
Regeneron Pharmaceuticals Inc
REGNHealthcare|Biotechnology|USA
$763.04
+1.19 (+0.16%)
DCF (FCF)
$641.30
Tangible Book
$283.77
Graham Number
$532.32
Earnings Power
$496.16
Clinical Trials (506)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT07053423 A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease. | Chronic Obstructive Pulmonary Disease | P4 | Recruiting | 218 | RCT, Double-blind | Dupilumab, Placebo |
| NCT06665971 Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE) | Eosinophilic Esophagitis (EoE) | P4 | Recruiting | 30 | Open-label | Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT] |
| NCT03935971 The Effects of Dupilumab on Allergic Contact Dermatitis | Allergic Contact Dermatitis | P4 | Active | 17 | Open-label | Dupilumab |
| NCT03694158 Investigating Dupilumab's Effect in Asthma by Genotype | Asthma | P4 | Active | 150 | RCT, Double-blind | Dupilumab |
| NCT06572228 Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma | Asthma | P4 | Recruiting | 250 | RCT, Double-blind | dupilumab, Matching Placebo, ICS/LABA |
| NCT05268107 Ethnic Differences in Mechanisms of Action of Dupilumab | Atopic Dermatitis | P4 | Recruiting | 30 | Open-label | Dupilumab |
| NCT06662994 High Dose Aflibercept in Diabetic Macular Edema in Patients With Previous Vitrectomy | Diabetic Macular Edema (DME) | P4 | Recruiting | 15 | Open-label | Aflibercept 8 mg (VEGF Trap-Eye, BAY86-5321) |
| NCT05042258 Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis | Atopic Dermatitis, Sleep Disturbance | P4 | Recruiting | 40 | Open-label | Dupilumab |
| NCT04380038 Viral Infection in Asthma (VIA) Study | Asthma | P4 | Recruiting | 60 | RCT, Double-blind | Dupilumab Injectable Product |
| NCT05285839 Dupixent and Narrowband UVB for Atopic Dermatitis | Atopic Dermatitis | P4 | Recruiting | 40 | Open-label | Dupixent |
| NCT02612454 Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD) | Atopic Dermatitis | P3 | Active | 880 | Open-label | Dupilumab |
| NCT06091254 A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma | Follicular Lymphoma (FL) | P3 | Recruiting | 822 | RCT, Open-label | Odronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone/prednisolone, Bendamustine |
| NCT06246916 A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head) | Melanoma | P3 | Recruiting | 560 | RCT, Open-label | fianlimab, cemiplimab, relatlimab+nivolumab |
| NCT06128629 MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) | Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | P3 | Recruiting | 1,200 | RCT, Double-blind | NTLA-2001, Placebo |
| NCT07213778 REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants | Symptomatic Venous Thromboembolism (VTE) | P3 | Recruiting | 2,000 | RCT, Double-blind | REGN7508, Acetylsalicylic Acid (ASA), Placebo |
| NCT06208306 A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD | Chronic Obstructive Pulmonary Disease | P3 | Active | 700 | RCT, Double-blind | Itepekimab (SAR440340), Placebo |
| NCT07222761 A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM) | Relapsed and/or Refractory Multiple Myeloma (RRMM) | P3 | Recruiting | 915 | RCT, Open-label | Linvoseltamab, Carfilzomib, Daratumumab, Dexamethasone, Pomalidomide, Bortezomib |
| NCT06091865 A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma | Diffuse Large B-cell Lymphoma (DLBCL) | P3 | Active | 904 | RCT, Open-label | Odronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone/Prednisolone |
| NCT06932562 A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant | Multiple Myeloma | P3 | Recruiting | 1,000 | RCT, Open-label | Linvoseltamab, Daratumumab, Lenalidomide, Dexamethasone |
| NCT07220785 Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy | Generalized Lipodystrophy | P3 | Recruiting | 28 | RCT, Double-blind | Mibavademab, Placebo |
| NCT05070858 A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis | Generalized Myasthenia Gravis | P3 | Active | 288 | RCT, Double-blind | Pozelimab + Cemdisiran, Cemdisiran, Pozelimab |
| NCT06191315 Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS) | Wheezing, Asthma | P3 | Recruiting | 90 | RCT, Double-blind | Dupilumab, Placebo |
| NCT03969004 Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma | Cutaneous Squamous Cell Carcinoma | P3 | Active | 415 | RCT, Double-blind | Cemiplimab, Placebo |
| NCT05744921 A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works | Paroxysmal Nocturnal Hemoglobinuria | P3 | Recruiting | 202 | Open-label | Pozelimab, Cemdisiran |
| NCT06834360 A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | P3 | Recruiting | 210 | RCT, Double-blind | Itepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS) |
| NCT05785767 A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) | Advanced Non-Small Cell Lung Cancer | P2P3 | Active | 850 | RCT, Double-blind | fianlimab, cemiplimab, Placebo |
| NCT07112378 A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis | Eosinophilic Esophagitis (EoE) | P3 | Recruiting | 20 | RCT, Single-blind | dupilumab |
| NCT05608291 A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery | Melanoma | P3 | Active | 1,564 | RCT, Double-blind | Fianlimab, Cemiplimab, Pembrolizumab, Placebo |
| NCT06834347 A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | P3 | Recruiting | 210 | RCT, Double-blind | Itepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS) |
| NCT05347771 Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents | Asthma | P2 | Active | 240 | RCT, Double-blind | Dupilumab, Placebo |
| NCT04050436 Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer | Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma | P2 | Active | 231 | RCT, Open-label | Cemiplimab, RP1 |
| NCT05864144 A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors | Solid Tumor, Adult, Advanced Solid Tumor | P1P2 | Active | 98 | Open-label | SNS-101 (anti-VISTA), Cemiplimab |
| NCT04291105 Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients | Melanoma, Head and Neck Squamous Cell Carcinoma | P2 | Recruiting | 87 | Open-label | VV1, Cemiplimab |
| NCT03294083 A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma | Renal Cell Carcinoma | P1P2 | Active | 89 | RCT, Open-label | Pexastimogene Devacirepvec (Pexa-Vec), Cemiplimab |
| NCT05519475 A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition | Metabolic Dysfunction-associated Steatohepatitis (MASH) | P2 | Recruiting | 90 | RCT, Double-blind | ALN-HSD, Placebo |
| NCT05828511 A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment | Multiple Myeloma | P1P2 | Recruiting | 149 | Open-label | Linvoseltamab |
| NCT02991469 A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS) | Juvenile Idiopathic Arthritis | P2 | Recruiting | 51 | Open-label | Sarilumab SAR153191 (REGN88) |
| NCT06855212 Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC | Head and Neck Squamous Cell Carcinoma | P2 | Recruiting | 21 | Open-label | Cemiplimab, Cetuximab |
| NCT07181941 Response-Based Dose Reduction of Linvoseltamab in the Treatment of Relapsed, Refractory, or Triple-Class Relapsed/Refractory Multiple Myeloma | Recurrent Multiple Myeloma, Refractory Multiple Myeloma | P1P2 | Recruiting | 30 | Open-label | Linvoseltamab |
| NCT06594991 A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma | Advanced Melanoma | P2 | Recruiting | 88 | Open-label | Fianlimab, Cemiplimab, Ipilimumab |
| NCT05553834 PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung | Non-small Cell Lung Cancer (NSCLC) | P2 | Active | 60 | Open-label | — |
| NCT06449313 Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node Involvement | Non-small Cell Lung Cancer Stage III | P2 | Recruiting | 21 | Open-label | Cemiplimab-Rwlc |
| NCT06226610 Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic | Pruritis | P2 | Recruiting | 46 | RCT, Double-blind | Dupilumab |
| NCT03761108 Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma | Multiple Myeloma | P1P2 | Recruiting | 387 | Open-label | Linvoseltamab |
| NCT06981325 Evaluation of Efficacy and Safety of Cemiplimab as First Line Treatment for Advanced Basal Cell Carcinoma (BCC) Patients | Basal Cell Carcinoma (BCC), First Line Treatment | P2 | Recruiting | 34 | Open-label | Cemiplimab |
| NCT07175428 Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation | Atrial Fibrillation (AF) | P2 | Recruiting | 1,200 | RCT, Single-blind | REGN7508, REGN9933, Apixaban |
| NCT07431086 Study of Olatorepatide in Adult Participants Living With Overweight or Obesity in the US | Overweight or Obesity | P2 | Recruiting | 120 | RCT, Double-blind | Olatorepatide, Placebo |
| NCT05929664 Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery | Locally Advanced Basal Cell Carcinoma, Basal Cell Carcinoma | P2 | Recruiting | 70 | Open-label | Cemiplimab, Fianlimab |
| NCT06887088 Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases | Melanoma BRAF V600E/K Mutated, Melanoma and Brain Metastases | P2 | Recruiting | 33 | Open-label | Encorafenib + Binimetinib, cemiplimab+fianlimab |
| NCT06910124 Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse | Multiple Myeloma | P2 | Recruiting | 32 | Open-label | Linvoseltamab, Lenalidomide |
| NCT05557591 A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1) | Advanced Non-Small Cell Lung Cancer | P2 | Active | 51 | RCT, Open-label | BNT116, Cemiplimab |
| NCT06299111 A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC) | Venous Thromboembolism | P2 | Active | 195 | RCT, Double-blind | REGN9933, REGN7508, Placebo |
| NCT06465329 A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer | P2 | Recruiting | 120 | RCT, Open-label | Cemiplimab, Platinum-based chemotherapy, REGN7075 |
| NCT06623656 Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC | Carcinoma, Non-Small-Cell Lung | P2 | Recruiting | 112 | RCT, Open-label | Cemiplimab, Platinum based chemotherapy |
| NCT05720325 Dupilumab Effects Against Aeroallergen Challenge | Asthma, Allergic | P2 | Recruiting | 88 | RCT, Double-blind | Dupilumab |
| NCT06691113 A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps | P2 | Active | 60 | RCT, Double-blind | Itepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS) |
| NCT07218770 A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants | Active Noninfectious Uveitis Affecting the Posterior Segment | P1P2 | Recruiting | 72 | Open-label | REGN7041 |
| NCT05831176 A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have | Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD) | P2 | Active | 22 | Open-label | Dupilumab |
| NCT06161441 A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery | Resectable Non-small Cell Lung Cancer | P2 | Active | 195 | RCT, Double-blind | Fianlimab, Cemiplimab, Pemetrexed, Paclitaxel, Carboplatin, Cisplatin, Placebo |
| NCT06421636 A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body | Non-Transfusion Dependent Beta-Thalassemia (NTDT) | P2 | Recruiting | 95 | RCT, Double-blind | REGN7999, Placebo |
| NCT07433673 Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC) | Colon and Rectal Cancer | P2 | Recruiting | 20 | Open-label | Cemiplimab |
| NCT07154290 A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC) | Advanced/Metastatic Non-Small Cell Lung Cancer | P2 | Recruiting | 300 | RCT, Open-label | Ubamatamab, REGN7075, Sarilumab |
| NCT03564340 Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers | Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer | P1P2 | Recruiting | 890 | Open-label | Ubamatamab, Cemiplimab, Sarilumab, Tocilizumab |
| NCT04626635 A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers | Advanced Solid Tumors | P1P2 | Recruiting | 933 | Open-label | REGN7075, Cemiplimab, Platinum-based doublet chemotherapy, Bevacizumab, Trifluridine-tipiracil |
| NCT06292780 A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis) | Relapsed/Refractory Systemic Light Chain Amyloidosis | P1P2 | Recruiting | 220 | Open-label | Linvoseltamab |
| NCT07188896 A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC) | Advanced Renal Cell Carcinoma (aRCC), Metastatic Renal Cell Carcinoma ( mRCC) | P2 | Recruiting | 120 | RCT, Open-label | Fianlimab, Ipilimumab, Nivolumab, Cemiplimab |
| NCT04590326 A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab | Ovarian Cancer, Fallopian Tube Cancer | P1P2 | Recruiting | 612 | Open-label | REGN5668, Cemiplimab, Ubamatamab, Sarilumab, Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] |
| NCT07187401 A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor | Paroxysmal Nocturnal Hemoglobinuria (PNH), Persistent Anemia | P1P2 | Recruiting | 24 | RCT, Double-blind | ALN-CFB, Placebo |
| NCT03916627 Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients | Non-small Cell Lung Cancer, Hepatocellular Carcinoma | P2 | Active | 65 | RCT, Open-label | cemiplimab, Platinum Doublet, fianlimab |
| NCT04988074 Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca | HPV-Related Squamous Cell Carcinoma | P2 | Recruiting | 32 | Open-label | Cemiplimab |
| NCT06790602 Cemiplimab Plus Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma | Pancreatic Ductal Adenocarcinoma (mPDAC) | P2 | Recruiting | 43 | Open-label | Cemiplimab Plus Gemcitabine |
| NCT03888105 A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies | B-cell Non-Hodgkin Lymphoma (B-NHL) | P2 | Active | 515 | Open-label | Odronextamab |
| NCT06769698 A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma (HNSCC) | P2 | Recruiting | 120 | RCT, Double-blind | FDC fianlimab+cemiplimab, Cemiplimab, Placebo |
| NCT06444880 Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies | SMARCB1-Deficient Malignancies | P2 | Recruiting | 40 | Open-label | Ubamatamab, Cemiplimab |
| NCT06571708 Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) | Bladder Cancer, Muscle-Invasive Bladder Carcinoma | P2 | Recruiting | 36 | RCT, Open-label | Gemcitabine, Cisplatin, Cemiplimab, Fianlimab |
| NCT07235917 A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea | Functional Hypothalamic Amenorrhea (FHA) | P2 | Recruiting | 34 | RCT, Double-blind | Mibavademab |
| NCT06373146 A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity | Obesity | P2 | Active | 392 | RCT, Double-blind | Tirzepatide, Mibavademab, Tirzepatide-Placebo, Mibavademab-Placebo |
| NCT05092347 A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA) | Chronic Kidney Disease (CKD) | P1P2 | Recruiting | 56 | Open-label | Vonsetamig |
| NCT06379789 A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B | Hemophilia B | P1P2 | Recruiting | 130 | Open-label | REGV131, LNP1265 |
| NCT05031455 Mechanisms of Dupilumab in AERD | Aspirin-exacerbated Respiratory Disease | P2 | Recruiting | 16 | Open-label | Aspirin Challenge |
| NCT05961709 The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer | Colon Cancer | P2 | Recruiting | 50 | Open-label | Cemiplimab |
| NCT06121180 Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma | Metastatic Uveal Melanoma | P2 | Recruiting | 32 | Open-label | ZIV-Aflibercept, Cemiplimab |
| NCT04077099 A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer | NSCLC | P1P2 | Recruiting | 231 | Open-label | REGN5093 |
| NCT05955508 A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma | Smoldering Multiple Myeloma (SMM) | P2 | Active | 40 | RCT, Open-label | Linvoseltamab |
| NCT06902376 XL092 and Cemiplimab in BRAF WT Thyroid Cancer | Anaplastic Thyroid Cancer, Thyroid Cancer | P1 | Recruiting | 12 | Open-label | Cemiplimab, XL092 |
| NCT06836609 A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) | Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis | P1 | Recruiting | 132 | RCT, Double-blind | ALN-CIDEB, Placebo |
| NCT06975787 Dose Escalation Study With Bispecific Antibodies in Adult Patients With Lupus Nephritis | Lupus Nephritis (LN) | P1 | Recruiting | 90 | Open-label | Vonsetamig, Odronextamab |
| NCT07216066 First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD) | Parkinsons Disease | P1 | Recruiting | 46 | RCT, Double-blind | ALN-SNCA, Placebo |
| NCT06452771 A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults | Healthy Volunteers With Hyperlipidemia | P1 | Active | 59 | RCT, Double-blind | ALN-ANG3, Placebo (PB) |
| NCT06469281 A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers | Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma | P1 | Recruiting | 90 | Open-label | Cemiplimab, Bevacizumab |
| NCT06369467 Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy | Food Allergy | P1 | Recruiting | 6 | Open-label | linvoseltamab, dupilumab |
| NCT06826768 A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC | Prostate Cancer | P1 | Recruiting | 60 | Open-label | REGN5678, Cemiplimab |
| NCT07214727 A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease | Alzheimer's Disease | P1 | Recruiting | 50 | RCT, Double-blind | ALN-5288, Placebo |
| NCT04975152 Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma | Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma | P1 | Active | 36 | Open-label | Cemiplimab-Rwlc |
| NCT05259709 A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With Cemiplimab | Advanced Solid Tumor, Metastatic Solid Tumor | P1 | Recruiting | 50 | Open-label | 89Zr˗DFO˗REGN5054, cemiplimab |
| NCT05685173 A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas | B-cell Non-Hodgkins Lymphoma (B-NHL) | P1 | Recruiting | 91 | Open-label | Odronextamab, REGN5837 |
| NCT05704634 A Phase Ib Study to Evaluate the Safety and Preliminary Efficacy of IL6-receptor Antibody Sarilumab in Combination With antiPD1 Antibody Cemiplimab for Patients With Non-small Cell Lung Cancer. | Lung Cancer | P1 | Active | 56 | RCT, Open-label | Cemiplimab, Kevzara (Sarilumab) |
| NCT03233139 Safety and Pharmacokinetics of Cemiplimab Anti-programmed Death-ligand 1 (Anti-PD-1) and Other Agents in Japanese Adult Patients With Advanced Malignancies | Advanced Malignancies | P1 | Active | 146 | Open-label | Cemiplimab, Ipilimumab, Platinum-doublet chemotherapy, Gemcitabine, Pemetrexed, Paclitaxel, Fianlimab |
| NCT02651662 A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies | Relapsed/Refractory Aggressive B-Cell Lymphoma | P1 | Active | 105 | Open-label | cemiplimab, odronextamab |
| NCT06669234 Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults | Healthy Volunteer | P1 | Active | 56 | RCT, Double-blind | ALN-F1202, Matching Placebo |
| NCT04722523 A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer | Head and Neck Cancer, Head Cancer | P1 | Recruiting | 40 | Open-label | Cisplatin, Carboplatin, Docetaxel, Cetuximab, Cemiplimab, Paclitaxel |
| NCT07444203 Transformative Research in Diabetic Nephropathy 2.0 | Diabetic Nephropathies, Kidney Diseases | Recruiting | 200 | — | Sodium-glucose cotransporter 2 inhibitors (SGLT2i), Renin-angiotensin-aldosterone system blockade, Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Mineralocorticoid Receptor Antagonists(MRAs) | |
| NCT07064330 Next-gen Flow Cytometry to Find Immune Profiles, Treatment Response, and Toxicity Markers in Skin Cancer Patients Treated With Cemiplimab. | Cutaneous Squamous Cell Carcinoma (CSCC) | Recruiting | 30 | — | Cemiplimab | |
| NCT06695897 A Non-interventional Observational Study to Assess Long-term Efficacy and Safety of Dupilumab for the Treatment of Patients (>= 12 Years) With Eosinophilic Esophagitis Under Real-world-conditions in Germany | Eosinophilic Esophagitis | Recruiting | 150 | — | Dupilumab | |
| NCT03936335 An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis (AD) | Adverse Pregnancy Outcomes, Atopic Dermatitis | Recruiting | 3,930 | — | dupilumab | |
| NCT04550962 Description of Characteristics, Such as Age, Previous and Concurrent Treatments, Associated Diseases, of Patients With Asthma Treated With Dupilumab (DUPIXENT) | Asthma | Active | 376 | — | Dupilumab SAR231893 | |
| NCT05991323 Real-World Effectiveness of Dupilumab in Patients With Prurigo Nodularis: An Observational Study | Prurigo Nodularis | Active | 100 | — | Dupilumab | |
| NCT06099704 Observational Study of Canadian Patients (6 Years or Older) Receiving Dupixent® for Moderate to Severe Atopic Dermatitis | Moderate to Severe Atopic Dermatitis | Active | 305 | — | — | |
| NCT07217535 Rutgers University Study of the Genetics of Kidney Disease | Kidney Disease, Kidney Disease, Chronic | Recruiting | 50,000 | — | — | |
| NCT00707694 The Longevity Genes in Founder Populations Project | Extreme Longevity | Recruiting | 2,000 | — | — | |
| NCT06269133 Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) Patients | Advanced Non-small Cell Lung Cancer | Active | 1,000 | — | REGN2810 | |
| NCT04959448 Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) | Chronic Rhinosinusitis With Nasal Polyposis | Active | 717 | — | DUPIXENT® | |
| NCT05246267 Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis | Chronic Rhinosinusitis With Nasal Polyps | Recruiting | 60 | — | Dupilumab | |
| NCT06439654 Atlantic Lipid Lowering Treatment Optimization Program | Familial Hypercholesterolemia, Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia | N/A | Recruiting | 250 | Open-label | — |
| NCT06219629 Parkinson's Disease Progression Study | Parkinson Disease | Active | 82 | — | — | |
| NCT04287621 Registry of Asthma Patients Initiating DUPIXENT® | Asthma | Active | 718 | — | DUPIXENT® | |
| NCT06773897 Rutgers University Study of the Genetics of Breast Cancer. | Breast Cancer Risk, Breast Cancer Prevention | Recruiting | 25,000 | — | — | |
| NCT07052396 Study to Evaluate Long-term Effectiveness and Safety, Patient Characteristics and Subjective Patient-reported Outcomes of Dupilumab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Under Real-world Conditions | Chronic Obstructive Pulmonary Disease (COPD) | Recruiting | 350 | — | Dupilumab | |
| NCT06129552 Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis | Recruiting | 300 | — | — | |
| NCT05106387 An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant | Chronic Kidney Disease (CKD) | Recruiting | 20 | — | Noninterventional | |
| NCT02986984 Transformative Research in Diabetic Nephropathy | Diabetic Nephropathies, Diabetic Glomerulosclerosis | Recruiting | 400 | — | — | |
| NCT03428646 Study of Patients Receiving DUPIXENT® for Atopic Dermatitis (AD) | Dermatitis, Atopic | Active | 858 | — | Dupilumab | |
| NCT05363319 An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe | Non-small Cell Lung Cancer | Recruiting | 500 | — | Cemiplimab, Platinum-based chemotherapy | |
| NCT05568459 A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy | Hemophilia B | Active | 11 | — | — | |
| NCT07223411 Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma | Locally Advanced Melanoma | Recruiting | 20 | — | Fianlimab + Cemiplimab, Relatlimab + Nivolumab | |
| NCT06479863 Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients With Sporadic Inclusion Body Myositis | Sporadic Inclusion Body Myositis (sIBM), Idiopathic Inflammatory Myopathies | Early P1 | Recruiting | 10 | Open-label | — |
| NCT06798298 A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T Cells | Long Term Safety Following GM T Cell Therapy | Recruiting | 50 | — | — | |
| NCT03389893 Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis | Atopic Dermatitis (AD) | P4 | Terminated | 72 | RCT, Double-blind | Dupilumab, Placebo |
| NCT04988022 Dupilumab in the Treatment of Keloids | Keloid | P4 | Completed | 44 | RCT, Double-blind | Dupilumab, Placebo |
| NCT03694197 Long Term Safety Study of PRALUENT | Heterozygous Familial Hypercholesterolemia, Non-familial Hypercholesterolemia | P4 | Terminated | 1,389 | Open-label | Praluent |
| NCT05265234 Dupilmuab for Atopic Dermatitis Monitored With Noninvasive Imaging. | Eczema, Atopic Dermatitis | P4 | Unknown | 15 | Open-label | Dupilumab |
| NCT04998604 EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients | Chronic Rhinosinusitis With Nasal Polyps, Asthma | P4 | Completed | 360 | RCT, Double-blind | Dupilumab, Omalizumab, Placebo |
| NCT02559180 Treatment of Diabetic Macular Edema With Aflibercept in Subjects Previously Treated With Ranibizumab or Bevacizumab | Diabetic Retinopathy, Macular Edema | P4 | Completed | 20 | Open-label | aflibercept |
| NCT03022292 The IAI-OCTA Study; a Study of OCT-Angiography Analysis Efficacy | Wet Macular Degeneration | P4 | Completed | 26 | Open-label | Aflibercept Ophthalmic |
| NCT01543568 Study for Recalcitrant Age Related Macular Degeneration | Age Related Macular Degeneration | P4 | Completed | 46 | Open-label | aflibercept 2.0 mg |
| NCT02581891 Managing Neovascular (Known as "Wet") Age-related Macular Degeneration Over 2 Years Using Different Treatment Schedules of 2 mg Intravitreal Aflibercept Injected in the Eye | Macular Degeneration | P4 | Completed | 287 | RCT, Open-label | Eylea (Intravitreal Aflibercept, VEGF Trap-Eye, BAY86-5321), Eylea (Intravitreal Aflibercept, VEGF Trap-Eye, BAY86-5321) |
| NCT02957682 Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo | Hypercholesterolemia | P4 | Completed | 2,176 | RCT, Double-blind | Praluent (Alirocumab), Placebo |
| NCT04400318 The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma | Asthma | P4 | Completed | 109 | RCT, Double-blind | Dupilumab, Placebo |
| NCT05036733 Effects of Interleukin (IL)- 4R-alpha Inhibition on Respiratory Microbiome and Immunologic Correlates in Severe Asthma | Asthma | P4 | Completed | 15 | Open-label | Dupilumab |
| NCT03767738 Study to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe | Chorioretinal Vascular Disease | P4 | Completed | 65 | Open-label | Intravitreal Aflibercept Injection (IAI) |
| NCT01722045 Study to Assess Best Corrected Visual Acuity (BCVA) in Patients With Neovascular Age-Related Macular Degeneration (AMD) Who Are Administered VEGF Trap-Eye (Intravitreal Aflibercept Injection) | Age - Related Macular Degeneration (AMD) | P4 | Completed | 154 | Open-label | Intravitreal Aflibercept Injection (IAI) |
| NCT02092532 Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial) | Neovascular Polypoidal Choroidal Vasculopathy | P4 | Unknown | 20 | Open-label | Rescue Intravitreal Aflibercept Injection |
| NCT01857544 Study of Intravitreal Aflibercept Injection for Persistent CRVO-associated Macular Edema Despite Prior Anti-VEGF Therapy | Retinal Vein Occlusion | P4 | Unknown | 10 | Open-label | Aflibercept |
| NCT04708145 Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial | Diabetic Retinopathy | P4 | Completed | 41 | RCT, Open-label | Aflibercept Injection |
| NCT04502862 A Phase 4, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Effect of Dupilumab on Sleep Disturbance in Patients With Uncontrolled Persistent Asthma | Asthma | P4 | Completed | 202 | RCT, Double-blind | SAR231893, Placebo |
| NCT03059277 Intravitreal Alfibercept for Center Involved DME Previously Managed With Intravitreal Ranibizumab | Diabetic Macular Edema | P4 | Withdrawn | — | Open-label | Intravitreal Aflibercept |
| NCT06012448 The Immunologic Effects of Dupilumab in the Treatment of Dermal Hypersensitivity Reaction | Dermal Hypersensitivity Reaction | P4 | Completed | 10 | Open-label | Dupilumab |
| NCT03293030 Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis | Atopic Dermatitis, Atopic Dermatitis Eczema | P4 | Completed | 17 | Open-label | Dupilumab |
| NCT04520308 An Open-label, Single-arm Longitudinal Study With Dupilumab for Patients With Atopic Dermatitis | Atopic Dermatitis, AD | P4 | Unknown | 45 | Open-label | Dupilumab Only Product |
| NCT01451645 Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol | Intercritical Gout | P4 | Completed | 82 | RCT, Double-blind | Colchicine (Colcrys®), placebo, allopurinol |
| NCT02642159 Efficacy and Safety of Alirocumab Versus Usual Care on Top of Maximally Tolerated Statin Therapy in Patients With Type 2 Diabetes and Mixed Dyslipidemia (ODYSSEY DM-Dyslipidemia) | Dyslipidemia | P4 | Completed | 413 | RCT, Open-label | Alirocumab, Statins, Ezetimibe, Fenofibrate, Nicotinic acid, Omega-3 fatty acids, Antihyperglycemic Drug |
| NCT02689518 EAGLE: Evaluating Genotypes Using Intravitreal Aflibercept Injection | Macular Degeneration, Wet Macular Degeneration | P4 | Completed | 50 | Open-label | Intravitreal aflibercept injection |
| NCT02503540 Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO | Retinal Vein Occlusion, Diabetic Macular Edema | P4 | Completed | 31 | Open-label | Aflibercept |
| NCT01670162 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) | Age Related Macular Degeneration, Pigment Epithelial Detachment | P4 | Unknown | 30 | Open-label | Aflibercept |
| NCT04203797 A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma | Asthma | P4 | Completed | 40 | RCT, Double-blind | dupilumab, Matching placebo |
| NCT03667014 The Impact of Dupilumab on Quality of Life in Moderate to Severe Atopic Dermatitis Patients | Atopic Dermatitis, Atopic Dermatitis Eczema | P4 | Completed | 34 | Open-label | Dupilumab |
| NCT02992301 Assessment of Atherosclerotic Plaque Characteristics Change by DCE-MRI With Alirocumab | Atherosclerosis, Hyperlipidemia | P4 | Unknown | 35 | Open-label | Alirocumab |
| NCT04447417 Dupilumab Skin Barrier Function Study in Atopic Dermatitis | Atopic Dermatitis | P4 | Completed | 52 | Open-label | Dupilumab SAR231893 |
| NCT03468296 Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept | Neovascular Age-related Macular Degeneration | P4 | Unknown | 22 | RCT, Open-label | Intravitreal Aflibercept Injection 2mg |
| NCT01722656 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment | Submacular Vascularized Pigment Epithelial Detachments | P4 | Completed | 40 | Open-label | Aflibercept |
| NCT01870427 NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions | Macular Edema With Central Retinal Vein Occlusions | P4 | Completed | 20 | Open-label | Aflibercept (2.0 mg) |
| NCT04718870 Dupilumab-PEdiatric Skin Barrier Function and LIpidomics STudy in Patients With Atopic Dermatitis | Dermatitis Atopic | P4 | Completed | 41 | Open-label | Dupilumab SAR231893 |
| NCT06352073 Dupilumab for Eosinophilic Esophagitis With Severe Strictures | Eosinophilic Esophagitis, EoE | P4 | By Invite | 30 | Open-label | Dupilumab |
| NCT02305238 Japanese Treat and Extend Study of Aflibercept in Neovascular Age-related Macular Degeneration | Wet Macular Degeneration | P4 | Completed | 288 | RCT, Open-label | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) |
| NCT05590585 Dupilumab in Adolescent and Adult Skin of Color Participants: Open-label Moderate-to-severe Eczema Trial | Moderate-to-Severe Atopic Dermatitis, Atopic Eczema | P4 | Completed | 124 | Open-label | dupilumab |
| NCT03542110 The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial | Saphenous Vein Graft Atherosclerosis | P4 | Terminated | 46 | RCT, Double-blind | Alirocumab 150 MG/ML subcutaneous injection, Matching Placebo subcutaneous injection |
| NCT05247866 Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic Esophagitis | Eosinophilic Esophagitis | P4 | Completed | 21 | Open-label | Dupilumab |
| NCT03449758 Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis | Rheumatoid Arthritis | P4 | Completed | 84 | Open-label | SARILUMAB, Azathioprine, Chloroquine, Hydroxychloroquine, Leflunomide, Methotrexate, Sulfasalazine |
| NCT01871376 Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation | Polypoidal Choroidal Vasculopathy | P4 | Completed | 25 | Open-label | Intravitreal aflibercept injection 2.0mg |
| NCT04033367 SAR231893-LPS15497- "Dupilumab Effect on Sleep in AD Patients" | Atopic Dermatitis | P4 | Completed | 188 | RCT, Double-blind | Dupilumab, Placebo |
| NCT01617148 Wet Macular Degeneration Study to Compare Ranibizumab or Bevacizumab to Aflibercept | Exudative Macular Degeneration | P4 | Completed | 26 | Open-label | Aflibercept |
| NCT02938949 Alirocumab in Patients With Acute Myocardial Infarction | Myocardial Infarction, Hypercholesterolemia | P4 | Completed | 20 | RCT, Double-blind | alirocumab, placebo |
| NCT02984982 Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia | Hypercholesterolemia, Acute Coronary Syndrome | P4 | Completed | 206 | RCT, Open-label | Alirocumab SAR236553, Atorvastatin, Rosuvastatin, Fenofibrate, Bezafibrate, Ezetimibe, Antiplatelets, Anticoagulants |
| NCT00561470 Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Treatment of Patients With Metastatic Colorectal Cancer After Failure of an Oxaliplatin Based Regimen | Colorectal Neoplasms, Neoplasm Metastasis | P3 | Completed | 1,226 | RCT, Double-blind | Placebo, Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin), FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) |
| NCT01627249 Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema | Diabetic Macular Edema | P3 | Completed | 660 | RCT, Single-blind | 2.0 mg intravitreal aflibercept, 1.25 mg intravitreal bevacizumab, 0.3 mg intravitreal ranibizumab |
| NCT04315298 Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19 | COVID-19 | P2P3 | Completed | 1,912 | RCT, Double-blind | Sarilumab, Placebo |
| NCT01709578 To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET) | Rheumatoid Arthritis | P3 | Completed | 546 | RCT, Double-blind | Sarilumab, placebo, hydroxychloroquine, methotrexate, sulfasalazine, leflunomide |
| NCT03346434 Safety, Pharmacokinetics and Efficacy of Dupilumab in Patients ≥6 Months to <6 Years With Moderate-to-Severe Atopic Dermatitis (Liberty AD PRESCHOOL) | Dermatitis, Atopic | P2P3 | Completed | 202 | Open-label | Dupilumab, Matching placebo |
| NCT03399786 Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia | Homozygous Familial Hypercholesterolemia | P3 | Completed | 65 | RCT, Double-blind | evinacumab, Placebo |
| NCT02134028 Long-Term Safety Evaluation of Dupilumab in Patients With Asthma (LIBERTY ASTHMA TRAVERSE) | Asthma | P3 | Completed | 2,282 | Open-label | Dupilumab |
| NCT04577820 Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP) | Fibrodyplasia Ossificans Progressiva (FOP), Heterotopic Ossification (HO) | P3 | Withdrawn | — | Open-label | garetosmab |
| NCT04183335 Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (LIBERTY-PN PRIME) | Neurodermatitis | P3 | Completed | 151 | RCT, Double-blind | Dupilumab SAR231893, Placebo, Moisturizers, Low to medium potent topical corticosteroids, Topical calcineurin inhibitors |
| NCT04015180 Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090 | Retinopathy of Prematurity (ROP) | P3 | Completed | 100 | Open-label | Eylea (Aflibercept, BAY86-5321) |
| NCT03088540 Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) | Carcinoma,Non-Small-Cell Lung, Lung Carcinomas, Non-Small-Cell | P3 | Completed | 712 | RCT, Open-label | Pemetrexed, Paclitaxel, Gemcitabine, Cisplatin, Carboplatin, cemiplimab |
| NCT03782532 Efficacy and Safety Study of Dupilumab in Patients With Persistent Asthma | Asthma | P3 | Completed | 486 | RCT, Double-blind | Dupilumab SAR231893, Placebo, Asthma Controller Therapies (include prednisone/prednisolone), Asthma Reliever Therapies |
| NCT00958438 PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2) | Gout | P3 | Completed | 248 | RCT, Double-blind | Placebo, Rilonacept, Rilonacept |
| NCT00288704 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) | Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria | P3 | Completed | 104 | RCT, Double-blind | rilonacept 160 mg, Placebo, rilonacept 160 mg |
| NCT01482910 VEGF Trap-Eye: Investigation of Efficacy and Safety in Chinese Subjects With Wet AMD (Age-Related Macular Degeneration) | Macular Degeneration | P3 | Completed | 304 | RCT, Double-blind | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Visudyne |
| NCT04678882 Dupilumab in Japanese Patients With Atopic Dermatitis | Atopic Dermatitis | P3 | Completed | 62 | RCT, Double-blind | Placebo, Dupilumab SAR231893 |
| NCT07318610 Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease | Peripheral Artery Disease (PAD) | P3 | Not Yet Recruiting | 7,050 | RCT, Double-blind | REGN7508, REGN9933, Placebo, Rivaroxaban |
| NCT02912468 A Controlled Clinical Study of Dupilumab in Patients With Bilateral Nasal Polyps | Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) | P3 | Completed | 276 | RCT, Double-blind | Dupilumab SAR231893 (REGN668), Placebo, Mometasone furoate 50 micrograms |
| NCT03257267 Study of Cemiplimab in Adults With Cervical Cancer | Squamous Cell Carcinoma (SCC), Recurrent or Metastatic, Platinum-refractory Cervical Cancer | P3 | Completed | 608 | RCT, Open-label | Cemiplimab, Investigator Choice (IC) Chemotherapy |
| NCT03344692 Effect of Alirocumab on Postprandial Hyperlipemia in Patients With Type 2 Diabetes | Type2 Diabetes | P3 | Completed | 22 | RCT, Double-blind | Alirocumab |
| NCT04327388 Sarilumab COVID-19 | Corona Virus Infection | P3 | Completed | 420 | RCT, Double-blind | Sarilumab SAR153191, Placebo |
| NCT01363440 Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema | Diabetic Macular Edema | P3 | Completed | 466 | RCT, Double-blind | Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) |
| NCT01730040 Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I) | Hypercholesterolemia | P3 | Completed | 355 | RCT, Double-blind | Alirocumab, Atorvastatin, Ezetimibe, Rosuvastatin, Placebo |
| NCT01949311 Open-label Study of Dupilumab in Patients With Atopic Dermatitis | Atopic Dermatitis | P3 | Completed | 2,733 | Open-label | Dupilumab |
| NCT02414854 Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest) | Asthma | P3 | Completed | 1,902 | RCT, Double-blind | Dupilumab, Placebo, Inhaled corticosteroid (ICS) therapy, Albuterol/Salbutamol, Levalbuterol/Levosalbutamol |
| NCT04452318 COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR Assay | Healthy Participants | P3 | Completed | 3,303 | RCT, Double-blind | REGN10933 + REGN10987, Placebo |
| NCT02107898 Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN) | Hypercholesterolemia | P3 | Completed | 216 | RCT, Double-blind | Placebo (for alirocumab), Alirocumab, Lipid-Modifying Therapy (LMT) |
| NCT02755649 A Study to Assess the Efficacy and Safety of Dupilumab in Participants With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically Advisable | Atopic Dermatitis | P3 | Completed | 325 | RCT, Double-blind | Dupilumab, Matching Placebo |
| NCT05989126 Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS) | Diabetic Macular Edema (DME), Neovascular Age-Related Macular Degeneration (nAMD) | P3 | Completed | 35 | Open-label | aflibercept 8 mg PFS |
| NCT03345914 Study to Investigate the Efficacy and Safety of Dupilumab Administered With Topical Corticosteroids (TCS) in Participants ≥6 to <12 Years With Severe Atopic Dermatitis (AD) | Dermatitis, Atopic | P3 | Completed | 367 | RCT, Double-blind | Dupilumab, Matching Placebo |
| NCT02476006 Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE) | Hypercholesterolemia | P3 | Completed | 998 | Open-label | ALIROCUMAB SAR236553 (REGN727), placebo (for injection training only), ezetimibe, atorvastatin, rosuvastatin, simvastatin |
| NCT03054428 Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe Atopic Dermatitis | Moderate-to-Severe Atopic Dermatitis, Dermatitis, Dermatitis Atopic | P3 | Completed | 251 | RCT, Double-blind | Dupilumab, Placebo |
| NCT00964795 Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD) | Neovascular Age-related Macular Degeneration | P3 | Completed | 323 | Open-label | Intravitreal Aflibercept Injection 2mg |
| NCT02585778 Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin) | Hypercholesterolaemia | P3 | Completed | 517 | RCT, Double-blind | Alirocumab, Placebo, Lipid-Modifying Therapy (LMT), Antihyperglycemic Drug |
| NCT04394351 Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE) | Eosinophilic Esophagitis (EoE) | P3 | Completed | 102 | RCT, Double-blind | Dupilumab, Matching Placebo |
| NCT04206553 A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid | Bullous Pemphigoid | P2P3 | Completed | 106 | RCT, Double-blind | dupilumab, Matching Placebo, Oral corticosteroids (OCS) |
| NCT07430956 Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable | Atrial Fibrillation (AF) | P3 | Not Yet Recruiting | 2,628 | RCT, Double-blind | REGN7508, REGN9933, Placebo |
| NCT07424144 An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | P3 | By Invite | 380 | RCT, Double-blind | Itepekimab (SAR440340), Placebo |
| NCT01249664 VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV) | Myopia, Pathological | P3 | Completed | 122 | RCT, Double-blind | VEGF Trap-Eye (BAY86-5321) |
| NCT01623115 Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy | Hypercholesterolemia | P3 | Completed | 486 | RCT, Double-blind | Alirocumab, Placebo (for alirocumab), Lipid Modifying Therapy (LMT) |
| NCT04684524 Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) (LIBERTY-AFRS-AI) | Allergic Fungal Rhinosinusitis | P3 | Completed | 62 | RCT, Double-blind | Dupilumab SAR231893, Placebo |
| NCT02447276 Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip | Osteoarthritis, Knee, Osteoarthritis, Hip | P2P3 | Completed | 421 | RCT, Double-blind | REGN475, Placebo |
| NCT04004208 Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy | Retinopathy of Prematurity (ROP) | P3 | Completed | 113 | RCT, Open-label | Eylea (Aflibercept, BAY86-5321) |
| NCT03600805 Evaluation of Efficacy and Safety of Sarilumab in Patients With GCA | Giant Cell Arteritis | P3 | Terminated | 83 | RCT, Double-blind | Sarilumab SAR153191, Sarilumab matching placebo, Prednisone, Prednisone matching placebo |
| NCT02023879 Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II) | Hypercholesterolemia | P3 | Completed | 233 | RCT, Double-blind | Alirocumab, Placebo (for Alirocumab), Non-statin LMT |
| NCT03480568 Alirocumab in Patients on a Stable Dialysis Regimen | Hemodialysis, Peritoneal Dialysis | P3 | Unknown | 20 | Open-label | Alirocumab 150 MG/ML [Praluent] |
| NCT04202679 Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (PRIME2) | Neurodermatitis | P3 | Completed | 160 | RCT, Double-blind | Dupilumab SAR231893, Placebo, Moisturizers, Low to medium potent topical corticosteroids, Topical calcineurin inhibitors |
| NCT02584504 Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin | Hypercholesterolemia | P3 | Completed | 163 | RCT, Double-blind | Alirocumab, Placebo, Atorvastatin, Non-statin Lipid-Modifying Therapy |
| NCT05131204 Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria | Paroxysmal Nocturnal Hemoglobinuria | P3 | Terminated | 3 | RCT, Open-label | Cemdisiran, Eculizumab, Pozelimab, Ravulizumab |
| NCT03161093 A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip | Osteoarthritis, Knee, Osteoarthritis, Hip | P3 | Completed | 3,307 | RCT, Double-blind | Fasinumab, Naproxen, Fasinumab-matching placebo, Naproxen-matching placebo |
| NCT02396316 Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients | Glaucoma, Neovascular | P3 | Completed | 54 | RCT, Double-blind | Aflibercept (Eylea, BAY 86-5321), Sham Injection |
| NCT07493304 Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers | Venous Thromboembolism (VTE) | P3 | Not Yet Recruiting | 1,600 | RCT, Open-label | REGN7508, Apixaban |
| NCT02634333 Anti-VEGF Treatment for Prevention of PDR/DME | Diabetic Retinopathy, Diabetic Macular Edema | P3 | Completed | 399 | RCT, Double-blind | Prompt aflibercept, Deferred aflibercept |
| NCT04423718 Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye | Neovascular Age-Related Macular Degeneration | P3 | Completed | 1,011 | RCT, Double-blind | Aflibercept High Dose VEGF Trap-Eye (BAY86-5321), Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321) |
| NCT03510715 An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia | Hypercholesterolemia | P3 | Completed | 18 | Open-label | Alirocumab SAR236553 (REGN727), Atorvastatin, Simvastatin, Fluvastatin, Pravastatin, Lovastatin, Rosuvastatin, Ezetimibe, Cholestyramine, Nicotinic acid, Fenofibrate, Omega-3 fatty acids |
| NCT02718326 Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR) | Nonproliferative Diabetic Retinopathy | P3 | Completed | 402 | RCT, Double-blind | Intravitreal aflibercept injection [IAI], Sham |
| NCT02683239 Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip | Osteoarthritis of the Knee or Hip | P3 | Completed | 5,331 | RCT, Double-blind | Fasinumab, Placebo |
| NCT01954394 Open Label Study of Long Term Safety Evaluation of Alirocumab | Hypercholesterolemia | P3 | Completed | 986 | Open-label | Alirocumab, Lipid-Modifying Therapy (LMT) |
| NCT00637377 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD) | Macular Degeneration | P3 | Completed | 1,240 | RCT, Double-blind | Ranibizumab, Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321), Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321), Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321) |
| NCT02528214 Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma | Asthma | P3 | Completed | 210 | RCT, Double-blind | Dupilumab, Placebo, Oral corticosteroid therapy (prednisone/prednisolone), Inhaled corticosteroid (ICS) therapy, Albuterol/Salbutamol, Levalbuterol/Levosalbutamol |
| NCT03620747 Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in Patients With Asthma (Long-Term Follow-Up) | Asthma | P3 | Completed | 393 | Open-label | Dupilumab SAR231893 (REGN668) |
| NCT03067844 Vascular Effects of Alirocumab in Acute MI-Patients | Coronary Vessel, Coronary Circulation | P3 | Completed | 294 | RCT, Double-blind | Alirocumab |
| NCT01661270 A Study of Aflibercept Versus Placebo With FOLFIRI in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin Chemotherapy | Colorectal Cancer Metastatic | P3 | Completed | 332 | RCT, Double-blind | Aflibercept, Placebo |
| NCT02332590 Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH) | Rheumatoid Arthritis | P3 | Completed | 369 | RCT, Double-blind | Sarilumab, Adalimumab, Placebo (for sarilumab), Placebo (for adalimumab) |
| NCT04751487 Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD) | Chronic Obstructive Pulmonary Disease | P3 | Completed | 1,239 | RCT, Double-blind | Itepekimab SAR440340, Placebo |
| NCT01146652 Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND) | Rheumatoid Arthritis | P3 | Completed | 2,023 | Open-label | SAR153191 (REGN88) |
| NCT02277769 Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis | Dermatitis, Atopic | P3 | Completed | 708 | RCT, Double-blind | Dupilumab, Placebo (for Dupilumab) |
| NCT03304379 Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip | Osteoarthritis, Knee, Osteoarthritis, Hip | P3 | Completed | 1,650 | RCT, Double-blind | Fasinumab, Matching placebo |
| NCT00519285 Aflibercept in Combination With Docetaxel in Metastatic Androgen Independent Prostate Cancer | Prostatic Neoplasms, Neoplasm Metastasis | P3 | Completed | 1,224 | RCT, Double-blind | Aflibercept, Placebo (for aflibercept), Docetaxel, Prednisone or Prednisolone |
| NCT01764997 An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate | Rheumatoid Arthritis | P3 | Terminated | 776 | RCT, Double-blind | Sarilumab, Etanercept, Methotrexate, Placebo (for sarilumab), Placebo (for etanercept), Adalimumab |
| NCT04162470 REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate Its Long Term Safety, Efficacy and Tolerability. | Paroxysmal Nocturnal Hemoglobinuria | P3 | Terminated | 24 | Open-label | REGN3918 |
| NCT04429503 Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease | Diabetic Macular Edema, Type 1 Diabetes Mellitus | P2P3 | Completed | 660 | RCT, Double-blind | aflibercept, High-dose aflibercept |
| NCT06602739 A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy | Allergic Conjunctivitis | P3 | Completed | 54 | RCT, Double-blind | REGN5713, REGN5715, Placebo |
| NCT02620020 A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain | Low Back Pain | P2P3 | Completed | 563 | RCT, Double-blind | Fasinumab, placebo |
| NCT07484230 A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Adult Japanese Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | P3 | Not Yet Recruiting | 20 | RCT, Double-blind | Itepekimab (SAR440340), Placebo |
| NCT01670721 Colorectal Cancer Metastatic | Colorectal Cancer Metastatic | P3 | Completed | 175 | Open-label | AFLIBERCEPT, Irinotecan, Fluorouracil, Leucovorin |
| NCT00943072 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) | Macular Edema Secondary to Central Retinal Vein Occlusion | P3 | Completed | 189 | RCT, Double-blind | VEGF Trap-Eye 2.0mg, Sham |
| NCT02325791 Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm Infants | Respiratory Syncytial Virus Infections | P3 | Completed | 1,177 | RCT, Double-blind | Suptavumab 30 mg/kg, Placebo Matched to Suptavumab, Suptavumab 30 mg/kg- 1 Dose, Suptavumab 30 mg/kg - 2 Doses |
| NCT02898454 Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps | Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) | P3 | Completed | 448 | RCT, Double-blind | Dupilumab SAR231893 (REGN668), Placebo, Mometasone furoate nasal spray |
| NCT01512966 Japanese Safety Study of VEGF Trap-Eye in DME (Diabetic Macular Edema) | Macular Edema | P3 | Completed | 73 | Open-label | VEGF Trap-Eye (BAY86-5321) |
| NCT04425629 Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19 | COVID-19 | P3 | Terminated | 10,078 | Open-label | casirivimab+imdevimab combination therapy |
| NCT02326220 Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy | Heterozygous Familial Hypercholesterolemia | P3 | Completed | 62 | RCT, Double-blind | Placebo, Alirocumab |
| NCT01926782 Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1) | Hypercholesterolemia | P3 | Completed | 803 | RCT, Double-blind | Placebo (for alirocumab), Alirocumab, Statin |
| NCT01768572 To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN) | Rheumatoid Arthritis | P3 | Completed | 202 | RCT, Double-blind | sarilumab SAR153191 (REGN88), tocilizumab, hydroxychloroquine, methotrexate, sulfasalazine, leflunomide, subcutaneous placebo, intravenous placebo |
| NCT03409744 Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia | Homozygous Familial Hypercholesterolemia | P3 | Completed | 116 | Open-label | evinacumab |
| NCT02260986 Study to Assess the Efficacy and Long-term Safety of Dupilumab (REGN668/SAR231893) in Adult Participants With Moderate-to-Severe Atopic Dermatitis | Atopic Dermatitis | P3 | Completed | 740 | RCT, Double-blind | Dupilumab, Placebo (for Dupilumab) |
| NCT03560466 Assessment of the Safety and Efficacy of Dupilumab in Children With Asthma (Liberty Asthma Excursion) | Asthma | P3 | Completed | 378 | Open-label | Dupilumab (SAR231893/REGN668), Asthma controller therapies (incl. prednisone/prednisolone), Asthma reliever therapies |
| NCT01709500 Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy) | Heterozygous Familial Hypercholesterolemia | P3 | Completed | 249 | RCT, Double-blind | LMT (atorvastatin, simvastatin, or rosuvastatin), alirocumab, Placebo |
| NCT00855920 Study Utilizing Rilonacept in Gout Exacerbations | Acute Gout Flare | P3 | Completed | 225 | RCT, Double-blind | Rilonacept, Indomethacin |
| NCT04678856 Dupilumab in CRSsNP | Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis | P3 | Completed | 71 | RCT, Double-blind | Dupilumab SAR231893, Placebo |
| NCT00829829 PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1 | Intercritical Gout | P3 | Completed | 241 | RCT, Double-blind | Rilonacept 80 mg, Rilonacept 160 mg |
| NCT02057250 To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis | RA | P3 | Completed | 217 | RCT, Open-label | Sarilumab, Methotrexate, Sulfasalazine, Leflunomide, Hydroxychloroquine |
| NCT02715726 Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia | Hypercholesterolemia | P3 | Completed | 615 | RCT, Double-blind | Alirocumab, Placebo for alirocumab, ezetimibe, placebo for ezetimibe, atorvastatin, rosuvastatin, simvastatin |
| NCT03633617 Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE) | Eosinophilic Esophagitis | P3 | Completed | 321 | RCT, Double-blind | Dupilumab, Placebo |
| NCT03600818 Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica | Polymyalgia Rheumatica | P3 | Terminated | 118 | RCT, Double-blind | Sarilumab SAR153191 (REGN88), Sarilumab-matching placebo, Prednisone, Prednisone-matching placebo, Prednisone |
| NCT07393282 A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM) | High Risk Smoldering Multiple Myeloma (HR-SMM) | P3 | Not Yet Recruiting | 270 | RCT, Open-label | Linvoseltamab, Daratumumab |
| NCT04502966 Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction | Allergic Rhinoconjunctivitis, Grass Pollen Allergy | P2 | Completed | 108 | RCT, Double-blind | Dupixent®, Grazax®, Dupixent® Placebo, Grazax® Placebo |
| NCT03682770 Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy) | Peanut Allergy | P2 | Completed | 148 | RCT, Double-blind | Dupilumab, Placebo matching dupilumab, AR101 |
| NCT07058012 A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE) | Colo-rectal Cancer | P2 | Not Yet Recruiting | 79 | Open-label | Cemiplimab, cemiplimab plus fianlimab, cemiplimab + REGN7075 |
| NCT07224022 Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer | Colon Cancer | P2 | Not Yet Recruiting | 24 | Open-label | Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] |
| NCT03956550 A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee | Osteoarthritis of the Knee, Pain | P2 | Terminated | 259 | RCT, Double-blind | REGN5069, Matching Placebo |
| NCT03886493 Neoadjuvant Dupilumab in Men With Localized High-Risk Prostate Cancer | Prostate Cancer | P2 | Terminated | 7 | Open-label | Dupilumab |
| NCT04148352 Dupilumab and Milk OIT for the Treatment of Cow's Milk Allergy | Allergies Food Milk | P2 | Terminated | 33 | RCT, Double-blind | Dupilumab |
| NCT01239017 A Study of the Safety and Efficacy of Subcutaneously Administered REGN475 in Patients With Osteoarthritis of the Knee | Osteoarthritis | P2 | Withdrawn | — | RCT, Double-blind | REGN475 |
| NCT04311606 Anti-VEGF Therapy for Acute Thyroid Eye Disease | Thyroid Eye Disease | P2 | Completed | 11 | RCT, Double-blind | Sub-tenon injection of saline followed by a sub-tenon injection of aflibercept, Sub-tenon injection of hyaluronidase (HA) followed by a sub-tenon injection of aflibercept, Sub-tenon injection of hyaluronidase (HA) alone |
| NCT03710941 Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis | Sporadic Inclusion Body Myositis | P2 | Withdrawn | — | RCT, Double-blind | REGN2477+REGN1033, Matching placebo |
| NCT06384820 Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC) | Cutaneous Squamous Cell Carcinoma | P2 | Withdrawn | — | RCT, Open-label | cemiplimab, fianlimab |
| NCT02418754 Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD) | Neovascular Age-Related Macular Degeneration | P2 | Terminated | 505 | RCT, Double-blind | REGN2176-3, Intravitreal Aflibercept Injection (IAI) |
| NCT00789477 DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical Impact | Diabetic Macular Edema | P2 | Completed | 221 | RCT, Double-blind | Intravitreal Aflibercept Injection |
| NCT03175367 Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia | Hypercholesterolemia | P2 | Completed | 272 | RCT, Double-blind | Evinacumab, Matching placebo |
| NCT03787095 Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Suppressive cART | HIV Infections | P1P2 | Terminated | 5 | RCT, Double-blind | Cemiplimab, Placebo |
| NCT03004001 Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome | Nephrotic Syndrome | P2 | Terminated | 3 | RCT, Double-blind | Alirocumab, Alirocumab placebo, Atorvastatin |
| NCT00944892 A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee | Osteoarthritis of the Knee | P1P2 | Completed | 200 | RCT, Double-blind | REGN475 |
| NCT04916002 A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer | Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma | P2 | Terminated | 77 | Open-label | vidutolimod, cemiplimab |
| NCT05088460 A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD) | Familial Partial Lipodystrophy, Metabolic Abnormalities | P2 | Terminated | 20 | RCT, Double-blind | REGN4461, Matching Placebo |
| NCT04831450 Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC) | Head and Neck Squamous Cell Carcinoma, HNSCC | P2 | Withdrawn | — | Open-label | Cemiplimab-Rwlc |
| NCT01604824 A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene | Hypercholesterolemia | P2 | Completed | 23 | RCT, Double-blind | Alirocumab, Placebo |
| NCT07318597 Phase 2 Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH) | Pulmonary Arterial Hypertension (PAH) | P2 | Not Yet Recruiting | 99 | RCT, Double-blind | REGN13335, Placebo |
| NCT06385262 TOP 2301: Neoadjuvant Chemo for NSCLC | Non Small Cell Lung Cancer | P2 | SUSPENDED | 126 | RCT, Open-label | Alirocumab, Cemiplimab, Chemotherapy |
| NCT04242173 Cemiplimab-rwlc for Unresectable Locally Recurrent and/or Metastatic CSCC | Cutaneous Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma of the Head and Neck | P2 | Terminated | 3 | Open-label | Cemiplimab-Rwlc |
| NCT00991172 A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain | Sciatica | P2 | Completed | 159 | RCT, Double-blind | REGN475, REGN475, Placebo Injection |
| NCT01988246 Prevention of Macular Edema In Patients With Diabetic Retinopathy Undergoing Cataract Surgery | Diabetic Retinopathy | P1P2 | Completed | 30 | RCT, Single-blind | Aflibercept, Sham |
| NCT05128383 Study to Assess Efficacy and Safety of Dupilumab in the Treatment of Keloids | Keloid | P2 | Completed | 20 | Open-label | Dupilumab |
| NCT05202288 Impact of Delay Between Administration of Inmazeb Administration and Vaccination by Ervebo on Vaccine Immune Response on Healthy Volunteers | Ebola Virus Disease | P2 | Not Yet Recruiting | 132 | RCT, Open-label | Ervebo, Inmazeb |
| NCT04154943 Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma | Cutaneous Squamous Cell Carcinoma | P2 | Completed | 79 | Open-label | Cemiplimab |
| NCT01859988 Study of Dupilumab Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis | Atopic Dermatitis | P2 | Completed | 380 | RCT, Double-blind | Dupilumab, Placebo |
| NCT02407756 A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema) | Atopic Dermatitis | P2 | Completed | 78 | Open-label | Dupilumab |
| NCT04046107 Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy | Hepatitis B Virus | P1P2 | Withdrawn | — | Open-label | Cemiplimab |
| NCT04442269 Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED) | Allergic Bronchopulmonary Aspergillosis | P2 | Completed | 62 | RCT, Double-blind | dupilumab, Placebo |
| NCT03838731 Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge | Cat Allergy, Mild Asthma | P2 | Completed | 56 | RCT, Double-blind | REGN1908-1909, Placebo |
| NCT04159415 Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy | Generalized Lipodystrophy | P2 | Completed | 16 | RCT, Double-blind | Placebo, Low-Dose REGN4461, High-dose REGN4461 |
| NCT01217814 Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-α Blockers | Rheumatoid Arthritis | P2 | Terminated | 16 | RCT, Double-blind | Sarilumab, Placebo, Golimumab, methotrexate (MTX), Folic/folinic acid |
| NCT01548404 Study of Dupilumab in Adult Patients With Extrinsic Moderate-to-Severe Atopic Dermatitis | Atopic Dermatitis | P2 | Completed | 109 | RCT, Double-blind | Placebo, Dupilumab |
| NCT04526899 A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment | Melanoma Stage III, Melanoma Stage IV | P2 | Completed | 184 | RCT, Open-label | BNT111, Cemiplimab |
| NCT05326412 Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD | Chronic Obstructive Pulmonary Disease | P2 | Completed | 49 | Open-label | Itepekimab SAR440340 |
| NCT01979016 Study to Determine the Safety and Effectiveness of Dupilumab for Treatment of Atopic Dermatitis (AD) | Atopic Dermatitis (AD) | P2 | Completed | 54 | RCT, Double-blind | Dupilumab, Placebo |
| NCT00284141 Study of AVE0005 (VEGF Trap) in Locally Advanced or Metastatic Platinum- and Erlotinib- Resistant Non-small-cell-lung Adenocarcinoma | Pulmonary Diseases, Neoplasms, Lung | P2 | Completed | 98 | Open-label | Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®) |
| NCT06237309 REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction | Heart Failure | P2 | Terminated | 89 | RCT, Double-blind | REGN5381, Placebo |
| NCT04811716 Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy | Paroxysmal Nocturnal Hemoglobinuria | P2 | Completed | 24 | RCT, Open-label | Pozelimab, Cemdisiran |
| NCT04992273 COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age | COVID-19 | P2 | Terminated | 7 | Open-label | casirivimab+imdevimab |
| NCT05618808 A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants | Venous Thromboembolism | P2 | Completed | 373 | RCT, Open-label | REGN9933, Enoxaparin, Apixiban |
| NCT01605708 Study to Assess the Clinical Activity of a Sequential Dose of REGN846 on Refractory Pruritus in Patients With Atopic Dermatitis | Pruritus, Atopic Dermatitis | P1P2 | Terminated | 19 | RCT, Double-blind | REGN846 |
| NCT03430063 A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer | Advanced Non-Small Cell Lung Carcinoma | P2 | Terminated | 28 | RCT, Open-label | SDREGN2810, SDREGN2810/ipi, HDREGN2810 |
| NCT06280391 A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis | Bronchiectasis | P2 | Completed | 312 | RCT, Double-blind | Itepekimab (SAR440340), Placebo |
| NCT02890992 An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia | Hypercholesterolaemia | P2 | Completed | 42 | Open-label | alirocumab SAR236553 (REGN727), statins, ezetimibe, cholestyramine, fenofibrate, omega-3 fatty acids, nicotinic acid |
| NCT00396591 AVE0005 (VEGF Trap) in Patients With Recurrent Symptomatic Malignant Ascites | Ovarian Neoplasms | P2 | Completed | 16 | Open-label | Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®) |
| NCT04426695 Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19 | COVID-19 | P1P2 | Completed | 2,252 | RCT, Double-blind | REGN10933+REGN10987 combination therapy, Placebo |
| NCT02085005 Capecitabine Plus Aflibercept as Maintenance Therapy Following Capecitabine Plus Oxaliplatin Plus Aflibercept in Patients With Metastatic Colorectal Cancer | Colorectal Cancer Metastatic | P2 | Withdrawn | — | Open-label | Capecitabine, Aflibercept AVE0005, Oxaliplatin SR96669 |
| NCT07455851 A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed/Refractory Multiple Myeloma | Relapsed Refractory Multiple Myeloma (RRMM) | P1P2 | Not Yet Recruiting | 150 | Open-label | Linvoseltamab, REGN17372+Linvoseltamab |
| NCT03188666 A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva | Fibrodysplasia Ossificans Progressiva | P2 | Completed | 44 | RCT, Double-blind | REGN2477, Matching placebo |
| NCT01053702 Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Pain Resulting From Thermal Injury | Thermal Injury Pain | P2 | Withdrawn | — | RCT, Double-blind | R475, Placebo |
| NCT04339062 Cemiplimab in AlloSCT/SOT Recipients With CSCC | Cutaneous Squamous Cell Carcinoma, Advanced Cancer | P1P2 | Completed | 12 | Open-label | Cemiplimab, Everolimus, Sirolimus, Prednisone |
| NCT02573233 Evaluation of Dupilumab's Effects on Airway Inflammation in Patients With Asthma | Asthma | P2 | Completed | 42 | RCT, Double-blind | Placebo, Dupilumab SAR231893/REGN668, fluticasone propionate and salmeterol, budesonide and formoterol, mometasone furoate and formoterol |
| NCT00527423 Randomized, Single-Masked, Long-Term, Safety and Tolerability Study of VEGF Trap-Eye in AMD | Macular Degeneration | P2 | Completed | 157 | Single-blind | VEGF Trap Eye |
| NCT00327171 Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer | Neoplasms, Cancer of the Ovary | P2 | Completed | 218 | RCT, Double-blind | Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®) |
| NCT02760498 Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma | Advanced Cutaneous Squamous Cell Carcinoma | P2 | Completed | 432 | Open-label | cemiplimab |
| NCT03387852 Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants | Asthma | P2 | Completed | 296 | RCT, Double-blind | SAR440340, Dupilumab, Fluticasone or Fluticasone/salmeterol combination, Placebo for SAR440340, Placebo for dupilumab |
| NCT01882868 A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan | Colorectal Cancer Metastatic | P2 | Completed | 62 | Open-label | Aflibercept, Levofolinate, Irinotecan, 5-FU |
| NCT01920893 An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis | Nasal Polyps | P2 | Completed | 60 | RCT, Double-blind | Placebo (for dupilumab), Dupilumab, Mometasone furoate nasal spray |
| NCT02265952 Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH) | Homozygous Familial Hypercholesterolemia | P2 | Completed | 9 | Open-label | REGN1500 250 mg SC/15 mg/kg IV/450 mg SC |
| NCT01001715 Single Injection of REGN475/SAR164877 in Treatment of Vertebral Fracture Pain | Back Pain | P2 | Terminated | 41 | RCT, Double-blind | REGN475/SAR164877, Placebo (for REGN475/SAR164877) |
| NCT00320788 Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD) | Macular Degeneration | P2 | Completed | 159 | RCT, Double-blind | aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321) |
| NCT01724554 Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion | Central Retinal Vein Occlusion, Proliferative Diabetic Retinopathy | P1P2 | Completed | 24 | RCT, Open-label | Intravitreal Aflibercept Injection |
| NCT03359356 Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD) | Alopecia Areata | P2 | Completed | 60 | RCT, Double-blind | Dupilumab, Placebo |
| NCT03793608 Study to Evaluate Dupilumab Monotherapy in Pediatric Patients With Peanut Allergy | Peanut Allergy | P2 | Completed | 25 | Open-label | Dupilumab |
| NCT04852978 COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers | Healthy, Chronic Stable Illness | P2 | Completed | 295 | RCT, Open-label | casirivimab+imdevimab, Moderna mRNA-1273 vaccine |
| NCT01963598 Study of the Safety and Efficacy of REGN1033 (SAR391786) in Patients With Sarcopenia | Sarcopenia | P2 | Completed | 253 | RCT, Double-blind | REGN1033 (SAR391786), placebo |
| NCT01312961 Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma | Asthma | P2 | Completed | 104 | RCT, Double-blind | Dupilumab, Placebo (for Dupilumab), Fluticasone/Salmeterol combination therapy, Fluticasone monotherapy, Albuterol, Levalbuterol |
| NCT02379052 Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE) | Eosinophilic Esophagitis | P2 | Completed | 47 | RCT, Double-blind | Dupilumab, Placebo |
| NCT04888507 Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy | Paroxysmal Nocturnal Hemoglobinuria | P2 | Completed | 6 | Open-label | Pozelimab, Cemdisiran |
| NCT03949673 Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip | Osteoarthritis, Knee, Osteoarthritis, Hip | P2 | Terminated | 23 | Open-label | Fasinumab, Naproxen, Diclofenac, Celecoxib, Placebo |
| NCT01118728 Extension Study for Long Term Evaluation of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis | Ankylosing Spondylitis | P2 | Terminated | 223 | Open-label | Sarilumab |
| NCT00609544 Study of the Safety and Effectiveness of Rilonacept (IL-1 Trap) Administered Subcutaneously in Subjects With Non Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) and Anemia | Chronic Kidney Disease, Anemia | P2 | Withdrawn | — | RCT, Double-blind | Rilonacept |
| NCT07477704 A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia | Hypercholesterolemia | P2 | Not Yet Recruiting | 420 | RCT, Open-label | Alirocumab |
| NCT01710332 The Safety & Efficacy of Intravitreal Aflibercept Injection in Patients With Persistent Central Serous Chorioretinopathy | Central Serous Chorioretinopathy | P2 | Completed | 12 | RCT, Open-label | Intravitreal Aflibercept Injection |
| NCT03712904 Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma | Uveal Melanoma | P2 | Terminated | 3 | RCT, Open-label | Ziv-Aflibercept |
| NCT04666441 COVID-19 Study Assessing the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection | COVID-19 | P2 | Completed | 1,149 | RCT, Double-blind | REGN10933+REGN10987 combination therapy, Placebo |
| NCT01538719 IL1-TRAP, Rilonacept, in Systemic Sclerosis | Scleroderma, Systemic Sclerosis | P1P2 | Completed | 24 | RCT, Double-blind | Rilonacept |
| NCT01061723 Dose Ranging Study to Evaluate the Efficacy and Safety of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis | Ankylosing Spondylitis | P2 | Completed | 301 | RCT, Double-blind | Sarilumab, Placebo |
| NCT06122922 Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN) | Pulmonary Artery Hypertension | P2 | Withdrawn | — | Open-label | Hyperpolarized Xe129 |
| NCT03678545 Dupilumab in Eosinophilic Gastritis | Eosinophilic Gastritis, Eosinophilic Gastroenteritis | P2 | Completed | 41 | RCT, Double-blind | Dupilumab (blinded), Placebo (blinded) |
| NCT07450183 Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 | Lung Cancer (NSCLC) | P2 | Not Yet Recruiting | 33 | Open-label | Cemiplimab, Adjuvant chemotherapy |
| NCT06833190 REGN5381 in Adult Participants With Uncontrolled Hypertension | Uncontrolled Hypertension | P2 | Terminated | 34 | RCT, Double-blind | REGN5381, Placebo |
| NCT07281768 Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer | Colorectal Cancer | P2 | Not Yet Recruiting | 66 | RCT, Open-label | Oxaliplatin, Capecitabine, Cemiplimab, Fianlimab, REGN7075 |
| NCT02462889 IAI Versus Sham as Prophylaxis Against Conversion to Neovascular AMD | Age-Related Macular Degeneration | P2 | Completed | 128 | RCT, Single-blind | Intravitreal aflibercept injection, Placebo |
| NCT03738423 Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis | Atopic Dermatitis | P2 | Terminated | 129 | RCT, Double-blind | REGN3500, REGN3500-Matching Placebo |
| NCT05430919 Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants | Allergic Rhinitis, Conjunctivitis | P2 | Completed | 217 | RCT, Double-blind | REGN5713, REGN5714, REGN5715 |
| NCT03132636 PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy | Carcinoma, Basal Cell | P2 | Completed | 138 | Open-label | cemiplimab |
| NCT02210780 Study of Dupilumab and Immune Responses in Adults With Atopic Dermatitis (AD) | Atopic Dermatitis | P2 | Completed | 194 | RCT, Double-blind | Dupilumab, Placebo |
| NCT02712008 Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular Edema | Diabetic Macular Edema | P2 | Completed | 302 | RCT, Double-blind | REGN910-3, Intravitreal Aflibercept Injection (IAI) |
| NCT03679845 Study to Assess Sarilumab in Halting Progression of Morphea | Morphea, Plaque Form | P1P2 | Withdrawn | — | Open-label | Sarilumab |
| NCT07234058 Trial Assessing Fianlimab Plus Cemiplimab Plus Chemotherapy or Cemiplimab Plus Chemotherapy in Patients With Pleural Mesothelioma | Pleural Mesotheliomas | P2 | Not Yet Recruiting | 126 | RCT, Open-label | Cemiplimab, Fianlimab, Pemetrexed (Alimta), Cisplatin, Carboplatin (AUC 5) |
| NCT03085784 Intravitreal Aflibercept Injection for Radiation Retinopathy Trial | Radiation Retinopathy | P2 | Unknown | 40 | RCT, Open-label | Aflibercept |
| NCT04633278 CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma | Squamous Cell Carcinoma of Head and Neck | P2 | Terminated | 24 | Open-label | CMP-001, Pembrolizumab |
| NCT03669718 A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC | Squamous Cell Carcinoma of the Oropharynx, HPV16 Positive | P2 | Unknown | 194 | RCT, Double-blind | ISA101b, Cemiplimab |
| NCT06052852 Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies | Triple Negative Breast Cancer, Clear Cell Renal Cell Carcinoma | P1 | Terminated | 17 | Open-label | BDC-3042, Cemiplimab |
| NCT04826393 ASP8374 + Cemiplimab in Recurrent Glioma | Glioblastoma, Recurrent Glioblastoma | P1 | Completed | 14 | RCT, Open-label | ASP8374, cemiplimab |
| NCT04506645 Study to Assess the Safety, Tolerability, and Pharmacokinetics of REGN5381 (an NPR1 Agonist) in Adult Humans | Healthy | P1 | Completed | 90 | RCT, Double-blind | REGN5381 |
| NCT00479076 A Phase I Study of Intravenous Aflibercept in Combination With S-1 in Japanese Cancer Patients | Neoplasms | P1 | Completed | 22 | RCT, Open-label | aflibercept (AVE0005), S-1 |
| NCT01011959 A Multiple-dose Study of the Safety and Tolerability of REGN88(SAR153191) in Rheumatoid Arthritis Subjects | Rheumatoid Arthritis | P1 | Completed | 60 | RCT, Double-blind | REGN88 |
| NCT00383370 Safety and Tolerability of Intravitreal VEGF Trap Formulations in Subjects With Neovacular AMD | Neovascular Age Related Macular Degeneration | P1 | Completed | 20 | RCT, Double-blind | VEGF Trap, VEGF Trap |
| NCT02017639 Sarilumab Effect on the Pharmacokinetics of Simvastatin | Rheumatoid Arthritis | P1 | Completed | 19 | Open-label | sarilumab SAR153191 (REGN88), simvastatin |
| NCT01933763 An Ascending Single-Dose Study of the Safety, Tolerability and Bioeffect of REGN1193 | Healthy Volunteers | P1 | Completed | 56 | RCT, Double-blind | REGN1193 |
| NCT00856310 A Single-Dose Study of the Safety and Tolerability of REGN475(SAR164877) in Healthy Subjects | Healthy | P1 | Completed | 56 | RCT, Double-blind | REGN475 (SAR164877) |
| NCT03477864 Stereotactic Body Radiation Therapy With REGN2810 and/or Ipilimumab Before Surgery in Treating Participants With Progressive Advanced or Oligometastatic Prostate Cancer | Stage III Prostate Cancer, Stage IIIA Prostate Cancer | P1 | Withdrawn | — | RCT, Open-label | Ipilimumab, Anti-PD-1 Monoclonal Antibody REGN2810 |
| NCT01720576 Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1033 (SAR391786) | Healthy Volunteers | P1 | Completed | 60 | RCT, Double-blind | REGN1033 (SAR391786), Placebo |
| NCT01930552 A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies | Neoplasm Malignant | P1 | Completed | 20 | Open-label | Aflibercept AVE0005, Leucovorin, Irinotecan, 5-Fluorouracil |
| NCT01148615 A Study of Intravenous Aflibercept With Docetaxel in Chinese Patients With Solid Tumors | Neoplasm Malignant | P1 | Completed | 20 | Open-label | Aflibercept (AVE0005), Docetaxel (XRP6976) |
| NCT03746704 Study of ImmunoPet Imaging of PD-L1 in Tumors Using 89Zr-DFO-REGN3504 in Adult Participants With Advanced PD-L1 Positive Malignancies | Advanced PD-L1 Positive Malignancies | P1 | Terminated | 2 | Open-label | 89Zr˗DFO˗REGN3504 |
| NCT05481333 A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy Participants | Healthy | P1 | Completed | 64 | RCT, Double-blind | REGN7999, Placebo |
| NCT06024408 A Trial to Learn if Receiving ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk Factor | Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH) | P1 | Completed | 9 | RCT, Double-blind | ALN-PNP, Placebo |
| NCT05102136 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers | Healthy Volunteers | P1 | Completed | 56 | RCT, Double-blind | REGN9933, Placebo |
| NCT01484600 Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy Volunteers | Healthy | P1 | Completed | 36 | RCT, Open-label | REGN668: Injection Rate 1, REGN668: Injection Rate 2 |
| NCT02290951 Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies | Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia | P1 | Completed | 200 | Open-label | Odronextamab multiple dose levels, Odronextamab multiple dose levels |
| NCT00045266 VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma | Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific | P1 | Completed | — | Open-label | ziv-aflibercept |
| NCT01850680 Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid Arthritis | Rheumatoid Arthritis | P1 | Completed | 61 | RCT, Double-blind | sarilumab SAR153191 (REGN88), placebo, methotrexate, folic acid |
| NCT05603195 A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 80 | RCT, Double-blind | REGN7508 (IV), REGN7508 (SC), Matching Placebo (IV), Matching Placebo (SC) |
| NCT06444178 Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants | Healthy Volunteers | P1 | Completed | 224 | RCT, Open-label | Aspirin, REGN9933, REGN7508, Rivaroxaban |
| NCT01448317 Ascending Dose Study of the Safety and Tolerability of Alirocumab (SAR236553/REGN727) in Japanese Healthy Volunteers | Hypercholesterolemia | P1 | Completed | 32 | RCT, Double-blind | Alirocumab (Solution), Alirocumab (Lyophilized formulation), Placebo (Solution), Placebo (Lyophilized formulation) |
| NCT00083213 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma | Cancer | P1 | Completed | 25 | Open-label | ziv-aflibercept |
| NCT00876044 A Study to Evaluate the Effects of Aflibercept on QTc Interval in Cancer Patients | Cancer | P1 | Completed | 88 | RCT, Double-blind | aflibercept (AVE0005), placebo |
| NCT01259323 Sequential Ascending Dose Study to Assess the Safety and Tolerability of REGN668 (SAR231893) in Patients With Atopic Dermatitis | Dermatitis | P1 | Completed | 30 | RCT, Double-blind | REGN668, REGN668, REGN668 |
| NCT01026519 A Safety and Tolerability Study of REGN88(SAR153191) in Subjects With Rheumatoid Arthritis | Rheumatoid Arthritis | P1 | Completed | 32 | RCT, Double-blind | REGN88 |
| NCT01959971 Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol | Hypercholesterolemia | P1 | Completed | 20 | Single-blind | alirocumab, Placebo |
| NCT02741739 Study of the Blood Concentrations of Two Formulations of REGN1033 in Healthy Subjects | Healthy | P1 | Completed | 28 | RCT, Open-label | REGN1033 |
| NCT02383212 Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies | Advanced Cancer, Advanced Malignancies | P1 | Completed | 398 | Open-label | Cemiplimab, Cyclophosphamide, Docetaxel, Carboplatin, GM-CSF, Paclitaxel, Pemetrexed |
| NCT03005782 Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers | Malignancies | P1 | Completed | 333 | Open-label | REGN3767, cemiplimab |
| NCT02121080 Study of the Safety and Tolerability of REGN2222(SAR438584) in Healthy Adult Volunteers | Healthy Volunteers | P1 | Completed | 132 | RCT, Double-blind | REGN2222(SAR438584), placebo |
| NCT04616105 Study of the Safety, Tolerability, and Pharmacokinetics of REGN6490 in Healthy Japanese Adult Volunteers | Healthy Volunteer | P1 | Terminated | 19 | RCT, Double-blind | REGN6490, Placebo |
| NCT02958436 A Study of Intravenously or Subcutaneously Administered REGN3500 in Healthy Adult Subjects | Healthy Volunteers | P1 | Completed | 40 | RCT, Double-blind | REGN3500, Placebo |
| NCT05376553 Study of Cemiplimab - TP Induction Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck | Locally Advanced Head and Neck Squamous Cell Carcinoma | P1 | By Invite | 24 | Open-label | Cemiplimab, Cisplatin, Docetaxel |
| NCT02999711 Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma | Asthma, Moderate Asthma | P1 | Completed | 23 | RCT, Double-blind | REGN3500, Placebo |
| NCT01271972 Study of Nesvacumab (REGN910/ SAR307746) | Solid Tumors | P1 | Completed | 53 | Open-label | nesvacumab (REGN910/ SAR307746) |
| NCT05976386 Single Dose Comparability Study of New and Current Dupilumab Drug Products Subcutaneously Administered in Healthy Adults | Healthy Volunteers | P1 | Completed | 182 | RCT, Open-label | Dupilumab (SAR231893) |
| NCT03115996 Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN3918 in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 56 | RCT, Double-blind | REGN3918, Placebo |
| NCT02680184 Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy | Melanoma | P1 | Completed | 199 | Open-label | CMP-001, Pembrolizumab |
| NCT01055899 Safety Study of a Single Dose of REGN88(SAR153191)in Patients With Rheumatoid Arthritis | Rheumatoid Arthritis | P1 | Completed | 15 | RCT, Double-blind | REGN88, REGN88, REGN88 |
| NCT03530514 A Study to Examine the Safety, Tolerability and Biological Effects of REGN4461 in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 113 | RCT, Double-blind | REGN4461, Placebo |
| NCT05157997 Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail | COVID-19, Organ Transplant | P1 | Withdrawn | — | Open-label | Casirivimab and Imdevimab Antibody Cocktail |
| NCT01026597 Ascending Dose Study of the Safety and Tolerability of REGN727(SAR236553) in Healthy Volunteers | Healthy | P1 | Completed | 40 | RCT, Double-blind | REGN727, Placebo |
| NCT04519437 Study Assessing the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Repeated Subcutaneous Doses of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (REGN10933+REGN10987) in Adult Volunteers as Related to COVID-19 | Healthy, Chronic Stable Illness | P1 | Completed | 974 | RCT, Double-blind | REGN10933+REGN10987, Placebo |
| NCT01328522 Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients | Rheumatoid Arthritis | P1 | Completed | 32 | RCT, Single-blind | SAR153191 (REGN88) |
| NCT04601844 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers | Healthy | P1 | Completed | 19 | Open-label | Pozelimab, Cemdisiran |
| NCT02284425 Study of REGN1193 in Patients With Type 2 Diabetes Mellitus | Diabetes Mellitus, Type 2 | P1 | Terminated | 72 | RCT, Double-blind | REGN1193, Placebo |
| NCT02516618 Study of Fasinumab (REGN475) in Healthy Japanese and Caucasian Subjects | Healthy Volunteers | P1 | Completed | 72 | RCT, Double-blind | Fasinumab, Placebo |
| NCT05064085 Capecitabine In Combination With Cemiplimab In Patient With Metastatic Breast Cancer | Hormone Receptor-positive Breast Cancer | P1 | Completed | 13 | Open-label | Cemiplimab, Capecitabine |
| NCT06784349 ALN-APOC3 in Adult Participants With Dyslipidemia | Dyslipidemia | P1 | Completed | 32 | RCT, Double-blind | ALN-APOC3, Matching Placebo |
| NCT05293678 Safety and Tolerability of Regeneron Anti-SARS-CoV-2 Monoclonal Antibody/Ies in Adult Healthy Volunteers as Related to COVID-19 | Healthy | P1 | Completed | 104 | RCT, Double-blind | REGN15160 (IV), Matching Placebo (IV), REGN15160 (SC), Matching Placebo (SC) |
| NCT07365839 Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma | Hepatocellular Carcinoma | P1 | Not Yet Recruiting | 20 | RCT, Open-label | Arm 1 cemiplimab, Arm 2 cemiplimab and fianlimab |
| NCT01723735 Effect of Alirocumab (SAR236553/REGN727) Administered on Top of Ezetimibe or Fenofibrate on Lipid Profiles in Healthy Subjects | Hypercholesterolemia | P1 | Completed | 79 | RCT, Open-label | Alirocumab, Ezetimibe, Ezetimibe Placebo, Fenofibrate |
| NCT00320775 Safety and Tolerability Study of Intravitreal VEGF-Trap Administration in Patients With Neovascular AMD | Macular Degeneration | P1 | Completed | 51 | RCT, Open-label | VEGF Trap |
| NCT03050151 Study of Dupilumab Auto-injector Device When Used by Patients With Atopic Dermatitis | Atopic Disorders, Eczema, Atopic | P1 | Completed | 176 | RCT, Open-label | Dupilumab |
| NCT04491838 Study of a Single Subcutaneous Dose of Pozelimab Produced From Two Different Manufacturing Processes in Healthy Adult Participants | Healthy Volunteer | P1 | Completed | 40 | RCT, Open-label | Pozelimab |
| NCT02979015 A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects | Hypercholesterolemia | P1 | Completed | 35 | RCT, Double-blind | alirocumab SAR236553 (REGN727), placebo |
| NCT04465487 Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies | Squamous Cell Carcinoma of Head and Neck | P1 | Terminated | 38 | Open-label | REGN6569, Cemiplimab |
| NCT00921661 Study of Intravenous Aflibercept in Combination With FOLFIRI in Japanese Patients With Metastatic Colorectal Cancer | Colorectal Neoplasms, Neoplasm Metastasis | P1 | Completed | 16 | Open-label | AVE0005 (aflibercept) |
| NCT01537653 Safety, Tolerability and Pharmacokinetics of SAR231893 (REGN668) in Healthy Japanese Adult Male Subjects | Healthy | P1 | Completed | 32 | RCT, Double-blind | SAR231893 (REGN668), placebo |
| NCT05469347 Alirocumab in Patients with Sepsis | Sepsis | P1 | Completed | 50 | RCT, Double-blind | Alirocumab, Placebo |
| NCT03146416 Study of Evinacumab (REGN1500) in Caucasian and in Japanese Healthy Volunteers | Healthy Volunteers | P1 | Completed | 96 | RCT, Double-blind | Evinacumab, Placebo |
| NCT01537640 Comparison of the Pharmacokinetics and Safety of Two SAR231893 (REGN668) Drug Products in Healthy Subjects | Healthy | P1 | Completed | 30 | RCT, Double-blind | SAR231893 (REGN668) DP1, SAR231893 (REGN668) DP2 |
| NCT06137482 A Study to See How Safe and Tolerable Different Doses of REGN13335 Are When Administered Intravenously (IV) or Subcutaneously (SC) to Healthy Adult Participants | Healthy Volunteers | P1 | Completed | 56 | RCT, Double-blind | REGN13335, Matching Placebo |
| NCT01893528 Study to Assess the Safety and Tolerability of Ascending Single Doses of REGN2009 in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 49 | RCT, Double-blind | REGN2009 |
| NCT02404558 Single-dose Study to Describe the Safety of Sarilumab and Tocilizumab in Patients With Rheumatoid Arthritis | Rheumatoid Arthritis | P1 | Completed | 30 | RCT, Open-label | sarilumab SAR153191 (REGN88), tocilizumab |
| NCT00036946 VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma | Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific | P1 | Completed | — | — | ziv-aflibercept |
| NCT02127801 Single Ascending-dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Participants | Allergy | P1 | Completed | 74 | RCT, Double-blind | REGN1908-1909, placebo |
| NCT02744287 Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors | Metastatic Castration-resistant Prostate Cancer, Metastatic Prostate Cancer | P1 | Terminated | 52 | Open-label | BPX-601, Rimiducid |
| NCT02107872 Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1500 | Metabolic Disorders | P1 | Completed | 55 | RCT, Double-blind | REGN1500, placebo |
| NCT01868360 Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea | Corneal Neovascularization | P1 | Terminated | 2 | RCT, Open-label | Subconjunctival aflibercept |
| NCT01785329 Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects | Hypercholesterolemia | P1 | Completed | 60 | RCT, Open-label | alirocumab SAR236553 (REGN727) |
| NCT01074372 Ascending Dose Study of the Safety and Tolerability of REGN727 (SAR236553) in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 32 | RCT, Double-blind | REGN727, Placebo |
| NCT01015027 Ascending Dose Study of the Safety and Tolerability of REGN668(SAR231893) in Normal Healthy Volunteers | Healthy | P1 | Completed | 48 | RCT, Double-blind | REGN668 |
| NCT06665828 Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults | Healthy Volunteer | P1 | Completed | 72 | RCT, Double-blind | REGN9533, Matching Placebo |
| NCT05181683 COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult Volunteers | Healthy, Chronic Stable Illness | P1 | Completed | 45 | RCT, Open-label | Casirivimab+Imdevimab |
| NCT06970405 Study of Safety and Effects of Garetosmab in Healthy Obese Men and Post-Menopausal Women | Obesity | P1 | Withdrawn | — | RCT, Double-blind | Garetosmab, Matching Placebo |
| NCT05976373 A Study to Investigate the Pharmacokinetics (PK), Tolerability and Safety of Two Different Dupilumab Drug Products in Healthy Participants. | Healthy Volunteers | P1 | Completed | 38 | RCT, Open-label | Dupilumab (SAR231893) |
| NCT05291546 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants | Healthy Volunteers | P1 | Completed | 93 | RCT, Double-blind | REGN9035, REGN5381 |
| NCT00082823 Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma | Cancer | P1 | Completed | 25 | Open-label | ziv-aflibercept |
| NCT05505448 A Trial to Learn if a COVID-19 Therapeutic is Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants | Healthy | P1 | Completed | 48 | RCT, Double-blind | REGN14284, Matching Placebo |
| NCT02647086 Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD) | Atopic Dermatitis | P1 | Completed | 14 | Open-label | Dupilumab, Midazolam, Omeprazole, Warfarin, Caffeine, Metoprolol |
| NCT01688960 Nesvacumab (REGN910/ SAR307746) and Aflibercept ("Ziv-aflibercept" in the U.S.) in Patients With Advanced Solid Malignancies | Solid Tumors | P1 | Completed | 48 | Open-label | nesvacumab (REGN910/ SAR307746), nesvacumab (REGN910/ SAR307746), nesvacumab (REGN910/ SAR307746), aflibercept (ziv-aflibercept), aflibercept (ziv-aflibercept) |
| NCT01448239 Injection Site Tolerability, Safety, Pharmacokinetics and Pharmacodynamics Study After a Single Dose Subcutaneous Treatment of Alirocumab SAR236553 (REGN727) | Hypercholesterolemia | P1 | Completed | 24 | RCT, Double-blind | alirocumab SAR236553 (REGN727), alirocumab SAR236553 (REGN727) |
| NCT03580694 Study of REGN4659 in Combination With Cemiplimab in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) | Carcinoma, Non-Small-Cell Lung | P1 | Terminated | 17 | Open-label | REGN4659, Cemiplimab |
| NCT01443650 Injection Site Tolerability, Safety, Pharmacokinetics, Pharmacodynamics in Different Single-Dose Treatments of Alirocumab SAR236553 (REGN727) in Healthy Subjects | Hypercholesterolemia | P1 | Completed | 36 | RCT, Double-blind | alirocumab SAR236553 (REGN727) |
| NCT01749878 Study to Assess the Safety and Tolerability of Single Doses of REGN1500 | Hypertriglyceridemia | P1 | Completed | 99 | RCT, Double-blind | REGN1500, placebo |
| NCT00320814 Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema | Diabetic Macular Edema | P1 | Completed | 5 | Open-label | VEGF Trap-Eye |
| NCT01197391 Ascending Dose Study of the Safety and Tolerability of REGN728 in Healthy Volunteers | Healthy | P1 | Completed | 48 | RCT, Double-blind | REGN728 |
| NCT05013723 Impact of Monoclonal Antibody Treatment on Post-Acute COVID-19 Syndrome | Post-acute COVID-19 (PACS), or "long COVID" Syndrome | Completed | 260 | — | — | |
| NCT07502716 Compassionate Use of Ubamatamab | Renal Medullary Carcinoma (RMC), Epithelioid Sarcoma | AVAILABLE | — | — | ubamatamab | |
| NCT01783925 Eylea Post Marketing Surveillance(PMS) | Macular Degeneration | Completed | 3,206 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT02811692 Study for Collection of Aflibercept Data in Routine Practice | Eye Diseases | Completed | 425 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT05791695 A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022 | Intraocular Inflammation, Suspected Endophthalmitis | Completed | 155,413 | — | — | |
| NCT01714115 Use of Eylea for the Treatment of an Optic Nerve Hemangioma | Retinal Hemangioma | NO_LONGER_AVAILABLE | — | — | Aflibercept | |
| NCT06398080 An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting | Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD) | Withdrawn | — | — | aflibercept 8 mg | |
| NCT05546957 Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants | Healthy Volunteer | N/A | Completed | 60 | RCT, Open-label | Aspirin, rivaroxaban low dose, rivaroxaban high dose |
| NCT02341664 Patient and Provider Assessment of Lipid Management Registry | Hyperlipidemia, Hypercholesterolemia | Completed | 7,658 | — | — | |
| NCT05203380 Neuropsychologic Assessments of Dupilumab-Treated Adolescent Participants With Moderate-to-Severe Atopic Dermatitis | Moderate-to-severe Atopic Dermatitis | Completed | 45 | — | dupilumab | |
| NCT06769412 A Real-World Evidence Study for the Incidence of Retinal Vasculitis (RV) Among Adult Patients Receiving Aflibercept 2 mg in the United States (US) | Retinal Vasculitis | Completed | 550,000 | — | aflibercept 2 mg | |
| NCT01187563 A Study of Tocilizumab in Patients With Rheumatoid Arthritis | Rheumatoid Arthritis | Completed | 16 | — | — | |
| NCT02924311 Routine Clinical Practice for Use of Intravitreal Aflibercept Treatment in Patients With Diabetic Macular Edema | Diabetic Retinopathy | Completed | 402 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT03544866 The Impact of Pediatric Skin Disorders: The "Big" Study | Chronic Pediatric Skin Conditions | Completed | 1,666 | — | — | |
| NCT05338892 Real-World Clinical Outcomes in Adult Patients Who Initiate Systemic Treatment for Relapsed/Refractory Diffuse Large B-Cell Lymphoma | Diffuse Large B-Cell Lymphoma | Completed | 595 | — | — | |
| NCT05673967 Real-World Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma | Relapsed and Refractory Multiple Myeloma (RRMM) | Completed | 62 | — | — | |
| NCT06028594 Compassionate Use of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal Hemoglobinuria | Paroxysmal Nocturnal Hemoglobinuria | NO_LONGER_AVAILABLE | — | — | Pozelimab, Cemdisiran | |
| NCT02585401 Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada | Age-related Macular Degeneration (AMD), Central Retinal Vein Occlusion (CRVO) | Completed | 99 | — | Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321) | |
| NCT03836105 CemiplimAb Survivorship Epidemiology | Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma | Completed | 287 | — | cemiplimab | |
| NCT04617535 Compassionate Use of REGN-COV2 for the Treatment of COVID-19 | COVID-19 | NO_LONGER_AVAILABLE | — | — | REGN10933+REGN10987 combination therapy | |
| NCT04614571 T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge | Celiac Disease | N/A | Completed | 24 | Open-label | — |
| NCT02540369 To Describe the Use of Intravitreal Aflibercept and to Describe Follow-up as Well as Treatment Patterns in Patients With Wet Age-related Macular Degeneration (wAMD) or Diabetic Macular Edema (DME) in Routine Clinical Practice in Canada. | Wet Macular Degeneration | Completed | 2,150 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT04776694 Compassionate Use of Dupilumab | Type 2 Inflammatory Disorders | APPROVED_FOR_MARKETING | — | — | Dupilumab | |
| NCT05478824 IL13 Signaling in Allergic Asthma | Asthma, Allergic, Asthma | Completed | 28 | — | — | |
| NCT05870215 Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks | Asthma | Completed | 78 | — | — | |
| NCT03382587 Observational Study to Assess Intravitreal Aflibercept Injections Used in a "Treat and Extend" Regimen in Treatment-naïve Wet Age-related Macular Degeneration Patients | Wet Age-related Macular Degeneration | Completed | 163 | — | Aflibercept (Eylea, BAY86-5321) | |
| NCT03507374 PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis | Stroke, Intracranial Atherosclerosis | Early P1 | Terminated | 20 | RCT, Double-blind | Alirocumab, Placebo |
| NCT05906706 Compassionate Use of Dupilumab for Adult Patients With Bullous Pemphigoid | Bullous Pemphigoid | APPROVED_FOR_MARKETING | — | — | dupilumab | |
| NCT02321241 Real Life of Aflibercept in France in Patients Refractory to Ranibizumab: Observational Study in Wet AMD | Wet Macular Degeneration | Completed | 236 | — | Aflibercept (EYLEA, BAY-86-5321) | |
| NCT03411941 Evaluate the Effectiveness of Intravitreal (IVT) Aflibercept Injection in Clinical Practice in naïve Patients With Neovascular Age-related Macular Degeneration (nAMD) | Macular Degeneration | Completed | 116 | — | Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321) | |
| NCT04173442 Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy | Atopic Dermatitis (AD), Asthma | Completed | 581 | — | dupilumab | |
| NCT01771081 Evaluation of Changes in Visual Acuity in Patients With Diabetic Macular Edema (DME) Starting Treatment With an Approved Anti-VEGF Therapy | Ophthalmology, Macular Edema | Completed | 911 | — | Ranibizumab (or other DME treatment) | |
| NCT05619367 A Compassionate Use (CU) Program of Odronextamab | Relapsed or Refractory (R/R) Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL) | AVAILABLE | — | — | Odronextamab | |
| NCT05232110 Compassionate Use of Pozelimab | CD55-deficient Protein-losing Enteropathy | APPROVED_FOR_MARKETING | — | — | Pozelimab | |
| NCT05302297 Comparative Efficacy of Cemiplimab to Historical Standard of Care in France | Cancer/Squamous Cell Carcinoma of Skin | Completed | 305 | — | Cemiplimab | |
| NCT06064656 A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP) | Fibrodysplasia Ossificans Progressiva (FOP) | Completed | 131 | — | — | |
| NCT07301450 An Expanded Access Program of Garetosmab in Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP) | Fibrodysplasia Ossificans Progressiva (FOP) | TEMPORARILY_NOT_AVAILABLE | — | — | Garetosmab | |
| NCT01914380 Investigating the Effectiveness of Eylea in Patients With Wet Age-related Macular Degeneration | Wet Age-related Macular Degeneration | Completed | 988 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT02279537 Real Life of Aflibercept In FraNce: oBservatiOnnal Study in Wet AMD | Wet Macular Degeneration | Completed | 593 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT03161912 A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease | Macular Edema | Completed | 2,481 | — | Aflibercept (Eylea, BAY86-5321) | |
| NCT03378219 An Observational Study on Sarilumab-exposed Pregnancies | Rheumatoid Arthritis -Exposure During Pregnancy | Completed | 113 | — | Sarilumab SAR153191 (REGN88) | |
| NCT03278262 The Impact of Baseline Visual Acuity on the Treatment Outcomes in Patients Treated With AflIbercept in Real-life Clinical Setting | Wet Macular Degeneration | Completed | 2,312 | — | Aflibercept (Eylea, BAY86-5321) | |
| NCT02541084 Caregiver Burden of Wet Age-related Macular Degeneration (wAMD) in Japan | Wet Macular Degeneration | Completed | 72 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT03379558 Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study | Hypercholesterolemia | Terminated | 37 | — | ALIROCUMAB SAR236553 (REGN727) | |
| NCT01756248 EYLEA Age-Related Macular Degeneration (AMD) Post-marketing Surveillance in Japan | Macular Degeneration | Completed | 3,872 | — | Aflibercept(Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT01756261 EYLEA [AMD-QOL(Age-Related Macular Degeneration-Quality of Life)] Post-marketing Surveillance in Japan | Macular Degeneration | Completed | 757 | — | Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321) | |
| NCT02828033 Rilonacept for Treatment of Autoimmune Neurosensory Hearing Loss | Autoimmune Neurosensory Hearing Loss (ANSHL) | Early P1 | Unknown | 10 | Open-label | Rilonacept |