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Regeneron Pharmaceuticals Inc

REGN
Healthcare|Biotechnology|USA
$763.04
+1.19 (+0.16%)
DCF (FCF)
$641.30
Tangible Book
$283.77
Graham Number
$532.32
Earnings Power
$496.16

Clinical Trials (506)

TrialConditionsPhaseStatusEnrollmentDesignDrug
NCT07053423
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
Chronic Obstructive Pulmonary Disease
P4
Recruiting218RCT, Double-blindDupilumab, Placebo
NCT06665971
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis (EoE)
P4
Recruiting30Open-labelDupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
NCT03935971
The Effects of Dupilumab on Allergic Contact Dermatitis
Allergic Contact Dermatitis
P4
Active17Open-labelDupilumab
NCT03694158
Investigating Dupilumab's Effect in Asthma by Genotype
Asthma
P4
Active150RCT, Double-blindDupilumab
NCT06572228
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
Asthma
P4
Recruiting250RCT, Double-blinddupilumab, Matching Placebo, ICS/LABA
NCT05268107
Ethnic Differences in Mechanisms of Action of Dupilumab
Atopic Dermatitis
P4
Recruiting30Open-labelDupilumab
NCT06662994
High Dose Aflibercept in Diabetic Macular Edema in Patients With Previous Vitrectomy
Diabetic Macular Edema (DME)
P4
Recruiting15Open-labelAflibercept 8 mg (VEGF Trap-Eye, BAY86-5321)
NCT05042258
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis
Atopic Dermatitis, Sleep Disturbance
P4
Recruiting40Open-labelDupilumab
NCT04380038
Viral Infection in Asthma (VIA) Study
Asthma
P4
Recruiting60RCT, Double-blindDupilumab Injectable Product
NCT05285839
Dupixent and Narrowband UVB for Atopic Dermatitis
Atopic Dermatitis
P4
Recruiting40Open-labelDupixent
NCT02612454
Study to Assess the Long-term Safety of Dupilumab Administered in Participants ≥6 Months to <18 Years of Age With Atopic Dermatitis (AD)
Atopic Dermatitis
P3
Active880Open-labelDupilumab
NCT06091254
A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
Follicular Lymphoma (FL)
P3
Recruiting822RCT, Open-labelOdronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone/prednisolone, Bendamustine
NCT06246916
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Melanoma
P3
Recruiting560RCT, Open-labelfianlimab, cemiplimab, relatlimab+nivolumab
NCT06128629
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
P3
Recruiting1,200RCT, Double-blindNTLA-2001, Placebo
NCT07213778
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Symptomatic Venous Thromboembolism (VTE)
P3
Recruiting2,000RCT, Double-blindREGN7508, Acetylsalicylic Acid (ASA), Placebo
NCT06208306
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
Chronic Obstructive Pulmonary Disease
P3
Active700RCT, Double-blindItepekimab (SAR440340), Placebo
NCT07222761
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Relapsed and/or Refractory Multiple Myeloma (RRMM)
P3
Recruiting915RCT, Open-labelLinvoseltamab, Carfilzomib, Daratumumab, Dexamethasone, Pomalidomide, Bortezomib
NCT06091865
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
Diffuse Large B-cell Lymphoma (DLBCL)
P3
Active904RCT, Open-labelOdronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone/Prednisolone
NCT06932562
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
Multiple Myeloma
P3
Recruiting1,000RCT, Open-labelLinvoseltamab, Daratumumab, Lenalidomide, Dexamethasone
NCT07220785
Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy
Generalized Lipodystrophy
P3
Recruiting28RCT, Double-blindMibavademab, Placebo
NCT05070858
A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
Generalized Myasthenia Gravis
P3
Active288RCT, Double-blindPozelimab + Cemdisiran, Cemdisiran, Pozelimab
NCT06191315
Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
Wheezing, Asthma
P3
Recruiting90RCT, Double-blindDupilumab, Placebo
NCT03969004
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma
Cutaneous Squamous Cell Carcinoma
P3
Active415RCT, Double-blindCemiplimab, Placebo
NCT05744921
A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works
Paroxysmal Nocturnal Hemoglobinuria
P3
Recruiting202Open-labelPozelimab, Cemdisiran
NCT06834360
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps
P3
Recruiting210RCT, Double-blindItepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS)
NCT05785767
A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)
Advanced Non-Small Cell Lung Cancer
P2P3
Active850RCT, Double-blindfianlimab, cemiplimab, Placebo
NCT07112378
A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE)
P3
Recruiting20RCT, Single-blinddupilumab
NCT05608291
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
Melanoma
P3
Active1,564RCT, Double-blindFianlimab, Cemiplimab, Pembrolizumab, Placebo
NCT06834347
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps
P3
Recruiting210RCT, Double-blindItepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS)
NCT05347771
Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents
Asthma
P2
Active240RCT, Double-blindDupilumab, Placebo
NCT04050436
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
Cutaneous Squamous Cell Carcinoma, Advanced Cutaneous Squamous Cell Carcinoma
P2
Active231RCT, Open-labelCemiplimab, RP1
NCT05864144
A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Solid Tumor, Adult, Advanced Solid Tumor
P1P2
Active98Open-labelSNS-101 (anti-VISTA), Cemiplimab
NCT04291105
Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients
Melanoma, Head and Neck Squamous Cell Carcinoma
P2
Recruiting87Open-labelVV1, Cemiplimab
NCT03294083
A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma
Renal Cell Carcinoma
P1P2
Active89RCT, Open-labelPexastimogene Devacirepvec (Pexa-Vec), Cemiplimab
NCT05519475
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
Metabolic Dysfunction-associated Steatohepatitis (MASH)
P2
Recruiting90RCT, Double-blindALN-HSD, Placebo
NCT05828511
A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment
Multiple Myeloma
P1P2
Recruiting149Open-labelLinvoseltamab
NCT02991469
A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)
Juvenile Idiopathic Arthritis
P2
Recruiting51Open-labelSarilumab SAR153191 (REGN88)
NCT06855212
Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC
Head and Neck Squamous Cell Carcinoma
P2
Recruiting21Open-labelCemiplimab, Cetuximab
NCT07181941
Response-Based Dose Reduction of Linvoseltamab in the Treatment of Relapsed, Refractory, or Triple-Class Relapsed/Refractory Multiple Myeloma
Recurrent Multiple Myeloma, Refractory Multiple Myeloma
P1P2
Recruiting30Open-labelLinvoseltamab
NCT06594991
A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma
Advanced Melanoma
P2
Recruiting88Open-labelFianlimab, Cemiplimab, Ipilimumab
NCT05553834
PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung
Non-small Cell Lung Cancer (NSCLC)
P2
Active60Open-label
NCT06449313
Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node Involvement
Non-small Cell Lung Cancer Stage III
P2
Recruiting21Open-labelCemiplimab-Rwlc
NCT06226610
Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic
Pruritis
P2
Recruiting46RCT, Double-blindDupilumab
NCT03761108
Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma
Multiple Myeloma
P1P2
Recruiting387Open-labelLinvoseltamab
NCT06981325
Evaluation of Efficacy and Safety of Cemiplimab as First Line Treatment for Advanced Basal Cell Carcinoma (BCC) Patients
Basal Cell Carcinoma (BCC), First Line Treatment
P2
Recruiting34Open-labelCemiplimab
NCT07175428
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Atrial Fibrillation (AF)
P2
Recruiting1,200RCT, Single-blindREGN7508, REGN9933, Apixaban
NCT07431086
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity in the US
Overweight or Obesity
P2
Recruiting120RCT, Double-blindOlatorepatide, Placebo
NCT05929664
Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery
Locally Advanced Basal Cell Carcinoma, Basal Cell Carcinoma
P2
Recruiting70Open-labelCemiplimab, Fianlimab
NCT06887088
Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases
Melanoma BRAF V600E/K Mutated, Melanoma and Brain Metastases
P2
Recruiting33Open-labelEncorafenib + Binimetinib, cemiplimab+fianlimab
NCT06910124
Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse
Multiple Myeloma
P2
Recruiting32Open-labelLinvoseltamab, Lenalidomide
NCT05557591
A Trial to Learn How the Cancer Vaccine BNT116 in Combination With Cemiplimab Works and How Safe the Combination is in Adults With Advanced Non-small Cell Lung Cancer (EMPOWERVAX Lung 1)
Advanced Non-Small Cell Lung Cancer
P2
Active51RCT, Open-labelBNT116, Cemiplimab
NCT06299111
A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
Venous Thromboembolism
P2
Active195RCT, Double-blindREGN9933, REGN7508, Placebo
NCT06465329
A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer
P2
Recruiting120RCT, Open-labelCemiplimab, Platinum-based chemotherapy, REGN7075
NCT06623656
Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC
Carcinoma, Non-Small-Cell Lung
P2
Recruiting112RCT, Open-labelCemiplimab, Platinum based chemotherapy
NCT05720325
Dupilumab Effects Against Aeroallergen Challenge
Asthma, Allergic
P2
Recruiting88RCT, Double-blindDupilumab
NCT06691113
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps
Chronic Rhinosinusitis Without Nasal Polyps
P2
Active60RCT, Double-blindItepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS)
NCT07218770
A Study of REGN7041 for Active Noninfectious Uveitis in Adult Participants
Active Noninfectious Uveitis Affecting the Posterior Segment
P1P2
Recruiting72Open-labelREGN7041
NCT05831176
A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD)
P2
Active22Open-labelDupilumab
NCT06161441
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
Resectable Non-small Cell Lung Cancer
P2
Active195RCT, Double-blindFianlimab, Cemiplimab, Pemetrexed, Paclitaxel, Carboplatin, Cisplatin, Placebo
NCT06421636
A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body
Non-Transfusion Dependent Beta-Thalassemia (NTDT)
P2
Recruiting95RCT, Double-blindREGN7999, Placebo
NCT07433673
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
Colon and Rectal Cancer
P2
Recruiting20Open-labelCemiplimab
NCT07154290
A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Advanced/Metastatic Non-Small Cell Lung Cancer
P2
Recruiting300RCT, Open-labelUbamatamab, REGN7075, Sarilumab
NCT03564340
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer
P1P2
Recruiting890Open-labelUbamatamab, Cemiplimab, Sarilumab, Tocilizumab
NCT04626635
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
Advanced Solid Tumors
P1P2
Recruiting933Open-labelREGN7075, Cemiplimab, Platinum-based doublet chemotherapy, Bevacizumab, Trifluridine-tipiracil
NCT06292780
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
Relapsed/Refractory Systemic Light Chain Amyloidosis
P1P2
Recruiting220Open-labelLinvoseltamab
NCT07188896
A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC)
Advanced Renal Cell Carcinoma (aRCC), Metastatic Renal Cell Carcinoma ( mRCC)
P2
Recruiting120RCT, Open-labelFianlimab, Ipilimumab, Nivolumab, Cemiplimab
NCT04590326
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
Ovarian Cancer, Fallopian Tube Cancer
P1P2
Recruiting612Open-labelREGN5668, Cemiplimab, Ubamatamab, Sarilumab, Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)]
NCT07187401
A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor
Paroxysmal Nocturnal Hemoglobinuria (PNH), Persistent Anemia
P1P2
Recruiting24RCT, Double-blindALN-CFB, Placebo
NCT03916627
Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients
Non-small Cell Lung Cancer, Hepatocellular Carcinoma
P2
Active65RCT, Open-labelcemiplimab, Platinum Doublet, fianlimab
NCT04988074
Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca
HPV-Related Squamous Cell Carcinoma
P2
Recruiting32Open-labelCemiplimab
NCT06790602
Cemiplimab Plus Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma
Pancreatic Ductal Adenocarcinoma (mPDAC)
P2
Recruiting43Open-labelCemiplimab Plus Gemcitabine
NCT03888105
A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies
B-cell Non-Hodgkin Lymphoma (B-NHL)
P2
Active515Open-labelOdronextamab
NCT06769698
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC)
P2
Recruiting120RCT, Double-blindFDC fianlimab+cemiplimab, Cemiplimab, Placebo
NCT06444880
Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies
SMARCB1-Deficient Malignancies
P2
Recruiting40Open-labelUbamatamab, Cemiplimab
NCT06571708
Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
P2
Recruiting36RCT, Open-labelGemcitabine, Cisplatin, Cemiplimab, Fianlimab
NCT07235917
A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
Functional Hypothalamic Amenorrhea (FHA)
P2
Recruiting34RCT, Double-blindMibavademab
NCT06373146
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity
Obesity
P2
Active392RCT, Double-blindTirzepatide, Mibavademab, Tirzepatide-Placebo, Mibavademab-Placebo
NCT05092347
A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
Chronic Kidney Disease (CKD)
P1P2
Recruiting56Open-labelVonsetamig
NCT06379789
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Hemophilia B
P1P2
Recruiting130Open-labelREGV131, LNP1265
NCT05031455
Mechanisms of Dupilumab in AERD
Aspirin-exacerbated Respiratory Disease
P2
Recruiting16Open-labelAspirin Challenge
NCT05961709
The Phoenix Trial: Phase II Trial of Cemiplimab for the Non-operative Management of Localized dMMR Colon Cancer
Colon Cancer
P2
Recruiting50Open-labelCemiplimab
NCT06121180
Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma
Metastatic Uveal Melanoma
P2
Recruiting32Open-labelZIV-Aflibercept, Cemiplimab
NCT04077099
A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
NSCLC
P1P2
Recruiting231Open-labelREGN5093
NCT05955508
A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma
Smoldering Multiple Myeloma (SMM)
P2
Active40RCT, Open-labelLinvoseltamab
NCT06902376
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
Anaplastic Thyroid Cancer, Thyroid Cancer
P1
Recruiting12Open-labelCemiplimab, XL092
NCT06836609
A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis
P1
Recruiting132RCT, Double-blindALN-CIDEB, Placebo
NCT06975787
Dose Escalation Study With Bispecific Antibodies in Adult Patients With Lupus Nephritis
Lupus Nephritis (LN)
P1
Recruiting90Open-labelVonsetamig, Odronextamab
NCT07216066
First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)
Parkinsons Disease
P1
Recruiting46RCT, Double-blindALN-SNCA, Placebo
NCT06452771
A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults
Healthy Volunteers With Hyperlipidemia
P1
Active59RCT, Double-blindALN-ANG3, Placebo (PB)
NCT06469281
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers
Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma
P1
Recruiting90Open-labelCemiplimab, Bevacizumab
NCT06369467
Short-Term Linvoseltamab Treatment on Top of Chronic Dupilumab Treatment for Adults With Severe Immunoglobulin E (IgE)-Mediated Food Allergy
Food Allergy
P1
Recruiting6Open-labellinvoseltamab, dupilumab
NCT06826768
A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC
Prostate Cancer
P1
Recruiting60Open-labelREGN5678, Cemiplimab
NCT07214727
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Alzheimer's Disease
P1
Recruiting50RCT, Double-blindALN-5288, Placebo
NCT04975152
Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma
Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
P1
Active36Open-labelCemiplimab-Rwlc
NCT05259709
A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With Cemiplimab
Advanced Solid Tumor, Metastatic Solid Tumor
P1
Recruiting50Open-label89Zr˗DFO˗REGN5054, cemiplimab
NCT05685173
A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas
B-cell Non-Hodgkins Lymphoma (B-NHL)
P1
Recruiting91Open-labelOdronextamab, REGN5837
NCT05704634
A Phase Ib Study to Evaluate the Safety and Preliminary Efficacy of IL6-receptor Antibody Sarilumab in Combination With antiPD1 Antibody Cemiplimab for Patients With Non-small Cell Lung Cancer.
Lung Cancer
P1
Active56RCT, Open-labelCemiplimab, Kevzara (Sarilumab)
NCT03233139
Safety and Pharmacokinetics of Cemiplimab Anti-programmed Death-ligand 1 (Anti-PD-1) and Other Agents in Japanese Adult Patients With Advanced Malignancies
Advanced Malignancies
P1
Active146Open-labelCemiplimab, Ipilimumab, Platinum-doublet chemotherapy, Gemcitabine, Pemetrexed, Paclitaxel, Fianlimab
NCT02651662
A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies
Relapsed/Refractory Aggressive B-Cell Lymphoma
P1
Active105Open-labelcemiplimab, odronextamab
NCT06669234
Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults
Healthy Volunteer
P1
Active56RCT, Double-blindALN-F1202, Matching Placebo
NCT04722523
A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer
Head and Neck Cancer, Head Cancer
P1
Recruiting40Open-labelCisplatin, Carboplatin, Docetaxel, Cetuximab, Cemiplimab, Paclitaxel
NCT07444203
Transformative Research in Diabetic Nephropathy 2.0
Diabetic Nephropathies, Kidney Diseases
Recruiting200Sodium-glucose cotransporter 2 inhibitors (SGLT2i), Renin-angiotensin-aldosterone system blockade, Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Mineralocorticoid Receptor Antagonists(MRAs)
NCT07064330
Next-gen Flow Cytometry to Find Immune Profiles, Treatment Response, and Toxicity Markers in Skin Cancer Patients Treated With Cemiplimab.
Cutaneous Squamous Cell Carcinoma (CSCC)
Recruiting30Cemiplimab
NCT06695897
A Non-interventional Observational Study to Assess Long-term Efficacy and Safety of Dupilumab for the Treatment of Patients (>= 12 Years) With Eosinophilic Esophagitis Under Real-world-conditions in Germany
Eosinophilic Esophagitis
Recruiting150Dupilumab
NCT03936335
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis (AD)
Adverse Pregnancy Outcomes, Atopic Dermatitis
Recruiting3,930dupilumab
NCT04550962
Description of Characteristics, Such as Age, Previous and Concurrent Treatments, Associated Diseases, of Patients With Asthma Treated With Dupilumab (DUPIXENT)
Asthma
Active376Dupilumab SAR231893
NCT05991323
Real-World Effectiveness of Dupilumab in Patients With Prurigo Nodularis: An Observational Study
Prurigo Nodularis
Active100Dupilumab
NCT06099704
Observational Study of Canadian Patients (6 Years or Older) Receiving Dupixent® for Moderate to Severe Atopic Dermatitis
Moderate to Severe Atopic Dermatitis
Active305
NCT07217535
Rutgers University Study of the Genetics of Kidney Disease
Kidney Disease, Kidney Disease, Chronic
Recruiting50,000
NCT00707694
The Longevity Genes in Founder Populations Project
Extreme Longevity
Recruiting2,000
NCT06269133
Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) Patients
Advanced Non-small Cell Lung Cancer
Active1,000REGN2810
NCT04959448
Study Assessing Long-teRm Outcomes of dupiluMAb (DUPIXENT®) Treatment in Adult Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Chronic Rhinosinusitis With Nasal Polyposis
Active717DUPIXENT®
NCT05246267
Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis With Nasal Polyps
Recruiting60Dupilumab
NCT06439654
Atlantic Lipid Lowering Treatment Optimization Program
Familial Hypercholesterolemia, Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia
N/A
Recruiting250Open-label
NCT06219629
Parkinson's Disease Progression Study
Parkinson Disease
Active82
NCT04287621
Registry of Asthma Patients Initiating DUPIXENT®
Asthma
Active718DUPIXENT®
NCT06773897
Rutgers University Study of the Genetics of Breast Cancer.
Breast Cancer Risk, Breast Cancer Prevention
Recruiting25,000
NCT07052396
Study to Evaluate Long-term Effectiveness and Safety, Patient Characteristics and Subjective Patient-reported Outcomes of Dupilumab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Under Real-world Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Recruiting350Dupilumab
NCT06129552
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis
Recruiting300
NCT05106387
An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
Chronic Kidney Disease (CKD)
Recruiting20Noninterventional
NCT02986984
Transformative Research in Diabetic Nephropathy
Diabetic Nephropathies, Diabetic Glomerulosclerosis
Recruiting400
NCT03428646
Study of Patients Receiving DUPIXENT® for Atopic Dermatitis (AD)
Dermatitis, Atopic
Active858Dupilumab
NCT05363319
An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe
Non-small Cell Lung Cancer
Recruiting500Cemiplimab, Platinum-based chemotherapy
NCT05568459
A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy
Hemophilia B
Active11
NCT07223411
Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma
Locally Advanced Melanoma
Recruiting20Fianlimab + Cemiplimab, Relatlimab + Nivolumab
NCT06479863
Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients With Sporadic Inclusion Body Myositis
Sporadic Inclusion Body Myositis (sIBM), Idiopathic Inflammatory Myopathies
Early P1
Recruiting10Open-label
NCT06798298
A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T Cells
Long Term Safety Following GM T Cell Therapy
Recruiting50
NCT03389893
Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis
Atopic Dermatitis (AD)
P4
Terminated72RCT, Double-blindDupilumab, Placebo
NCT04988022
Dupilumab in the Treatment of Keloids
Keloid
P4
Completed44RCT, Double-blindDupilumab, Placebo
NCT03694197
Long Term Safety Study of PRALUENT
Heterozygous Familial Hypercholesterolemia, Non-familial Hypercholesterolemia
P4
Terminated1,389Open-labelPraluent
NCT05265234
Dupilmuab for Atopic Dermatitis Monitored With Noninvasive Imaging.
Eczema, Atopic Dermatitis
P4
Unknown15Open-labelDupilumab
NCT04998604
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
Chronic Rhinosinusitis With Nasal Polyps, Asthma
P4
Completed360RCT, Double-blindDupilumab, Omalizumab, Placebo
NCT02559180
Treatment of Diabetic Macular Edema With Aflibercept in Subjects Previously Treated With Ranibizumab or Bevacizumab
Diabetic Retinopathy, Macular Edema
P4
Completed20Open-labelaflibercept
NCT03022292
The IAI-OCTA Study; a Study of OCT-Angiography Analysis Efficacy
Wet Macular Degeneration
P4
Completed26Open-labelAflibercept Ophthalmic
NCT01543568
Study for Recalcitrant Age Related Macular Degeneration
Age Related Macular Degeneration
P4
Completed46Open-labelaflibercept 2.0 mg
NCT02581891
Managing Neovascular (Known as "Wet") Age-related Macular Degeneration Over 2 Years Using Different Treatment Schedules of 2 mg Intravitreal Aflibercept Injected in the Eye
Macular Degeneration
P4
Completed287RCT, Open-labelEylea (Intravitreal Aflibercept, VEGF Trap-Eye, BAY86-5321), Eylea (Intravitreal Aflibercept, VEGF Trap-Eye, BAY86-5321)
NCT02957682
Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo
Hypercholesterolemia
P4
Completed2,176RCT, Double-blindPraluent (Alirocumab), Placebo
NCT04400318
The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
Asthma
P4
Completed109RCT, Double-blindDupilumab, Placebo
NCT05036733
Effects of Interleukin (IL)- 4R-alpha Inhibition on Respiratory Microbiome and Immunologic Correlates in Severe Asthma
Asthma
P4
Completed15Open-labelDupilumab
NCT03767738
Study to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe
Chorioretinal Vascular Disease
P4
Completed65Open-labelIntravitreal Aflibercept Injection (IAI)
NCT01722045
Study to Assess Best Corrected Visual Acuity (BCVA) in Patients With Neovascular Age-Related Macular Degeneration (AMD) Who Are Administered VEGF Trap-Eye (Intravitreal Aflibercept Injection)
Age - Related Macular Degeneration (AMD)
P4
Completed154Open-labelIntravitreal Aflibercept Injection (IAI)
NCT02092532
Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy (RIVAL Trial)
Neovascular Polypoidal Choroidal Vasculopathy
P4
Unknown20Open-labelRescue Intravitreal Aflibercept Injection
NCT01857544
Study of Intravitreal Aflibercept Injection for Persistent CRVO-associated Macular Edema Despite Prior Anti-VEGF Therapy
Retinal Vein Occlusion
P4
Unknown10Open-labelAflibercept
NCT04708145
Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Retinopathy for Subjects Who Completed the 2-Year PANORAMA Trial
Diabetic Retinopathy
P4
Completed41RCT, Open-labelAflibercept Injection
NCT04502862
A Phase 4, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Effect of Dupilumab on Sleep Disturbance in Patients With Uncontrolled Persistent Asthma
Asthma
P4
Completed202RCT, Double-blindSAR231893, Placebo
NCT03059277
Intravitreal Alfibercept for Center Involved DME Previously Managed With Intravitreal Ranibizumab
Diabetic Macular Edema
P4
WithdrawnOpen-labelIntravitreal Aflibercept
NCT06012448
The Immunologic Effects of Dupilumab in the Treatment of Dermal Hypersensitivity Reaction
Dermal Hypersensitivity Reaction
P4
Completed10Open-labelDupilumab
NCT03293030
Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis
Atopic Dermatitis, Atopic Dermatitis Eczema
P4
Completed17Open-labelDupilumab
NCT04520308
An Open-label, Single-arm Longitudinal Study With Dupilumab for Patients With Atopic Dermatitis
Atopic Dermatitis, AD
P4
Unknown45Open-labelDupilumab Only Product
NCT01451645
Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol
Intercritical Gout
P4
Completed82RCT, Double-blindColchicine (Colcrys®), placebo, allopurinol
NCT02642159
Efficacy and Safety of Alirocumab Versus Usual Care on Top of Maximally Tolerated Statin Therapy in Patients With Type 2 Diabetes and Mixed Dyslipidemia (ODYSSEY DM-Dyslipidemia)
Dyslipidemia
P4
Completed413RCT, Open-labelAlirocumab, Statins, Ezetimibe, Fenofibrate, Nicotinic acid, Omega-3 fatty acids, Antihyperglycemic Drug
NCT02689518
EAGLE: Evaluating Genotypes Using Intravitreal Aflibercept Injection
Macular Degeneration, Wet Macular Degeneration
P4
Completed50Open-labelIntravitreal aflibercept injection
NCT02503540
Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO
Retinal Vein Occlusion, Diabetic Macular Edema
P4
Completed31Open-labelAflibercept
NCT01670162
On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD)
Age Related Macular Degeneration, Pigment Epithelial Detachment
P4
Unknown30Open-labelAflibercept
NCT04203797
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma
Asthma
P4
Completed40RCT, Double-blinddupilumab, Matching placebo
NCT03667014
The Impact of Dupilumab on Quality of Life in Moderate to Severe Atopic Dermatitis Patients
Atopic Dermatitis, Atopic Dermatitis Eczema
P4
Completed34Open-labelDupilumab
NCT02992301
Assessment of Atherosclerotic Plaque Characteristics Change by DCE-MRI With Alirocumab
Atherosclerosis, Hyperlipidemia
P4
Unknown35Open-labelAlirocumab
NCT04447417
Dupilumab Skin Barrier Function Study in Atopic Dermatitis
Atopic Dermatitis
P4
Completed52Open-labelDupilumab SAR231893
NCT03468296
Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept
Neovascular Age-related Macular Degeneration
P4
Unknown22RCT, Open-labelIntravitreal Aflibercept Injection 2mg
NCT01722656
Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment
Submacular Vascularized Pigment Epithelial Detachments
P4
Completed40Open-labelAflibercept
NCT01870427
NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions
Macular Edema With Central Retinal Vein Occlusions
P4
Completed20Open-labelAflibercept (2.0 mg)
NCT04718870
Dupilumab-PEdiatric Skin Barrier Function and LIpidomics STudy in Patients With Atopic Dermatitis
Dermatitis Atopic
P4
Completed41Open-labelDupilumab SAR231893
NCT06352073
Dupilumab for Eosinophilic Esophagitis With Severe Strictures
Eosinophilic Esophagitis, EoE
P4
By Invite30Open-labelDupilumab
NCT02305238
Japanese Treat and Extend Study of Aflibercept in Neovascular Age-related Macular Degeneration
Wet Macular Degeneration
P4
Completed288RCT, Open-labelAflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT05590585
Dupilumab in Adolescent and Adult Skin of Color Participants: Open-label Moderate-to-severe Eczema Trial
Moderate-to-Severe Atopic Dermatitis, Atopic Eczema
P4
Completed124Open-labeldupilumab
NCT03542110
The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial
Saphenous Vein Graft Atherosclerosis
P4
Terminated46RCT, Double-blindAlirocumab 150 MG/ML subcutaneous injection, Matching Placebo subcutaneous injection
NCT05247866
Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic Esophagitis
Eosinophilic Esophagitis
P4
Completed21Open-labelDupilumab
NCT03449758
Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis
Rheumatoid Arthritis
P4
Completed84Open-labelSARILUMAB, Azathioprine, Chloroquine, Hydroxychloroquine, Leflunomide, Methotrexate, Sulfasalazine
NCT01871376
Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation
Polypoidal Choroidal Vasculopathy
P4
Completed25Open-labelIntravitreal aflibercept injection 2.0mg
NCT04033367
SAR231893-LPS15497- "Dupilumab Effect on Sleep in AD Patients"
Atopic Dermatitis
P4
Completed188RCT, Double-blindDupilumab, Placebo
NCT01617148
Wet Macular Degeneration Study to Compare Ranibizumab or Bevacizumab to Aflibercept
Exudative Macular Degeneration
P4
Completed26Open-labelAflibercept
NCT02938949
Alirocumab in Patients With Acute Myocardial Infarction
Myocardial Infarction, Hypercholesterolemia
P4
Completed20RCT, Double-blindalirocumab, placebo
NCT02984982
Evaluation of Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia
Hypercholesterolemia, Acute Coronary Syndrome
P4
Completed206RCT, Open-labelAlirocumab SAR236553, Atorvastatin, Rosuvastatin, Fenofibrate, Bezafibrate, Ezetimibe, Antiplatelets, Anticoagulants
NCT00561470
Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Treatment of Patients With Metastatic Colorectal Cancer After Failure of an Oxaliplatin Based Regimen
Colorectal Neoplasms, Neoplasm Metastasis
P3
Completed1,226RCT, Double-blindPlacebo, Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin), FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin)
NCT01627249
Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema
Diabetic Macular Edema
P3
Completed660RCT, Single-blind2.0 mg intravitreal aflibercept, 1.25 mg intravitreal bevacizumab, 0.3 mg intravitreal ranibizumab
NCT04315298
Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19
COVID-19
P2P3
Completed1,912RCT, Double-blindSarilumab, Placebo
NCT01709578
To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)
Rheumatoid Arthritis
P3
Completed546RCT, Double-blindSarilumab, placebo, hydroxychloroquine, methotrexate, sulfasalazine, leflunomide
NCT03346434
Safety, Pharmacokinetics and Efficacy of Dupilumab in Patients ≥6 Months to <6 Years With Moderate-to-Severe Atopic Dermatitis (Liberty AD PRESCHOOL)
Dermatitis, Atopic
P2P3
Completed202Open-labelDupilumab, Matching placebo
NCT03399786
Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Homozygous Familial Hypercholesterolemia
P3
Completed65RCT, Double-blindevinacumab, Placebo
NCT02134028
Long-Term Safety Evaluation of Dupilumab in Patients With Asthma (LIBERTY ASTHMA TRAVERSE)
Asthma
P3
Completed2,282Open-labelDupilumab
NCT04577820
Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Fibrodyplasia Ossificans Progressiva (FOP), Heterotopic Ossification (HO)
P3
WithdrawnOpen-labelgaretosmab
NCT04183335
Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (LIBERTY-PN PRIME)
Neurodermatitis
P3
Completed151RCT, Double-blindDupilumab SAR231893, Placebo, Moisturizers, Low to medium potent topical corticosteroids, Topical calcineurin inhibitors
NCT04015180
Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090
Retinopathy of Prematurity (ROP)
P3
Completed100Open-labelEylea (Aflibercept, BAY86-5321)
NCT03088540
Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC)
Carcinoma,Non-Small-Cell Lung, Lung Carcinomas, Non-Small-Cell
P3
Completed712RCT, Open-labelPemetrexed, Paclitaxel, Gemcitabine, Cisplatin, Carboplatin, cemiplimab
NCT03782532
Efficacy and Safety Study of Dupilumab in Patients With Persistent Asthma
Asthma
P3
Completed486RCT, Double-blindDupilumab SAR231893, Placebo, Asthma Controller Therapies (include prednisone/prednisolone), Asthma Reliever Therapies
NCT00958438
PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2)
Gout
P3
Completed248RCT, Double-blindPlacebo, Rilonacept, Rilonacept
NCT00288704
Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)
Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria
P3
Completed104RCT, Double-blindrilonacept 160 mg, Placebo, rilonacept 160 mg
NCT01482910
VEGF Trap-Eye: Investigation of Efficacy and Safety in Chinese Subjects With Wet AMD (Age-Related Macular Degeneration)
Macular Degeneration
P3
Completed304RCT, Double-blindAflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Visudyne
NCT04678882
Dupilumab in Japanese Patients With Atopic Dermatitis
Atopic Dermatitis
P3
Completed62RCT, Double-blindPlacebo, Dupilumab SAR231893
NCT07318610
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
Peripheral Artery Disease (PAD)
P3
Not Yet Recruiting7,050RCT, Double-blindREGN7508, REGN9933, Placebo, Rivaroxaban
NCT02912468
A Controlled Clinical Study of Dupilumab in Patients With Bilateral Nasal Polyps
Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)
P3
Completed276RCT, Double-blindDupilumab SAR231893 (REGN668), Placebo, Mometasone furoate 50 micrograms
NCT03257267
Study of Cemiplimab in Adults With Cervical Cancer
Squamous Cell Carcinoma (SCC), Recurrent or Metastatic, Platinum-refractory Cervical Cancer
P3
Completed608RCT, Open-labelCemiplimab, Investigator Choice (IC) Chemotherapy
NCT03344692
Effect of Alirocumab on Postprandial Hyperlipemia in Patients With Type 2 Diabetes
Type2 Diabetes
P3
Completed22RCT, Double-blindAlirocumab
NCT04327388
Sarilumab COVID-19
Corona Virus Infection
P3
Completed420RCT, Double-blindSarilumab SAR153191, Placebo
NCT01363440
Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema
Diabetic Macular Edema
P3
Completed466RCT, Double-blindIntravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321)
NCT01730040
Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I)
Hypercholesterolemia
P3
Completed355RCT, Double-blindAlirocumab, Atorvastatin, Ezetimibe, Rosuvastatin, Placebo
NCT01949311
Open-label Study of Dupilumab in Patients With Atopic Dermatitis
Atopic Dermatitis
P3
Completed2,733Open-labelDupilumab
NCT02414854
Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest)
Asthma
P3
Completed1,902RCT, Double-blindDupilumab, Placebo, Inhaled corticosteroid (ICS) therapy, Albuterol/Salbutamol, Levalbuterol/Levosalbutamol
NCT04452318
COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR Assay
Healthy Participants
P3
Completed3,303RCT, Double-blindREGN10933 + REGN10987, Placebo
NCT02107898
Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)
Hypercholesterolemia
P3
Completed216RCT, Double-blindPlacebo (for alirocumab), Alirocumab, Lipid-Modifying Therapy (LMT)
NCT02755649
A Study to Assess the Efficacy and Safety of Dupilumab in Participants With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically Advisable
Atopic Dermatitis
P3
Completed325RCT, Double-blindDupilumab, Matching Placebo
NCT05989126
Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS)
Diabetic Macular Edema (DME), Neovascular Age-Related Macular Degeneration (nAMD)
P3
Completed35Open-labelaflibercept 8 mg PFS
NCT03345914
Study to Investigate the Efficacy and Safety of Dupilumab Administered With Topical Corticosteroids (TCS) in Participants ≥6 to <12 Years With Severe Atopic Dermatitis (AD)
Dermatitis, Atopic
P3
Completed367RCT, Double-blindDupilumab, Matching Placebo
NCT02476006
Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)
Hypercholesterolemia
P3
Completed998Open-labelALIROCUMAB SAR236553 (REGN727), placebo (for injection training only), ezetimibe, atorvastatin, rosuvastatin, simvastatin
NCT03054428
Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe Atopic Dermatitis
Moderate-to-Severe Atopic Dermatitis, Dermatitis, Dermatitis Atopic
P3
Completed251RCT, Double-blindDupilumab, Placebo
NCT00964795
Open-label Extension Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Neovascular ("Wet") Age-related Macular Degeneration (AMD)
Neovascular Age-related Macular Degeneration
P3
Completed323Open-labelIntravitreal Aflibercept Injection 2mg
NCT02585778
Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)
Hypercholesterolaemia
P3
Completed517RCT, Double-blindAlirocumab, Placebo, Lipid-Modifying Therapy (LMT), Antihyperglycemic Drug
NCT04394351
Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis (EoE)
P3
Completed102RCT, Double-blindDupilumab, Matching Placebo
NCT04206553
A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid
Bullous Pemphigoid
P2P3
Completed106RCT, Double-blinddupilumab, Matching Placebo, Oral corticosteroids (OCS)
NCT07430956
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable
Atrial Fibrillation (AF)
P3
Not Yet Recruiting2,628RCT, Double-blindREGN7508, REGN9933, Placebo
NCT07424144
An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps
P3
By Invite380RCT, Double-blindItepekimab (SAR440340), Placebo
NCT01249664
VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV)
Myopia, Pathological
P3
Completed122RCT, Double-blindVEGF Trap-Eye (BAY86-5321)
NCT01623115
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy
Hypercholesterolemia
P3
Completed486RCT, Double-blindAlirocumab, Placebo (for alirocumab), Lipid Modifying Therapy (LMT)
NCT04684524
Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) (LIBERTY-AFRS-AI)
Allergic Fungal Rhinosinusitis
P3
Completed62RCT, Double-blindDupilumab SAR231893, Placebo
NCT02447276
Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip
Osteoarthritis, Knee, Osteoarthritis, Hip
P2P3
Completed421RCT, Double-blindREGN475, Placebo
NCT04004208
Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy
Retinopathy of Prematurity (ROP)
P3
Completed113RCT, Open-labelEylea (Aflibercept, BAY86-5321)
NCT03600805
Evaluation of Efficacy and Safety of Sarilumab in Patients With GCA
Giant Cell Arteritis
P3
Terminated83RCT, Double-blindSarilumab SAR153191, Sarilumab matching placebo, Prednisone, Prednisone matching placebo
NCT02023879
Phase III Study To Evaluate Alirocumab in Patients With Hypercholesterolemia Not Treated With a Statin (ODYSSEY CHOICE II)
Hypercholesterolemia
P3
Completed233RCT, Double-blindAlirocumab, Placebo (for Alirocumab), Non-statin LMT
NCT03480568
Alirocumab in Patients on a Stable Dialysis Regimen
Hemodialysis, Peritoneal Dialysis
P3
Unknown20Open-labelAlirocumab 150 MG/ML [Praluent]
NCT04202679
Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (PRIME2)
Neurodermatitis
P3
Completed160RCT, Double-blindDupilumab SAR231893, Placebo, Moisturizers, Low to medium potent topical corticosteroids, Topical calcineurin inhibitors
NCT02584504
Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin
Hypercholesterolemia
P3
Completed163RCT, Double-blindAlirocumab, Placebo, Atorvastatin, Non-statin Lipid-Modifying Therapy
NCT05131204
Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria
P3
Terminated3RCT, Open-labelCemdisiran, Eculizumab, Pozelimab, Ravulizumab
NCT03161093
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
Osteoarthritis, Knee, Osteoarthritis, Hip
P3
Completed3,307RCT, Double-blindFasinumab, Naproxen, Fasinumab-matching placebo, Naproxen-matching placebo
NCT02396316
Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients
Glaucoma, Neovascular
P3
Completed54RCT, Double-blindAflibercept (Eylea, BAY 86-5321), Sham Injection
NCT07493304
Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers
Venous Thromboembolism (VTE)
P3
Not Yet Recruiting1,600RCT, Open-labelREGN7508, Apixaban
NCT02634333
Anti-VEGF Treatment for Prevention of PDR/DME
Diabetic Retinopathy, Diabetic Macular Edema
P3
Completed399RCT, Double-blindPrompt aflibercept, Deferred aflibercept
NCT04423718
Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye
Neovascular Age-Related Macular Degeneration
P3
Completed1,011RCT, Double-blindAflibercept High Dose VEGF Trap-Eye (BAY86-5321), Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321)
NCT03510715
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia
Hypercholesterolemia
P3
Completed18Open-labelAlirocumab SAR236553 (REGN727), Atorvastatin, Simvastatin, Fluvastatin, Pravastatin, Lovastatin, Rosuvastatin, Ezetimibe, Cholestyramine, Nicotinic acid, Fenofibrate, Omega-3 fatty acids
NCT02718326
Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR)
Nonproliferative Diabetic Retinopathy
P3
Completed402RCT, Double-blindIntravitreal aflibercept injection [IAI], Sham
NCT02683239
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
Osteoarthritis of the Knee or Hip
P3
Completed5,331RCT, Double-blindFasinumab, Placebo
NCT01954394
Open Label Study of Long Term Safety Evaluation of Alirocumab
Hypercholesterolemia
P3
Completed986Open-labelAlirocumab, Lipid-Modifying Therapy (LMT)
NCT00637377
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)
Macular Degeneration
P3
Completed1,240RCT, Double-blindRanibizumab, Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321), Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321), Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321)
NCT02528214
Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma
Asthma
P3
Completed210RCT, Double-blindDupilumab, Placebo, Oral corticosteroid therapy (prednisone/prednisolone), Inhaled corticosteroid (ICS) therapy, Albuterol/Salbutamol, Levalbuterol/Levosalbutamol
NCT03620747
Continuation of TRAVERSE- LTS12551 Evaluating Dupilumab Safety in Patients With Asthma (Long-Term Follow-Up)
Asthma
P3
Completed393Open-labelDupilumab SAR231893 (REGN668)
NCT03067844
Vascular Effects of Alirocumab in Acute MI-Patients
Coronary Vessel, Coronary Circulation
P3
Completed294RCT, Double-blindAlirocumab
NCT01661270
A Study of Aflibercept Versus Placebo With FOLFIRI in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin Chemotherapy
Colorectal Cancer Metastatic
P3
Completed332RCT, Double-blindAflibercept, Placebo
NCT02332590
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Rheumatoid Arthritis
P3
Completed369RCT, Double-blindSarilumab, Adalimumab, Placebo (for sarilumab), Placebo (for adalimumab)
NCT04751487
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease
P3
Completed1,239RCT, Double-blindItepekimab SAR440340, Placebo
NCT01146652
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
Rheumatoid Arthritis
P3
Completed2,023Open-labelSAR153191 (REGN88)
NCT02277769
Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
Dermatitis, Atopic
P3
Completed708RCT, Double-blindDupilumab, Placebo (for Dupilumab)
NCT03304379
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
Osteoarthritis, Knee, Osteoarthritis, Hip
P3
Completed1,650RCT, Double-blindFasinumab, Matching placebo
NCT00519285
Aflibercept in Combination With Docetaxel in Metastatic Androgen Independent Prostate Cancer
Prostatic Neoplasms, Neoplasm Metastasis
P3
Completed1,224RCT, Double-blindAflibercept, Placebo (for aflibercept), Docetaxel, Prednisone or Prednisolone
NCT01764997
An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate
Rheumatoid Arthritis
P3
Terminated776RCT, Double-blindSarilumab, Etanercept, Methotrexate, Placebo (for sarilumab), Placebo (for etanercept), Adalimumab
NCT04162470
REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate Its Long Term Safety, Efficacy and Tolerability.
Paroxysmal Nocturnal Hemoglobinuria
P3
Terminated24Open-labelREGN3918
NCT04429503
Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease
Diabetic Macular Edema, Type 1 Diabetes Mellitus
P2P3
Completed660RCT, Double-blindaflibercept, High-dose aflibercept
NCT06602739
A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy
Allergic Conjunctivitis
P3
Completed54RCT, Double-blindREGN5713, REGN5715, Placebo
NCT02620020
A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain
Low Back Pain
P2P3
Completed563RCT, Double-blindFasinumab, placebo
NCT07484230
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Adult Japanese Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
Chronic Rhinosinusitis With Nasal Polyps
P3
Not Yet Recruiting20RCT, Double-blindItepekimab (SAR440340), Placebo
NCT01670721
Colorectal Cancer Metastatic
Colorectal Cancer Metastatic
P3
Completed175Open-labelAFLIBERCEPT, Irinotecan, Fluorouracil, Leucovorin
NCT00943072
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
Macular Edema Secondary to Central Retinal Vein Occlusion
P3
Completed189RCT, Double-blindVEGF Trap-Eye 2.0mg, Sham
NCT02325791
Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm Infants
Respiratory Syncytial Virus Infections
P3
Completed1,177RCT, Double-blindSuptavumab 30 mg/kg, Placebo Matched to Suptavumab, Suptavumab 30 mg/kg- 1 Dose, Suptavumab 30 mg/kg - 2 Doses
NCT02898454
Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps
Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)
P3
Completed448RCT, Double-blindDupilumab SAR231893 (REGN668), Placebo, Mometasone furoate nasal spray
NCT01512966
Japanese Safety Study of VEGF Trap-Eye in DME (Diabetic Macular Edema)
Macular Edema
P3
Completed73Open-labelVEGF Trap-Eye (BAY86-5321)
NCT04425629
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult and Pediatric Patients With COVID-19
COVID-19
P3
Terminated10,078Open-labelcasirivimab+imdevimab combination therapy
NCT02326220
Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy
Heterozygous Familial Hypercholesterolemia
P3
Completed62RCT, Double-blindPlacebo, Alirocumab
NCT01926782
Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1)
Hypercholesterolemia
P3
Completed803RCT, Double-blindPlacebo (for alirocumab), Alirocumab, Statin
NCT01768572
To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)
Rheumatoid Arthritis
P3
Completed202RCT, Double-blindsarilumab SAR153191 (REGN88), tocilizumab, hydroxychloroquine, methotrexate, sulfasalazine, leflunomide, subcutaneous placebo, intravenous placebo
NCT03409744
Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Homozygous Familial Hypercholesterolemia
P3
Completed116Open-labelevinacumab
NCT02260986
Study to Assess the Efficacy and Long-term Safety of Dupilumab (REGN668/SAR231893) in Adult Participants With Moderate-to-Severe Atopic Dermatitis
Atopic Dermatitis
P3
Completed740RCT, Double-blindDupilumab, Placebo (for Dupilumab)
NCT03560466
Assessment of the Safety and Efficacy of Dupilumab in Children With Asthma (Liberty Asthma Excursion)
Asthma
P3
Completed378Open-labelDupilumab (SAR231893/REGN668), Asthma controller therapies (incl. prednisone/prednisolone), Asthma reliever therapies
NCT01709500
Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy)
Heterozygous Familial Hypercholesterolemia
P3
Completed249RCT, Double-blindLMT (atorvastatin, simvastatin, or rosuvastatin), alirocumab, Placebo
NCT00855920
Study Utilizing Rilonacept in Gout Exacerbations
Acute Gout Flare
P3
Completed225RCT, Double-blindRilonacept, Indomethacin
NCT04678856
Dupilumab in CRSsNP
Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis
P3
Completed71RCT, Double-blindDupilumab SAR231893, Placebo
NCT00829829
PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1
Intercritical Gout
P3
Completed241RCT, Double-blindRilonacept 80 mg, Rilonacept 160 mg
NCT02057250
To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis
RA
P3
Completed217RCT, Open-labelSarilumab, Methotrexate, Sulfasalazine, Leflunomide, Hydroxychloroquine
NCT02715726
Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia
Hypercholesterolemia
P3
Completed615RCT, Double-blindAlirocumab, Placebo for alirocumab, ezetimibe, placebo for ezetimibe, atorvastatin, rosuvastatin, simvastatin
NCT03633617
Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis
P3
Completed321RCT, Double-blindDupilumab, Placebo
NCT03600818
Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica
Polymyalgia Rheumatica
P3
Terminated118RCT, Double-blindSarilumab SAR153191 (REGN88), Sarilumab-matching placebo, Prednisone, Prednisone-matching placebo, Prednisone
NCT07393282
A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)
High Risk Smoldering Multiple Myeloma (HR-SMM)
P3
Not Yet Recruiting270RCT, Open-labelLinvoseltamab, Daratumumab
NCT04502966
Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction
Allergic Rhinoconjunctivitis, Grass Pollen Allergy
P2
Completed108RCT, Double-blindDupixent®, Grazax®, Dupixent® Placebo, Grazax® Placebo
NCT03682770
Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy)
Peanut Allergy
P2
Completed148RCT, Double-blindDupilumab, Placebo matching dupilumab, AR101
NCT07058012
A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)
Colo-rectal Cancer
P2
Not Yet Recruiting79Open-labelCemiplimab, cemiplimab plus fianlimab, cemiplimab + REGN7075
NCT07224022
Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer
Colon Cancer
P2
Not Yet Recruiting24Open-labelCemiplimab + Fianlimab [Fixed Dose Combination (FDC)]
NCT03956550
A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee
Osteoarthritis of the Knee, Pain
P2
Terminated259RCT, Double-blindREGN5069, Matching Placebo
NCT03886493
Neoadjuvant Dupilumab in Men With Localized High-Risk Prostate Cancer
Prostate Cancer
P2
Terminated7Open-labelDupilumab
NCT04148352
Dupilumab and Milk OIT for the Treatment of Cow's Milk Allergy
Allergies Food Milk
P2
Terminated33RCT, Double-blindDupilumab
NCT01239017
A Study of the Safety and Efficacy of Subcutaneously Administered REGN475 in Patients With Osteoarthritis of the Knee
Osteoarthritis
P2
WithdrawnRCT, Double-blindREGN475
NCT04311606
Anti-VEGF Therapy for Acute Thyroid Eye Disease
Thyroid Eye Disease
P2
Completed11RCT, Double-blindSub-tenon injection of saline followed by a sub-tenon injection of aflibercept, Sub-tenon injection of hyaluronidase (HA) followed by a sub-tenon injection of aflibercept, Sub-tenon injection of hyaluronidase (HA) alone
NCT03710941
Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis
Sporadic Inclusion Body Myositis
P2
WithdrawnRCT, Double-blindREGN2477+REGN1033, Matching placebo
NCT06384820
Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC)
Cutaneous Squamous Cell Carcinoma
P2
WithdrawnRCT, Open-labelcemiplimab, fianlimab
NCT02418754
Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)
Neovascular Age-Related Macular Degeneration
P2
Terminated505RCT, Double-blindREGN2176-3, Intravitreal Aflibercept Injection (IAI)
NCT00789477
DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical Impact
Diabetic Macular Edema
P2
Completed221RCT, Double-blindIntravitreal Aflibercept Injection
NCT03175367
Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia
Hypercholesterolemia
P2
Completed272RCT, Double-blindEvinacumab, Matching placebo
NCT03787095
Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Suppressive cART
HIV Infections
P1P2
Terminated5RCT, Double-blindCemiplimab, Placebo
NCT03004001
Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome
Nephrotic Syndrome
P2
Terminated3RCT, Double-blindAlirocumab, Alirocumab placebo, Atorvastatin
NCT00944892
A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee
Osteoarthritis of the Knee
P1P2
Completed200RCT, Double-blindREGN475
NCT04916002
A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer
Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
P2
Terminated77Open-labelvidutolimod, cemiplimab
NCT05088460
A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD)
Familial Partial Lipodystrophy, Metabolic Abnormalities
P2
Terminated20RCT, Double-blindREGN4461, Matching Placebo
NCT04831450
Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)
Head and Neck Squamous Cell Carcinoma, HNSCC
P2
WithdrawnOpen-labelCemiplimab-Rwlc
NCT01604824
A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene
Hypercholesterolemia
P2
Completed23RCT, Double-blindAlirocumab, Placebo
NCT07318597
Phase 2 Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH)
P2
Not Yet Recruiting99RCT, Double-blindREGN13335, Placebo
NCT06385262
TOP 2301: Neoadjuvant Chemo for NSCLC
Non Small Cell Lung Cancer
P2
SUSPENDED126RCT, Open-labelAlirocumab, Cemiplimab, Chemotherapy
NCT04242173
Cemiplimab-rwlc for Unresectable Locally Recurrent and/or Metastatic CSCC
Cutaneous Squamous Cell Carcinoma, Cutaneous Squamous Cell Carcinoma of the Head and Neck
P2
Terminated3Open-labelCemiplimab-Rwlc
NCT00991172
A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain
Sciatica
P2
Completed159RCT, Double-blindREGN475, REGN475, Placebo Injection
NCT01988246
Prevention of Macular Edema In Patients With Diabetic Retinopathy Undergoing Cataract Surgery
Diabetic Retinopathy
P1P2
Completed30RCT, Single-blindAflibercept, Sham
NCT05128383
Study to Assess Efficacy and Safety of Dupilumab in the Treatment of Keloids
Keloid
P2
Completed20Open-labelDupilumab
NCT05202288
Impact of Delay Between Administration of Inmazeb Administration and Vaccination by Ervebo on Vaccine Immune Response on Healthy Volunteers
Ebola Virus Disease
P2
Not Yet Recruiting132RCT, Open-labelErvebo, Inmazeb
NCT04154943
Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma
Cutaneous Squamous Cell Carcinoma
P2
Completed79Open-labelCemiplimab
NCT01859988
Study of Dupilumab Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
Atopic Dermatitis
P2
Completed380RCT, Double-blindDupilumab, Placebo
NCT02407756
A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema)
Atopic Dermatitis
P2
Completed78Open-labelDupilumab
NCT04046107
Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy
Hepatitis B Virus
P1P2
WithdrawnOpen-labelCemiplimab
NCT04442269
Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)
Allergic Bronchopulmonary Aspergillosis
P2
Completed62RCT, Double-blinddupilumab, Placebo
NCT03838731
Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge
Cat Allergy, Mild Asthma
P2
Completed56RCT, Double-blindREGN1908-1909, Placebo
NCT04159415
Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy
Generalized Lipodystrophy
P2
Completed16RCT, Double-blindPlacebo, Low-Dose REGN4461, High-dose REGN4461
NCT01217814
Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-α Blockers
Rheumatoid Arthritis
P2
Terminated16RCT, Double-blindSarilumab, Placebo, Golimumab, methotrexate (MTX), Folic/folinic acid
NCT01548404
Study of Dupilumab in Adult Patients With Extrinsic Moderate-to-Severe Atopic Dermatitis
Atopic Dermatitis
P2
Completed109RCT, Double-blindPlacebo, Dupilumab
NCT04526899
A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment
Melanoma Stage III, Melanoma Stage IV
P2
Completed184RCT, Open-labelBNT111, Cemiplimab
NCT05326412
Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD
Chronic Obstructive Pulmonary Disease
P2
Completed49Open-labelItepekimab SAR440340
NCT01979016
Study to Determine the Safety and Effectiveness of Dupilumab for Treatment of Atopic Dermatitis (AD)
Atopic Dermatitis (AD)
P2
Completed54RCT, Double-blindDupilumab, Placebo
NCT00284141
Study of AVE0005 (VEGF Trap) in Locally Advanced or Metastatic Platinum- and Erlotinib- Resistant Non-small-cell-lung Adenocarcinoma
Pulmonary Diseases, Neoplasms, Lung
P2
Completed98Open-labelAflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
NCT06237309
REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction
Heart Failure
P2
Terminated89RCT, Double-blindREGN5381, Placebo
NCT04811716
Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy
Paroxysmal Nocturnal Hemoglobinuria
P2
Completed24RCT, Open-labelPozelimab, Cemdisiran
NCT04992273
COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
COVID-19
P2
Terminated7Open-labelcasirivimab+imdevimab
NCT05618808
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
Venous Thromboembolism
P2
Completed373RCT, Open-labelREGN9933, Enoxaparin, Apixiban
NCT01605708
Study to Assess the Clinical Activity of a Sequential Dose of REGN846 on Refractory Pruritus in Patients With Atopic Dermatitis
Pruritus, Atopic Dermatitis
P1P2
Terminated19RCT, Double-blindREGN846
NCT03430063
A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer
Advanced Non-Small Cell Lung Carcinoma
P2
Terminated28RCT, Open-labelSDREGN2810, SDREGN2810/ipi, HDREGN2810
NCT06280391
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
Bronchiectasis
P2
Completed312RCT, Double-blindItepekimab (SAR440340), Placebo
NCT02890992
An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
Hypercholesterolaemia
P2
Completed42Open-labelalirocumab SAR236553 (REGN727), statins, ezetimibe, cholestyramine, fenofibrate, omega-3 fatty acids, nicotinic acid
NCT00396591
AVE0005 (VEGF Trap) in Patients With Recurrent Symptomatic Malignant Ascites
Ovarian Neoplasms
P2
Completed16Open-labelAflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
NCT04426695
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
COVID-19
P1P2
Completed2,252RCT, Double-blindREGN10933+REGN10987 combination therapy, Placebo
NCT02085005
Capecitabine Plus Aflibercept as Maintenance Therapy Following Capecitabine Plus Oxaliplatin Plus Aflibercept in Patients With Metastatic Colorectal Cancer
Colorectal Cancer Metastatic
P2
WithdrawnOpen-labelCapecitabine, Aflibercept AVE0005, Oxaliplatin SR96669
NCT07455851
A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed/Refractory Multiple Myeloma
Relapsed Refractory Multiple Myeloma (RRMM)
P1P2
Not Yet Recruiting150Open-labelLinvoseltamab, REGN17372+Linvoseltamab
NCT03188666
A Study to Examine the Safety, Tolerability and Effects on Abnormal Bone Formation of REGN2477 in Patients With Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva
P2
Completed44RCT, Double-blindREGN2477, Matching placebo
NCT01053702
Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Pain Resulting From Thermal Injury
Thermal Injury Pain
P2
WithdrawnRCT, Double-blindR475, Placebo
NCT04339062
Cemiplimab in AlloSCT/SOT Recipients With CSCC
Cutaneous Squamous Cell Carcinoma, Advanced Cancer
P1P2
Completed12Open-labelCemiplimab, Everolimus, Sirolimus, Prednisone
NCT02573233
Evaluation of Dupilumab's Effects on Airway Inflammation in Patients With Asthma
Asthma
P2
Completed42RCT, Double-blindPlacebo, Dupilumab SAR231893/REGN668, fluticasone propionate and salmeterol, budesonide and formoterol, mometasone furoate and formoterol
NCT00527423
Randomized, Single-Masked, Long-Term, Safety and Tolerability Study of VEGF Trap-Eye in AMD
Macular Degeneration
P2
Completed157Single-blindVEGF Trap Eye
NCT00327171
Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer
Neoplasms, Cancer of the Ovary
P2
Completed218RCT, Double-blindAflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
NCT02760498
Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma
Advanced Cutaneous Squamous Cell Carcinoma
P2
Completed432Open-labelcemiplimab
NCT03387852
Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants
Asthma
P2
Completed296RCT, Double-blindSAR440340, Dupilumab, Fluticasone or Fluticasone/salmeterol combination, Placebo for SAR440340, Placebo for dupilumab
NCT01882868
A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan
Colorectal Cancer Metastatic
P2
Completed62Open-labelAflibercept, Levofolinate, Irinotecan, 5-FU
NCT01920893
An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis
Nasal Polyps
P2
Completed60RCT, Double-blindPlacebo (for dupilumab), Dupilumab, Mometasone furoate nasal spray
NCT02265952
Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
Homozygous Familial Hypercholesterolemia
P2
Completed9Open-labelREGN1500 250 mg SC/15 mg/kg IV/450 mg SC
NCT01001715
Single Injection of REGN475/SAR164877 in Treatment of Vertebral Fracture Pain
Back Pain
P2
Terminated41RCT, Double-blindREGN475/SAR164877, Placebo (for REGN475/SAR164877)
NCT00320788
Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)
Macular Degeneration
P2
Completed159RCT, Double-blindaflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321), aflibercept injection (VEGF Trap-Eye, BAY86-5321)
NCT01724554
Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion
Central Retinal Vein Occlusion, Proliferative Diabetic Retinopathy
P1P2
Completed24RCT, Open-labelIntravitreal Aflibercept Injection
NCT03359356
Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD)
Alopecia Areata
P2
Completed60RCT, Double-blindDupilumab, Placebo
NCT03793608
Study to Evaluate Dupilumab Monotherapy in Pediatric Patients With Peanut Allergy
Peanut Allergy
P2
Completed25Open-labelDupilumab
NCT04852978
COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers
Healthy, Chronic Stable Illness
P2
Completed295RCT, Open-labelcasirivimab+imdevimab, Moderna mRNA-1273 vaccine
NCT01963598
Study of the Safety and Efficacy of REGN1033 (SAR391786) in Patients With Sarcopenia
Sarcopenia
P2
Completed253RCT, Double-blindREGN1033 (SAR391786), placebo
NCT01312961
Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma
Asthma
P2
Completed104RCT, Double-blindDupilumab, Placebo (for Dupilumab), Fluticasone/Salmeterol combination therapy, Fluticasone monotherapy, Albuterol, Levalbuterol
NCT02379052
Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis
P2
Completed47RCT, Double-blindDupilumab, Placebo
NCT04888507
Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy
Paroxysmal Nocturnal Hemoglobinuria
P2
Completed6Open-labelPozelimab, Cemdisiran
NCT03949673
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
Osteoarthritis, Knee, Osteoarthritis, Hip
P2
Terminated23Open-labelFasinumab, Naproxen, Diclofenac, Celecoxib, Placebo
NCT01118728
Extension Study for Long Term Evaluation of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis
Ankylosing Spondylitis
P2
Terminated223Open-labelSarilumab
NCT00609544
Study of the Safety and Effectiveness of Rilonacept (IL-1 Trap) Administered Subcutaneously in Subjects With Non Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) and Anemia
Chronic Kidney Disease, Anemia
P2
WithdrawnRCT, Double-blindRilonacept
NCT07477704
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
Hypercholesterolemia
P2
Not Yet Recruiting420RCT, Open-labelAlirocumab
NCT01710332
The Safety & Efficacy of Intravitreal Aflibercept Injection in Patients With Persistent Central Serous Chorioretinopathy
Central Serous Chorioretinopathy
P2
Completed12RCT, Open-labelIntravitreal Aflibercept Injection
NCT03712904
Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma
Uveal Melanoma
P2
Terminated3RCT, Open-labelZiv-Aflibercept
NCT04666441
COVID-19 Study Assessing the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection
COVID-19
P2
Completed1,149RCT, Double-blindREGN10933+REGN10987 combination therapy, Placebo
NCT01538719
IL1-TRAP, Rilonacept, in Systemic Sclerosis
Scleroderma, Systemic Sclerosis
P1P2
Completed24RCT, Double-blindRilonacept
NCT01061723
Dose Ranging Study to Evaluate the Efficacy and Safety of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis
Ankylosing Spondylitis
P2
Completed301RCT, Double-blindSarilumab, Placebo
NCT06122922
Xenon MRI in Stable Pulmonary Hypertension (Jupiter AUGEAN)
Pulmonary Artery Hypertension
P2
WithdrawnOpen-labelHyperpolarized Xe129
NCT03678545
Dupilumab in Eosinophilic Gastritis
Eosinophilic Gastritis, Eosinophilic Gastroenteritis
P2
Completed41RCT, Double-blindDupilumab (blinded), Placebo (blinded)
NCT07450183
Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1
Lung Cancer (NSCLC)
P2
Not Yet Recruiting33Open-labelCemiplimab, Adjuvant chemotherapy
NCT06833190
REGN5381 in Adult Participants With Uncontrolled Hypertension
Uncontrolled Hypertension
P2
Terminated34RCT, Double-blindREGN5381, Placebo
NCT07281768
Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer
Colorectal Cancer
P2
Not Yet Recruiting66RCT, Open-labelOxaliplatin, Capecitabine, Cemiplimab, Fianlimab, REGN7075
NCT02462889
IAI Versus Sham as Prophylaxis Against Conversion to Neovascular AMD
Age-Related Macular Degeneration
P2
Completed128RCT, Single-blindIntravitreal aflibercept injection, Placebo
NCT03738423
Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis
Atopic Dermatitis
P2
Terminated129RCT, Double-blindREGN3500, REGN3500-Matching Placebo
NCT05430919
Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants
Allergic Rhinitis, Conjunctivitis
P2
Completed217RCT, Double-blindREGN5713, REGN5714, REGN5715
NCT03132636
PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy
Carcinoma, Basal Cell
P2
Completed138Open-labelcemiplimab
NCT02210780
Study of Dupilumab and Immune Responses in Adults With Atopic Dermatitis (AD)
Atopic Dermatitis
P2
Completed194RCT, Double-blindDupilumab, Placebo
NCT02712008
Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular Edema
Diabetic Macular Edema
P2
Completed302RCT, Double-blindREGN910-3, Intravitreal Aflibercept Injection (IAI)
NCT03679845
Study to Assess Sarilumab in Halting Progression of Morphea
Morphea, Plaque Form
P1P2
WithdrawnOpen-labelSarilumab
NCT07234058
Trial Assessing Fianlimab Plus Cemiplimab Plus Chemotherapy or Cemiplimab Plus Chemotherapy in Patients With Pleural Mesothelioma
Pleural Mesotheliomas
P2
Not Yet Recruiting126RCT, Open-labelCemiplimab, Fianlimab, Pemetrexed (Alimta), Cisplatin, Carboplatin (AUC 5)
NCT03085784
Intravitreal Aflibercept Injection for Radiation Retinopathy Trial
Radiation Retinopathy
P2
Unknown40RCT, Open-labelAflibercept
NCT04633278
CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Squamous Cell Carcinoma of Head and Neck
P2
Terminated24Open-labelCMP-001, Pembrolizumab
NCT03669718
A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC
Squamous Cell Carcinoma of the Oropharynx, HPV16 Positive
P2
Unknown194RCT, Double-blindISA101b, Cemiplimab
NCT06052852
Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies
Triple Negative Breast Cancer, Clear Cell Renal Cell Carcinoma
P1
Terminated17Open-labelBDC-3042, Cemiplimab
NCT04826393
ASP8374 + Cemiplimab in Recurrent Glioma
Glioblastoma, Recurrent Glioblastoma
P1
Completed14RCT, Open-labelASP8374, cemiplimab
NCT04506645
Study to Assess the Safety, Tolerability, and Pharmacokinetics of REGN5381 (an NPR1 Agonist) in Adult Humans
Healthy
P1
Completed90RCT, Double-blindREGN5381
NCT00479076
A Phase I Study of Intravenous Aflibercept in Combination With S-1 in Japanese Cancer Patients
Neoplasms
P1
Completed22RCT, Open-labelaflibercept (AVE0005), S-1
NCT01011959
A Multiple-dose Study of the Safety and Tolerability of REGN88(SAR153191) in Rheumatoid Arthritis Subjects
Rheumatoid Arthritis
P1
Completed60RCT, Double-blindREGN88
NCT00383370
Safety and Tolerability of Intravitreal VEGF Trap Formulations in Subjects With Neovacular AMD
Neovascular Age Related Macular Degeneration
P1
Completed20RCT, Double-blindVEGF Trap, VEGF Trap
NCT02017639
Sarilumab Effect on the Pharmacokinetics of Simvastatin
Rheumatoid Arthritis
P1
Completed19Open-labelsarilumab SAR153191 (REGN88), simvastatin
NCT01933763
An Ascending Single-Dose Study of the Safety, Tolerability and Bioeffect of REGN1193
Healthy Volunteers
P1
Completed56RCT, Double-blindREGN1193
NCT00856310
A Single-Dose Study of the Safety and Tolerability of REGN475(SAR164877) in Healthy Subjects
Healthy
P1
Completed56RCT, Double-blindREGN475 (SAR164877)
NCT03477864
Stereotactic Body Radiation Therapy With REGN2810 and/or Ipilimumab Before Surgery in Treating Participants With Progressive Advanced or Oligometastatic Prostate Cancer
Stage III Prostate Cancer, Stage IIIA Prostate Cancer
P1
WithdrawnRCT, Open-labelIpilimumab, Anti-PD-1 Monoclonal Antibody REGN2810
NCT01720576
Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1033 (SAR391786)
Healthy Volunteers
P1
Completed60RCT, Double-blindREGN1033 (SAR391786), Placebo
NCT01930552
A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies
Neoplasm Malignant
P1
Completed20Open-labelAflibercept AVE0005, Leucovorin, Irinotecan, 5-Fluorouracil
NCT01148615
A Study of Intravenous Aflibercept With Docetaxel in Chinese Patients With Solid Tumors
Neoplasm Malignant
P1
Completed20Open-labelAflibercept (AVE0005), Docetaxel (XRP6976)
NCT03746704
Study of ImmunoPet Imaging of PD-L1 in Tumors Using 89Zr-DFO-REGN3504 in Adult Participants With Advanced PD-L1 Positive Malignancies
Advanced PD-L1 Positive Malignancies
P1
Terminated2Open-label89Zr˗DFO˗REGN3504
NCT05481333
A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy Participants
Healthy
P1
Completed64RCT, Double-blindREGN7999, Placebo
NCT06024408
A Trial to Learn if Receiving ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk Factor
Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH)
P1
Completed9RCT, Double-blindALN-PNP, Placebo
NCT05102136
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers
Healthy Volunteers
P1
Completed56RCT, Double-blindREGN9933, Placebo
NCT01484600
Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy Volunteers
Healthy
P1
Completed36RCT, Open-labelREGN668: Injection Rate 1, REGN668: Injection Rate 2
NCT02290951
Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies
Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
P1
Completed200Open-labelOdronextamab multiple dose levels, Odronextamab multiple dose levels
NCT00045266
VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma
Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
P1
CompletedOpen-labelziv-aflibercept
NCT01850680
Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed61RCT, Double-blindsarilumab SAR153191 (REGN88), placebo, methotrexate, folic acid
NCT05603195
A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants
Healthy Volunteer
P1
Completed80RCT, Double-blindREGN7508 (IV), REGN7508 (SC), Matching Placebo (IV), Matching Placebo (SC)
NCT06444178
Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants
Healthy Volunteers
P1
Completed224RCT, Open-labelAspirin, REGN9933, REGN7508, Rivaroxaban
NCT01448317
Ascending Dose Study of the Safety and Tolerability of Alirocumab (SAR236553/REGN727) in Japanese Healthy Volunteers
Hypercholesterolemia
P1
Completed32RCT, Double-blindAlirocumab (Solution), Alirocumab (Lyophilized formulation), Placebo (Solution), Placebo (Lyophilized formulation)
NCT00083213
Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Cancer
P1
Completed25Open-labelziv-aflibercept
NCT00876044
A Study to Evaluate the Effects of Aflibercept on QTc Interval in Cancer Patients
Cancer
P1
Completed88RCT, Double-blindaflibercept (AVE0005), placebo
NCT01259323
Sequential Ascending Dose Study to Assess the Safety and Tolerability of REGN668 (SAR231893) in Patients With Atopic Dermatitis
Dermatitis
P1
Completed30RCT, Double-blindREGN668, REGN668, REGN668
NCT01026519
A Safety and Tolerability Study of REGN88(SAR153191) in Subjects With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed32RCT, Double-blindREGN88
NCT01959971
Effect of Alirocumab on Lipid Metabolism in Adults With Elevated LDL-Cholesterol
Hypercholesterolemia
P1
Completed20Single-blindalirocumab, Placebo
NCT02741739
Study of the Blood Concentrations of Two Formulations of REGN1033 in Healthy Subjects
Healthy
P1
Completed28RCT, Open-labelREGN1033
NCT02383212
Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies
Advanced Cancer, Advanced Malignancies
P1
Completed398Open-labelCemiplimab, Cyclophosphamide, Docetaxel, Carboplatin, GM-CSF, Paclitaxel, Pemetrexed
NCT03005782
Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers
Malignancies
P1
Completed333Open-labelREGN3767, cemiplimab
NCT02121080
Study of the Safety and Tolerability of REGN2222(SAR438584) in Healthy Adult Volunteers
Healthy Volunteers
P1
Completed132RCT, Double-blindREGN2222(SAR438584), placebo
NCT04616105
Study of the Safety, Tolerability, and Pharmacokinetics of REGN6490 in Healthy Japanese Adult Volunteers
Healthy Volunteer
P1
Terminated19RCT, Double-blindREGN6490, Placebo
NCT02958436
A Study of Intravenously or Subcutaneously Administered REGN3500 in Healthy Adult Subjects
Healthy Volunteers
P1
Completed40RCT, Double-blindREGN3500, Placebo
NCT05376553
Study of Cemiplimab - TP Induction Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Locally Advanced Head and Neck Squamous Cell Carcinoma
P1
By Invite24Open-labelCemiplimab, Cisplatin, Docetaxel
NCT02999711
Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma
Asthma, Moderate Asthma
P1
Completed23RCT, Double-blindREGN3500, Placebo
NCT01271972
Study of Nesvacumab (REGN910/ SAR307746)
Solid Tumors
P1
Completed53Open-labelnesvacumab (REGN910/ SAR307746)
NCT05976386
Single Dose Comparability Study of New and Current Dupilumab Drug Products Subcutaneously Administered in Healthy Adults
Healthy Volunteers
P1
Completed182RCT, Open-labelDupilumab (SAR231893)
NCT03115996
Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN3918 in Healthy Volunteers
Healthy Volunteers
P1
Completed56RCT, Double-blindREGN3918, Placebo
NCT02680184
Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy
Melanoma
P1
Completed199Open-labelCMP-001, Pembrolizumab
NCT01055899
Safety Study of a Single Dose of REGN88(SAR153191)in Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed15RCT, Double-blindREGN88, REGN88, REGN88
NCT03530514
A Study to Examine the Safety, Tolerability and Biological Effects of REGN4461 in Healthy Volunteers
Healthy Volunteers
P1
Completed113RCT, Double-blindREGN4461, Placebo
NCT05157997
Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail
COVID-19, Organ Transplant
P1
WithdrawnOpen-labelCasirivimab and Imdevimab Antibody Cocktail
NCT01026597
Ascending Dose Study of the Safety and Tolerability of REGN727(SAR236553) in Healthy Volunteers
Healthy
P1
Completed40RCT, Double-blindREGN727, Placebo
NCT04519437
Study Assessing the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Repeated Subcutaneous Doses of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (REGN10933+REGN10987) in Adult Volunteers as Related to COVID-19
Healthy, Chronic Stable Illness
P1
Completed974RCT, Double-blindREGN10933+REGN10987, Placebo
NCT01328522
Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients
Rheumatoid Arthritis
P1
Completed32RCT, Single-blindSAR153191 (REGN88)
NCT04601844
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers
Healthy
P1
Completed19Open-labelPozelimab, Cemdisiran
NCT02284425
Study of REGN1193 in Patients With Type 2 Diabetes Mellitus
Diabetes Mellitus, Type 2
P1
Terminated72RCT, Double-blindREGN1193, Placebo
NCT02516618
Study of Fasinumab (REGN475) in Healthy Japanese and Caucasian Subjects
Healthy Volunteers
P1
Completed72RCT, Double-blindFasinumab, Placebo
NCT05064085
Capecitabine In Combination With Cemiplimab In Patient With Metastatic Breast Cancer
Hormone Receptor-positive Breast Cancer
P1
Completed13Open-labelCemiplimab, Capecitabine
NCT06784349
ALN-APOC3 in Adult Participants With Dyslipidemia
Dyslipidemia
P1
Completed32RCT, Double-blindALN-APOC3, Matching Placebo
NCT05293678
Safety and Tolerability of Regeneron Anti-SARS-CoV-2 Monoclonal Antibody/Ies in Adult Healthy Volunteers as Related to COVID-19
Healthy
P1
Completed104RCT, Double-blindREGN15160 (IV), Matching Placebo (IV), REGN15160 (SC), Matching Placebo (SC)
NCT07365839
Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma
Hepatocellular Carcinoma
P1
Not Yet Recruiting20RCT, Open-labelArm 1 cemiplimab, Arm 2 cemiplimab and fianlimab
NCT01723735
Effect of Alirocumab (SAR236553/REGN727) Administered on Top of Ezetimibe or Fenofibrate on Lipid Profiles in Healthy Subjects
Hypercholesterolemia
P1
Completed79RCT, Open-labelAlirocumab, Ezetimibe, Ezetimibe Placebo, Fenofibrate
NCT00320775
Safety and Tolerability Study of Intravitreal VEGF-Trap Administration in Patients With Neovascular AMD
Macular Degeneration
P1
Completed51RCT, Open-labelVEGF Trap
NCT03050151
Study of Dupilumab Auto-injector Device When Used by Patients With Atopic Dermatitis
Atopic Disorders, Eczema, Atopic
P1
Completed176RCT, Open-labelDupilumab
NCT04491838
Study of a Single Subcutaneous Dose of Pozelimab Produced From Two Different Manufacturing Processes in Healthy Adult Participants
Healthy Volunteer
P1
Completed40RCT, Open-labelPozelimab
NCT02979015
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects
Hypercholesterolemia
P1
Completed35RCT, Double-blindalirocumab SAR236553 (REGN727), placebo
NCT04465487
Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies
Squamous Cell Carcinoma of Head and Neck
P1
Terminated38Open-labelREGN6569, Cemiplimab
NCT00921661
Study of Intravenous Aflibercept in Combination With FOLFIRI in Japanese Patients With Metastatic Colorectal Cancer
Colorectal Neoplasms, Neoplasm Metastasis
P1
Completed16Open-labelAVE0005 (aflibercept)
NCT01537653
Safety, Tolerability and Pharmacokinetics of SAR231893 (REGN668) in Healthy Japanese Adult Male Subjects
Healthy
P1
Completed32RCT, Double-blindSAR231893 (REGN668), placebo
NCT05469347
Alirocumab in Patients with Sepsis
Sepsis
P1
Completed50RCT, Double-blindAlirocumab, Placebo
NCT03146416
Study of Evinacumab (REGN1500) in Caucasian and in Japanese Healthy Volunteers
Healthy Volunteers
P1
Completed96RCT, Double-blindEvinacumab, Placebo
NCT01537640
Comparison of the Pharmacokinetics and Safety of Two SAR231893 (REGN668) Drug Products in Healthy Subjects
Healthy
P1
Completed30RCT, Double-blindSAR231893 (REGN668) DP1, SAR231893 (REGN668) DP2
NCT06137482
A Study to See How Safe and Tolerable Different Doses of REGN13335 Are When Administered Intravenously (IV) or Subcutaneously (SC) to Healthy Adult Participants
Healthy Volunteers
P1
Completed56RCT, Double-blindREGN13335, Matching Placebo
NCT01893528
Study to Assess the Safety and Tolerability of Ascending Single Doses of REGN2009 in Healthy Volunteers
Healthy Volunteers
P1
Completed49RCT, Double-blindREGN2009
NCT02404558
Single-dose Study to Describe the Safety of Sarilumab and Tocilizumab in Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
P1
Completed30RCT, Open-labelsarilumab SAR153191 (REGN88), tocilizumab
NCT00036946
VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma
Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
P1
Completedziv-aflibercept
NCT02127801
Single Ascending-dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Participants
Allergy
P1
Completed74RCT, Double-blindREGN1908-1909, placebo
NCT02744287
Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors
Metastatic Castration-resistant Prostate Cancer, Metastatic Prostate Cancer
P1
Terminated52Open-labelBPX-601, Rimiducid
NCT02107872
Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1500
Metabolic Disorders
P1
Completed55RCT, Double-blindREGN1500, placebo
NCT01868360
Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea
Corneal Neovascularization
P1
Terminated2RCT, Open-labelSubconjunctival aflibercept
NCT01785329
Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects
Hypercholesterolemia
P1
Completed60RCT, Open-labelalirocumab SAR236553 (REGN727)
NCT01074372
Ascending Dose Study of the Safety and Tolerability of REGN727 (SAR236553) in Healthy Volunteers
Healthy Volunteers
P1
Completed32RCT, Double-blindREGN727, Placebo
NCT01015027
Ascending Dose Study of the Safety and Tolerability of REGN668(SAR231893) in Normal Healthy Volunteers
Healthy
P1
Completed48RCT, Double-blindREGN668
NCT06665828
Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults
Healthy Volunteer
P1
Completed72RCT, Double-blindREGN9533, Matching Placebo
NCT05181683
COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult Volunteers
Healthy, Chronic Stable Illness
P1
Completed45RCT, Open-labelCasirivimab+Imdevimab
NCT06970405
Study of Safety and Effects of Garetosmab in Healthy Obese Men and Post-Menopausal Women
Obesity
P1
WithdrawnRCT, Double-blindGaretosmab, Matching Placebo
NCT05976373
A Study to Investigate the Pharmacokinetics (PK), Tolerability and Safety of Two Different Dupilumab Drug Products in Healthy Participants.
Healthy Volunteers
P1
Completed38RCT, Open-labelDupilumab (SAR231893)
NCT05291546
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants
Healthy Volunteers
P1
Completed93RCT, Double-blindREGN9035, REGN5381
NCT00082823
Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Cancer
P1
Completed25Open-labelziv-aflibercept
NCT05505448
A Trial to Learn if a COVID-19 Therapeutic is Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants
Healthy
P1
Completed48RCT, Double-blindREGN14284, Matching Placebo
NCT02647086
Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)
Atopic Dermatitis
P1
Completed14Open-labelDupilumab, Midazolam, Omeprazole, Warfarin, Caffeine, Metoprolol
NCT01688960
Nesvacumab (REGN910/ SAR307746) and Aflibercept ("Ziv-aflibercept" in the U.S.) in Patients With Advanced Solid Malignancies
Solid Tumors
P1
Completed48Open-labelnesvacumab (REGN910/ SAR307746), nesvacumab (REGN910/ SAR307746), nesvacumab (REGN910/ SAR307746), aflibercept (ziv-aflibercept), aflibercept (ziv-aflibercept)
NCT01448239
Injection Site Tolerability, Safety, Pharmacokinetics and Pharmacodynamics Study After a Single Dose Subcutaneous Treatment of Alirocumab SAR236553 (REGN727)
Hypercholesterolemia
P1
Completed24RCT, Double-blindalirocumab SAR236553 (REGN727), alirocumab SAR236553 (REGN727)
NCT03580694
Study of REGN4659 in Combination With Cemiplimab in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small-Cell Lung
P1
Terminated17Open-labelREGN4659, Cemiplimab
NCT01443650
Injection Site Tolerability, Safety, Pharmacokinetics, Pharmacodynamics in Different Single-Dose Treatments of Alirocumab SAR236553 (REGN727) in Healthy Subjects
Hypercholesterolemia
P1
Completed36RCT, Double-blindalirocumab SAR236553 (REGN727)
NCT01749878
Study to Assess the Safety and Tolerability of Single Doses of REGN1500
Hypertriglyceridemia
P1
Completed99RCT, Double-blindREGN1500, placebo
NCT00320814
Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema
Diabetic Macular Edema
P1
Completed5Open-labelVEGF Trap-Eye
NCT01197391
Ascending Dose Study of the Safety and Tolerability of REGN728 in Healthy Volunteers
Healthy
P1
Completed48RCT, Double-blindREGN728
NCT05013723
Impact of Monoclonal Antibody Treatment on Post-Acute COVID-19 Syndrome
Post-acute COVID-19 (PACS), or "long COVID" Syndrome
Completed260
NCT07502716
Compassionate Use of Ubamatamab
Renal Medullary Carcinoma (RMC), Epithelioid Sarcoma
AVAILABLEubamatamab
NCT01783925
Eylea Post Marketing Surveillance(PMS)
Macular Degeneration
Completed3,206Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT02811692
Study for Collection of Aflibercept Data in Routine Practice
Eye Diseases
Completed425Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT05791695
A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022
Intraocular Inflammation, Suspected Endophthalmitis
Completed155,413
NCT01714115
Use of Eylea for the Treatment of an Optic Nerve Hemangioma
Retinal Hemangioma
NO_LONGER_AVAILABLEAflibercept
NCT06398080
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting
Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD)
Withdrawnaflibercept 8 mg
NCT05546957
Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants
Healthy Volunteer
N/A
Completed60RCT, Open-labelAspirin, rivaroxaban low dose, rivaroxaban high dose
NCT02341664
Patient and Provider Assessment of Lipid Management Registry
Hyperlipidemia, Hypercholesterolemia
Completed7,658
NCT05203380
Neuropsychologic Assessments of Dupilumab-Treated Adolescent Participants With Moderate-to-Severe Atopic Dermatitis
Moderate-to-severe Atopic Dermatitis
Completed45dupilumab
NCT06769412
A Real-World Evidence Study for the Incidence of Retinal Vasculitis (RV) Among Adult Patients Receiving Aflibercept 2 mg in the United States (US)
Retinal Vasculitis
Completed550,000aflibercept 2 mg
NCT01187563
A Study of Tocilizumab in Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
Completed16
NCT02924311
Routine Clinical Practice for Use of Intravitreal Aflibercept Treatment in Patients With Diabetic Macular Edema
Diabetic Retinopathy
Completed402Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT03544866
The Impact of Pediatric Skin Disorders: The "Big" Study
Chronic Pediatric Skin Conditions
Completed1,666
NCT05338892
Real-World Clinical Outcomes in Adult Patients Who Initiate Systemic Treatment for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
Completed595
NCT05673967
Real-World Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma
Relapsed and Refractory Multiple Myeloma (RRMM)
Completed62
NCT06028594
Compassionate Use of Pozelimab and Cemdisiran Combination Therapy in Patients With Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria
NO_LONGER_AVAILABLEPozelimab, Cemdisiran
NCT02585401
Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada
Age-related Macular Degeneration (AMD), Central Retinal Vein Occlusion (CRVO)
Completed99Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
NCT03836105
CemiplimAb Survivorship Epidemiology
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma
Completed287cemiplimab
NCT04617535
Compassionate Use of REGN-COV2 for the Treatment of COVID-19
COVID-19
NO_LONGER_AVAILABLEREGN10933+REGN10987 combination therapy
NCT04614571
T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge
Celiac Disease
N/A
Completed24Open-label
NCT02540369
To Describe the Use of Intravitreal Aflibercept and to Describe Follow-up as Well as Treatment Patterns in Patients With Wet Age-related Macular Degeneration (wAMD) or Diabetic Macular Edema (DME) in Routine Clinical Practice in Canada.
Wet Macular Degeneration
Completed2,150Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT04776694
Compassionate Use of Dupilumab
Type 2 Inflammatory Disorders
APPROVED_FOR_MARKETINGDupilumab
NCT05478824
IL13 Signaling in Allergic Asthma
Asthma, Allergic, Asthma
Completed28
NCT05870215
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
Asthma
Completed78
NCT03382587
Observational Study to Assess Intravitreal Aflibercept Injections Used in a "Treat and Extend" Regimen in Treatment-naïve Wet Age-related Macular Degeneration Patients
Wet Age-related Macular Degeneration
Completed163Aflibercept (Eylea, BAY86-5321)
NCT03507374
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
Stroke, Intracranial Atherosclerosis
Early P1
Terminated20RCT, Double-blindAlirocumab, Placebo
NCT05906706
Compassionate Use of Dupilumab for Adult Patients With Bullous Pemphigoid
Bullous Pemphigoid
APPROVED_FOR_MARKETINGdupilumab
NCT02321241
Real Life of Aflibercept in France in Patients Refractory to Ranibizumab: Observational Study in Wet AMD
Wet Macular Degeneration
Completed236Aflibercept (EYLEA, BAY-86-5321)
NCT03411941
Evaluate the Effectiveness of Intravitreal (IVT) Aflibercept Injection in Clinical Practice in naïve Patients With Neovascular Age-related Macular Degeneration (nAMD)
Macular Degeneration
Completed116Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
NCT04173442
Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy
Atopic Dermatitis (AD), Asthma
Completed581dupilumab
NCT01771081
Evaluation of Changes in Visual Acuity in Patients With Diabetic Macular Edema (DME) Starting Treatment With an Approved Anti-VEGF Therapy
Ophthalmology, Macular Edema
Completed911Ranibizumab (or other DME treatment)
NCT05619367
A Compassionate Use (CU) Program of Odronextamab
Relapsed or Refractory (R/R) Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL)
AVAILABLEOdronextamab
NCT05232110
Compassionate Use of Pozelimab
CD55-deficient Protein-losing Enteropathy
APPROVED_FOR_MARKETINGPozelimab
NCT05302297
Comparative Efficacy of Cemiplimab to Historical Standard of Care in France
Cancer/Squamous Cell Carcinoma of Skin
Completed305Cemiplimab
NCT06064656
A Non-Interventional Study of Clinical Characteristics and Mortality of US Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Fibrodysplasia Ossificans Progressiva (FOP)
Completed131
NCT07301450
An Expanded Access Program of Garetosmab in Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Fibrodysplasia Ossificans Progressiva (FOP)
TEMPORARILY_NOT_AVAILABLEGaretosmab
NCT01914380
Investigating the Effectiveness of Eylea in Patients With Wet Age-related Macular Degeneration
Wet Age-related Macular Degeneration
Completed988Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT02279537
Real Life of Aflibercept In FraNce: oBservatiOnnal Study in Wet AMD
Wet Macular Degeneration
Completed593Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT03161912
A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease
Macular Edema
Completed2,481Aflibercept (Eylea, BAY86-5321)
NCT03378219
An Observational Study on Sarilumab-exposed Pregnancies
Rheumatoid Arthritis -Exposure During Pregnancy
Completed113Sarilumab SAR153191 (REGN88)
NCT03278262
The Impact of Baseline Visual Acuity on the Treatment Outcomes in Patients Treated With AflIbercept in Real-life Clinical Setting
Wet Macular Degeneration
Completed2,312Aflibercept (Eylea, BAY86-5321)
NCT02541084
Caregiver Burden of Wet Age-related Macular Degeneration (wAMD) in Japan
Wet Macular Degeneration
Completed72Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT03379558
Praluent® (Alirocumab) Pregnancy Exposure Registry: An OTIS Pregnancy Surveillance Study
Hypercholesterolemia
Terminated37ALIROCUMAB SAR236553 (REGN727)
NCT01756248
EYLEA Age-Related Macular Degeneration (AMD) Post-marketing Surveillance in Japan
Macular Degeneration
Completed3,872Aflibercept(Eylea, VEGF Trap-Eye, BAY86-5321)
NCT01756261
EYLEA [AMD-QOL(Age-Related Macular Degeneration-Quality of Life)] Post-marketing Surveillance in Japan
Macular Degeneration
Completed757Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
NCT02828033
Rilonacept for Treatment of Autoimmune Neurosensory Hearing Loss
Autoimmune Neurosensory Hearing Loss (ANSHL)
Early P1
Unknown10Open-labelRilonacept