Lung Cancer Non Small Cell, Head and Neck Squamous Cell Carcinoma | P2 | Active | 63 | Open-label | IO102-IO103 in combination with pembrolizumab |
| NCT06123338 A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer | Esophageal Cancer, Gastric Adenocarcinoma | P2 | Recruiting | 49 | Open-label | Pembrolizumab, Trastuzumab, Oxaliplatin, Capecitabine, 5-Fluorouracil, Docetaxel |
| NCT04184050 Study of HPN217 in Participants With Relapsed/Refractory Multiple Myeloma MK-4002 (MK-4002-001) | Multiple Myeloma in Relapse, Multiple Myeloma | P1 | Active | 100 | Open-label | MK-4002 |
| NCT02293980 A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001) | ccRCC, RCC | P1 | Active | 110 | Open-label | MK-3795, Nivolumab, Cabozantinib, Bezlutifan |
| NCT02974738 A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001) | Advanced Solid Tumors, Solid Tumor | P1 | Active | 120 | Open-label | Belzutifan |
| NCT05597306 Venetoclax and Bomedemstat in Patients With Relapsed/Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia | P1 | Recruiting | 18 | Open-label | Bomedemstat, Venetoclax |
| NCT07199465 A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077) | Cytomegalovirus Prophylaxis | P1 | Recruiting | 40 | Open-label | Letermovir |
| NCT03932409 Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer | Endometrial Cancer | P1 | Active | 45 | Open-label | Pembrolizumab, Paclitaxel, Carboplatin |
| NCT02998567 Combination Study of Guadecitabine/ASTX727 and Pembrolizumab | Non Small Cell Lung Cancer | P1 | Recruiting | 60 | Open-label | Guadecitabine, Pembrolizumab, ASTX727 |
| NCT06580587 A Study of MK-8527 in Healthy Lactating Female Participants (MK-8527-009) | Healthy, HIV Pre-exposure Prophylaxis | P1 | Active | 12 | Open-label | MK-8527 |
| NCT04846920 A Study of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018) | Carcinoma, Renal Cell | P1 | Active | 52 | Open-label | Belzutifan |
| NCT06475235 Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL | Lymphoma, Primary Central Nervous System Lymphoma | P1 | Recruiting | 15 | Open-label | Pembrolizumab, Methotrexate, Temozolomide, Rituximab |
| NCT06641908 Anti-GD2 ADC M3554 in Advanced Solid Tumors | Advanced Solid Tumor | P1 | Recruiting | 52 | Open-label | M3554 |
| NCT05081180 Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors | Central Nervous System Tumors | P1 | Active | 17 | Open-label | Avelumab, Lenvatinib |
| NCT03260491 U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer (NSCLC) | P1 | Active | 312 | Open-label | HER3-DXd (FL-DP), HER3-DXd (CTM-1 Lyo-DP), HER3-DXd (CTM-3 Lyo-DP) |
| NCT00404989 Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People. | HIV Infections, Hepatitis B | Recruiting | 24,258 | — | — | |
| NCT05421806 A Cohort Study of Use of Doravirine (DOR) Based Regimens in Clinical Practice in Europe DoRavirine Europe Real World/ | HIV I Infection | Active | 500 | — | — | |
| NCT07348250 Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease | Parkinson's Disease (PD), Parkinson's Disease | Early P1 | Recruiting | 22 | Open-label | [18F]MK-0947 |
| NCT05266664 Preterm Immune System Development and Response to Immunization | Immune System Disorder, Preterm | Recruiting | 145 | — | — | |
| NCT04165798 KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01) | Carcinoma, Non-Small-Cell Lung | Recruiting | 1,065 | — | — | |
| NCT06036810 Spanish Decision Tool for Ovarian Cancer Maintenance Therapy | Ovarian Cancer | N/A | Recruiting | 70 | Open-label | — |
| NCT06068582 Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis | Multiple Sclerosis | N/A | Recruiting | 270 | RCT, Double-blind | — |
| NCT06053749 An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden | Multiple Sclerosis (MS) | Active | 4 | — | Avonex (IFNβ-1-a, Biogen Netherlands B.V), Rebif (IFNβ-1-a, Merck Europe B.V.), Extavia (IFNβ-1-b, Novartis Europharm Limited), Betaseron (IFN-β-1-b, BAY86-5046, Bayer AG), Plegridy (Peg IFNβ-1-a, Biogen Netherlands B.V), MS disease modifying drugs (MSDMDs) | |
| NCT04471493 Pediatric and Ambulatory Research in Infectious Diseases | Otitis, Bronchiolitis | Recruiting | 400,000 | — | — | |
| NCT01133600 Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens | Diabetic Foot | P4 | Terminated | 6 | RCT, Open-label | Cubicin, Vancomycin |
| NCT01196169 Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty | Staphylococcal Infections, Methicillin-resistant Staphylococcus Aureus | P4 | Terminated | 28 | RCT, Open-label | Daptomycin, Vancomycin |
| NCT02355938 Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury | Clostridium Difficile, Spinal Cord Injury | P4 | Terminated | 12 | RCT, Double-blind | Fidaxomicin 200 mg, Placebo, Vancomycin |
| NCT02421120 Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients | Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation | P4 | Completed | 21 | Open-label | Ceftolozane/Tazobactam |
| NCT00638157 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) | Infective Endocarditis | P4 | Terminated | 24 | RCT, Double-blind | daptomycin, daptomycin and gentamicin |
| NCT00572260 A Pilot Study of Daptomycin for Antimicrobial Prophylaxis | Antimicrobial Prophylaxis | P4 | Terminated | 11 | Open-label | daptomycin 6 mg/kg IV |
| NCT00711802 Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections | Skin Diseases, Infectious | P4 | Completed | 396 | RCT, Single-blind | Daptomycin, Standard of Care (SOC) |
| NCT00295178 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas | Cellulitis | P4 | Completed | 80 | RCT, Single-blind | Daptomycin, Vancomycin |
| NCT01175707 Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting | Complicated Skin or Skin Structure Infection | P4 | Terminated | 80 | RCT, Open-label | Daptomycin, Vancomycin |
| NCT01419184 Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA | Staphylococcal Skin Infections | P4 | Completed | 250 | RCT, Open-label | Daptomycin, Vancomycin |
| NCT00651131 Cubicin(R) for Complicated Post-surgical Wound Infections | Wound Infections | P4 | Terminated | 69 | RCT, Open-label | daptomycin |
| NCT01728376 Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005) | Bacteremia | P4 | Completed | 82 | RCT, Open-label | Daptomycin, Comparator |
| NCT01775397 A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System | Clostridium Difficile | P4 | Terminated | 12 | RCT, Double-blind | Fidaxomicin, Vancomycin, Placebo |
| NCT00708201 A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy | Postoperative Ileus | P4 | Completed | 280 | RCT, Double-blind | Alvimopan, Placebo |
| NCT00102947 Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections | Soft Tissue Infections | P4 | Terminated | 72 | RCT, Open-label | daptomycin (up to 14 days) |
| NCT01287832 Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs) | Bacteremia | P4 | Terminated | 11 | RCT, Open-label | Vancomycin, Daptomycin |
| NCT01104662 Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment | Complicated Skin and Skin Structure Infections, S. Aureus Bacteremia | P4 | Terminated | 92 | RCT, Single-blind | Vancomycin, Daptomycin, Semi-Synthetic Penicillin |
| NCT00663403 Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD) | Critically Ill, Hemodialysis | P4 | Completed | 8 | Open-label | Daptomycin |
| NCT01818141 Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin | Clostridium Difficile Infection | P4 | Completed | 34 | RCT, Open-label | Vancomycin, Fidaxomicin |
| NCT03010423 Efficacy Study of Oral Nicorandil on Improving Microvascular Function in Female Non-obstructive Coronary Artery Disease (CAD) Participants | Non-obstructive Coronary Artery Disease | P4 | Terminated | 8 | Open-label | Nicorandil |
| NCT00407771 The Effects of Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention | Coronary Artery Disease | P4 | Unknown | 44 | RCT, Open-label | Tirofiban |
| NCT01057160 Rizatriptan 10 MG RPD in the Treatment of Acute Migraine | Migraine | P4 | Completed | 195 | RCT, Open-label | Rizatriptan |
| NCT02342418 Single Dose PK of IV Tedizolid Phosphate in Morbidly Obese and Non-Obese Adults | Obesity | P4 | Completed | 19 | Open-label | Tedizolid phosphate |
| NCT01245101 Addition of Raltegravir to Established Antiretroviral Suppressive Therapy | HIV | P4 | Terminated | 15 | RCT, Open-label | Raltegravir, Raltegravir |
| NCT00406094 Singulair Use in Non-Allergic Rhinitis Eosinophil Syndrome (NARES) | Rhinitis | P4 | Unknown | 6 | RCT, Double-blind | montelukast, placebo |
| NCT02724111 Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery | Neuromuscular Blockade, Surgery | P4 | Completed | 90 | RCT, Double-blind | sufficient dose of rocuronium, sugammadex 10 min after position change |
| NCT05562999 Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function | Neuromuscular Blockade, Innate Inflammatory Response | P4 | Completed | 100 | RCT, Double-blind | Rocuronium Bromide, Rocuronium Bromide |
| NCT01396395 Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina | Stable Angina, Coronary Disease | P4 | Completed | 402 | RCT, Open-label | Nicorandil, Standard Treatment |
| NCT01756079 A Study to Evaluate the Efficacy and Safety of Boceprevir Added to Standard of Care Therapy in Previously Treated Participants With Chronic Hepatitis C Genotype 1 and Cirrhosis (MK-3034-105) | Hepatitis C | P4 | Completed | 58 | Open-label | boceprevir, PegIFN-2b, RBV |
| NCT01587118 An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder | Posttraumatic Stress Disorder | P4 | Completed | 18 | Open-label | Adjunctive asenapine |
| NCT00752622 Treatment With Infliximab in a Medical Setting (Study P05587) | Crohn's Disease | P4 | Terminated | 100 | RCT, Open-label | Infliximab 5 mg/kg, Infliximab 5 mg/kg every 6 weeks, Infliximab 7 mg/kg every 8 weeks |
| NCT04689737 Removal of Doravirine by Hemodialysis in HIV-Infected Patients With End-stage Renal Disease (ESRD) | HIV-infected Participants With ESRD Undergoing Routine Hemodialysis | P4 | Completed | 8 | Open-label | Doravirine |
| NCT04274153 HPV Vaccination Study in Postpartum Women | HPV, Immunization | P4 | Completed | 225 | Open-label | Gardasil9 |
| NCT00910689 Drug and Non-Drug Treatment Of Severe Migraine | Migraine Headache | P4 | Completed | 232 | RCT, Double-blind | Propranolol or nadolol, Placebo control, Optimal Acute Therapy |
| NCT03087513 A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo | Posterior Cervical Decompression and Fusion | P4 | Completed | 40 | RCT, Double-blind | Sugammadex Injection [Bridion], Placebo |
| NCT00222664 Qidong Hepatitis B Intervention Study | Hepatitis B, Liver Neoplasms | P4 | Completed | 80,000 | RCT, Open-label | Hep-V Vax |
| NCT00307307 Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. | Established Carotid Atherosclerosis | P4 | Completed | 69 | RCT, Double-blind | Niacin/simvastatin compared to simvastatin alone at 2 doses |
| NCT01210144 EXpression PRofile Endometrium Samples Study | In Vitro Fertilization | P4 | Terminated | 27 | RCT, Open-label | Gonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist, Gonadotropin-releasing hormone (GnRH) Antagonist |
| NCT00686725 Standard Temodal (Temozolomide) Regimen Versus Standard Regimen Plus Early Postsurgery Temodal for Newly Diagnosed Glioblastoma Multiforme (Study P05572) | Glioblastoma | P4 | Completed | 99 | RCT, Open-label | Temozolomide |
| NCT01027806 Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children | Obstructive Sleep Apnea | P4 | Terminated | 64 | RCT, Double-blind | Montelukast |
| NCT00781768 Odansetron and Dexamethasone Alone vs. Odansetron, Dexamethason and Apreptant to Prevent Nausea | Nausea, Vomiting | P4 | Completed | 181 | RCT, Double-blind | Standard PO (Zofran + Dexamethason), Aprepitant (MK-869) + Standard PO |
| NCT00650663 Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377) | Hypercholesterolemia, Atherosclerosis | P4 | Completed | 247 | RCT, Double-blind | Ezetimibe + Simvastatin, Simvastatin |
| NCT02294084 Sitagliptin and Brown Adipose Tissue | Neoplasms, Adipose Tissue | P4 | Completed | 30 | RCT, Double-blind | Sitagliptin, placebo |
| NCT00934713 The Effect of Montelukast Treatment in Wheezy Infants | Lung Disease, Obstructive, Signs and Symptoms, Respiratory | P4 | Completed | 112 | RCT, Double-blind | montelukast |
| NCT01066039 Phase 4 Study to Assess the Effect of Bisoprolol on Glycemic Level in Type II Diabetic Subjects With Suboptimal Blood Pressure Control | Hypertension, Diabetes Mellitus, Type II | P4 | Completed | 202 | Open-label | Bisoprolol |
| NCT01384331 New Treatments for Troublesome Bleeding in Implanon Users | Menstrual Problem | P4 | Unknown | 200 | RCT, Double-blind | Marvelon |
| NCT05289271 Safety, Tolerability, and Immunogenicity of Vaxelis™ in Children Previously Vaccinated With Vaxelis™ or Hexyon™ (V419-016) | Vaccines, Combined, Hexavalent Vaccine | P4 | Completed | 168 | Open-label | Vaxelis™ |
| NCT01616160 An Open-label Study to Identify Molecular Markers of Steroid Resistance | Nasal Polyps | P4 | Terminated | 11 | Open-label | mometasone furoate |
| NCT01960725 An Alternate Dosing Schedule for Pentavalent Rotavirus Vaccine (RotaTeq) | Diarrhea, Gastroenteritis | P4 | Completed | 66 | Open-label | RV5 (Pentavalent Rotavirus Vaccine) |
| NCT03098121 Efficacy and Tolerability of Grazoprevir and Elbasvir in Patients With Chronic Genotype 1 HCV and HIV Co-infection | Chronic Hepatitis C | P4 | Completed | 40 | Open-label | grazoprevir and elbasvir |
| NCT01928199 Efficacy Study of Sitagliptin to Prevent New-onset Diabetes After Kidney Transplant | Posttransplant Diabetes Mellitus | P4 | Completed | 61 | RCT, Double-blind | Sitagliptin, Placebo |
| NCT05435209 Effectiveness of the Q-HPV Vaccine 9-years Post Vaccination Among HIV Positive Adolescents | HPV Infection, HPV Vaccination | P4 | Completed | 158 | Open-label | Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine |
| NCT01364298 Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management | Diabetic Peripheral Neuropathic Pain | P4 | Completed | 353 | RCT, Open-label | Gabapentin/B-complex, Pregabalin |
| NCT03350698 Occupational Exposure to Human Papilloma Virus (HPV) and Prophylactic Vaccination | Papillomavirus Vaccines | P4 | Unknown | 100 | Open-label | Gardasil-9 |
| NCT01448291 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers | Vaginosis, Bacterial | P4 | Unknown | 30 | Open-label | Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring |
| NCT00289913 Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068) | Hepatitis A Virus | P4 | Completed | 1,274 | RCT, Open-label | Comparator: VAQTA™, Comparator: Infanrix™, Comparator: PedvaxHIB™ |
| NCT01448486 A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIV | Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND) | P4 | Terminated | 6 | RCT, Open-label | Raltegravir |
| NCT00444379 Anti-Retrovirals for Kaposi's Sarcoma | Kaposi's Sarcoma, HIV Infections | P4 | Completed | 224 | RCT, Single-blind | Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir |
| NCT03378479 Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients | Aspergillosis; Pulmonary, Invasive (Etiology) | P4 | Completed | 88 | RCT, Open-label | SOC +Posaconazole 18 MG/ML (milligram/milliliter) |
| NCT01379157 Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia | Ventilator Associated Pneumonia | P4 | Completed | 8 | RCT, Open-label | Imipenem, Imipenem |
| NCT01606800 Efficacy and Safety of Short Course Therapy With Peginterferon Alpha-2b (PEG-IFN Alfa-2b) and Ribavirin (RBV) for Chronic Hepatitis C (Genotype 4) Participants Achieving a Rapid Virological Response at Week 4 of Treatment (MK-8908B-059) | Hepatitis C, Chronic | P4 | Terminated | 45 | RCT, Open-label | PEG-IFN alfa-2b, ribavirin |
| NCT01922011 Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) | Acute Hematogenous Osteomyelitis | P3 | Completed | 149 | RCT, Double-blind | Daptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent) |
| NCT00328692 PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function | Heart Failure, Congestive | P3 | Completed | 932 | RCT, Double-blind | rolofylline, Comparator: Placebo (unspecified) |
| NCT01170221 TR-701 FA vs. Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections. | Skin and Subcutaneous Tissue Bacterial Infections | P3 | Completed | 667 | RCT, Double-blind | TR-701 FA, Linezolid |
| NCT00388401 Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus | Ileus | P3 | Completed | 510 | RCT, Double-blind | Alvimopan |
| NCT01696643 Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation | Opioid-Induced Constipation | P3 | Terminated | 1,407 | RCT, Double-blind | CB-5945, Placebo |
| NCT00241722 Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain | Bowel Dysfunction, Constipation | P3 | Completed | 805 | RCT, Double-blind | Alvimopan, Placebo |
| NCT01853982 Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia | Ventilator-Associated Pneumonia (VAP) | P3 | Terminated | 4 | RCT, Open-label | Ceftolozane/Tazobactam, Piperacillin/Tazobactam |
| NCT03520959 A Phase 3, Randomized, Double-blind, Placebo-controlled Study For Subjects With Locally-advanced Unresectable or Metastatic Synovial Sarcoma (V943-003, IMDZ-04-1702) | Synovial Sarcoma, Cancer | P3 | Terminated | 1 | RCT, Double-blind | LV305, G305 |
| NCT01901302 Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation | Opioid-Induced Constipation | P3 | Terminated | 61 | RCT, Double-blind | CB-5945, Placebo |
| NCT02604433 An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia | Erythrocyte Transfusion, Beta-Thalassemia | P3 | Completed | 336 | RCT, Double-blind | Luspatercept |
| NCT00314951 Fidaxomicin Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) (MK-5119-018) | Clostridium Infections, Diarrhea | P3 | Completed | 629 | RCT, Double-blind | Fidaxomicin, Vancomycin, Matching Placebo to Fidaxomicin |
| NCT00540072 Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae | Pneumonia, Bacterial | P3 | Completed | — | RCT, Double-blind | daptomycin |
| NCT01216241 Daptomycin Versus Placebo in Patients With Neutropenia and Fever | Febrile Neutropenia | P3 | Terminated | 36 | RCT, Double-blind | Daptomycin, Daptomycin |
| NCT00055198 Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria | Gram-Positive Bacterial Infections | P3 | Terminated | 75 | Open-label | daptomycin |
| NCT00448422 Safety and Efficacy of Prulifloxacin vs Placebo in Treatment of Acute Gastroenteritis in Adult Travelers | Acute Bacterial Gastroenteritis | P3 | Completed | 268 | RCT, Double-blind | prulifloxacin |
| NCT01691248 Safety and Efficacy of Fidaxomicin Versus Placebo for Prophylaxis Against Clostridium Difficile-Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation (MK-5119-001) | Clostridium Difficile-Associated Diarrhea (CDAD) | P3 | Completed | 611 | RCT, Double-blind | fidaxomicin, Placebo |
| NCT01421511 TR-701 FA vs Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections | Skin and Subcutaneous Tissue Bacterial Infections | P3 | Completed | 666 | RCT, Double-blind | TR-701 FA, Linezolid |
| NCT00388258 Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus | Ileus | P3 | Completed | 451 | RCT, Double-blind | Alvimopan |
| NCT00354458 PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function | Heart Failure, Congestive | P3 | Completed | 1,102 | RCT, Double-blind | rolofylline, Comparator: Placebo (unspecified) |
| NCT00259922 Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain | Bowel Dysfunction, Constipation | P3 | Completed | 485 | RCT, Double-blind | Placebo, Alvimopan, Alviompan |
| NCT04317040 Efprezimod Alfa (CD24Fc, MK-7110) as a Non-antiviral Immunomodulator in COVID-19 Treatment (MK-7110-007) | Coronavirus Disease 2019 (COVID-19) | P3 | Completed | 234 | RCT, Double-blind | Efprezimod alfa, Placebo |
| NCT01597505 Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005) | Clostridium Difficile Infection | P3 | Completed | 606 | RCT, Double-blind | Surotomycin, Vancomycin, Placebo |
| NCT02070757 Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008) | Healthcare-Associated Pneumonia, Ventilator-Associated Pneumonia | P3 | Completed | 726 | RCT, Double-blind | Ceftolozane/tazobactam, Meropenem |
| NCT00256932 Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain | Bowel Dysfunction, Constipation | P3 | Completed | 518 | RCT, Double-blind | alvimopan, Placebo |
| NCT02631070 A Study of Luspatercept (ACE-536) to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes | Myelodysplastic Syndromes | P3 | Completed | 229 | RCT, Double-blind | Luspatercept |
| NCT04811092 Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13) | Pulmonary Arterial Hypertension | P3 | Completed | 321 | RCT, Double-blind | Sotatercept |
| NCT00538694 Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia | Pneumonia, Bacterial | P3 | Completed | — | RCT, Double-blind | daptomycin |
| NCT01755767 Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma (HCC) Who Have Been Treated With One Prior Therapy | Hepatocellular Carcinoma | P3 | Completed | 383 | RCT, Double-blind | Tivantinib, Placebo |
| NCT04576988 A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR) | Pulmonary Arterial Hypertension | P3 | Completed | 324 | RCT, Double-blind | Sotatercept, Placebo, Background PAH Therapy |
| NCT01244191 Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer | Non Squamous, Non-small-cell Lung Cancer | P3 | Terminated | 1,048 | RCT, Double-blind | Tivantinib, Placebo, Erlotinib |
| NCT01901341 The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation | Opioid-Induced Constipation | P3 | Terminated | 44 | RCT, Double-blind | CB-5945, Placebo |
| NCT01704651 Accelerating Gastrointestinal Recovery | Ovarian Cancer, Fallopian Tube Cancer | P3 | Completed | 146 | RCT, Double-blind | Alvimopan, Placebo |
| NCT00205842 Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus | Ileus | P3 | Completed | 660 | RCT, Double-blind | alvimopan |
| NCT00468728 PAR-101/OPT-80 Versus Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhea (CDAD) | Clostridium Infections, Diarrhea | P3 | Completed | 535 | RCT, Double-blind | PAR-101/OPT-80, Vancomycin |
| NCT02276482 Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012) | Skin Diseases, Infectious, Skin Diseases, Bacterial | P3 | Completed | 120 | RCT, Single-blind | Tedizolid Phophate, Antibiotic comparator, Aztreonam, Metronidazole |
| NCT00388479 Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus | Ileus | P3 | Completed | 666 | RCT, Double-blind | Alvimopan |
| NCT02019420 Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002) | Pneumonia | P3 | Completed | 726 | RCT, Double-blind | Tedizolid phosphate, Linezolid |
| NCT01345929 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis | Complicated Urinary Tract Infection, Pyelonephritis | P3 | Completed | 558 | RCT, Double-blind | CXA-201, Levofloxacin |
| NCT01901328 Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation | Opioid-Induced Constipation | P3 | Terminated | 49 | RCT, Double-blind | CB-5945, Placebo |
| NCT00701636 Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery | Late Effects of Surgery, Staphylococcus Aureus | P3 | Completed | 30 | Open-label | daptomycin |
| NCT04095858 Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) | Hematopoietic Stem Cell Transplantation, Acute Graft Versus Host Disease | P3 | Terminated | 11 | RCT, Double-blind | Efprezimod alfa, Placebo, Methotrexate, Tacrolimus |
| NCT00093067 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus | Bacterial Endocarditis, Bacteremia | P3 | Completed | — | RCT, Open-label | daptomycin |
| NCT04896008 A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) | Pulmonary Arterial Hypertension | P3 | Completed | 173 | RCT, Double-blind | Sotatercept |
| NCT01598311 A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006) | Clostridium Difficile Infection | P3 | Completed | 608 | RCT, Double-blind | CB-183,315, Vancomycin, Placebo |
| NCT00443690 Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy | Heart Failure, Congestive | P3 | Completed | 480 | RCT, Double-blind | rolofylline, Comparator: Placebo (unspecified) |
| NCT01445678 Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Meropenem in Complicated Intraabdominal Infections | Complicated Intra-abdominal Infection | P3 | Completed | 494 | RCT, Double-blind | CXA-201 and metronidazole, Meropenem |
| NCT07365319 A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer. | Non Small Cell Lung Cancer (Squamous or Non Squamous), Stage 4 NSCLC | P2P3 | Not Yet Recruiting | 750 | RCT, Double-blind | EIK1001, Pembrolizumab (KEYTRUDA®), Placebo, Paclitaxel + Carboplatin, Nab-paclitaxel + Carboplatin, Pemetrexed + Cisplatin /Carboplatin |
| NCT03480802 A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults Infected With Human Immunodeficiency Virus (HIV) (V114-018) | Pneumococcal Infections | P3 | Completed | 302 | RCT, Double-blind | V114, Prevnar 13™, PNEUMOVAX™23 |
| NCT00686881 Efficacy of Peginterferon Alfa-2b (SCH 054031) vs Glycyrrhizin in Interferon (IFN)-Treated Patients With Chronic Hepatitis C and F2/F3 Liver Fibrosis (P04773) | Hepatitis C, Chronic | P3 | Terminated | 261 | RCT, Open-label | Peginterferon alfa-2b (PegIFN-2b), Comparator: Stronger neo minophagen C (SNMC) |
| NCT00325130 Concomitant Use of Gardasil (V501) (Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diphtheria, Tetanus, Pertussis Vaccine and Meningococcal Conjugate Vaccine in Adolescents (V501-025) | Neoplasms, Glandular and Epithelial, Diphtheria | P3 | Completed | 1,042 | RCT, Open-label | Comparator: Quadrivalent Human Papillomavirus (HPV) vaccine, Comparator: Menactra™ (Concomitant), Comparator: Adacel™ (Concomitant), Comparator: Menactra™ (Non-concomitant), Comparator: Adacel™ |
| NCT01089647 Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA) | Obstructive Sleep Apnea | P3 | Completed | 34 | RCT, Double-blind | budesonide and montelukast, Placebo |
| NCT04676412 Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) [MK-7902-007/E7080-G000-314/LEAP-007] - China Extension Study | Non-small Cell Lung Cancer | P3 | Completed | 107 | RCT, Double-blind | Pembrolizumab, Lenvatinib, Placebo for lenvatinib |
| NCT03635567 Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826) | Cervical Cancer | P3 | Completed | 617 | RCT, Double-blind | Pembrolizumab, Paclitaxel, Cisplatin, Carboplatin, Bevacizumab, Placebo to pembrolizumab |
| NCT01937247 Redesigned Process in the Operating Room | Non-operative Time, General Surgery, Above 18 Years of Age | P2P3 | Completed | 120 | RCT, Double-blind | patient will be reversed with sugammadex 4mg/kg IV |
| NCT00686790 Efficacy of Peginterferon Alfa-2b in Previously Untreated Subjects With Chronic Hepatitis B and D Co-infection (Study P04603) | Hepatitis D, Chronic, Hepatitis B, Chronic | P3 | Completed | 68 | Open-label | Peginterferon alfa-2b (PegIntron, SCH 54031) |
| NCT01299376 MK-0954E Phase III Long-Term Study in Participants With Hypertension (MK-0954E-356) | Hypertension | P3 | Completed | 286 | RCT, Double-blind | L50/H12.5/A5, L50/H12.5, Placebo to L50/H12.5/A5, Placebo to L50/H12.5 |
| NCT00534248 Study to Evaluate the Safety and Effectiveness of Zostavax™ in Subjects 50 - 59 Years of Age (V211-022) | Shingles | P3 | Completed | 22,439 | RCT, Double-blind | Zoster Vaccine, Live (Zostavax™), Comparator: Placebo |
| NCT01302691 MK-0954E Study in Participants With Hypertension (MK-0954E-357) | Hypertension | P3 | Completed | 327 | RCT, Double-blind | losartan potassium + hydrochlorothiazide + amlodipine besylate (MK-0954E), Losartan potassium, Amlodipine besylate, Placebo to MK-0954E, Placebo to losartan potassium, Placebo to amlodipine besylate |
| NCT00552097 Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) | Atherosclerosis, Hypercholesterolemia | P3 | Completed | 720 | RCT, Double-blind | ezetimibe (plus simvastatin), placebo (plus simvastatin) |
| NCT00954265 Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG) | Embryonic Development, Pregnancy | P3 | Unknown | 130 | RCT, Single-blind | 10000 IU urinary HCG, 250 mcg recombinant HCG |
| NCT00833053 Dose Optimization of Infliximab in Moderate to Severe Plaque Psoriasis (Study P05315) | Psoriasis | P3 | Terminated | 39 | RCT, Open-label | Infliximab, Infliximab and methotrexate |
| NCT01534351 Comparison of Finasteride and Tamsulosin for Treatment of Benign Prostatic Hyperplasia (BPH) (MK-0906A-149 AM2) | Benign Prostatic Hyperplasia | P3 | Terminated | 1 | RCT, Double-blind | Finasteride, Tamsulosin, Finasteride-matching placebo, Tamsulosin-matching placebo |
| NCT03969901 Safety, Tolerability, Efficacy and Pharmacokinetics of Imipenem/Cilastatin/Relebactam (MK-7655A) in Pediatric Participants With Gram-negative Bacterial Infection (MK-7655A-021) | Suspected or Documented Gram-negative Bacterial Infection | P2P3 | Completed | 115 | RCT, Open-label | IMI/REL, Active Control, Oral Switch |
| NCT00035295 Treatment of Patients With Major Depressive Disorder With MK0869 (0869-061) | Major Depressive Disorder | P3 | Completed | 584 | RCT, Double-blind | MK0869, aprepitant, Comparator: placebo |
| NCT00080444 Study of Aprepitant (MK-0869) for Chemotherapy-Induced Nausea and Vomiting (CINV) in Adolescent Participants (MK-0869-097) | Vomiting | P3 | Completed | 50 | RCT, Double-blind | aprepitant, ondansetron, dexamethasone, placebo to aprepitant, placebo to dexamethasone, rescue medication |
| NCT02784171 Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma | Mesothelioma | P2P3 | Completed | 520 | RCT, Open-label | Cisplatin, Pemetrexed, Pembrolizumab |
| NCT00536263 PegIntron Treatment of Chronic Hepatitis B e Antigen-Positive Patients (P05170/MK-4031-327) | Hepatitis B, Chronic | P3 | Completed | 671 | RCT, Open-label | pegylated interferon alpha-2b, pegylated interferon alpha-2b, pegylated interferon alpha-2b |
| NCT00237484 Effect of Infliximab on the Efficacy of Peg-Intron/Ribavirin in Patients With Hepatitis C (Study P04257AM4)(COMPLETED) | Hepatitis C, Chronic | P3 | Completed | 89 | RCT, Open-label | Induction dose of (a) infliximab followed by combination of (b) pegylated interferon alfa-2b and (c) ribavirin, Combination of (a) pegylated interferon alfa-2b and (b) ribavirin |
| NCT04193176 Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042) | Chronic Cough | P3 | Completed | 376 | RCT, Double-blind | Gefapixant, Placebo |
| NCT00750919 Twenty-six Week Extension Trial of Org 50081 (Esmirtazapine) in Outpatients With Chronic Primary Insomnia (176003/P05721/MK-8265-007) | Sleep Initiation and Maintenance Disorders, Mental Disorders | P3 | Terminated | 184 | Open-label | esmirtazapine |
| NCT00984152 Trial of TDF/FTC + Raltegravir Versus TDF/FTC + Efavirenz in HIV-1-Infected Women | HIV-1 Infections | P3 | Withdrawn | — | RCT, Open-label | TDF/FTC Once-Daily + Raltegravir 400 mg Orally Twice-Daily, TDF/FTC + Efavirenz (Atripla) Once-Daily |
| NCT00759109 Pegylated Alfa-2b Interferon Therapy of Patients With Hepatitis C-related Cirrhosis and High Liver Cell Proliferation (P02733/MK-4031-085) | Carcinoma, Hepatocellular | P3 | Completed | 150 | RCT, Open-label | Peginterferon alfa-2b |
| NCT00433927 5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC) | Neoplasm Metastasis, Colorectal Cancer | P3 | Unknown | 568 | RCT, Open-label | 5-FU, folinic acid, irinotecan, cetuximab, bevacizumab |
| NCT00251641 The Effects of Infliximab Versus Methotrexate in the Treatment of Moderate to Severe Psoriasis (Study P04271AM2)(COMPLETED) | Psoriasis | P3 | Completed | 868 | RCT, Open-label | infliximab, methotrexate |
| NCT03950856 Lot-to-Lot Consistency of V114 in Healthy Adults (V114-020) | Pneumococcal Infections, Pneumonia, Pneumococcal | P3 | Completed | 2,340 | RCT, Double-blind | V114, Prevnar 13™ |
| NCT01945294 Short Duration Versus Standard Response-Guided Therapy With Boceprevir Combined With PegIntron and Ribavirin in Previously Untreated Non-Cirrhotic Asian Participants With Chronic HCV Genotype 1 (MK-3034-107) | Hepatitis C, Chronic | P3 | Completed | 257 | RCT, Open-label | Boceprevir, Peg-interferon alfa-2b, Ribavirin |
| NCT01761266 A Multicenter, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-line Treatment of Participants With Unresectable Hepatocellular Carcinoma | Hepatocellular Carcinoma (HCC) | P3 | Completed | 954 | RCT, Open-label | Lenvatinib, Sorafenib |
| NCT01457937 Boceprevir/PegIFN α-2b/Riba in HCV+ Gt1 Menopausal Women, Nonresponders to PegIFN/Riba or Treatment-naives (MEN_BOC) | Chronic Hepatitis C, Menopause | P3 | Unknown | 240 | RCT, Open-label | Pegylated Interferon, Ribavirin, Boceprevir |
| NCT01841697 Study to Evaluate the Safety and Efficacy of the Addition of Omarigliptin (MK-3102) Compared With the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-026) | Type 2 Diabetes | P3 | Completed | 642 | RCT, Double-blind | Omarigliptin, Sitagliptin, Placebo to omarigliptin, Placebo to Sitagliptin, Open-label Metformin, Open-label Glimepiride |
| NCT00381017 Effects of Low-dose Maintenance Peg Interferon Alfa-2b Therapy Versus Supportive Care in Patients With Cirrhotic Hepatitis C With HIV (Study P04371) | Hepatitis C, Liver Cirrhosis | P3 | Withdrawn | — | RCT, Open-label | Peg interferon alpha-2b |
| NCT00564460 On Label, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Finasteride in Patients Undergoing Transurethral Resection of the Prostate (TURP) | Benign Prostatic Hyperplasia | P3 | Withdrawn | — | RCT, Double-blind | Finasteride, Placebo |
| NCT00092196 Study of MK0869 for the Prevention of Chemotherapy-Induced Nausea and Vomiting (0869-071)(COMPLETED) | Nausea, Vomiting | P3 | Completed | 820 | RCT, Open-label | MK0869, aprepitant / Duration of Treatment: 3 days |
| NCT06450366 A Study to Evaluate the Efficacy and Safety of Enlicitide (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018/CORALreef AddOn) | Hypercholesterolemia | P3 | Completed | 301 | RCT, Double-blind | Enlicitide, Ezetimibe, Bempedoic Acid |
| NCT01860729 A Study of the Safety and Efficacy of Anacetrapib (MK-0859) Among Participants With Hypercholesterolemia When Added to Ongoing Statin Therapy (MK-0859-022) | Hypercholesterolemia | P3 | Completed | 589 | RCT, Double-blind | Anacetrapib, Placebo |
| NCT00131430 An Eighteen Month Efficacy and Safety Study in Obese Patients (0364-020)(COMPLETED) | Obesity and Obesity-related Medical Conditions | P2P3 | Completed | 500 | RCT, Double-blind | taranabant |
| NCT00708500 Boceprevir in Subjects With Chronic Hepatitis C Genotype 1 Who Failed Prior Treatment With Peginterferon/Ribavirin (Study P05101AM3)(COMPLETED) | Hepatitis C, Chronic | P3 | Completed | 404 | RCT, Double-blind | Boceprevir (SCH 503034), Pegylated interferon alfa-2b (SCH 54031), Ribavirin (SCH 18908), Boceprevir placebo |
| NCT01803607 Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Oral Bisphosphonate (MK-0822-076) | Osteoporosis | P3 | Terminated | 135 | RCT, Double-blind | odanacatib |
| NCT00039871 PEG-Intron Plus Rebetol Treatment of Chronic Hepatitis C Subjects Who Failed Response to Alpha-Interferon Plus Ribavirin (Study P02370) | Hepatitis, Hepatitis C, Chronic | P3 | Completed | 2,333 | Open-label | PegIntron (peginterferon alfa-2b; SCH 54031), REBETOL (ribavirin; SCH 18908) |
| NCT01228734 A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC) in Chinese Rat Sarcoma Viral Oncogene Homolog (RAS) Wild-type Patients | Metastatic Colorectal Cancer | P3 | Completed | 553 | RCT, Open-label | Cetuximab, Oxaliplatin, Folinic Acid, 5Fluorouracil |
| NCT01114425 Safety Study of Isentress® + Truvada® in Post-exposure Treatment of HIV Infection | HIV Infections | P3 | Completed | 149 | Open-label | raltegravir (Isentress), Truvada® |
| NCT04066491 Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTC | Biliary Tract Cancer, Cholangiocarcinoma | P2P3 | Terminated | 309 | RCT, Double-blind | M7824, Placebo, Gemcitabine, Cisplatin |
| NCT00002393 A Study of Indinavir Taken With or Without DMP 266 | HIV Infections | P3 | Completed | 300 | — | Indinavir sulfate, Efavirenz |
| NCT00689390 Three-year Follow-up of Participants After Administration of Boceprevir or Narlaprevir for the Treatment of Chronic Hepatitis C (P05063) | Hepatitis C, Chronic, Hepacivirus | P2P3 | Terminated | 1,954 | Open-label | Boceprevir, Narlaprevir, Peginterferon alfa-2b, Ribavirin |
| NCT01485614 Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083) | Diabetes Mellitus, Type 2 Diabetes | P3 | Completed | 200 | RCT, Double-blind | Sitagliptin, Metformin, Placebo to sitagliptin, Placebo to metformin, Glycemic Rescue 1, Glycemic Rescue 2 |
| NCT01241552 A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) | Clostridium Difficile Infection | P3 | Completed | 1,452 | RCT, Double-blind | MK-3415, MK-6072, MK-3415A, Placebo, SOC |
| NCT00034632 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) | Mycoses | P3 | Completed | — | Open-label | Posaconazole oral suspension |
| NCT00835380 A Study of 2 Doses of VAQTA™ in Healthy Children 12 to 23 Months of Age (V251-069) | Hepatitis A Virus Infection | P3 | Completed | 80 | Open-label | Hepatitis A Vaccine, Purified Inactivated (VAQTA™) |
| NCT01839188 Spanish Mixed HEXA/PENTA/HEXA Schedule (V419-010) | Neisseria Meningitidis, Bacterial Infections | P3 | Completed | 385 | Open-label | PR5I, Pediacel®, NeisVac-C®, RotaTeq®, Prevenar 13® |
| NCT01076088 Safety and Efficacy of Co-Administration of Sitagliptin and Metformin in China (MK-0431-121) | Type 2 Diabetes Mellitus | P3 | Completed | 744 | RCT, Double-blind | Sitagliptin 50 mg, Metformin 500 mg, Sitagliptin 100 mg, Placebo, Metformin 850 mg |
| NCT00092079 A Study of MK0217A and Dietary Supplement in Men and Postmenopausal Women With Osteoporosis (0217A-227) | Osteoporosis, Vitamin D Deficiency | P3 | Completed | 652 | RCT, Double-blind | MK0217A, alendronate sodium (+) cholecalciferol / Duration of Treatment: 24 weeks |
| NCT00298831 Use of Sugammadex at the End of Case in Routine Anesthesia (MK-8616-023) | Anesthesia, General | P3 | Completed | 224 | Open-label | Sugammadex, Rocuronium |
| NCT01294683 A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) | Primary Hypercholesterolemia, Dyslipidemia | P3 | Terminated | 977 | RCT, Double-blind | Simvastatin, Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM), Extended Release (ER) niacin/laropiprant (N/LRPT), Placebo |
| NCT01012258 Cetuximab With Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck in Chinese Subjects | Squamous Cell Carcinoma of the Head and Neck | P3 | Completed | 70 | Open-label | Cetuximab + concomitant boost radiotherapy |
| NCT01465178 Improving the Understanding of the Response to Vitamin D Supplementation | Vitamin D Deficiency | P3 | Completed | 62 | RCT, Double-blind | — |
| NCT05119855 Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076) | Papillomavirus Infections, Coronavirus Disease (COVID-19) | P3 | Completed | 165 | RCT, Open-label | 9vHPV Vaccine, mRNA-1273 Vaccine |
| NCT00421148 Dose-Finding Pediatric and Adult Trial With Sugammadex (Org 25969, MK-8616, SCH 900616) (19.4.306) (MK-8616-034) (P05961) | Anesthesia | P3 | Completed | 94 | RCT, Double-blind | Sugammadex 0.5 mg/kg, Sugammadex 1 mg/kg, Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Placebo, Rocuronium bromide |
| NCT05464420 A Study to Evaluate the Safety, Tolerability, Immunogenicity, and Lot Consistency of V116 in Adults 18 to 49 Years of Age (V116-004, STRIDE-4) | Pneumococcal Disease | P3 | Completed | 2,162 | RCT, Double-blind | V116, PPSV23 |
| NCT00393523 Hepatitis B Vaccine Booster Study (V232-058)(COMPLETED) | Hepatitis B | P3 | Completed | 1,478 | RCT, Single-blind | Comparator: Modified Process Hepatitis B Vaccine, Comparator: Comparator: ENGERIX-B |
| NCT00820755 Trial With Cetuximab in Maintenance Therapy After Platinum Based Chemotherapy in First Line Treatment of Non-small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer (NSCLC) | P3 | Completed | 583 | RCT, Open-label | Cetuximab plus Platinum-based Doublet Chemotherapy, Cetuximab 500 mg/m^2, Cetuximab 250 mg/m^2 |
| NCT00116324 Predicting the Response to Montelukast by Genetic Variation in Asthmatics | Asthma | P3 | Completed | 150 | RCT, Double-blind | Montelukast |
| NCT00003880 Paclitaxel Plus Carboplatin With or Without SCH-58500 in Treating Patients With Newly Diagnosed Stage III Ovarian or Stage III Primary Peritoneal Cancer | Ovarian Cancer, Primary Peritoneal Cavity Cancer | P2P3 | Terminated | 132 | RCT | recombinant adenovirus-p53 SCH-58500, carboplatin, paclitaxel |
| NCT03507413 Metformin Therapy in Non-diabetic AAA Patients | Abdominal Aortic Aneurysm | P2P3 | Unknown | 170 | RCT, Double-blind | Metformin Glucophage 500mg (IR) tablets M90, Placebo Oral Tablet |
| NCT04223791 Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018) | HIV Infection | P3 | Completed | 643 | RCT, Double-blind | DOR/ISL, BIC/FTC/TAF, Placebo to BIC/FTC/TAF, Placebo to FDC DOR/ISL |
| NCT03845140 L-PZQ ODT in Schistosoma Infected Children | Schistosomiasis | P3 | Completed | 288 | RCT, Open-label | L-PZQ ODT 50 mg/kg, Biltricide®, L-PZQ ODT 60 mg/kg |
| NCT00935480 IntensVIH: Impact Of Therapy Intensification By An Integrase Inhibitor +/- CCR5 Inhibitor On The Lymphoid Reservoir For Hiv-1 In Chronically Infected Patients | HIV Infections | P3 | Completed | 17 | RCT, Open-label | Isentress®, Celsentri® |
| NCT03260894 Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302) | Renal Cell Carcinoma (RCC) | P3 | Completed | 129 | RCT, Open-label | Pembrolizumab, Epacadostat, Sunitinib, Pazopanib |
| NCT00985166 A Study of ProQuad in Healthy 4 to 6 Year Old Children (V221-014) | Measles, Mumps | P3 | Completed | 801 | RCT, Double-blind | ProQuad (Measles, Mumps, Rubella and Varicella (Oka-Merck) Virus Vaccine Live), Comparator: M-M-R II, Comparator: Varivax, Comparator: Placebo |
| NCT00403715 Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease | Dry Eye Disease | P3 | Completed | 500 | RCT, Double-blind | diquafosol tetrasodium (INS365) Ophthalmic Solution |
| NCT00559468 Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028) | Anesthesia, General | P3 | Completed | 52 | RCT, Single-blind | Sugammadex, Rocuronium, Sevoflurane, Propofol |
| NCT02382900 Two-dose Schedule of Quadrivalent HPV Recombinant Vaccine in 11-year-old Boys in Mexico City | Human Papilloma Virus | P3 | Unknown | 500 | Open-label | quadrivalent human papillomavirus (types 6, 11, 16,18) recombinant vaccine |
| NCT00404352 REbif FLEXible Dosing in Early Multiple Sclerosis (MS) | Multiple Sclerosis | P3 | Completed | 517 | RCT, Double-blind | RNF, RNF, Placebo |
| NCT00716833 Etoricoxibe - Preemptive and Postoperative Analgesia for Abdominal and Thoracic Surgery | Pain, Abdominal Surgery | P3 | Terminated | 87 | RCT, Double-blind | Etoricoxibe, Placebo |
| NCT01432730 A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006) | Chronic Cough | P2 | Completed | 24 | RCT, Double-blind | Gefapixant, Placebo |
| NCT03136185 Bomedemstat (IMG-7289/MK-3543) in Participants With Myelofibrosis (IMG-7289-CTP-102/MK-3543-002) | Myelofibrosis, Post-polycythemia Vera Myelofibrosis (PPV-MF) | P1P2 | Completed | 90 | Open-label | Bomedemstat |
| NCT02476890 Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014) | Refractory Chronic Cough | P2 | Completed | 36 | RCT, Double-blind | Gefapixant 100 mg, Placebo |
| NCT02296476 A Dose-finding Study of Birabresib (MK-8628) in Participants With Recurrent Glioblastoma Multiforme (MK-8628-002) | Glioblastoma Multiforme | P2 | Terminated | 12 | Open-label | Birabresib |
| NCT00626275 Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Participants With Rheumatoid Arthritis | Rheumatoid Arthritis | P2 | Completed | 46 | RCT, Double-blind | ADL5859, Naproxen, Placebo, ADL5859, Placebo |
| NCT05569538 Bomedemstat (IMG-7289) Plus Ruxolitinib for Myelofibrosis | Myelofibrosis | P2 | Unknown | 40 | Open-label | Bomedemstat |
| NCT01146574 A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis. | Anemia | P2 | Completed | 50 | RCT, Single-blind | Sotatercept, Placebo |
| NCT05191797 Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer | Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma | P1P2 | Terminated | 3 | Open-label | Bomedemstat, Atezolizumab |
| NCT00993863 Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction | Acute Pain | P2 | Completed | 201 | RCT, Double-blind | Placebo, ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg, ibuprofen 400 mg |
| NCT04254978 Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003) | Essential Thrombocythemia | P2 | Completed | 73 | Open-label | Bomedemstat |
| NCT00102700 ARQ 501 in Combination With Gemcitabine in Subjects With Pancreatic Cancer | Pancreatic Cancer, Adenocarcinoma | P2 | Completed | 66 | Open-label | ARQ 501 in combination with gemcitabine |
| NCT02349425 A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010) | Refractory Chronic Cough | P2 | Completed | 59 | RCT, Double-blind | Gefapixant, Placebo (for gefapixant) |
| NCT04552704 CD24Fc for the Treatment of Immune Related Adverse Events in Patients With Advanced Solid Tumors, TIRAEC Study | Advanced Malignant Solid Neoplasm | P1P2 | Terminated | 3 | RCT, Double-blind | CD24 Extracellular Domain-IgG1 Fc Domain Recombinant Fusion Protein CD24Fc, Placebo Administration |
| NCT01239758 Extension Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy | Duchenne Muscular Dystrophy | P2 | Terminated | 11 | Open-label | ACE-031 (Extension of cohort 1 from core study, A031-03), ACE-031 (Extension of cohort 2 from core study, A031-03), ACE-031 (Extension of cohort 3 from core study, A031-03) |
| NCT05558696 A Study of Bomedemstat (MK-3543) in Participants With Polycythemia Vera (MK-3543-004) | Polycythemia Vera | P2 | Completed | 20 | Open-label | Bomedemstat |
| NCT05223920 An Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005) | Thrombocythemia, Essential, Primary Myelofibrosis | P2 | Completed | 81 | Open-label | Bomedemstat |
| NCT01749540 Study to Evaluate the Safety and Efficacy of Luspatercept (ACE-536) in Participants With Beta-thalassemia (A536-04/MK-6143-002) | B-Thalassemia | P2 | Completed | 64 | Open-label | luspatercept |
| NCT00988741 Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapy | Unresectable Hepatocellular Carcinoma | P2 | Completed | 107 | RCT, Double-blind | ARQ 197, Placebo |
| NCT00159627 Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF). | Heart Failure, Congestive | P2 | Completed | 52 | RCT, Double-blind | KW-3902IV |
| NCT01554579 A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee | Osteoarthritis of the Knee | P2 | Completed | 171 | RCT, Double-blind | Gefapixant, Sugar Pill |
| NCT01178411 An Extension Protocol for Subjects Who Were Previously Enrolled in Other Tivantinib (ARQ 197) Protocols | Advanced Solid Tumors | P1P2 | Completed | 60 | Open-label | Tivantinib, Anti-Cancer Combination Therapy |
| NCT03577028 Study of HPN424 in Patients With Advanced Prostate Cancer | Advanced Prostate Cancer | P1P2 | Terminated | 104 | Open-label | HPN424 Fixed IV 1.3 to 150 ng/kg, HPN424 Prime Step IV 36 ng/kg Target, HPN424 1 Prime Step IV 225-300 ng/kg Target, HPN424 2 Prime Step IV 300 ng/kg Target, HPN424 2 Prime Step IV 450 ng/kg Target, HPN424 Fixed SC |
| NCT01519778 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study | Major Cutaneous Abscess, Cellulitis | P2 | Completed | 200 | Open-label | TR701 FA |
| NCT04504916 A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002) | Triple-negative Breast Cancer, Non-squamous Non-small-cell Lung Cancer | P2 | Terminated | 102 | Open-label | Zilovertamab vedotin |
| NCT00558207 A Randomized Phase 2 Study of ARQ 197 Versus Gemcitabine in Treatment-Naïve Patients With Unresectable Locally Advanced or Metastatic Pancreatic Adenocarcinoma | Pancreatic Neoplasms | P2 | Completed | 43 | RCT, Open-label | ARQ 197, gemcitabine |
| NCT00467272 Catheter Related - Gram Positive Bloodstream Infections | Bloodstream Infection | P2 | Completed | 30 | Open-label | Daptomycin |
| NCT01070290 A Study of ARQ 197 Versus Investigator's Choice of Second-Line Chemotherapy in Patients With Locally Advanced or Metastatic Gastric Cancer Who Have Progressive Neoplastic Disease Following Treatment With One Prior Chemotherapy Regimen | Gastric Cancer | P2 | Withdrawn | — | RCT, Open-label | ARQ 197, Oxaliplatin, capecitabine or irinotecan |
| NCT02397460 Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015) | Refractory Chronic Cough | P2 | Completed | 50 | RCT, Double-blind | Gefapixant, Placebo |
| NCT02842827 A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001) | Acute Myeloid Leukemia, Myelodysplastic Syndrome | P1P2 | Completed | 45 | Open-label | bomedemstat, tretinoin |
| NCT03094832 Study of Miransertib (MK-7075) in Participants With PIK3CA-related Overgrowth Spectrum and Proteus Syndrome (MOSAIC) (MK-7075-002) | PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome | P1P2 | Terminated | 50 | Open-label | Miransertib |
| NCT02024087 Study of Dalantercept and Sorafenib in Patients With Advanced Hepatocellular Carcinoma | Advanced Adult Hepatocellular Carcinoma | P1P2 | Completed | 21 | Open-label | Dalantercept plus sorafenib |
| NCT02268409 Extension Study to Evaluate the Safety and Efficacy of Luspatercept in Participants With β-Thalassemia Previously Enrolled in A536-04 (A536-06/MK-6143-004) | β-Thalassemia | P2 | Completed | 51 | Open-label | luspatercept |
| NCT00358930 A Study of ARQ 501 in Patients With Squamous Cell Carcinoma of the Head and Neck | Head and Neck Neoplasms, Carcinoma, Squamous Cell | P2 | Completed | 60 | Open-label | ARQ 501 |
| NCT01085591 Study of CB-183,315 in Participants With Clostridium Difficile Infection | Clostridium Difficile Infection, Diarrhea | P2 | Completed | 210 | RCT, Double-blind | CB-183,315, Placebo, Vancomycin |
| NCT01993329 A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009) | Asthma | P2 | Completed | 20 | RCT, Double-blind | Gefapixant 50 mg, Gefapixant 300 mg, Placebo to mimic 50 mg tablets, Placebo to mimic 300 mg tablets |
| NCT02927080 Study of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD) | Facioscapulohumeral Muscular Dystrophy | P2 | Terminated | 95 | RCT, Double-blind | ACE-083, ACE-083 or placebo |
| NCT03342404 A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia | Thalassemia | P2 | Completed | 145 | RCT, Double-blind | Luspatercept |
| NCT01752920 Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations | Solid Tumor | P1P2 | Completed | 119 | Open-label | Derazantinib low dose range, Derazantinib middle dose range, Derazantinib high dose range, Derazantinib at recommended phase 2 dose (RP2D) |
| NCT03738150 A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension | Pulmonary Arterial Hypertension | P2 | Completed | 21 | Open-label | Sotatercept |
| NCT00979953 Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee | Osteoarthritis of the Knee | P2 | Completed | 408 | RCT, Double-blind | ADL5859, ADL5747, Oxycodone CR, Placebo |
| NCT01569438 The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Participants With Interstitial Cystitis /Bladder Pain Syndrome (MK-7264-005) | Bladder Pain Syndrome | P2 | Terminated | 107 | RCT, Double-blind | Gefapixant, Placebo |
| NCT03960541 Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003) | HIV Infections, Dyslipidemias | P2 | Terminated | 8 | RCT, Double-blind | Efprezimod alfa (human CD24 extracellular domain and human IgG1 Fc fusion protein), Saline Solution |
| NCT00761215 Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections | Skin Diseases, Infectious, Skin Diseases, Bacterial | P2 | Completed | 192 | RCT, Double-blind | TR-701 200 mg, TR-701 300 mg, TR-701 400 mg |
| NCT00652782 Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients | Congestive Heart Failure, Renal Impairment | P2 | Completed | 160 | RCT, Double-blind | rolofyline, Comparator Placebo (unspecified) |
| NCT01207427 Evaluation of the Efficacy and Safety of ADL5945 for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain | Opioid Induced Constipation | P2 | Completed | 131 | RCT, Double-blind | Placebo, ADL5945 0.1 mg, ADL5945 0.25 mg |
| NCT03496207 A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH) | Pulmonary Arterial Hypertension | P2 | Completed | 106 | RCT, Double-blind | Placebo, Sotatercept |
| NCT02303782 A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in Patients With Newly-diagnosed Acute Myeloid Leukemia (AML) Not Candidate for Standard Intensive Induction Therapy (SIIT) | Acute Myeloid Leukemia | P1P2 | Withdrawn | — | RCT, Open-label | OTX015, Vidaza (azacitidine) |
| NCT01727336 Study of Dalantercept and Axitinib in Patients With Advanced Renal Cell Carcinoma | Advanced Renal Cell Carcinoma | P2 | Terminated | 160 | RCT, Double-blind | Dalantercept and axitinib, Placebo and axitinib |
| NCT00695903 Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia | Endocarditis, Bacterial, Infective Endocarditis | P2 | Terminated | 38 | RCT, Double-blind | daptomycin, vancomycin |
| NCT01749514 Study of Luspatercept for the Treatment of Anemia in Patients With Myelodysplastic Syndrome (MDS) (MK-6143-001) | Anemia | P2 | Completed | 116 | Open-label | Luspatercept |
| NCT02663622 Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-002) | Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation | P2 | Completed | 44 | RCT, Double-blind | Efprezimod alfa, Methotrexate, Tacrolimus, Placebo |
| NCT00310518 Safety and Efficacy Study of ARQ 501 in Adult Patients With Leiomyosarcoma | Cancer | P2 | Completed | 30 | Open-label | ARQ 501 |
| NCT01275755 Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain | Constipation | P2 | Completed | 81 | RCT, Double-blind | Placebo, ADL5945 0.25 mg |
| NCT00777309 A Randomized Phase 2 Study of Erlotinib + ARQ 197 Versus Erlotinib + Placebo in Previously Treated Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) | Non Small Cell Lung Cancer | P2 | Completed | 167 | RCT, Double-blind | ARQ 197, Erlotinib, Placebo |
| NCT02609984 Study to Compare the Safety and Efficacy of CMB305 With Atezolizumab to Atezolizumab Alone in Participants With Sarcoma (IMDZ-C232/V943A-002) | Sarcoma, Myxoid/Round Cell Liposarcoma | P2 | Terminated | 89 | RCT, Open-label | CMB305, atezolizumab |
| NCT00228592 HepeX-B in Post Hepatic Allografts for Treatment of End Stage Liver Disease Due to Hepatitis B Infection | Hepatitis B, Liver Transplantation | P2 | Terminated | — | RCT, Open-label | HepeX-B, Hepatitis B Immune Globulin (HBIg) |
| NCT01058642 Study to Assess the Efficacy, Safety, and Tolerability of ADL5747 in Participants With Postherpetic Neuralgia | Postherpetic Neuralgia | P2 | Terminated | 41 | RCT, Double-blind | ADL5747, Placebo, Pregabalin |
| NCT03108066 MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003) | VHL Gene Mutation, VHL | P2 | Completed | 4 | Open-label | MK-3795 |
| NCT00101998 Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication | Constipation, Bowel Dysfunction | P2 | Completed | 233 | RCT, Double-blind | alvimopan, placebo |
| NCT02612610 A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012) | Refractory Chronic Cough | P2 | Completed | 253 | RCT, Double-blind | Gefapixant, Placebo (for gefapixant) |
| NCT01458392 Study of Dalantercept in Patients With Squamous Cell Carcinoma of the Head and Neck | Squamous Cell Carcinoma of the Head and Neck | P2 | Completed | 46 | Open-label | Dalantercept |
| NCT00557609 Phase 2 Study in Patients With MiT Tumors | Renal Cell Carcinoma (RCC), Alveolar Soft Part Sarcoma (ASPS) | P2 | Completed | 47 | Open-label | ARQ 197 |
| NCT02268383 Extension Study to Evaluate Long-Term Effects of Luspatercept in Patients With Myelodysplastic Syndromes (MDS) (A536-05/MK-6143-003) | Myelodysplastic Syndromes | P2 | Completed | 75 | Open-label | Luspatercept |
| NCT00331045 Clinical Evaluation Of Alvimopan (SB767905) On Constipation And Related Symptoms Associated With Opioid | Cancer, Constipation | P2 | Terminated | 21 | RCT, Double-blind | alvimopan, Placebo, Alvimopan 0.5 mg/day, Alvimopan 1 mg/day |
| NCT02502097 A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016) | Idiopathic Pulmonary Fibrosis, Cough | P2 | Completed | 51 | RCT, Double-blind | Gefapixant |
| NCT03124459 Study of ACE-083 in Patients With Charcot-Marie-Tooth Disease | Charcot-Marie-Tooth Disease | P2 | Terminated | 63 | RCT, Double-blind | ACE-083, Placebo |
| NCT00448864 Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement | Blood Loss, Surgical | P2 | Terminated | 75 | RCT, Double-blind | Ecallantide, Placebo |
| NCT01591863 Safety, Tolerability, and Pharmacokinetics of Fidaxomicin in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD) | Clostridium Difficile-associated Diarrhea | P2 | Completed | 38 | Open-label | fidaxomicin |
| NCT00428844 Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci | Osteomyelitis | P2 | Completed | 75 | RCT, Open-label | daptomycin, daptomycin, vancomycin, teicoplanin, nafcillin, oxacillin, flucloxacillin |
| NCT02501473 Study of Intratumoral G100 With Or Without Pembrolizumab or Rituximab In Participants With Follicular Non-Hodgkin's Lymphoma (MK-3475-174/IMDZ-G142) | Follicular Low Grade Non-Hodgkin's Lymphoma | P1P2 | Terminated | 52 | RCT, Open-label | G100, Pembrolizumab, Rituximab |
| NCT01099761 Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy | Duchenne Muscular Dystrophy | P2 | Terminated | 24 | RCT, Double-blind | ACE-031 0.5 mg/kg q4wk, ACE-031 1.0 mg/kg q2wk |
| NCT03216499 HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma | Recurrent Glioblastoma | P2 | Completed | 24 | Open-label | HIF-2alpha Inhibitor PT2385 |
| NCT00622063 An Extension Study for Patients Previously Treated With ARQ 501 | Cancer | P1P2 | Completed | 1 | Open-label | ARQ 501 |
| NCT00816023 A Dose-ranging Safety and Efficacy Study of Ecallantide to Reduce Surgical Blood Loss Volume | Bloodloss, Surgical Procedures, Operative | P2 | Completed | 276 | RCT, Double-blind | ecallantide, placebo |
| NCT00507247 Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus | Staphylococcus Aureus | P2 | Completed | 11 | Open-label | Daptomycin |
| NCT02612623 An 8-Week Refractory Chronic Cough Study (MK-7264-021) | Refractory Chronic Cough | P2 | Completed | 24 | RCT, Double-blind | Gefapixant, Placebo (for gefapixant) |
| NCT00135577 Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects | Cancer, Bowel Dysfunction | P2 | Completed | 67 | Double-blind | alvimopan, placebo |
| NCT01147640 Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections | Complicated Intra-abdominal Infection | P2 | Completed | 122 | RCT, Double-blind | CXA-101/ tazobactam and metronidazole, meropenem plus saline placebo |
| NCT00888940 Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery | Bloodloss, Surgical Procedures, Operative | P2 | Completed | 243 | RCT, Double-blind | Ecallantide, Cyklokapron(R) |
| NCT00097422 OPT-80 in Clostridium Difficile-Associated Diarrhea (CDAD) | Diarrhea | P2 | Completed | — | RCT, Open-label | OPT-80 |
| NCT01258569 Entereg Laparoscopic Colon Resection Study | Laparoscopic Colonic Resection | P2 | Completed | 135 | RCT, Double-blind | Entereg, Entereg, placebo |
| NCT00159614 Effect of KW-3902IV in Combination With IV Furosemide on Renal Function in Subjects With CHF and Renal Impairment | Heart Failure, Congestive, Renal Insufficiency | P2 | Completed | 30 | RCT, Double-blind | KW-3902IV |
| NCT00426933 Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infections | Soft Tissue Infections | P2 | Completed | 100 | RCT, Open-label | Daptomycin, Vancomycin |
| NCT00603265 Safety and Efficacy Study of ADL5859 in Participants With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy | Peripheral Neuropathy, Neuropathic Pain | P2 | Completed | 226 | RCT, Double-blind | ADL5859, Duloxetine, Placebo |
| NCT02406781 Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial | Sarcoma | P2 | Completed | 129 | Open-label | Combination of MK3475 with Metronomic CP, Combination of MK3475 with Metronomic CP and G100 |
| NCT00921024 Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections | Complicated Urinary Tract Infection | P2 | Completed | 129 | RCT, Double-blind | CXA-101, Ceftazidime |
| NCT02477709 A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF) | Idiopathic Pulmonary Fibrosis | P2 | Completed | 6 | Open-label | Gefapixant |
| NCT01395758 Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer | Metastatic Non-Small Cell Lung Cancer | P2 | Completed | 96 | RCT, Open-label | ARQ 197 plus erlotinib, Pemetrexed, docetaxel or gemcitabine |
| NCT04060407 CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI) | Metastatic Melanoma | P1P2 | Withdrawn | — | Open-label | CD24Fc, Ipilimumab, Nivolumab |
| NCT04996797 A Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Moderately to Severely Active Ulcerative Colitis (MK-7240-005) | Ulcerative Colitis | P2 | Completed | 178 | RCT, Double-blind | Tulisokibart |
| NCT03943290 Extension Study to Evaluate the Long-Term Effects of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD) and Charcot-Marie Tooth (CMT) Disease Types 1 and X (CMT1 and CMTX) | Facioscapulohumeral Muscular Dystrophy, Charcot-Marie-Tooth Disease | P2 | Terminated | 62 | RCT, Open-label | ACE-083 |
| NCT05013905 A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease | Crohn Disease | P2 | Completed | 55 | Open-label | PRA023 IV |
| NCT00451113 Sitagliptin in the Elderly | Type 2 Diabetes | P2 | Completed | 12 | RCT, Single-blind | Sitagliptin 100 mg |
| NCT03160079 Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts | B-Cell Acute Lymphoblastic Leukemia, Adult | P1P2 | Completed | 16 | Open-label | blinatumomab, pembrolizumab |
| NCT01234857 A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3) | Breast Cancer | P2 | Completed | 115 | RCT, Open-label | ridaforolimus + dalotuzumab, exemestane, ridaforolimus, dalotuzumab |
| NCT04704219 Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61) | Renal Cell Carcinoma | P2 | Completed | 160 | Open-label | Pembrolizumab, Lenvatinib |
| NCT01269658 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Vehicle in Subjects With Blepharitis (P08636) | Blepharitis | P2 | Terminated | 40 | RCT, Double-blind | Azithromycin ophthalmic solution, 1%, Vehicle |
| NCT03840915 M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC) | Carcinoma, Non-Small-Cell Lung | P1P2 | Completed | 70 | Open-label | Cisplatin, Carboplatin, Pemetrexed, Nab-paclitaxel, Gemcitabine, Docetaxel, M7824, Carboplatin, Carboplatin, Bintrafusp alfa, Paclitaxel |
| NCT02975336 A Phase II Study of M2951 in SLE | Systemic Lupus Erythematosus | P2 | Terminated | 469 | RCT, Double-blind | Placebo, M2951, M2951, M2951, M2951 |
| NCT03258398 A Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer | Microsatellite Stable Relapsed or Refractory Colorectal Cancer | P2 | Completed | 56 | RCT, Open-label | eFT508, Avelumab |
| NCT03325166 Pembrolizumab and Magnetic Resonance Imaging With Ferumoxytol in Treating Patients With Non-small Cell Lung Cancer and Brain Metastases | Lung Carcinoma Metastatic in the Brain, Stage IV Lung Non-Small Cell Cancer AJCC v7 | P2 | Terminated | 2 | Open-label | Ferumoxytol, Pembrolizumab |
| NCT03523702 The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial | Non-small Cell Lung Cancer, NSCLC | P2 | Completed | 25 | Open-label | PembroRT |
| NCT00711555 Emend for Multiple-day Emetogenic Chemotherapy | Nausea, Vomiting | P2 | Completed | 22 | Open-label | aprepitant, ondansetron, dexamethasone |
| NCT00239655 A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI)(0812-003)(COMPLETED) | Relapsing-Remitting Multiple Sclerosis | P2 | Terminated | 120 | RCT, Double-blind | MK0812 |
| NCT00481663 A Study of Different Doses of Sitagliptin (MK-0431) in Participants With Type 2 Diabetes Mellitus (MK-0431-014) | Type II Diabetes Mellitus | P2 | Completed | 555 | RCT, Double-blind | Sitagliptin, Placebo to sitagliptin, Metformin, Rescue |
| NCT04447755 A Study of Lenvatinib (MK-7902) in Pediatric Participants With Relapsed or Refractory Solid Malignancies (MK-7902-013/E7080) | Relapsed or Refractory Solid Tumors | P2 | Completed | 127 | Open-label | Lenvatinib |
| NCT00645333 Phase I/II Study of MK-0752 Followed by Docetaxel in Advanced or Metastatic Breast Cancer | Metastatic Breast Cancer | P1P2 | Completed | 30 | Open-label | MK-0752, Docetaxel, Pegfilgrastim |
| NCT01192087 Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy | Adenoid Cystic Carcinoma | P1P2 | Unknown | 49 | Open-label | Cetuximab |
| NCT03430700 Trial of Pembrolizumab Following Weekly Paclitaxel for Platinum-resistant Ovarian, Fallopian Tube or Peritoneal Cancer | Ovarian Cancer, Fallopian Tube Cancer | P2 | Unknown | 28 | Open-label | Pembrolizumab |
| NCT05998447 GEN-001 Plus Pembrolizumab for Patients With Advanced Refractory Biliary Tract Cancer | Biliary Tract Cancer | P2 | Terminated | 10 | Open-label | GEN-001, Pembrolizumab, mFOLFOX |
| NCT05493618 Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma. | Multiple Myeloma, Refractory | P1P2 | Withdrawn | — | Open-label | Pembrolizumab, Belantamab mafodotin, Dexamethasone |
| NCT00231790 A Placebo-Controlled Study of MK0634 in Patients With Overactive Bladder (0634-007) | Urinary Incontinence | P2 | Completed | 848 | RCT, Double-blind | MK-0634 50 mg, MK-0634 125 mg, Placebo for MK-0634 |
| NCT03568097 Immunotherapy in Combination With Chemotherapy in Small-cell Lung Cancer | Small Cell Lung Carcinoma | P2 | Unknown | 55 | Open-label | Avelumab |
| NCT00703690 MK0767 in Metabolic Syndrome-Dyslipidemia (0767-016) | Metabolic X Syndrome Dyslipidemia | P2 | Terminated | 436 | RCT, Double-blind | MK0767, Comparator: fenofibrate, Comparator: Placebo (unspecified) |
| NCT02892201 Pembrolizumab in HNSCC With Residual Disease After Radiation | Head and Neck Squamous Cell Carcinoma | P2 | Terminated | 9 | Open-label | Pembrolizumab |
| NCT00797667 MK0974 (Telcagepant) for Migraine Prophylaxis in Patients With Episodic Migraine (0974-049) | Migraine | P2 | Terminated | 660 | RCT, Double-blind | Telcagepant 140 mg, Telcagepant 280 mg, 140 mg telcagepant placebo, 280 mg telcagepant placebo |
| NCT03051672 Phase II PEMBROLIZUMAB + PALLIATIVE RADIOTHERAPY IN BC | Metastatic Breast Cancer | P2 | Terminated | 8 | Open-label | Pembrolizumab |
| NCT00504530 r-hLIF for Improving Embryo Implantation in IVF | Infertility Implantation Failure | P1P2 | Completed | 50 | RCT, Double-blind | Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF) |
| NCT02105454 Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) + Ribavirin in Participants With Chronic Hepatitis C Who Failed Prior Direct-Acting Antiviral Therapy (MK-5172-048) | Hepatitis C Virus | P2 | Completed | 79 | Open-label | Grazoprevir (GZR), Elbasvir (EBR), Ribavirin (RBV) |
| NCT04361851 Study of Dara-Pembro for Multiple Myeloma Patients | Multiple Myeloma | P2 | Withdrawn | — | Open-label | Pembrolizumab |
| NCT00254553 A Study to Test a Measure of Symptoms of Older Men With Low Testosterone On and Off Testosterone Replacement Treatment (P05815) | Hypogonadism | P2 | Terminated | 150 | RCT, Double-blind | Testim 1% (testosterone gel), Placebo |
| NCT01651936 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Trial to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 in Participants With Rheumatoid Arthritis (MK-8457-010) | Rheumatoid Arthritis | P2 | Terminated | 56 | RCT, Double-blind | MK-8457 100 mg, Methotrexate, Dose-match placebo |
| NCT04483544 Pembrolizumab and Olaparib in Cervical Cancer Patients | Cervical Cancer, Cervical Carcinoma | P2 | Terminated | 8 | Open-label | pembrolizumab, olaparib |
| NCT01045798 Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067) | Invasive Candidiasis | P2 | Terminated | 15 | RCT, Double-blind | Caspofungin acetate, Placebo |
| NCT00610441 Dose Finding Study in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)(174007/P05805/MK-8777-003) | Attention Deficit Hyperactivity Disorder | P2 | Completed | 67 | RCT, Double-blind | MK-8777, Placebo |
| NCT00486044 Evaluating Simvastatin's Potential Role in Therapy | Alzheimer Disease | P2 | Completed | 103 | RCT, Double-blind | Simvastatin, Placebo |
| NCT00003760 Irofulvene in Treating Patients With Stage III or Stage IV Pancreatic Cancer | Pancreatic Cancer | P2 | Completed | 3 | Open-label | irofulven |
| NCT00242476 A Study to Assess the Effectiveness of an Investigational Drug in Elderly Subjects With Low Vitamin D Levels (0822A-009) | Vitamin D Deficiency | P2 | Completed | 216 | RCT, Double-blind | MK0822A |
| NCT00725725 Org 25935 Versus Placebo as Augmentation to Cognitive-behavioral Therapy to Treat Panic Disorder (P05705) | Panic Disorder | P2 | Terminated | 46 | RCT, Double-blind | Org 25935, Org 25935, Placebo |
| NCT03609359 Lenvatinib and Pembrolizumab Simultaneous Combination Study | Advanced Gastric Cancer | P2 | Completed | 29 | Open-label | Lenvatinib, Pembrolizumab |
| NCT00679718 A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease | Dry Eye Disease | P2 | Completed | 150 | RCT, Double-blind | diquafosol tetrasodium (INS365) ophthalmic solution |
| NCT00482898 A Study of MK0359 in Patients With Chronic Asthma (0359-013) | Asthma | P2 | Completed | 56 | RCT, Double-blind | MK0359 |
| NCT04944992 A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) | Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis | P2 | Completed | 145 | RCT, Open-label | Efinopegdutide 20 mg/mL, Semaglutide 1.34 mg/mL |
| NCT00832377 COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED) | Glaucoma | P2 | Completed | 37 | Open-label | timolol/dorzolamide combination |
| NCT00546819 ZOSTAVAX™ in Patients on Chronic/Maintenance Corticosteroids (V211-017) (COMPLETED) | Herpes Zoster | P2 | Completed | 309 | RCT, Double-blind | Zoster Vaccine, Live, Comparator: Placebo |
| NCT03637803 Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors | Oncology, Solid Tumor | P1P2 | Terminated | 63 | Open-label | MRx0518, Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA] |
| NCT02971956 Pembrolizumab in Refractory Advanced Esophageal Cancer | Esophageal Cancer, Squamous Cell Esophagus Cancer | P2 | Completed | 49 | Open-label | Pembrolizumab |
| NCT00266812 Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED) | Carcinoma, Non-Small-Cell Lung | P2 | Terminated | 35 | RCT, Open-label | Temozolomide and radiotherapy |
| NCT01710501 A Study of Different Doses of Grazoprevir (MK-5172) Given With Pegylated Interferon Alfa-2b and Ribavirin to Treatment-Naïve Participants With Chronic Hepatitis C (MK-5172-038) | Chronic Hepatitis C (CHC) | P2 | Completed | 87 | RCT, Double-blind | Grazoprevir, pegylated interferon alfa-2b, Ribavirin, Placebo |
| NCT05597839 Study of DF9001 in Patients With Advanced Solid Tumors | Solid Tumor, Adult | P1P2 | Completed | 24 | Open-label | DF9001, KEYTRUDA® (pembrolizumab) |
| NCT00736970 Oral Deforolimus With Trastuzumab for Patients With HER2-positive Trastuzumab-Refractory Metastatic Breast Cancer (8669-009) | Breast Cancer, Breast Neoplasms | P2 | Completed | 34 | Open-label | ridaforolimus, trastuzumab |
| NCT00551018 Efficacy and Safety of VICRIVIROC in HIV-Infected Treatment-Naïve Subjects (Study P04875) | HIV Infections | P2 | Completed | 218 | RCT, Open-label | Vicriviroc, emtricitabine and tenofovir disoproxil fumarate |
| NCT04815720 Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC) | P1P2 | Completed | 49 | Open-label | pepinemab + pembrolizumab |
| NCT01432574 Study of Gardasil in Mid-Adult Males (MAM) | Human Papillomavirus | P2 | Completed | 150 | Open-label | Gardasil |
| NCT02332720 Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Virus (HCV) Genotype (GT) 3, GT4, GT5, and GT6 Infection (MK-3682-012) | Hepatitis C | P2 | Completed | 413 | RCT, Open-label | Grazoprevir, Uprifosbuvir, Elbasvir, Ruzasvir, MK-3682B, Ribavirin (RBV) |
| NCT00673062 Study of the Effect of SCH 900538 on Congestion in Subjects With Seasonal Allergic Rhinitis (Study P05031)(COMPLETED) | Seasonal Allergic Rhinitis | P2 | Completed | 265 | RCT, Double-blind | SCH 900538, Pseudoephedrine, Placebo Capsules |
| NCT03004183 SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC | Metastatic Non-small Cell Lung Cancer, Metastatic Triple-negative Breast Cancer | P2 | Completed | 57 | Open-label | ADV/HSV-tk, Valacyclovir, Pembrolizumab |
| NCT00092170 An Investigational Agent for the Treatment of Complicated Intra-Abdominal Infections or Acute Pelvic Infections (0826-038) | Infections, Pelvic Infections | P2 | Completed | 100 | RCT, Open-label | MK0826, ertapenem sodium, Comparator: Ticarcillin/Clavulanate |
| NCT04811027 Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC | HNSCC | P2 | Completed | 171 | RCT, Open-label | eftilagimod alpha, pembrolizumab (KEYTRUDA®) |
| NCT03184571 Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) | Lung Cancer Metastatic, NSCLC Stage IV | P2 | Completed | 99 | Open-label | Pembrolizumab, Bemcentinib |
| NCT00739830 Clinical Trial of Ridaforolimus Compared to Progestin or Chemotherapy for Advanced Endometrial Carcinoma (MK-8669-007 AM6) | Endometrial Cancer | P2 | Completed | 130 | RCT, Open-label | ridaforolimus, medroxyprogesterone acetate tablets OR megestrol acetate, chemotherapy |
| NCT00311857 Safety Study of Cetuximab, Radiotherapy and Temozolomide in Primary Glioblastoma Multiforme(GERT) | Glioblastoma Multiforme | P1P2 | Unknown | 46 | Open-label | Cetuximab, Temozolomide |
| NCT00230230 Comparison of SCH 486757 to Codeine and Placebo in Subjects With Persistent Postviral Cough (Study P03069AM2)(COMPLETED) | Cough | P2 | Completed | 91 | RCT, Double-blind | SCH 486757 |
| NCT00988728 Efficacy & Safety of SCH 900435 in Schizophrenia (Study P06079)(WITHDRAWN) | Schizophrenia | P2 | Withdrawn | — | RCT, Double-blind | SCH 900435 (Org 25935), Placebo, Olanzapine |
| NCT00725075 Adjuvant Treatment With a Glycine Uptake Inhibitor in Participants With Negative Symptoms of Schizophrenia (P05695) (MK-8435-001) | Schizophrenia | P2 | Completed | 215 | RCT, Double-blind | MK-8435 (Org 25935) 4-8 mg, Placebo, MK-8435 (Org 25935) 12-16 mg |
| NCT02097108 Changes in Lipids and Lipoproteins in HIV Infected Women After Switch From Protease Inhibitor to Raltegravir | HIV Infections | P2 | Completed | 11 | Open-label | Raltegravir |
| NCT06361810 PSMA Therapy and Immunotherapy in Kidney Cancer | Metastatic Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma | P1P2 | Withdrawn | — | Open-label | Pembrolizumab, 177Lu-PNT2002, (F-18)-DCFPyL |
| NCT03598608 Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003) | Hodgkin Disease, Lymphoma, Non-Hodgkin | P1P2 | Completed | 137 | Open-label | pembrolizumab, Favezelimab |
| NCT00083343 Caspofungin for the Treatment of Non-blood Candida Infections (0991-045) | Candidiasis | P2 | Completed | 48 | Open-label | MK0991, caspofungin acetate/Duration of Treatment: variable |
| NCT01748240 Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine Failure | Myelodysplastic Syndrome | P2 | Terminated | 21 | Open-label | Azacitidine and oral vorinostat |
| NCT05599789 Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004) | Non Small Cell Lung Cancer Metastatic | P2 | Unknown | 47 | Open-label | Pembrolizumab in Combination with Plinabulin and Docetaxel |
| NCT01717287 A Study of the Safety, Tolerability, and Antiretroviral Activity of Raltegravir (MK-0518) in Combination With Other Antiretroviral Therapies in Russian Children and Adolescents Infected With Human Immunodeficiency Virus (HIV-1) (MK-0518-248) | HIV Infection | P2 | Completed | 32 | Open-label | Raltegravir Film-coated Tablet, Raltegravir Chewable Tablet, Other Anti-Retroviral Therapy |
| NCT00321802 Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins | Atrial Fibrillation | P2 | Completed | 40 | RCT, Double-blind | Simvastatin, Placebo |
| NCT03278379 Avelumab in G2-3 NET | Neuroendocrine Tumors | P2 | Completed | 17 | Open-label | Avelumab |
| NCT00853762 Atacicept in Multiple Sclerosis Extension Study, Phase II | Relapsing Multiple Sclerosis | P2 | Terminated | 74 | RCT, Double-blind | Atacicept 25 mg, Atacicept 75 mg, Atacicept 150 mg, Atacicept 150 mg |
| NCT03349450 DPX-Survivac and Checkpoint Inhibitor in DLBCL | Adult Diffuse Large Cell Lymphoma, Recurrent | P2 | Completed | 25 | Open-label | DPX-Survivac, Pembrolizumab, Cyclophosphamide 50mg |
| NCT00362024 MK0952 in Patients With Mild-to-Moderate Alzheimer's Disease (0952-004)(COMPLETED) | Alzheimer's Disease | P2 | Terminated | 24 | RCT, Double-blind | MK0952, Comparator: Placebo |
| NCT04099641 An Open Label Study of Bavituximab and Pembrolizumab in Advanced Gastric and GEJ Cancer Patients | Gastric Cancer, GastroEsophageal Cancer | P2 | Completed | 80 | Open-label | Bavituximab, Pembrolizumab Injection |
| NCT00609154 Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates | Type 2 Diabetes | P1P2 | Terminated | 20 | RCT, Open-label | glucagon like peptide-1 |
| NCT03342937 KeyLargo: Pembrolizumab + Oxaliplatin + Capecitabine in Gastric Cancer | Gastric Cancer, Esophagus Cancer | P2 | Completed | 36 | Open-label | Oxaliplatin+Capecitabine+Pembrolizumab |
| NCT05162586 The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW) | Systemic Lupus Erythematosus | P2 | Completed | 456 | RCT, Double-blind | Enpatoran low dose, Enpatoran medium dose, Enpatoran high dose, Placebo |
| NCT05545969 Neoadjuvant Pembrolizumab and Lenvatinib for Mucosal Melanoma | Mucosal Melanoma | P2 | Withdrawn | — | Open-label | Pembrolizumab, Lenvatinib |
| NCT00397683 A 52-Week Study to Assess the Effects of MK0822 on Knee Osteoarthritis (MK-0822-011) | Osteoarthritis | P2 | Terminated | 2 | RCT, Double-blind | MK0822 |
| NCT04655183 Study of M4344 in Combination With Niraparib | Advanced Solid Tumor, Breast Cancer | P1P2 | Withdrawn | — | RCT, Open-label | Niraparib, M4344, Niraparib, M4344, Niraparib, Niraparib |
| NCT01186705 Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type, PIK3CA-Mutated, Colorectal Cancer | Colon Cancer, Rectal Cancer | P2 | Terminated | 1 | Open-label | MK-2206 |
| NCT02064920 Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318) | Alzheimer's Disease | P2 | Completed | 36 | RCT, Double-blind | Placebo, Donepezil, Donepezil |
| NCT04729348 Pembrolizumab And Lenvatinib In Leptomeningeal Metastases | Solid Tumor, Solid Tumor, Adult | P2 | Terminated | 10 | Open-label | Pembrolizumab, Lenvatinib |
| NCT01260974 Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients | Fungemia, Mycoses | P2 | Unknown | 38 | Open-label | Caspofungin |
| NCT00082524 Documented Candida or Aspergillus Infections in Pediatric Patients (0991-043) | Aspergillosis, Candidiasis | P2 | Completed | 50 | Open-label | caspofungin acetate |
| NCT00543868 MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001) | Stomach Ulcer, Duodenal Ulcer | P2 | Completed | 462 | RCT, Double-blind | MK0782 |
| NCT00130182 A Study in Pediatric Patients With Cystic Fibrosis Lung Disease | Cystic Fibrosis | P2 | Completed | 13 | RCT, Double-blind | denufosol tetrasodium (INS37217) |
| NCT03173560 Trial to Assess Safety and Efficacy of Lenvatinib (18 mg vs. 14 mg) in Combination With Everolimus in Participants With Renal Cell Carcinoma | Renal Cell Carcinoma | P2 | Completed | 343 | RCT, Open-label | lenvatinib, everolimus |
| NCT03029598 Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma | P1P2 | Completed | 29 | Open-label | Carboplatin, Pembrolizumab |
| NCT01012336 Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin | Chemotherapy-Induced Nausea and Vomiting, Ovarian Cancer | P2 | Completed | 89 | Open-label | Aprepitant/Ramosetron/Dexamethasone |
| NCT00420511 Beta-Cell Function and Sitagliptin Trial (BEST) | Type 2 Diabetes Mellitus | P2 | Completed | 21 | RCT, Double-blind | Sitagliptin, Placebo, metformin |
| NCT00684593 A Study to Assess the Clinical Effects of Navarixin in Participants With Psoriasis (MK-7123-009) | Psoriasis | P2 | Completed | 31 | RCT, Double-blind | Navarixin 10 mg |
| NCT05986071 I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers | Breast Cancer | P1P2 | Not Yet Recruiting | 57 | Open-label | M1774, Fulvestrant injection |
| NCT00508664 Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA) | Squamous Cell Carcinoma of the Hypopharynx, Larynx Carcinoma | P2 | Completed | 180 | RCT, Open-label | Cetuximab, Docetaxel, Cisplatin (TP), 5-Fluorouracil (TPF) (only until Feb 2009) |
| NCT00539721 A Randomized Controlled Study of Rolapitant for the Prevention of Nausea and Vomiting Following Surgery (Study P04937AM1)(COMPLETED) | Postoperative Nausea and Vomiting | P2 | Completed | 619 | RCT, Double-blind | Rolapitant Dose 1, Rolapitant Dose 2, Rolapitant Dose 3, Rolapitant Dose 4, Ondansetron, Placebo |
| NCT02886624 Short Duration Therapy of Acute Hepatitis C Genotypes 1 or 4 | Acute Hepatitis C, HIV | P2 | Completed | 30 | Open-label | Grazoprevir/Elbasvir |
| NCT07511023 Phase 2 Trial Of Sacituzumab Tirumotecan For Treatment Of Refractory Metastatic Or Unresectable Squamous Cell Carcinoma Of The Anus/Rectum | Phase 2, Sacituzumab Tirumotecan | P2 | Not Yet Recruiting | 20 | Open-label | Sacituzumab Tirumotecan |
| NCT03514017 Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | P2 | Terminated | 5 | Open-label | Pembrolizumab, Ibrutinib |
| NCT03990961 Pembrolizumab for Patients With PD-L1 Diffuse Large B Cell Lymphoma (DLBCL) | Diffuse Large B Cell Lymphoma, Lymphoma | P2 | Terminated | 5 | Open-label | Pembrolizumab |
| NCT02599779 A Proof of Principle Study of Pembrolizumab With SBRT in TKI mRCC Patients | Stage IV Renal Cell Cancer AJCC V7 | P2 | Completed | 4 | Open-label | Pembrolizumab |
| NCT04931979 SRT in Combination With Pembrolizumab in Patients With Recurrent Prostate Cancer After Radical Prostatectomy | Urologic Cancer, Biochemical Recurrence of Malignant Neoplasm of Prostate | P2 | Unknown | 49 | Open-label | Pembrolizumab Injection [Keytruda] |
| NCT04358237 Lurbinectedin (PM01183) Combined With Pembrolizumab in Small Cell Lung Cancer. | Small Cell Lung Carcinoma | P1P2 | Completed | 28 | Open-label | Lurbinectedin, Pembrolizumab |
| NCT01134627 Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS] | Multiple Sclerosis, Relapsing-Remitting | P2 | Terminated | 305 | RCT, Double-blind | Minocycline, Placebo |
| NCT03331562 A SU2C Catalyst® Trial of a PD1 Inhibitor With or Without a Vitamin D Analog for the Maintenance of Pancreatic Cancer | Pancreatic Cancer, Pancreas Adenocarcinoma | P2 | Completed | 24 | RCT, Double-blind | Pembrolizumab, paricalcitol, placebo |
| NCT03149822 Study of Pembrolizumab and Cabozantinib in Patients With Metastatic Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | P1P2 | Completed | 45 | Open-label | Cabozantinib, Pembrolizumab |
| NCT03025035 Pembrolizumab in Combination With Olaparib in Advanced BRCA-mutated or HDR-defect Breast Cancer | Breast Cancer | P2 | Completed | 14 | Open-label | Pembrolizumab, Olaparib |
| NCT00387140 A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005) | Pain, Postoperative, Tooth Extraction | P2 | Completed | 89 | RCT, Double-blind | MK2295 |
| NCT02630368 A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX) | Solid Tumors, Soft-tissue Sarcoma | P1P2 | Unknown | 197 | RCT, Open-label | Cyclophosphamide and JX-594 dose escalation, Cyclophosphamide and JX-594, Cyclophosphamide, Avelumab and JX-594 and Cyclophosphamide |
| NCT03674567 Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination with Pembrolizumab | Advanced Cancer | P1P2 | Completed | 323 | Open-label | FLX475, pembrolizumab (KEYTRUDA®) |
| NCT00555399 Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM) | Glioblastoma Multiforme, Anaplastic Glioma | P1P2 | Terminated | 55 | RCT, Open-label | Vorinostat, Isotretinoin, Temozolomide |
| NCT00783601 MK0524 Asthma POC Study (0524-008)(COMPLETED) | Asthma | P2 | Completed | 130 | RCT, Double-blind | Comparator: MK0524 + placebo, Comparator: MK0524 + montelukast, Comparator: placebo + montelukast, Comparator: Placebo |
| NCT03077828 Pembrolizumab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma | Lymphocyte-Rich Classical Hodgkin Lymphoma, Recurrent Lymphocyte-Depleted Classical Hodgkin Lymphoma | P2 | Unknown | 43 | Open-label | Carboplatin, Etoposide, Ifosfamide, Pembrolizumab |
| NCT03379506 Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079) | HCV Infection | P2 | Completed | 57 | Open-label | EBR/GZR FDC Tablet, Placebo, Grazoprevir Oral Granules, Elbasvir Oral Granules |
| NCT00910000 Vorinostat, Carboplatin and Gemcitabine in Women With Recurrent, Platinum-Sensitive Ovarian Cancer | Ovarian Cancer, Fallopian Tube Cancer | P1P2 | Terminated | 15 | Open-label | Vorinostat, Carboplatin, Gemcitabine |
| NCT03654326 A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034) | Endometriosis-related Pain | P2 | Completed | 187 | RCT, Double-blind | Gefapixant, Placebo, Naproxen |
| NCT07368985 Pembrolizumab and Lenvatinib in Patients With High Risk Locally Advanced Cervix Cancer | Cervical Cancer by FIGO Stage 2018, Squamous Cell Carcinoma FIGO 2018 Stage IIIA, IIIB, IIIC1-IIIC2 | P2 | Not Yet Recruiting | 87 | Open-label | pembrolizumab and lenvatinib |
| NCT02255110 A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma | Soft Tissue Sarcoma | P2 | Terminated | 6 | Open-label | TH-302, Doxorubicin |
| NCT00825487 Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies | Metastatic Solid Tumors, Refractory/Relapsed Hematologic Malignancies | P1 | Completed | 50 | Open-label | ARQ 621 |
| NCT02387125 Phase 1b Safety Study of CMB305 in Patients With Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1 | Sarcoma, Melanoma | P1 | Terminated | 79 | Open-label | CMB305, G100, Metronomic CPA |
| NCT03006926 A Trial of Lenvatinib Plus Pembrolizumab in Participants With Hepatocellular Carcinoma | Hepatocellular Carcinoma | P1 | Completed | 104 | Open-label | lenvatinib, pembrolizumab (200 mg) |
| NCT00075933 ARQ 501 in Subjects With Cancer | Cancer | P1 | Completed | 80 | Open-label | ARQ 501 |
| NCT02553356 PT2385-102 Food Effect Study of PT2385 in Healthy Volunteers | Healthy | P1 | Completed | 16 | RCT, Open-label | PT2385 |
| NCT03478319 A Study of ACE-2494 in Healthy Subjects | Healthy Volunteers | P1 | Completed | 48 | RCT, Double-blind | ACE-2494 or placebo |
| NCT05603182 A Study of PRA052 in Healthy Volunteers | Healthy | P1 | Completed | 96 | RCT, Double-blind | PRA052 |
| NCT02508740 Single Oral Dose of Bevenopran in Patients With Varying Degrees of Renal Impairment | Renal Impairment | P1 | Terminated | 31 | RCT, Open-label | bevenopran |
| NCT03445169 A Food Effect Study in Healthy Volunteers With Belzutifan (PT2977, MK-6482) Tablets | Healthy | P1 | Completed | 16 | RCT, Open-label | Belzutifan |
| NCT02257489 Phase 1 Study of ACE-083 in Healthy Subjects | Musculoskeletal Diseases | P1 | Completed | 58 | RCT, Double-blind | ACE-083 |
| NCT00658554 Bioequivalence Study of ARQ 197 Amorphous and Crystalline Polymorphs A and B in Normal Healthy Volunteers | Healthy | P1 | Completed | 24 | RCT, Open-label | ARQ 197 |
| NCT00398840 A Study of ARQ 171 in Patients With Advanced Solid Tumors | Cancer | P1 | Terminated | 14 | Open-label | ARQ 171 |
| NCT01397604 The Effects of GLA on Human Volunteers | Healthy Volunteers | P1 | Completed | 32 | RCT, Double-blind | GLA-AF, GLA-SE |
| NCT02083627 A Study to Assess the Effects of Multiple Doses of Fidaxomicin on a Single Dose of Rosuvastatin in Healthy Male Subjects | Drug-Drug Interaction (DDI), Intestinal Absorption | P1 | Completed | 25 | RCT, Open-label | rosuvastatin, fidaxomicin |
| NCT01156077 Pharmacokinetic (PK) Study of Oral and IV TR-701 FA in Adolescent Patients | Bacterial Infection | P1 | Completed | 20 | Open-label | TR-701 FA, TR-701 FA |
| NCT02035657 A Proof-of-Concept Trial of GLA-SE in Patients With Merkel Cell Carcinoma | Merkel Cell Carcinoma | P1 | Completed | 10 | Open-label | GLA-SE |
| NCT01019395 Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics | Gram Positive Bacterial Infection | P1 | Completed | 23 | Open-label | Daptomycin |
| NCT04676178 A Study of PRA023 in Healthy Volunteers | Healthy | P1 | Completed | 69 | RCT, Double-blind | PRA023 |
| NCT00709540 A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women | Osteoporosis | P1 | Completed | 40 | RCT, Double-blind | ACE-011 or placebo |
| NCT01496677 Pharmacokinetics, Safety, and Tolerability of TR-701 Free Acid (FA) in Elderly Subjects | Healthy Subjects | P1 | Completed | 28 | RCT, Open-label | TR-701 FA 200 mg, TR-701 FA 200 mg |
| NCT01225536 Dose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS Mutations | Solid Tumor | P1 | Completed | 24 | Open-label | ARQ 736 |
| NCT00490737 Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021) | End-Stage Renal Disease | P1 | Completed | 12 | Open-label | daptomycin |
| NCT01724320 A Phase I, First-in-man Study of OTX008 Given Subcutaneously as a Single Agent to Patients With Advanced Solid Tumors | Solid Tumors | P1 | Unknown | 20 | Open-label | OTX008 |
| NCT02508753 Safety Study Designed to Study the Effects of Two Different Doses of CXA-101/Tazobactam, a Low Dose and a High Dose, on the QT/QTc Intervals in Healthy Subjects | Healthy | P1 | Completed | 52 | RCT, Double-blind | CXA-101/tazobactam, CXA-101/tazobactam, Moxifloxacin, placebo |
| NCT05354349 Bioavailability of SC Formulation and Japanese Ethnobridging Study for PRA023 | Healthy | P1 | Completed | 49 | RCT, Double-blind | PRA023 IV Low Dose, PRA023 SC, Placebo IV, Placebo SC, PRA023 IV High Dose |
| NCT02492776 A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations | Healthy | P1 | Completed | 14 | Open-label | Omeprazole, Gefapixant, Gefapixant |
| NCT04948554 A Study of MK-2225 / ACE-1334 in Participants With Systemic Sclerosis With and Without Interstitial Lung Disease (MK-2225-002) | Systemic Sclerosis With and Without Interstitial Lung Disease | P1 | Terminated | 5 | RCT, Double-blind | MK-2225, Placebo |
| NCT00679835 PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infections | Gram Positive Infection, Concurrent Antibiotic Treatment | P1 | Completed | 24 | Open-label | daptomycin |
| NCT00876655 Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid Phosphate | Healthy | P1 | Completed | 12 | RCT, Open-label | TR-701 di-sodium phosphate salt, TR-701 free acid phosphate |
| NCT03872206 Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression | Advanced Cancers Associated With Mesothelin Expression | P1 | Completed | 95 | Open-label | HPN536 Fixed IV 6 to 560 ng/kg, HPN536 1 Prime Step IV 600-1200 ng/kg Target, 2 Prime Step IV 900-14000 ng/kg Target |
| NCT00802555 Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC) | Cirrhosis, Hepatocellular Carcinoma | P1 | Completed | 21 | Open-label | ARQ 197 |
| NCT00827177 Dose Escalation Study of ARQ 197 in Combination With Sorafenib in Adult Patients With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 87 | Open-label | Treatment with ARQ 197 in combination with sorafenib |
| NCT01149720 Determination of the Relative Bioavailability of ARQ 197 Tablet Formulation With Capsule C Formulation as a Reference in Subjects With Advanced Solid Tumors | Solid Tumors | P1 | Completed | 24 | RCT, Open-label | Tivantinib (ARQ 197) Capsule, Tivantinib (ARQ 197) Tablet, Tivantinib (ARQ 197) Capsule D, oral |
| NCT00671814 Single and Multiple Ascending Dose Pharmacokinetic Study of TR701 in Healthy Adults | Healthy Subjects | P1 | Completed | 80 | RCT, Double-blind | TR-701, linezolid, placebo |
| NCT02015416 A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer | Melanoma, Ovarian Cancer | P1 | Completed | 13 | Open-label | IDC-G305 |
| NCT01431833 A PK and Safety Study in Subjects With Hepatic Impairment | Hepatic Impairment | P1 | Completed | 32 | Open-label | TR-701 FA |
| NCT03833180 A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001) | Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma | P1 | Completed | 91 | Open-label | Zilovertamab vedotin |
| NCT01432717 Study of ACE-536 in Healthy Postmenopausal Women | Anemia | P1 | Completed | 40 | RCT, Double-blind | ACE-536 |
| NCT01473095 Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma | Solid Tumor, Malignant Lymphoma | P1 | Completed | 120 | Open-label | ARQ 092 |
| NCT01713582 A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001) | Acute Myeloid Leukemia, Diffuse Large B-cell Lymphoma | P1 | Completed | 141 | Open-label | OTX015/Birabresib |
| NCT01577459 A Phase 1 Crossover Study of Blood Pressure and Heart Rate Response | Healthy Subjects | P1 | Completed | 18 | RCT, Double-blind | TR-701 FA with PSE |
| NCT00651638 A Study of ARQ 197 in Healthy Volunteers to Assess the Pharmacokinetic (PK) Profile in Extensive and Poor Metabolizers as Defined by Cytochrome P450 2C19 (CYP 2C19) Genotype | Healthy | P1 | Completed | 17 | Open-label | Treatment with ARQ 197 |
| NCT01461460 A Thorough QT Study of TR-701free Acid (FA) in Healthy Subjects | Healthy Volunteer | P1 | Completed | 48 | RCT, Double-blind | TR-701 FA 1200 mg, Moxifloxacin 400 mg, TR-701 FA 200 mg plus Placebo, Placebo |
| NCT00882557 Study to Evaluate Daptomycin Given During Dialysis and After Dialysis | End-stage Renal Disease, Renal Failure Chronic Requiring Hemodialysis | P1 | Completed | 16 | RCT, Open-label | daptomycin, daptomycin |
| NCT00671359 Food Effects of Single Oral Dose of 600mg TR-701 | Healthy | P1 | Completed | 12 | RCT, Open-label | TR-701 600mg |
| NCT02790840 A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations | Healthy | P1 | Completed | 32 | Open-label | Omeprazole, Omeprazole, Gefapixant, Gefapixant |
| NCT01813448 A Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Fidaxomicin in Healthy Male Japanese and Caucasian Subjects | Pharmacokinetics of Fidaxomicin, Healthy Subjects | P1 | Completed | 36 | RCT, Double-blind | Fidaxomicin, Placebo |
| NCT02229877 A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264) | Healthy Volunteers | P1 | Completed | 18 | Single-blind | Omeprazole, Gefapixant, Gefapixant, Gefapixant |
| NCT01271998 Pulmonary Disposition of TR-700 Following Once-Daily Oral 200 mg | Bacterial Infection | P1 | Completed | 20 | Open-label | TR-701 FA |
| NCT01539473 A Phase 1 TR-701 FA Study of Blood Pressure Response Post Tyramine Challenge | Healthy Volunteers | P1 | Completed | 30 | RCT, Double-blind | TR-701 FA with Tyramine, Placebo-controlled withTyramine |
| NCT01502800 Clinical Trial of ARQ 761 in Advanced Solid Tumors | Solid Tumors | P1 | Completed | 91 | RCT, Open-label | ARQ 761, ARQ 761 Weekly Administration, Bi-Weekly Administration of ARQ 761, Two Consecutive Weeks Administration of ARQ 761 with one week of rest |
| NCT01442831 Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects | Healthy | P1 | Completed | 6 | Open-label | Human ADME |
| NCT02259114 A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) | NUT Midline Carcinoma, Triple Negative Breast Cancer | P1 | Completed | 47 | Open-label | Birabresib |
| NCT00755638 A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 (ActRIIB-IgG1)in Healthy Postmenopausal Volunteers | Muscle Loss | P1 | Completed | 48 | RCT, Double-blind | ACE-031 |
| NCT02650895 Safety Study of Efprezimod Alfa (CD24Fc, MK-7110) When Administered Intravenously in Healthy Adult Subjects (MK-7110-001) | Healthy Volunteers | P1 | Completed | 40 | RCT, Double-blind | Efprezimod alfa, Saline |
| NCT00952887 A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women | Muscular Atrophy | P1 | Completed | 70 | RCT, Double-blind | ACE-031, Placebo |
| NCT04222985 Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2 | Genital Herpes | P1 | Terminated | 24 | RCT, Double-blind | HSV 2 Formulation 1, HSV 2 Formulation 2, HSV 2 Formulation 3, HSV 2 Formulation 4, HSV 2 Formulation 5, HSV 2 Formulation 6, Sodium Chloride 0.9% |
| NCT02266706 Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010) | Proven or Suspected Gram-negative Bacterial Infection, Peri-operative Prophylaxis | P1 | Completed | 43 | Open-label | Ceftolozane/Tazobactam 1000/500 mg, Ceftolozane/Tazobactam 30/15 mg/kg, Ceftolozane/Tazobactam 20/10 mg/kg, Ceftolozane/Tazobactam 18/9 mg/kg, Ceftolozane/Tazobactam 12/6 mg/kg |
| NCT00136292 Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibiotics | Gram-positive Bacterial Infections | P1 | Completed | 33 | Open-label | daptomycin |
| NCT00612703 A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors | Cancer | P1 | Completed | 32 | Open-label | ARQ 197 |
| NCT01452828 A Pharmacokinetics and Safety Study in Subjects With Renal Impairment | Renal Impairment | P1 | Completed | 24 | Open-label | TR-701 FA single infusion, TR-701 FA, TR-701 FA |
| NCT00666601 Microdialysis and Pharmacokinetic Study of TR-701 | Healthy | P1 | Completed | 15 | Open-label | TR-700 (active moiety), TR-701 (pro-drug) |
| NCT03006887 Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors | Solid Tumors | P1 | Completed | 6 | Open-label | lenvatinib, pembrolizumab |
| NCT02476955 Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole | Solid Tumors, Ovarian Cancer | P1 | Terminated | 41 | Open-label | ARQ 092 + carboplatin + paclitaxel (Closed), ARQ 092 + paclitaxel (Closed), ARQ 092 + anastrozole |
| NCT00983255 Ascending Dose Pharmacokinetic (PK) and Absolute Bioavailability (BA) | Bacterial Infections | P1 | Completed | 90 | RCT, Double-blind | TR-701 FA for injection, 200 mg/vial, TR-701 FA tablets |
| NCT02761694 Vevorisertib (ARQ 751) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations (MK-4440-001) | Cancer, Solid Tumors | P1 | Terminated | 78 | Open-label | Vevorisertib, Fulvestrant, Paclitaxel |
| NCT02387372 Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007) | Critically Ill, Pneumonia | P1 | Completed | 37 | Open-label | Ceftolozane/Tazobactam - Multiple Doses, Ceftolozane/Tazobactam - Single Dose |
| NCT01623401 A Phase 1, Open-Label, 10 Day Safety Study | Healthy Subjects | P1 | Completed | 72 | Open-label | TR-701 FA |
| NCT00302172 ARQ 197 in Subjects With Metastatic Solid Tumors | Cancer, Tumor | P1 | Completed | 78 | Open-label | ARQ 197 |
| NCT00524524 An Exploratory Biomarker Study of ARQ 501 in Patients With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 9 | Open-label | ARQ 501 |
| NCT00612209 A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors | Cancer, Advanced Solid Tumors | P1 | Completed | 51 | Open-label | ARQ 197 |
| NCT02652936 A Pharmacokinetics Study of AF-130 in Healthy Subjects | Healthy Volunteers | P1 | Completed | 80 | RCT, Double-blind | AF-130, Placebo comparator |
| NCT02341599 Study of Pharmacokinetics of a Single IV Dose of CB-238,618 in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Subjects (MK-6183-001) | Healthy Volunteers, Renal Impairment | P1 | Completed | 40 | Open-label | MK-6183 |
| NCT00874042 Dose Escalation Study of ARQ 197 in Combination With Gemcitabine in Adult Patients With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 74 | Open-label | Treatment with ARQ 197 in combination with gemcitabine |
| NCT02122861 Phase 1 Study of Intradermal LV305 in Patients With Locally Advanced, Relapsed or Metastatic Cancer Expressing NY-ESO-1 | Melanoma - Currently Enrolling, Non-small Cell Lung Cancer - Enrollment Completed | P1 | Completed | 47 | Open-label | ID-LV305 |
| NCT00996957 Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma | Advanced Solid Tumors, Multiple Myeloma | P1 | Completed | 37 | Open-label | ACE-041 |
| NCT00099190 ARQ 501 in Combination With Docetaxel in Patients With Cancer | Carcinoma | P1 | Completed | 50 | Open-label | ARQ 501 |
| NCT00851643 Broad Spectrum HPV Vaccine Dose Escalation Study (V502-002) | Human Papilloma Virus, Cervical Cancer | P1 | Completed | 158 | RCT, Double-blind | Octavalent HPV with 15 mcg IMX / AAHS, Octavalent HPV with 30 mcg IMX / AAHS, Octavalent HPV with 60 mcg IMX / AAHS, Octavalent HPV with 120 mcg IMX / AAHS, Comparator: Quadrivalent HPV Vaccine (qHPV), (GARDASIL™) |
| NCT01288417 Pharmacokinetic Study of the HCV Protease Inhibitor Boceprevir and the HIV Integrase Inhibitor Raltegravir | HIV Infections, HCV Infections | P1 | Completed | 24 | RCT, Open-label | boceprevir, raltegravir |
| NCT00111813 Phase 1 Study of Vorinostat and Bortezomib in Multiple Myeloma (MK-0683-015 EXT 1 (AM1)) | Multiple Myeloma | P1 | Completed | 34 | Open-label | vorinostat, bortezomib |
| NCT02835105 A Study of Ascending Single Doses of Surotomycin in Healthy Participants (MK-4261-008) | Clostridium Difficile Associated Diarrhea (CDAD) | P1 | Completed | 40 | RCT, Double-blind | Surotomycin, Placebo |
| NCT06615869 A Study to Evaluate Molnupiravir Tablet Formulation Compared to the Molnupiravir Capsule Formulation in Healthy Adult Participants (MK-4482-011) | Healthy | P1 | Completed | 64 | RCT, Open-label | Molnupiravir |
| NCT06688045 A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013) | Healthy | P1 | Completed | 15 | Open-label | Nemtabrutinib, Itraconazole |
| NCT00302471 MK0429 Study in Prostate Cancer Patients With Metastatic Bone Disease (0429-011) | Prostatic Neoplasms | P1 | Completed | 29 | RCT, Double-blind | Comparator: MK0429, Comparator: MK0429, Comparator: MK0429, Comparator: MK0429 |
| NCT01174199 Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer | Prostate Cancer, Adenocarcinoma of the Prostate | P1 | Terminated | 13 | Open-label | vorinostat, temsirolimus |
| NCT00871871 Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed) | Hypertension | P1 | Completed | 64 | RCT, Double-blind | Hydrochlorothiazide (HCTZ), Comparator: Placebo to HCTZ, Isosorbide mononitrate (ISMN), Comparator: Placebo to ISMN |
| NCT06626464 A Study of MK-8189 Human Absorption, Metabolism, and Excretion in Healthy Male Participants (MK-8189-010) | Healthy | P1 | Completed | 6 | Open-label | [14C]MK-8189 |
| NCT01934647 Acute Dosing of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-003) | Pulmonary Arterial Hypertension | P1 | Terminated | 7 | Open-label | MK-8892 |
| NCT06619665 A Study of MK-6552 in Sleep Deprived Healthy Participants (MK-6552-003) | Healthy, Narcolepsy | P1 | Completed | 18 | RCT, Double-blind | MK-6552, MK-6552 placebo, Modafinil, Modafinil placebo |
| NCT01630616 A Study of Odanacatib When Administered to Adolescents and Young Adults Treated With Glucocorticoids (MK-0822-066) | Osteoporosis | P1 | Terminated | 19 | RCT, Double-blind | Odanacatib, Placebo |
| NCT06658652 The Effect of Food and Water Volume in Healthy Adult Participants Administered Enlicitide Decanoate (MK-0616) (MK-0616-022) | Healthy | P1 | Completed | 34 | RCT, Open-label | Enlicitide decanoate |
| NCT01014936 First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors | Patients With Solid Tumors, Either Refractory to Standard Therapy or for Which no Effective Standard Therapy is Available | P1 | Completed | 149 | Open-label | MSC2156119J |
| NCT01919125 Pharmacokinetics of IDX719 in Participants With Normal and Impaired Hepatic Function (MK-1894-008) | Hepatitis C, Chronic | P1 | Completed | 36 | Open-label | IDX719 |
| NCT00518297 DDI HV (ATV - Merck) | HIV Infections | P1 | Completed | 22 | Open-label | Raltegravir, Atazanavir, Atazanavir + Raltegravir |
| NCT00935259 Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED) | Hypercholesterolemia, Dyslipidemia | P1 | Completed | 31 | RCT, Double-blind | Simvastatin, Placebo |
| NCT06575595 Pharmacokinetic (PK) Characterization of Subcutaneous Tulisokibart (MK-7240-010) | Healthy | P1 | Completed | 60 | RCT, Open-label | Tulisokibart |
| NCT01640873 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8655 in Participants With Type 2 Diabetes (MK-8655-002) | Type 2 Diabetes | P1 | Completed | 33 | RCT, Double-blind | MK-8655, Placebo |
| NCT05277402 ADG116 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors | Advanced/Metastatic Solid Tumors | P1 | Completed | 6 | Open-label | ADG116 |
| NCT01713036 Oral Bioavailability and Mass Balance Trial With Pimasertib | Locally Advanced or Metastatic Solid Tumors | P1 | Completed | 6 | Open-label | Pimasertib |
| NCT00694356 Study of Dalotuzumab (MK-0646) in Adults With Solid Tumors (MK-0646-009) | Neoplasm | P1 | Completed | 15 | Open-label | Dalotuzumab |
| NCT01012102 EMD 640 744 in Montanide ISA 51 VG Administered in Subjects With Advanced Solid Tumors | Advanced Solid Tumors | P1 | Completed | 104 | RCT, Open-label | EMD 640744, EMD 640744, EMD 640744 |
| NCT02313272 Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas | Malignant Glioma | P1 | Completed | 32 | Open-label | Pembrolizumab, Bevacizumab |
| NCT00767364 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome | Short Bowel Syndrome | P1 | Completed | 8 | Open-label | Oral, live, pentavalent rotavirus vaccine; RotaTeq(R) |
| NCT01451437 Study of MK-8242 Alone and in Combination With Cytarabine in Participants With Acute Myelogenous Leukemia (P07649) | Acute Myelogenous Leukemia (AML) | P1 | Terminated | 26 | Open-label | MK-8242 |
| NCT01323855 A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512) | Parkinson Disease | P1 | Completed | 46 | Open-label | Preladenant |
| NCT01294735 Study of the Safety and Efficacy of MK-4827 Given With Temozolomide in Participants With Advanced Cancer (MK-4827-014 AM1) | Recurrence of Solid Tumor, Glioblastoma Multiforme | P1 | Completed | 19 | Open-label | MK-4827, Temozolomide |
| NCT02269423 Vaccine Treatment for Ebola Virus in Healthy Adults (V920-001) | Ebola Virus | P1 | Completed | 39 | RCT, Double-blind | V920 |
| NCT00559182 A Study of MK-8033 in Patients With Advanced Solid Tumors (MK-8033-001) | Advanced Cancer | P1 | Completed | 47 | Open-label | Comparator: MK-8033, Comparator: MK-8033 +/- omeprazole |
| NCT00954993 Pharmacokinetics of Vaniprevir (MK-7009) and Hepatitis C Virus RNA Levels After Vaniprevir Treatment (MK-7009-029) | Chronic Hepatitis C Infection | P1 | Terminated | 3 | Open-label | Vaniprevir |
| NCT00894114 A Study of Safety, Tolerability and Immunogenicity of a 1-Dose Regimen of MRKAd5 HIV-1 Gag Vaccine Versus the ALVAC_HIV Vaccine (V520-019) | HIV-1 Infection | P1 | Completed | 250 | RCT, Double-blind | V520, Comparator: ALVAC-HIV vaccine |
| NCT00849732 A Worldwide, Phase I, Dose-Escalating Study of a 3-Dose Regimen of the MRKAd5 (Clade B) Vaccine in Healthy Adults (V520-018) | HIV-1, HIV Infections | P1 | Completed | 360 | RCT, Double-blind | V520, Comparator: V520 (1x10^9 vp/d), Comparator: V520 (1x10^10 vp/d), Comparator: Placebo |
| NCT02364609 Pembrolizumab and Afatinib in Patients With Non-small Cell Lung Cancer With Resistance to Erlotinib | Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer | P1 | Completed | 11 | Open-label | Afatinib Dimaleate, Pembrolizumab |
| NCT00838929 Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases | Brain Metastases | P1 | Completed | 17 | Open-label | Vorinostat |
| NCT00944645 MK0524A Bioequivalence Study (0524A-059) | Dyslipidemia | P1 | Completed | 188 | RCT, Open-label | niacin (+) laropiprant (Source 1), Comparator: niacin (+) laropiprant (Source 2) |
| NCT00694083 Study of Ridaforolimus (MK-8669) in Participants With Solid Tumors (MK-8669-003)(COMPLETED) | Neoplasm | P1 | Completed | 13 | Open-label | Ridaforolimus |
| NCT00851266 A Study of a Bivalent Influenza Peptide Conjugate Vaccine in Healthy Adults | Influenza | P1 | Completed | 187 | RCT, Double-blind | V512, Comparator: Placebo to V512 |
| NCT01023737 Hydroxychloroquine + Vorinostat in Advanced Solid Tumors | Malignant Solid Tumour | P1 | Completed | 72 | Open-label | Hydroxychloroquine, Vorinostat |
| NCT01470690 Pharmacokinetic Study of the HCV Protease Inhibitor Bo-cePRevir and the Proton Pump Inhibitor OMeprazOle (PROMO) | HCV Infections, Gastric Acid-related Disorders | P1 | Completed | 24 | RCT, Open-label | boceprevir, Omeprazole |
| NCT03374254 Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651/KEYNOTE-651) | Metastatic Colorectal Cancer | P1 | Completed | 116 | Open-label | Pembrolizumab, Binimetinib, Oxaliplatin, Leucovorin, 5-Fluorouracil [5-FU], Irinotecan |
| NCT05466422 A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002) | Alzheimer Disease | P1 | Completed | 34 | RCT, Double-blind | MK-2214, Placebo |
| NCT02530502 Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma | Adult Glioblastoma | P1 | Terminated | 4 | Open-label | Pembrolizumab, Temozolomide |
| NCT02112942 Study Assessing Single and Multiple Doses of IDX21459 in Healthy and HCV-Infected Subjects | Chronic Hepatitis C | P1 | Terminated | 48 | RCT, Double-blind | IDX21459, Matching Placebo |
| NCT01215175 Safety and Tolerability Study for the Pneumococcal Conjugate Vaccine V114 Versus Prevnar™ (V114-001) | Pneumococcal Infections | P1 | Completed | 150 | RCT, Double-blind | Prevnar™, V114, Aluminum Adjuvanted, V114, Aluminum Nonadjuvanted |
| NCT00109109 A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004) | Multiple Myeloma | P1 | Terminated | 60 | Open-label | MK0683, vorinostat, Suberoylanilide Hydroxamic Acid (SAHA) / Duration of Treatment - Up to 8 Cycles or 6 months |
| NCT00106145 A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014) | Advanced Breast Cancer, Other Solid Tumors | P1 | Completed | 103 | Open-label | Comparator: MK0752, Notch Inhibitor, Comparator: MK0752, Notch Inhibitor - 450 mg, Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off, Comparator: MK0752, Notch Inhibitor - 1 day on, 6 off, Comparator: MK0752, Notch Inhibitor - 3 days on, 4 off 350 mg |
| NCT06633419 A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012) | Healthy | P1 | Completed | 14 | Open-label | Opevesostat, Prednisone, Fludrocortisone acetate, Carbamazepine |
| NCT02621398 Pembrolizumab, Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-IIIB Non-Small Cell Lung Cancer | Stage II Non-Small Cell Lung Cancer, Stage IIIA Non-Small Cell Lung Cancer | P1 | Completed | 23 | Open-label | Carboplatin, Paclitaxel, Pembrolizumab |
| NCT02910739 An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016) | Amnestic Mild Cognitive Impairment, Alzheimer's Disease | P1 | Completed | 16 | Open-label | MK-8931 |
| NCT01343407 A Two-part Study of the Effects of MK-1029 in Allergen-Challenged Asthmatics (MK-1029-003) | Asthma | P1 | Completed | 16 | RCT, Double-blind | MK-1029 10 mg, MK-1029 100 mg, Placebo for MK-1029 10 mg, Placebo for MK-1029 100 mg |
| NCT01324440 Safety, Tolerability, and Immunogenicity of a Single Dose of Merck 0657nI Staphylococcus Aureus Vaccine With or Without Merck Aluminum Adjuvant (V710-002) | Staphylococcal Infections | P1 | Completed | 64 | RCT, Double-blind | V710 (30 µg) with MAA, V710 (30 µg) without MAA |
| NCT07063238 A Clinical Study of MK-8527 in Healthy Adult Participants (MK-8527-014) | Healthy | P1 | Completed | 42 | RCT, Double-blind | MK-8527, Moxifloxacin, Placebo |
| NCT04665050 Safety, Tolerability, and Immunogenicity of a Polyvalent Pneumococcal Conjugate Vaccine (V116) in Japanese Adults (V116-002) | Pneumococcal Infection | P1 | Completed | 102 | RCT, Double-blind | V116, PNEUMOVAX™23 |
| NCT02835690 Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Pembrolizumab (MK-3475) in Chinese Participants With Non-Small-Cell Lung Cancer (MK-3475-032/KEYNOTE-032) | Non-Small-Cell Lung Cancer | P1 | Completed | 44 | RCT, Open-label | Pembrolizumab |
| NCT01798849 A Rising Single Dose Study of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics of MK-8892 (MK-8892-001) | Pulmonary Arterial Hypertension | P1 | Completed | 25 | RCT, Double-blind | MK-8892, Placebo for MK-8892 |
| NCT02699515 MSB0011359C (M7824) in Participants With Metastatic or Locally Advanced Solid Tumors | Solid Tumors | P1 | Completed | 114 | Open-label | MSB0011359C |
| NCT01656408 A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-8150 (MK-8150-002) | Hypertension, Isolated Systolic Hypertension | P1 | Completed | 103 | RCT, Double-blind | MK-8150, Placebo for MK-8150 |
| NCT00990821 A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012) | Chemotherapy-Induced Nausea and Vomiting, Postoperative Nausea and Vomiting | P1 | Completed | 188 | RCT, Double-blind | 90 mg MK-0517 (PS80), 100 mg MK-0517 (PS80), 100 MK-0517 (PS80) + 2 mg midazolam, 115 mg MK-0517 (PS80), 150 mg MK-0517 (PS80), 40 mg MK-0517 (non-PS80), 100 mg MK-0517 (non-PS80), 150 mg MK-0517 (Non-PS80), Placebo, 40 mg Aprepitant, 125 mg Aprepitant, 2 mg Midazolam |
| NCT03514719 PD-L1 Imaging in Non Small Cell Lung Cancer' (PINNACLE) | Non Small Cell Lung Cancer | P1 | Completed | 24 | Open-label | Avelumab |
| NCT03745144 Effects of Cladribine Tablets on the PK of Microgynon® | Relapsing Multiple Sclerosis (RMS) | P1 | Completed | 28 | RCT, Double-blind | Cladribine, Placebo, Microgynon® |
| NCT01840579 Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011) | Solid Tumor, Non-small Cell Lung Cancer | P1 | Completed | 57 | Open-label | Pembrolizumab 2 mg/kg, Pembrolizumab 10 mg/kg, Pembrolizumab 200 mg, Cisplatin 75 mg/m^2, Pemetrexed 500 mg/m^2, Carboplatin AUC 5 mg/mL/min, Carboplatin AUC 6 mg/mL/min, Paclitaxel 200 mg/m^2, Nab-paclitaxel 100 mg/m^2, Ipilimumab 1 mg/kg, Etoposide 100 mg/m^2, G-CSF (pegfilgrastim) 3.6 mg |
| NCT01537120 Evaluation of Continuous Glucose Monitoring in Participants With Type 2 Diabetes Mellitus (MK-0000-258 AM2) | Type 2 Diabetes Mellitus | P1 | Completed | 25 | Single-blind | Vildagliptin, Placebo |
| NCT00759785 A Study of Dalotuzumab (MK-0646) in Breast Cancer Patients (MK-0646-013) | Breast Cancer | P1 | Completed | 48 | RCT, Open-label | dalotuzumab (MK0646) |
| NCT00886613 A Study to Evaluate Immunity to Varicella Zoster Virus After Immunization With V212 Vaccine or Zostavax (V212-003) | Herpes Zoster | P1 | Completed | 120 | RCT, Double-blind | V212, Comparator: Zostavax™, Comparator: Placebo |
| NCT03871959 Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma | Adenocarcinoma of the Pancreas, Adenocarcinoma of the Colon | P1 | Completed | 54 | Open-label | Pembrolizumab, DEBIO1143 |
| NCT06880874 A Clinical Study to Evaluate Enlicitide (MK-0616) Formulations in Healthy Adult Participants (MK-0616-035) | Healthy | P1 | Completed | 40 | RCT, Open-label | Enlicitide |
| NCT05213481 Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants | Healthy | P1 | Completed | 18 | Open-label | Tepotinib, Carbamazepine |
| NCT00917696 Study to Evaluate ATP-induced Pain and ATP-induced Dermal Vasodilation by Iontophoresis (0000-118)(COMPLETED) | Osteoarthritis Pain | P1 | Completed | 44 | RCT, Double-blind | — |
| NCT00667433 Raltegravir as Early Therapy in African-Americans Living With HIV Study | HIV Infections | P1 | Completed | 38 | Open-label | Raltegravir + Truvada |
| NCT00888238 A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179) | Type 2 Diabetes Mellitus | P1 | Completed | 12 | RCT, Double-blind | sitagliptin, Comparator: Placebo |
| NCT01500382 A Study of the Pharmacokinetics and Pharmacodynamics of Vibegron (MK-4618) in Women With Overactive Bladder (MK-4618-004) | Overactive Bladder, Overactive Urinary Bladder | P1 | Terminated | 4 | RCT, Double-blind | Vibegron, Tolterodine ER, Prophylactic Antibiotic |
| NCT06843460 A Clinical Study of MK-7962 in Healthy Chinese Participants (MK-7962-021) | Healthy | P1 | Completed | 24 | RCT, Double-blind | Sotatercept |
| NCT03979274 A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers | Healthy | P1 | Completed | 44 | RCT, Open-label | Reference Eutirox®, Test Eutirox® |
| NCT02339324 Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b | Melanoma | P1 | Completed | 31 | Open-label | Pembrolizumab and high dose interferon alfa-2b (HDI) |
| NCT03552536 MK-8583 Single Dose Study in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8583-002) | HIV-1 Infection | P1 | Completed | 5 | Open-label | MK-8583 |
| NCT04075721 First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in Combination With Dexamethasone | Multiple Myeloma | P1 | Terminated | 10 | Open-label | M3258, M3258 20 mg |
| NCT03347292 Regorafenib Plus Pembrolizumab in First Line Systemic Treatment of HCC | Carcinoma, Hepatocellular | P1 | Completed | 58 | Open-label | Regorafenib(Stivarga, BAY73-4506), Pembrolizumab |
| NCT02549040 Bioavailability of Doravirine (MK-1439) Experimental Nano Formulations in Healthy Adults (MK-1439-046) | Human Immunodeficiency Virus-1 (HIV-1) | P1 | Completed | 16 | Open-label | Treatment A: Doravirine 100 mg film coated tablet, Treatment B: Doravirine 150 mg tablet (40% drug loaded granule), Treatment C: Doravirine 150 mg tablet (30% drug loaded granule), Treatment D: Doravirine 150 mg tablet (50% drug loaded granule), Treatment E: Doravirine 100 mg tablet (30% drug loaded granule) |
| NCT03724890 Study of Avelumab-M3814 Combinations | Oncology, Solid Tumors | P1 | Completed | 57 | Open-label | M3814, M3814, Avelumab |
| NCT00907517 Study of SCH 900776 (MK-8776) With and Without Cytarabine in Participants With Acute Leukemias (P05247) | Myelogenous Leukemia, Acute, Leukemia, Lymphocytic, Acute | P1 | Terminated | 24 | Open-label | MK-8776, Cytarabine |
| NCT05311618 Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors | Pancreatic Cancer, Breast Cancer | P1 | Unknown | 71 | Open-label | NGM438, Pembrolizumab (KEYTRUDA ®) |
| NCT04994522 A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021) | End Stage Renal Disease, Renal Impairment | P1 | Completed | 14 | Open-label | Belzutifan |
| NCT02437370 Pembrolizumab and Docetaxel or Gemcitabine Hydrochloride in Treating Patients Urothelial Cancer | Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter, Recurrent Bladder Carcinoma | P1 | Completed | 32 | Open-label | Pembrolizumab, Docetaxel, Gemcitabine Hydrochloride |
| NCT06836037 A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011) | Healthy | P1 | Completed | 56 | RCT, Double-blind | Efinopegdutide, Placebo |
| NCT00772967 A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED) | Osteoarthritis | P1 | Completed | 22 | RCT, Double-blind | Naproxen, Placebo, Ultracet |
| NCT03188523 Activity of MK-8504 in Anti-retroviral-naïve, Human Immunodeficiency Virus 1 (HIV-1) Infected Participants (MK-8504-002) | HIV-1 Infection | P1 | Completed | 12 | Open-label | MK-8504 |
| NCT07086079 A Study of Doravirine/Islatravir in Healthy Lactating Females (MK-8591A-061) | Healthy | P1 | Completed | 12 | Open-label | DOR/ISL |
| NCT04515641 Single-Dose Islatravir in Moderate Hepatic Impairment (MK-8591-030) | Human Immunodeficiency Virus (HIV) Infection | P1 | Completed | 12 | Open-label | Islatravir |
| NCT05519540 PK Study of Xevinapant (Debio 1143) in Healthy East Asian Participants | Healthy | P1 | Completed | 24 | Open-label | Xevinapant (Debio 1143) |
| NCT00424775 A Study of Carboplatin + Paclitaxel and MK0683 in Patients With Chemotherapy-naive Non-Small Cell Lung Cancer (NSCLC)(0683-066) | Neoplasms | P1 | Terminated | 3 | Open-label | MK0683, vorinostat |
| NCT00963547 A Study of MK-2206 in Combination With Trastuzumab and Lapatinib for the Treatment of HER2+ Solid Tumors (MK-2206-015) | Advanced Solid Tumors, Breast Cancer | P1 | Terminated | 33 | Open-label | MK-2206, Trastuzumab, Lapatinib |
| NCT01379300 A Study to Investigate Biomarkers After Single Doses of Anticoagulants in Healthy Young Male and Healthy Elderly Participants (MK-0000-216 AM1) | Thrombosis | P1 | Completed | 42 | RCT, Open-label | dabigatran etexilate, rivaroxaban |
| NCT01557504 A Study to Assess the Pharmacokinetics and the Ability for Pediatric Participants With Type 2 Diabetes to Swallow MK-0431A XR Tablets (MK-0431A-296) | Type 2 Diabetes Mellitus | P1 | Completed | 25 | RCT, Open-label | Sitagliptin/metformin XR, Placebo, Metformin, Thyroid hormone |
| NCT03982004 Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer | Metastatic Breast Cancer | P1 | Terminated | 1 | Open-label | Topical imiquimod, Pembrolizumab, Intra-lesional GM-CSF |
| NCT03317366 Expanded Access to Provide ARQ 092 for the Treatment of Overgrowth Diseases and/or Vascular Anomalies | Proteus Syndrome, PIK3CA-Related Overgrowth Spectrum (PROS) | NO_LONGER_AVAILABLE | — | — | ARQ 092 | |
| NCT01025271 Cerebrospinal Fluid Pharmacokinetics of Daptomycin | Meningitis | N/A | Terminated | 2 | Open-label | Daptomycin |
| NCT01216540 Vancomycin-Associated Nephrotoxicity | Nephrotoxicity | Completed | 398 | — | — | |
| NCT01012089 Study of the Pharmacokinetics of Daptomycin in Children With Renal Disease | Chronic Kidney Disease, Bacterial Infection | N/A | Completed | 6 | Open-label | Daptomycin |
| NCT00492193 Early Post-Op Recovery After Partial Large Bowel Resection | Diverticulitis, Colon Polyps | Completed | 139 | — | — | |
| NCT02762721 Analysis of Oncogenes in Intrahepatic Cholangiocarcinoma or Mixed Hepatocellular-Cholangiocarcinoma in Tumor Tissue Samples | Intrahepatic Cholangiocarcinoma, Mixed Hepatocellular Cholangiocarcinoma | Completed | 131 | — | — | |
| NCT01075451 Antimicrobial Drug Use and Resistant Staphylococcus Aureus | Staphylococcus Aureus | Completed | 41 | — | — | |
| NCT01813500 Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients | Crohn's Disease, Ulcerative Colitis | Completed | 400 | — | — | |
| NCT01150760 Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database | Ileus | Completed | 7,050 | — | Alvimopan | |
| NCT01143259 Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use | Ileus | N/A | Completed | 274 | RCT, Double-blind | Alvimopam, 300 mg Polyethylene |
| NCT02097953 Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin | Drug Interactions, Pharmacokinetics | Early P1 | Completed | 12 | Open-label | Daptomycin, Rifampin |
| NCT00261807 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections | Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections | N/A | Completed | 25 | Open-label | Daptomycin 6mg/kg/day |
| NCT07487441 Reverse Remodeling of the Pulmonary Vasculature: a Longitudinal, Investigational Study of the Effects of Sotatercept. | Pulmonary Arterial Hypertension (PAH), Pulmonary Hypertension | Not Yet Recruiting | 30 | — | — | |
| NCT04291040 Use of an Educational Multimedia Tool Versus Routine Care for the Uptake of Postpartum LARC in High-Risk Pregnancies | Pregnancy, High Risk, Contraception | N/A | Unknown | 380 | RCT, Open-label | — |
| NCT03213730 Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery | Brain Concussion, Post-Concussion Symptoms | N/A | Completed | 63 | RCT, Single-blind | — |
| NCT00724295 Safety and Efficacy of PegIntron and Rebetol Combination Therapy in Patients With Chronic Hepatitis C in Japan (Study P04505) | Hepatitis C, Chronic, Hepatitis C | Completed | 1,077 | — | peginterferon alfa-2b, ribavirin | |
| NCT00709228 Study of Patients With Chronic Hepatitis C Infected With HCV LVL G1 and Effect of Peg-Intron Plus Rebetol Treatment (Study P04793) | Hepatitis C | Completed | 496 | — | PegIntron, Rebetol | |
| NCT00724672 A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521) | Rheumatoid Arthritis | Withdrawn | — | — | etanercept, infliximab, adalimumab | |
| NCT04025502 Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects | Schizophrenia | Completed | 161 | — | — | |
| NCT03503565 Intraoperative Neuromuscular Blockade and Postoperative Atelectasis | Thoracic Surgery, One-lung Ventilation | Completed | 118 | — | — | |
| NCT00908011 Addition of Ezetimibe (Ezetrol®) to Ongoing Therapy With Rosuvastatin (Crestor®) in HIV Positive Patients Not Reaching Cholesterol Targets | Hypercholesterolemia, HIV Infections | N/A | Completed | 43 | RCT, Open-label | Ezetimibe, Rosuvastatin (standard care) |
| NCT00699855 Long Term Follow up Study of Predictive Markers in GHD and TS Children | Growth Hormon Deficiency, Turner Syndrome in Pre-pubertal Children | Completed | 182 | — | — | |
| NCT02657148 Immediate Postpartum Nexplanon Placement in Opioid Dependent Women | Opiate Addiction, Pregnancy | Completed | 200 | — | Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care | |
| NCT01422395 Effect of Oocyte Vitrification on Fertilization Rate, Embryo Quality and Development | Fertility | Early P1 | Completed | 40 | RCT, Single-blind | — |
| NCT00723892 Adherence in Patients Receiving PegIntron/Rebetol for Hepatitis C in Conjunction With a Psychotherapy Support Program (Study P04252) | Hepatitis C, Chronic, Hepacivirus | Completed | 614 | — | Peginterferon alfa-2b (PegIntron), Rebetol (Ribavirin) | |
| NCT02823457 VBMI to Increase Treatment Completion With MK-MK-5172/MK-8742 Among Veterans With Active Substance Use Disorders Genotype 1 Chronic Hepatitis C | Patient Adherence, Chronic Hepatitis C, Alcohol-related Disorders | N/A | Completed | 20 | Open-label | — |
| NCT02037919 Nexplanon Application Post-Abortion (NAPA) | Contraception, Abortion, Therapeutic | N/A | Completed | 148 | RCT, Open-label | — |
| NCT04923035 Paediatric Pneumococcal Pneumonia in Malaysia Prior to and During Pneumococcal Conjugate Vaccine (PCV) Implementation | Pneumonia, Pneumococcal, Pneumonia Childhood | Unknown | 1,010 | — | — | |
| NCT03153410 Pilot Study With CY, Pembrolizumab, GVAX, and IMC-CS4 (LY3022855) in Patients With Borderline Resectable Adenocarcinoma of the Pancreas | Pancreatic Cancer | Early P1 | Completed | 11 | Open-label | Cyclophosphamide, GVAX Pancreas Vaccine (GVAX), Pembrolizumab, IMC-CS4 |
| NCT02218320 Comparison of Virologic and Immunologic Responses to Raltegravir and Dolutegravir in the Gastrointestinal Tract of HIV-Positive Adults | Human Immunodeficiency Virus | Completed | 20 | — | Raltegravir, Dolutegravir | |
| NCT04024020 Chronic Insomnia and CSF Markers of Dementia | Insomnia Chronic | Completed | 30 | — | — | |
| NCT00748930 The Canadian Follow-up Program for the ATTRACT Study (P04868)(TERMINATED) | Arthritis, Rheumatoid | Terminated | 13 | — | — | |
| NCT00727311 Real-life Surveillance Study of Patients With Chronic Hepatitis C Treated With PegIntron Injector and Rebetol (Study P04538)(COMPLETED) | Hepatitis C, Chronic, Hepatitis C | Completed | 2,302 | — | PegIntron (peginterferon alfa-2b; SCH 54031) injector, Rebetol (ribavirin; SCH 18908) | |
| NCT01814722 Quality of Life of HIV-infected Participants Switched to Raltegravir Versus Other Antiretroviral Regimens (MK-0518-266) | Human Immunodeficiency Virus | Terminated | 63 | — | — | |
| NCT00418405 Hanyang University Medical Center Arthritis Network | Arthritis, Rheumatoid | Unknown | 1,500 | — | — | |
| NCT01645241 Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation | INFERTILITY, Fertility Preservation | N/A | Completed | 15 | Open-label | gonadotropins plus GnRH antagonists, ganirelix |
| NCT01207856 Randomised Controlled Clinical Trial of Cognitive Rehabilitation in Multiple Sclerosis | Multiple Sclerosis, Cognitive Rehabilitation | N/A | Completed | 65 | RCT, Single-blind | — |
| NCT00125060 Transesophageal Magnetic Resonance Imaging (MRI) in Conjunction With Lipid Lowering Measures | Heart Diseases | N/A | Completed | 72 | RCT, Double-blind | Simvastatin (20mg versus 80mg/day) |
| NCT00641641 The Effect of Raltegravir on HIV Decay During Primary and Chronic Infection | HIV Infection | N/A | Completed | 16 | Open-label | Tenofovir + emtricitabine + raltegravir. |
| NCT01164605 Pilot Study of Raltegravir Lipodystrophy IISP | HIV Infection | N/A | Unknown | 30 | Open-label | Raltegravir |
| NCT01632254 Study to Investigate the Sensitivity and Specificity of 3.0 Tesla MRI for Carotid Artery Plaque | Atherosclerosis | Unknown | 30 | — | — | |
| NCT04758351 Prospective Study on the Evaluation, Patient Reported Outcomes and Effectiveness of Treatment for Chronic Cough | Chronic Cough | Completed | 100 | — | — | |
| NCT01110577 Study of Magnetic Resonance Imaging (MRI) to Quantify Liver Fat in Diabetic and Pre-Diabetic Patients (0000-171) | Non-alcoholic Fatty Liver Disease (NAFLD) | Completed | 10 | — | — | |
| NCT00005232 Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other Variables | Cardiovascular Diseases, Heart Diseases | Completed | — | — | — | |
| NCT01582334 To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Argentina | Growth Disorders | Completed | 68 | — | — | |
| NCT00962819 Measles, Mumps, and Rubella (MMR) Immunity in College Students | Measles, Mumps | Completed | 74 | — | MMR vaccine | |
| NCT02256995 uChek Pilot Study for Urinalysis in the Antenatal Care Setting | Preeclampsia, Eclampsia | Unknown | 375 | — | — | |
| NCT03123575 Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy | HIV | Unknown | 1,000 | — | — | |
| NCT01363674 To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Greece | Growth Disorders | Completed | 180 | — | — | |
| NCT00738725 BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population | Plaque, Atherosclerotic Disease | Completed | 7,687 | — | — | |
| NCT06374134 The Impact of Community and Patient Engagement Practices on Vaccine Confidence in the United States | Vaccine Hesitancy | Not Yet Recruiting | 30 | — | — | |
| NCT00726609 Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641) | Mycoses | Completed | 214 | — | Posaconazole | |
| NCT02596984 Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients | Shock | N/A | Completed | 50 | Open-label | Caspofungin |
| NCT01400984 To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Slovakia | Growth Disorders | Completed | 92 | — | — | |
| NCT01706003 The Utility of Telemedicine in the Management of Migraine | Migraine Headaches | Completed | 45 | — | — | |
| NCT04196608 In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients | Ceftolozane/Tazobactam, Imipenem/Relebactam | Unknown | 1,005 | — | Ceftolozane/tazobactam, imipenem- relebactam | |
| NCT06229353 Developing and Evaluating a Novel Approach to Improve HPV Vaccination Coverage Among High-risk, Under-immunized Adults Via the Emergency Department | Human Papilloma Virus | Terminated | 34 | — | Gardasil 9 | |
| NCT02545270 Validation of a Subjective Rating Scale for Assessment of the Surgical Workspace in Laparoscopy | Hernia, Inguinal | N/A | Completed | 16 | RCT, Double-blind | — |
| NCT00774683 A Pilot Study to Characterize the Pharmacokinetics of Raltegravir in the Cervicovaginal Fluids of HIV-infected Women | HIV, AIDS | Completed | 1 | — | Raltegravir (Isentress®) | |
| NCT01787838 Improving Pneumococcal Vaccination Rates in an Ambulatory Pre-surgical Testing Setting | Community Acquired Pneumonia | N/A | Completed | 2,509 | Open-label | — |
| NCT01374282 Post Marketing Surveillance Study of Cuprimine | Scleroderma | NO_LONGER_AVAILABLE | — | — | Cuprimine (penicillamine) | |
| NCT01035060 Blood Flow, Muscle Regeneration and Sarcopenia | Sarcopenia | Completed | 68 | — | — | |
| NCT01446718 A Cohort Study to Assess Sustained Immunogenicity to qHPV Vaccine Among HIV-infected Girls and Boys Age 9-14 Years | Human Papillomavirus, HIV-1 Infection | Completed | 179 | — | Gardasil vaccine | |
| NCT00402818 RESTORE: Raptiva® (Efalizumab) Evaluation of Safety and Treatment Optimization | Plaque Psoriasis | Terminated | 294 | — | — | |
| NCT00736333 A Study to Evaluate Safety and Tolerability in Patients With Metastatic Breast Cancer Receiving Treatment With Caelyx (Study P04878)(COMPLETED) | Breast Neoplasm | Completed | 167 | — | Pegylated Liposomal Doxorubicin | |
| NCT01376921 To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Spain | Growth Disorders | Completed | 300 | — | — | |
| NCT01299714 Community Awareness, Resources and Education (CARE II): Project 3 | Uterine Cervical Cancer | Completed | 191 | — | — | |
| NCT00514878 Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV) | Nausea, Postoperative Nausea and Vomiting | Completed | 2,000 | — | — | |
| NCT01936376 A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving First Cycle of Cisplatin Chemotherapy for Head and Neck Cancers | Head and Neck Cancer | Unknown | 150 | — | — | |
| NCT00735826 A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract Cancer | Aerodigestive Tract Cancer, Lung Cancer | N/A | Completed | 10 | Open-label | Vorinostat |
| NCT01109550 Biliary Candidiasis - Optimization of Diagnostics and Therapy | Secondary Cholangitis, Bile Duct Strictures of Unknown Origin | Completed | 123 | — | — | |
| NCT00669929 Cost-Effectiveness Analysis of Rotavirus Vaccination for Children in Korea | Gastroenteritis, Rotavirus Vaccines | Unknown | 200 | — | — | |
| NCT01119703 Vaccine Hyporesponse in Healthy Elderly Participants (MK-0000-131 AM2) | Vaccine Response Impaired | Completed | 174 | — | Tetanus & Diphtheria booster vaccine (Td), TwinrixTM [Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine], Dukoral® Traveler's Diarrhea Vaccine (WC/rBS) | |
| NCT03655223 Early Check: Expanded Screening in Newborns | Spinal Muscular Atrophy, Fragile X Syndrome | By Invite | 30,000 | — | — | |
| NCT01196273 Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up | Coronary Heart Disease, Heart Failure | Completed | 1,424 | — | — | |
| NCT01082315 A Korean Post-marketing Surveillance Study on Erbitux® in Patients With Metastatic Colorectal Cancer Refractory to Irinotecan-containing Treatment | Colorectal Neoplasms | Completed | 730 | — | Erbitux (Cetuximab) | |
| NCT01015625 Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer | Synchronous Metastasized Breast Cancer, Circulating Tumor Cells | N/A | Completed | 90 | RCT, Open-label | — |
| NCT01284374 Parent-son-provider Decision-making About HPV Vaccination | Human Papillomavirus Vaccination | Completed | 62 | — | — | |
| NCT01213264 Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556) | Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery | Completed | 659 | — | Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice | |
| NCT00652509 Journey for Control of Diabetes Study (0431-111) | Type 2 Diabetes Mellitus | N/A | Completed | 621 | RCT, Open-label | — |
| NCT02909348 Immunophenotyping of Melanoma Patients on Treatment With Pembrolizumab | Neoplasms, Melanoma | Completed | 25 | — | Pembrolizumab | |
| NCT03308357 Comparison of the Performance of SB2-Infliximab With Originator Infliximab in the Measure of Serum Concentrations in Serum | Inflammatory Bowel Diseases | Unknown | 6 | — | — | |
| NCT02607293 A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation | Polycystic Ovary Syndrome | Completed | 1,064 | — | Gonal-f®, Long GnRH agonist, GnRH antagonist |