
Sanofi SA
SNYHealthcare|Drug Manufacturers - General|France
$43.50
-0.40 (-0.91%)
DCF (FCF)
$57.37
Tangible Book
$1.80
Graham Number
$12.04
Earnings Power
$35.15
Clinical Trials (501)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT05983068 A Study of Long-term Effect of Dupilumab on Skin Barrier Function in Pediatric Participants With Atopic Dermatitis | Dermatitis Atopic | P4 | Active | 48 | Open-label | dupilumab |
| NCT06101095 A Study Assessing Esophageal Function and Remodeling With Dupilumab Compared With Placebo for 24 Weeks Followed by 104 Weeks Open Label in Adult Participants With EoE (REMOdeling With Dupilumab in Eosinophilic Esophagitis Long-term Trial) | Eosinophilic Oesophagitis | P4 | Active | 69 | RCT, Double-blind | Dupilumab, Placebo |
| NCT07412470 A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation | Kidney Transplant Rejection | P2P3 | Recruiting | 526 | RCT, Open-label | Frexalimab, Frexalimab, Tacrolimus, rabbit anti-thymocyte globulin, mycophenolate mofetil, mycophenolate sodium, methylprednisolone, prednisone |
| NCT06191315 Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS) | Wheezing, Asthma | P3 | Recruiting | 90 | RCT, Double-blind | Dupilumab, Placebo |
| NCT07112378 A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis | Eosinophilic Esophagitis (EoE) | P3 | Recruiting | 20 | RCT, Single-blind | dupilumab |
| NCT04934475 MInimal Residual Disease Adapted Strategy | Multiple Myeloma | P3 | Active | 791 | RCT, Open-label | Isatuximab |
| NCT07086976 A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia | Autoimmune Haemolytic Anaemia | P3 | Recruiting | 90 | RCT, Double-blind | rilzabrutinib, placebo |
| NCT06143891 A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease. | Chronic Graft Versus Host Disease | P3 | Active | 260 | RCT, Double-blind | Belumosudil, Placebo, Prednisone, Prednisolone |
| NCT07285460 A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Years With Hemophilia A or B | Hemophilia | P3 | Recruiting | 85 | Open-label | Fitusiran, Clotting factor concentrates (CFC) or bypassing agents (BPA), Antithrombin concentrate (ATIIIC) |
| NCT06838000 Study of the Safety and Immunogenicity of Catch-up Vaccination With a 21-valent Pneumococcal Conjugate Vaccine (PCV21) in Healthy Infants, Toddlers, Children, and Adolescents | Pneumococcal Infections | P3 | Active | 1,268 | RCT, Single-blind | PCV21, 20vPCV |
| NCT06290128 A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work | Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic | P3 | Recruiting | 140 | RCT, Double-blind | Riliprubart, Placebo, Riliprubart, Placebo |
| NCT06082037 A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction | Lung Transplant Rejection | P3 | Recruiting | 180 | RCT, Double-blind | Belumosudil, Azithromycin, Placebo |
| NCT06372145 A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis. | Relapsing Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | P3 | Active | 2,500 | Open-label | Tolebrutinib, Placebo, Teriflunomide |
| NCT06647407 Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants | Meningococcal Immunization, Healthy Volunteers | P1P2 | Active | 750 | RCT, Double-blind | Pentavalent Meningococcal ABCYW vaccine, MenACYW conjugate vaccine, MenACYW conjugate vaccine, Meningococcal group B vaccine, Paracetamol, DTap-HepB-IPV-Hib vaccine, DTap-HepB-IPV-Hib vaccine, DTap-HepB-IPV-Hib vaccine, Rotavirus vaccine, Pneumococcal 13-valent conjugate vaccine |
| NCT05996627 Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease | Chronic Graft Versus Host Disease | P2 | Recruiting | 82 | RCT, Double-blind | Belumosudil, Placebo Administration |
| NCT06356571 A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma | Plasma Cell Myeloma Refractory | P2 | Recruiting | 64 | Open-label | Isatuximab SC-OBDS, Montelukast, Dexamethasone, Acetaminophen, Diphenhydramine, Methylprednisolone, Carfilzomib |
| NCT05346809 Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma | Lymphoma, Multiple Myeloma | P2 | Recruiting | 39 | RCT, Open-label | Isatuximab |
| NCT02991469 A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS) | Juvenile Idiopathic Arthritis | P2 | Recruiting | 51 | Open-label | Sarilumab SAR153191 (REGN88) |
| NCT04558931 Clinical Trial for Autologus NK Cells Alone or in Combination With Isatuximab as Maintenance for Multiple Myeloma | Multiple Myeloma | P2 | Recruiting | 62 | RCT, Open-label | CellProtect, Isatuximab |
| NCT07547436 A Study to Access Activity and Safety With SAR445399 Compared With Placebo in Participants Aged 18 to 80 Years of Age With Non-Cystic Fibrosis Bronchiectasis | Non-cystic Fibrosis Bronchiectasis | P2 | Recruiting | 70 | RCT, Double-blind | SAR445399, Placebo |
| NCT07479979 Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma | Relapse Multiple Myeloma, Refractory Multiple Myeloma | P1P2 | Recruiting | 62 | Open-label | Selinexor, Carfilzomib, Isatuximab, Dexamethasone |
| NCT06686654 Study of a Human Metapneumovirus/Respiratory Syncytial Virus mRNA Vaccine Candidate Encapsulated in a Lipid Nanoparticle-based Formulation in Adults Aged 60 Years and Older | Human Metapneumovirus Immunization, Respiratory Syncytial Virus Immunization | P1P2 | Active | 1,530 | RCT, Double-blind | Investigational hMPV/RSV vaccine, Investigational hMPV vaccine (monovalent), Investigational RSV vaccine (monovalent), Licensed RSV Vaccine, Placebo, Investigational RSV+hMPV vaccine |
| NCT06557772 A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease | Coeliac Disease, Celiac Disease | P2 | Active | 229 | RCT, Double-blind | Amlitelimab, Placebo |
| NCT07225569 A Study to Investigate Efficacy and Safety With SAR445399 in Adult Participants With Moderate to Severe Hidradenitis Suppurativa | Hidradenitis Suppurativa | P2 | Recruiting | 144 | RCT, Double-blind | SAR445399, Placebo |
| NCT05669989 International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab | Plasma Cell Myeloma | P2 | Active | 70 | Open-label | Isatuximab intravenous (IV), Cemiplimab (SAR439684), Dexamethasone, Lenalidomide, Pomalidomide, Isatuximab subcutaneous (SC), Carfilzomib |
| NCT05704049 A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma | Relapsed/Refractory Multiple Myeloma | P2 | Active | 118 | RCT, Open-label | Isatuximab, Carfilzomib, Dexamethasone, Dexamethasone IV, Montelukast, Acetaminophen, Diphenhydramine, Methylprednisolone |
| NCT05011123 Study on an Investigational Yellow Fever Vaccine Compared With Stamaril in Adults in Europe and Asia | Yellow Fever | P2 | Active | 690 | RCT, Double-blind | Yellow fever vaccine (produced on serum-free Vero cells), Yellow fever vaccine |
| NCT06392477 A Study to Evaluate the Safety and Activity of SAR448501/DR-0201 in Patients With Relapsed/ Refractory B-Cell Non-Hodgkin Lymphoma | B-cell Non Hodgkin Lymphoma | P1 | Recruiting | 96 | Open-label | SAR448501 |
| NCT07629336 SAR447971 First-in-human Study | Hidradenitis, Healthy Volunteers | P1 | Recruiting | 114 | RCT, Double-blind | SAR447971, Placebo |
| NCT07295028 Study of an RSV-hMPV-PIV3 Trivalent Vaccine Candidate VXB-251 in Older Adults | Lower Respiratory Tract Disease, Healthy Participants | P1 | Active | 240 | RCT, Double-blind | trivalent (RSV/hMPV/PIV3) vaccine candidate, trivalent (RSV/hMPV/PIV3) vaccine candidate, trivalent (RSV/hMPV/PIV3) vaccine candidate, bivalent (RSV/hMPV) unlicensed comparator, monovalent (RSV) unlicensed comparator, Biological/Vaccine: monovalent (hMPV) unlicensed comparator, monovalent (PIV3) unlicensed comparator |
| NCT07316114 A Study to Describe the Real-world Effectiveness, Safety and Patterns of Use of Dupilumab in Patients With Chronic Spontaneous Urticaria | Chronic Spontaneous Urticaria | Recruiting | 400 | — | Dupilumab | |
| NCT04657783 French National Cohort of People With Type 1 Diabetes | Diabetes Mellitus, Type 1, Cardiovascular Diseases | Recruiting | 15,000 | — | — | |
| NCT03428646 Study of Patients Receiving DUPIXENT® for Atopic Dermatitis (AD) | Dermatitis, Atopic | Active | 858 | — | Dupilumab | |
| NCT03549416 BioDay Registry: Data Collection Regarding the Use of New Systemic Treatment Options in Patients with Atopic Dermatitis | Atopic Dermatitis | Recruiting | 1,200 | — | — | |
| NCT00196742 Fabry Disease Registry & Pregnancy Sub-registry | Fabry Disease | Recruiting | 9,000 | — | — | |
| NCT07457580 Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs) | Type 1 Diabetes | Recruiting | 60 | — | Teplizumab | |
| NCT00567073 Pompe Pregnancy Sub-Registry | Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-onset) | Recruiting | 20 | — | — | |
| NCT07290803 This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment | Atopic Dermatitis | Recruiting | 1,000 | — | — | |
| NCT03402919 Comprehensive Assessment of Neurodegeneration and Dementia | Dementia, Mild Cognitive Impairment (MCI) | Recruiting | 1,573 | — | — | |
| NCT07118306 COPD Exacerbation Follow Up | COPD (Chronic Obstructive Pulmonary Disease) | Recruiting | 485 | — | — | |
| NCT04743609 RSV Burden in Outpatient and Hospital Settings | RSV Infection, Children, Only | N/A | Recruiting | 1,900 | Open-label | — |
| NCT04113330 Surveillance of Suspected Dengue Cases for Access to Care for Subjects Identified as Seronegative or Undetermined Before Receiving CYD Dengue Vaccine in Previous Clinical Studies in Colombia | Dengue Fever | Active | 918 | — | — | |
| NCT06393946 Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France | Chronic Rhinosinusitis With Nasal Polyposis | Active | 150 | — | Dupilumab | |
| NCT07380711 Long-term Real-world Study of Dupilumab in COPD : Patient Characteristics, Safety and Patient-reported Outcomes | Chronic Obstructive Pulmonary Disease COPD | Recruiting | 500 | — | — | |
| NCT06258057 Safety of Tetanus, Diphtheria, Acellular Pertussis With 5 Acellular Pertussis Components (Tdap5) Vaccination During Pregnancy | Pertussis (Whooping Cough) | Active | 365,000 | — | — | |
| NCT00402441 Risedronate in the Prevention of Osteoporosis in Postmenopausal Women | Osteoporosis, Postmenopausal | P4 | Completed | 260 | RCT, Double-blind | Risedronate (HMR4003) |
| NCT01307865 Volume Restoration of the Aging Midface With Sculptra Aesthetic | Problem of Aging | P4 | Completed | 15 | Open-label | injectable poly-L-lactic acid |
| NCT01436539 Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients | Chronic Hepatitis B | P4 | Unknown | 300 | RCT, Open-label | Adefovir Dipivoxil and polyene phosphatidylcholine, Adefovir Dipivoxil |
| NCT00362037 I SELECT - Irbesartan In Hypertensive Patients With Left Ventricular Hypertrophy | Hypertension | P4 | Completed | 281 | Open-label | Irbesartan (Aprovel) |
| NCT00708344 ACTUAL: Efficacy and Safety of Irbesartan/Hydrochlorothiazide Combination | Hypertension | P4 | Completed | 832 | RCT, Open-label | Irbesartan - Hydrochlorothiazide, Irbesartan - Hydrochlorothiazide |
| NCT00549965 Satisfaction and Compliance of Risedronate in PMO | Osteoporosis, Postmenopausal | P4 | Completed | 202 | RCT, Open-label | Risedronate Sodium |
| NCT00174681 Tulip Study: Testing the Usefulness of Lantus When Initiated Prematurely In Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | P4 | Completed | 390 | RCT, Open-label | Insulin Glargine |
| NCT00304265 Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine | Pertussis, Diphtheria | P4 | Completed | 215 | RCT, Open-label | COVAXIS™: Tetanus, diphtheria, acellular 5-component pertussis, or + inactivated poliovirus vaccine (REPEVAX®) |
| NCT00230607 Study of the Effects of Fabrazyme Treatment on Lactation and Infants | Fabry Disease, Alpha Galactosidase A Deficiency | P4 | Terminated | 7 | Open-label | agalsidase beta |
| NCT02831608 Study on the Effect of Influenza Vaccination After Heart Attack on Future Cardiovascular Prognosis | Myocardial Infarction, Influenza, Human | P4 | Completed | 2,571 | RCT, Double-blind | Influenza vaccine, Placebo |
| NCT00835926 A Study to Evaluate the Safety and Immune Responses to Fluzone® Vaccination | Influenza | P4 | Completed | 121 | Open-label | Influenza virus vaccine, Influenza virus vaccine |
| NCT00347958 Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine | Tetanus, Diphtheria | P4 | Completed | 545 | Open-label | Tetanus-diphtheria-acellular pertussis (Tdap) vaccine |
| NCT01278433 A Safety Study of IMOVAX Polio Vaccine in Selected Cities in China | Polio, Poliomyelitis | P4 | Completed | 5,007 | Open-label | IMOVAX Polio™: Inactivated Poliomyelitis Vaccine |
| NCT00547768 Comparative Study Evaluating the Effects of Fexofenadine HCI 180 mg With Orange Juice Versus Placebo With Orange Juice in a Skin Wheal and Flare Challenge Model. | Allergy | P4 | Completed | 36 | RCT, Double-blind | Fexofenadine HCI |
| NCT03389893 Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis | Atopic Dermatitis (AD) | P4 | Terminated | 72 | RCT, Double-blind | Dupilumab, Placebo |
| NCT00917436 Thiocolchicoside Injection and Capsule in Treatment of Acute Low Back Pain | Low Back Pain | P4 | Completed | 183 | — | Thiocolchicoside |
| NCT00636870 Fexofenadine (Allegra®) in Healthy Adults Who Have Been Identified as Slow Metabolizers for Desloratadine | Allergic Rhinitis | P4 | Completed | 220 | RCT, Double-blind | Fexofenadine |
| NCT04980027 Evaluation of the Safety and Efficacy of Insulin Glargine 300 U/ml (Gla-300) in Insulin-naïve Patients With Type 2 Diabetes Mellitus Uncontrolled on Oral Antihyperglycemic Drugs | Type 2 Diabetes Mellitus | P4 | Completed | 228 | Open-label | Insulin glargine (U300) |
| NCT02842359 Evaluation of the Fixed-dose Combination of Irbesartan/Atorvastatin in Type 2 Diabetic Patients Diagnosed With Hyperlipidemia and Hypertension | Type 2 Diabetes Mellitus | P4 | Completed | 11 | RCT, Open-label | Irbesartan/atorvastatin fixed dose combination, Irbesartan SR47436, Atorvastatin |
| NCT00074984 A Study of the Safety and Efficacy of Fabrazyme (Agalsidase Beta) as Compared to Placebo in Patients With Advanced Fabry Disease | Fabry Disease | P4 | Completed | 82 | RCT, Double-blind | Fabrazyme (agalsidase beta), Placebo |
| NCT01895049 Comparison Between Two Tacrolimus-based Immunosuppressant Regimens and Induction With Thymoglobulin in Kidney Transplants From Deceased Donors With Expanded Criteria | Kidney Transplantation, Cytomegalovirus | P4 | Completed | 171 | RCT, Open-label | Induction therapy with Thymoglobulin, prednisone, everolimus and late introduction of tacrolimus, Induction therapy with Thymoglobulin, prednisone, mycophenolate sodium and late introduction of tacrolimus |
| NCT01135017 Effects of Dronedarone on Atrial Fibrillation Burden in Subjects With Permanent Pacemakers | Atrial Fibrillation | P4 | Terminated | 112 | RCT, Double-blind | Dronedarone, Placebo (for Dronedarone) |
| NCT00390884 Safety and Immunogenicity of Fluzone® Vaccine in Children Who Received 2 Doses of the 2005-2006 Fluzone Formulation. | Influenza | P4 | Completed | 173 | Open-label | Influenza Virus Vaccine, Fluzone®, Influenza Virus Vaccine, Fluzone® |
| NCT02201004 TOFO Insulin Combination Trial | Type 2 Diabetes Mellitus | P4 | Completed | 211 | RCT, Double-blind | TOFOGLIFLOZIN CSG452, insulin, placebo |
| NCT00881270 Dermacyd Infantile - Acceptability. | Hygiene | P4 | Completed | 31 | Open-label | LACTIC ACID(ND) |
| NCT00518427 Evaluate Quality of Life in Type 2 Diabetes, Before and After Change to Insuline Glargine | Diabetes Type 2 | P4 | Completed | 26 | Open-label | Insulin Glargine |
| NCT00457249 A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older | Pertussis, Tetanus | P4 | Completed | 1,564 | RCT, Double-blind | ADACEL®: Tetanus, Reduced Diphtheria and Acellular Pertussis Adsorbed, DECAVAC®: Tetanus and Diphtheria Toxoids Adsorbed |
| NCT00489190 APIDRA Registration Study | Diabetes Mellitus, Type 1 | P4 | Completed | 45 | Open-label | Insulin Glulisine |
| NCT00761670 Efficacy Study on Cognitive Functions in Schizophrenic Patients | Schizophrenia | P4 | Completed | 37 | RCT, Open-label | amisulpride and risperidone |
| NCT02864927 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea | Meningitis, Meningococcal Meningitis | P4 | Completed | 1,311 | Open-label | Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine |
| NCT00413361 The Reduction of Systemic Lupus Erythematosus Flares :Study PLUS | Systemic Lupus Erythematosus | P4 | Completed | 543 | RCT, Double-blind | versus hydroxychloroquine |
| NCT00564187 Evaluation of Efficacy and Safety of the Dosage Adjustment of Aprovel® (Irbesartan) in Hypertensive Outpatients in Current Clinical Practice | Hypertension | P4 | Completed | 115 | RCT, Open-label | Irbesartan, Irbesartan |
| NCT04410965 Evaluation of the Relationship Between ABCG2 Mutation and Teriflunomide Exposure and Safety in Chinese RMS Patients Treated With Teriflunomide 14 mg Once Daily for 24 Weeks | Multiple Sclerosis | P4 | Completed | 82 | Open-label | TERIFLUNOMIDE |
| NCT00360139 Clinical Trial to Determine the Efficacy of Sculptra™ Dermal Filler for the Correction of Contour Deformities Caused by Lipoatrophy | Lipodystrophy, Emaciation | P4 | Withdrawn | 15 | RCT, Open-label | — |
| NCT00790387 Tirofiban and Enoxaparin in High Risk Coronary Intervention | Acute Coronary Syndrome | P4 | Completed | 60 | RCT, Open-label | Enoxaparin, Tirofiban, unfractionated heparin |
| NCT00255021 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand | Diphtheria, Tetanus | P4 | Completed | 186 | Open-label | Diphtheria, Tetanus, Polio, Acellular Pertussis and Hib Vac |
| NCT00637715 Once Daily Given Alfuzosin in the Treatment of BPH | Benign Prostatic Hyperplasia | P4 | Completed | 60 | Open-label | Alfuzosin |
| NCT05929651 Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy | Meningococcal Immunisation, Healthy Volunteers | P4 | Completed | 71 | Open-label | MenACYW conjugate vaccine |
| NCT00431522 Valproic Acid Sodium Salt in Bipolar Disorder | Bipolar Disorder | P4 | Completed | 58 | Open-label | Valproic acid, sodium salt |
| NCT01311557 Study of Adacel® Vaccine Administered to Persons 10 Years of Age | Tetanus, Diphtheria | P4 | Completed | 1,302 | Open-label | Adacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Adsorbed, Adacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Adsorbed |
| NCT00132951 KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-acquired Lower Respiratory Tract Infections | Respiratory Tract Infections, Chronic Bronchitis | P4 | Terminated | 2,051 | RCT, Double-blind | Telithromycin, Azithromycin |
| NCT02006225 Stem Cell Harvesting Using GCSF Plus Plerxiafor, in First -Line, for Heavily Pre- Treated Pediatric Oncology Patients. | Autologous Stem Cell Transplantation | P4 | Unknown | 30 | Open-label | Plerixafor |
| NCT00799838 Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients | Pharyngotonsillitis | P4 | Terminated | 106 | RCT, Double-blind | Ketoprofen, Placebo (for Ketoprofen), Amoxicillin |
| NCT01981967 Post-licensure Safety Study of IMOJEV® in Thailand | Japanese Encephalitis | P4 | Completed | 10,000 | Open-label | IMOJEV®: Live attenuated Japanese encephalitis chimeric virus vaccine, IMOJEV®: Live attenuated Japanese encephalitis chimeric virus vaccine |
| NCT00881374 Dermacyd Infantile (Lactic Acid)- Compatibility. | Hygiene | P4 | Completed | 50 | Open-label | LACTIC ACID(ND) |
| NCT00638118 Fexofenadine HCl 180 mg, Montelukast Sodium 10 mg and Placebo in Suppression of Wheal and Flare Induced by Seasonal Allergen | Allergic Rhinitis | P4 | Completed | 48 | RCT, Double-blind | Fexofenadine |
| NCT01202474 Apidra Children & Adolescents Study | Diabetes Mellitus, Type 1 | P4 | Completed | 100 | Open-label | INSULIN GLULISINE, INSULIN GLARGINE |
| NCT00850603 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® | Meningococcal Infections, Meningitis | P4 | Completed | 170 | RCT, Open-label | Meningococcal Polysaccharide Groups A\C\Y\W-135 Combined, Meningococcal Polysaccharide Groups A\C\Y\W-135 Combined, Meningococcal Polysaccharide Groups A\C\Y\W-135 Combined, Meningococcal Polysaccharide Groups A\C\Y\W-135 Combined, Meningococcal Polysaccharide Groups A\C\Y\W-135 Combined |
| NCT00648453 Effect of Plavix on NO (Nitrogen Monoxide) Production of the Endothelial Function | Peripheral Arterial Disease | P4 | Completed | 39 | Open-label | Clopidogrel (Plavix) |
| NCT02954692 A Study to Evaluate the Effectiveness and Safety Initiation and Titration of Insulin Glargine (U300) in Insulin-naïve Patients With Type 2 Diabetes Mellitus (T2DM) Controlled on Oral Antidiabetic Drug Treatment in Turkey | Type 2 Diabetes Mellitus | P4 | Completed | 112 | Open-label | INSULIN GLARGINE (U300), metformin, sulfonylurea, meglitinides, thiazolidinediones, alpha-glucosidase inhibitors, GLP1 Receptor Agonist, Dipeptidyl peptidase-IV (DPP-IV) inhibitors, Sodium-glucose transport-2 (SGLT-2) inhibitors |
| NCT00979628 Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM) | Type 2 Diabetes, Hyperglycemia | P4 | Completed | 375 | RCT, Open-label | sliding scale regular insulin (SSRI), Basal Bolus, Basal Plus |
| NCT00836953 Study to Collect Sera for Immunogenicity Testing in Children Vaccinated With Fluzone® | Influenza | P4 | Completed | 33 | Open-label | Influenza virus vaccine (Pediatric formulation) |
| NCT01107756 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen | Neoplasms (no Otherwise Specified) | P4 | Completed | 403 | Open-label | LENOGRASTIM (GRANOGYTE 34) |
| NCT00077753 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization | Venous Thromboembolism | P4 | Completed | 4,726 | RCT, Double-blind | enoxaparin sodium |
| NCT00077805 PREVAIL: PREvention of VTE After Acute Ischemic Stroke With LMWH Enoxaparin ( - VTE: Venous Thromboembolism - LMWH: Low Molecular Weight Heparin) | Acute Ischemic Stroke | P4 | Completed | — | RCT, Open-label | Enoxaparin sodium |
| NCT00699920 Cohort Study in Uganda Comparing Artesunate + Amiodaquine (Coarsucam) Versus Artemether + Lumenfantrine (Coartem) in the Treatment of Repeated Uncomplicated Plasmodium Falciparum Malaria Attacks | Malaria | P4 | Completed | 413 | RCT, Open-label | Coarsucam, Coartem |
| NCT01757574 Alemtuzumab in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD) | Chronic Inflammatory Demyelinating Neuropathy | P4 | Withdrawn | — | Open-label | Alemtuzumab infusion |
| NCT01437423 Regulatory Post-Marketing Surveillance Study for TETRAXIM™ | Diphtheria, Tetanus | P4 | Completed | 600 | Open-label | TETRAXIM™: Combined adsorbed diphtheria, tetanus, acellular pertussis and enhanced inactivated polio |
| NCT00831675 Study of Safety and Immunogenicity of Fluzone® in Healthy Children | Influenza | P4 | Completed | 30 | Open-label | Influenza Vaccine 2004-2005 Paediatric Formulation, Influenza Vaccine 2004-2005 Paediatric Formulation |
| NCT06716424 A Study to Investigate Safety and Efficacy of iGlarLixi in Adult Patients With Type 2 Diabetes Mellitus | Type 2 Diabetes | P4 | Completed | 105 | Open-label | iGlarLixi (insulin glargine/lixisenatide) |
| NCT02526550 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX | Encephalitis | P4 | Completed | 50 | Open-label | Live attenuated chimeric Japanese Encephalitis vaccine, Inactivated Hepatitis A vaccine |
| NCT01496313 To Compare The Effects Of Two Doses Of Vandetanib In Patients With Advanced Medullary Thyroid Cancer | Thyroid Cancer | P4 | Completed | 81 | RCT, Double-blind | 300mg vandetanib, 150mg vandetanib |
| NCT00077818 Enoxaparin Versus Unfractionated Heparin in Subjects Who Present to the Emergency Department With Acute Coronary Syndrome (RESCUE) | Acute Coronary Syndrome | P4 | Completed | — | RCT, Open-label | Enoxaparin sodium |
| NCT00245674 SOLIACS: Solian Solution in the Acute Setting | Schizophrenia | P4 | Completed | 300 | Open-label | amisulpride |
| NCT00911625 Glargine Dosing in Hospitalized Patients With Type 2 Diabetes and Renal Insufficiency | Type 2 Diabetes, Renal Insufficiency | P4 | Completed | 114 | RCT, Open-label | 0.5 units/kg daily insulin, 0.25 units/kg daily insulin |
| NCT00129870 CONCEPT: Comparison of Oxaliplatin vs Conventional Methods With Calcium/Magnesium in First-Line Metastatic Colorectal Cancer | Colorectal Cancer | P4 | Terminated | 180 | RCT, Open-label | oxaliplatin |
| NCT00701129 An Exploratory Study of the Safety and Efficacy of Prophylactic Immunomodulatory Treatment in Myozyme-naive Cross-Reacting Immunologic Material (CRIM[-]) Patients With Infantile-Onset Pompe Disease | Pompe Disease, Glycogen Storage Disease Type II | P4 | Completed | 4 | Open-label | Alglucosidase Alfa, Methotrexate, Rituximab |
| NCT00230217 Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancy | Tumors, Hyperuricemia | P4 | Completed | 94 | Open-label | Rasburicase (SR29142) |
| NCT04075513 Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients | Type 1 Diabetes Mellitus | P4 | Completed | 343 | RCT, Open-label | Insulin glargine, 300 U/ml, Insulin degludec, 100U/ml, Background therapy: Rapid acting insulin analogs |
| NCT00585182 Study to Evaluate Weight-based Enoxaparin Dosing in Obese Medical Patients at Risk for DVT | Obesity, Venous Thrombosis | P4 | Completed | 28 | Open-label | Enoxaparin 0.5 mg/kg once daily |
| NCT00174824 Comparison of Insulin Glargine and NPH Human Insulin in Progression of Diabetic Retinopathy in Type 2 Diabetic Patients | Diabetes Mellitus, Type 2 | P4 | Completed | 1,024 | RCT, Open-label | Insulin glargine |
| NCT01650779 A Study Evaluating Glycosphingolipid Clearance in Patients Treated With Agalsidase Alfa Who Switch to Agalsidase Beta | Fabry Disease | P4 | Completed | 15 | Open-label | Agalsidase beta |
| NCT01430819 Study of Fluzone® Influenza Virus Vaccine 2011-2012 Formulation (Intramuscular Route) Among Adults | Influenza | P4 | Completed | 300 | RCT, Double-blind | Influenza Virus Vaccine: Fluzone® 2011-2012 Formulation, Influenza Virus Vaccine: Fluzone® High-Dose 2011-2012 Formulation |
| NCT00601835 Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine Compared With U.S. Manufactured Td | Diphtheria, Tetanus | P4 | Completed | 3,651 | RCT, Double-blind | Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine, Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine |
| NCT01825382 Role of Mobile Technology to Improve Diabetes Care in Adults With Type 1 Diabetes: the REMOTE-T1D Study, a Pilot Study | Type 1 Diabetes | P4 | Completed | 100 | RCT, Open-label | — |
| NCT00642915 Insulin Glargine Benefits in Japanese Pts Outside of Japan (US or Brazil) | Diabetes Mellitus | P4 | Completed | 100 | Open-label | Lantus, Amaryl |
| NCT00563849 Leflunomide + Methotrexate in Rheumatoid Arthritis | Rheumatoid Arthritis | P4 | Completed | 74 | Open-label | Leflunomide |
| NCT01629589 Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents | Tetanus, Diphtheria | P4 | Completed | 423 | RCT, Open-label | Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Adacel®), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (BOOSTRIX®) |
| NCT00454272 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients | Infection, Febrile Neutropenia | P4 | Completed | 197 | RCT, Open-label | Teicoplanin, Vancomycin |
| NCT01430611 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children | Meningococcal Disease, Meningitis | P4 | Completed | 666 | RCT, Single-blind | Meningococcal (Groups A and C) Polysaccharide Vaccine, Meningococcal (Groups A and C) Polysaccharide Vaccine |
| NCT00653302 Phenotype Evaluation in Insulin Naive Patients Using Lantus (Insulin Glargine) | Type 2 Diabetes | P4 | Completed | 280 | Open-label | Lantus (insulin glargine) + Glucophage (Metformin) |
| NCT00627471 Type 2 Diabetes Management With Lantus® (Malbec: Manejo Con Lantus® de Diabéticos Tipo 2) | Type 2 Diabetes | P4 | Terminated | 9 | RCT, Open-label | Insulin Glargine, Insulin Glargine |
| NCT05047718 Factors Influencing the COVID-19 Vaccine Immune Response According to Age and Presence or Not of a Past History of COVID-19 | Covid19 | P4 | Completed | 54 | Open-label | COVID-19 vaccine Pfizer (3 doses), COVID-19 vaccine Pfizer (2 doses), COVID-19 mRNA Vaccine Moderna (3 doses), COVID-19 mRNA Vaccine Moderna (2 doses), COVID-19 mRNA Vaccine Moderna (1 dose) |
| NCT02915302 Safety and Immunogenicity of Fluzone® Quadrivalent Vaccine Administered to Healthy Children | Influenza | P4 | Completed | 1,950 | RCT, Single-blind | Fluzone Quadrivalent vaccine, No Preservative, Fluzone Quadrivalent vaccine, No Preservative |
| NCT01665807 A Time-motion Study Comparing Self- to Nurse-vaccination With Influenza Vaccine | Influenza, Vaccination Site Reactions (HT) | P4 | Completed | 868 | RCT, Open-label | Intanza, Vaxigrip |
| NCT00288223 Telithromycin in Acute Exacerbation of Chronic Bronchitis | Bronchitis, Chronic | P4 | Terminated | 54 | Open-label | Telithromycin |
| NCT00334581 Irbesartan in Chinese Hypertensive Diabetics With Microalbuminuria | Hypertension | P4 | Completed | 192 | RCT, Open-label | Irbesartan, Irbesartan |
| NCT00651911 Fasturtec TLS Treatment / Prophylysis | Tumor Lysis Syndrome | P4 | Completed | 45 | Open-label | urate oxidase |
| NCT03485677 Safety and Efficacy of Eliglustat With or Without Imiglucerase in Pediatric Patients With Gaucher Disease (GD) Type 1 and Type 3 | Gaucher's Disease Type I, Gaucher's Disease Type III | P3 | Completed | 57 | Open-label | Eliglustat GZ385660, Imiglucerase GZ437843 |
| NCT00174629 GILT Docetaxel - Non-Small Cell Lung Cancer | Lung Neoplasms | P3 | Completed | 449 | RCT, Open-label | Docetaxel/DDP, docetaxel/gemcitabine |
| NCT00772928 Study of the Effect of Pneumococcal Conjugate Vaccine (PCV) on Immunogenicity of Pentacel™ | Diphtheria, Tetanus | P3 | Completed | 1,167 | RCT, Open-label | Pentacel™: HCPDT-IPV//PRP-T Vaccine and Prevnar®, Pentacel™: HCPDT-IPV//PRP-T Vaccine and Prevnar® |
| NCT00356967 Efficacy and Safety of Dianicline Versus Placebo as an Aid to Smoking Cessation | Smoking | P3 | Completed | 602 | RCT, Double-blind | dianicline |
| NCT02787551 Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period | Type 2 Diabetes Mellitus | P3 | Completed | 514 | RCT, Open-label | Insulin glargine/lixisenatide fixed ratio combination, liraglutide, exenatide, exenatide extended-release, albiglutide, dulaglutide, Background therapy: Oral Anti-diabetic Drug (Metformin, Pioglitazone, SGLT2 inhibitor) |
| NCT00221637 Efficacy of Valproate in Peripheral Neuropathic Pain | Neuralgia, Neuropathic Peripheral Pain | P2P3 | Terminated | 40 | RCT, Double-blind | Sodium Valproate |
| NCT00362336 Comparison of DTaP-IPV-Hep B-PRP~T Combined Vaccine to CombAct-HIB® Concomitantly Given With Engerix B® Paediatric and OPV | Hepatitis B, Polio | P3 | Completed | 622 | RCT, Open-label | DTaP-IPV-HB-PRP~T, CombAct-HIB®, Engerix B® Pediatric |
| NCT00855530 Long Term Safety and Tolerability of SR58611 in Patients With Major Depressive Disorder | Major Depressive Disorders | P3 | Completed | 527 | Open-label | amibegron (SR58611A) |
| NCT00670228 Effect of Lantus and Apidra in Patients With Acute ST Elevation Myocardial Infarction | AMI | P3 | Terminated | 34 | RCT, Open-label | Insulin Glargine (LANTUS), Insulin Glulisine (Apidra), Standard Therapy |
| NCT00139295 Comparison of Hylastan to Methylprednisolone Acetate in Patients With Symptomatic Osteoarthritis of the Knee | Osteoarthritis, Knee | P3 | Completed | — | RCT, Double-blind | — |
| NCT00452725 Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome | Noonan Syndrome | P3 | Completed | 36 | Open-label | MAXOMAT ®, biosynthetic growth hormone |
| NCT01252355 Efficacy and Safety of Teriflunomide in Patients With Relapsing Multiple Sclerosis and Treated With Interferon-beta | Multiple Sclerosis Relapse | P3 | Terminated | 534 | RCT, Double-blind | Teriflunomide, Placebo (for teriflunomide), Interferon-beta (IFN-beta) |
| NCT01515748 Docetaxel+Oxaliplatin+S-1 (DOS) Regimen as Neoadjuvant Chemotherapy in Advanced Gastric Cancer | Gastric Cancer | P3 | Completed | 530 | RCT, Open-label | Docetaxel (XRP6976), Oxaliplatin (SR96669), S-1 (1-(2-tetrahydrofuryl)-5-fluorouracil + 5-chloro-2, 4-dihydroxypyridine (CDHP) (Gimeracil) + Oxo (Oteracil) |
| NCT00577421 Study to Assess BMD and Bone Turnover Response to 5 mg Daily Risedronate Treatment in Women With PMO | Postmenopausal Osteoporosis | P3 | Completed | 32 | Open-label | risedronate |
| NCT01121822 Immunogenicity and Safety of a Vaccine Against Influenza (2010-2011 Northern Hemisphere Season, Intramuscular Route) | Influenza | P3 | Completed | 129 | Open-label | Influenza virus vaccine (split virion, inactivated), Influenza virus vaccine (split virion, inactivated) |
| NCT00924573 Comparative Study of HOE490 O (Glimepiride and Metformin) Compared With Placebo on Top of Glimepiride | Type 2 Diabetes Mellitus | P3 | Completed | 189 | RCT, Double-blind | Metformin, placebo, Glimepiride (HOE490) |
| NCT00264927 Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion | Inappropriate ADH Syndrome, Hyponatremia | P3 | Completed | 77 | RCT, Double-blind | SR121463B |
| NCT00265642 Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C | Hepatitis C, Chronic | P3 | Completed | 166 | RCT, Double-blind | Irbesartan, placebo |
| NCT00785590 Dermacyd PH_DETINLYN (Lactic Acid) Sweet Flower - Photo Evaluation. | Hygiene | P3 | Completed | 26 | Open-label | Dermacyd PH_DETINLYN (Lactic Acid) |
| NCT00976027 Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older | Influenza | P3 | Terminated | 9,172 | RCT, Double-blind | Trivalent inactivated influenza vaccine High Dose, Trivalent inactivated influenza vaccine |
| NCT02992418 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects | Dengue Fever, Dengue Hemorrhagic Fever | P3 | Terminated | 688 | RCT, Open-label | CYD Dengue Vaccine, Tdap: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine adsorbed, Tdap: Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed |
| NCT03282240 Safety and Immunogenicity of High-Dose Quadrivalent Influenza Vaccine in Participants ≥65 Years in the US | Influenza | P3 | Completed | 2,670 | RCT, Double-blind | QIV-HD, Licensed TIV-HD1, Investigational TIV-HD2 |
| NCT01954394 Open Label Study of Long Term Safety Evaluation of Alirocumab | Hypercholesterolemia | P3 | Completed | 986 | Open-label | Alirocumab, Lipid-Modifying Therapy (LMT) |
| NCT05468320 Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura | P3 | Completed | 51 | Open-label | Caplacizumab, Corticosteroids, anti-CD20 antibody |
| NCT00519285 Aflibercept in Combination With Docetaxel in Metastatic Androgen Independent Prostate Cancer | Prostatic Neoplasms, Neoplasm Metastasis | P3 | Completed | 1,224 | RCT, Double-blind | Aflibercept, Placebo (for aflibercept), Docetaxel, Prednisone or Prednisolone |
| NCT00397098 Prevention of Relapse Study of SR58611A in Improved Patients With Generalized Anxiety Disorder | Anxiety Disorders | P3 | Terminated | 257 | RCT, Double-blind | SR58611A |
| NCT01712984 Study of Intradermal Quadrivalent Influenza Vaccine in Adults Aged 18 Through 64 Years | Influenza | P3 | Completed | 3,360 | RCT, Double-blind | Influenza Virus Vaccine USP Quadrivalent, (Zonal Purified Subvirion) 2012 2013 Formulation, Influenza Virus Vaccine USP Trivalent Types A and B (Zonal Purified Subvirion) Fluzone® Intradermal, Influenza Virus Vaccine USP Trivalent Types A and B (Zonal Purified Subvirion) Fluzone Intradermal |
| NCT04142242 Study to Assess the Safety and Immunogenicity of a Single Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine in Older Adults Who Received a Primary Vaccination (3 or More Years Earlier) in Study MET49 | Meningococcal Infection (Healthy Volunteers) | P3 | Completed | 471 | RCT, Open-label | Meningococcal Polysaccharide (serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine |
| NCT01646554 Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With Resectable Liver Metastases | Colorectal Cancer Metastatic, Liver Metastases | P2P3 | Withdrawn | — | RCT, Open-label | Modified FOLFOX6, Aflibercept |
| NCT01683266 Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus | Type 1 Diabetes Mellitus | P3 | Completed | 549 | RCT, Open-label | HOE901-U300 (Insulin glargine new formulation), Lantus (Insulin glargine) |
| NCT02012998 Study of the Immunogenicity and Safety of a Challenge Dose of HBVAXPRO in Healthy Children Vaccinated 10 Years Ago With 3 Doses of HEXAVAC or INFANRIX HEXA | Virus Diseases, Hepatitis B | P3 | Completed | 751 | Open-label | HBVAXPRO 5µg |
| NCT00554333 Comparative Study of Immunogenicity and Safety of Flu-ID Vaccine Versus Flu-IM Vaccine | Influenza | P3 | Completed | 795 | RCT, Open-label | Flu-ID 15μg, Inactivated adjuvanted Influenza Vaccine |
| NCT00397553 Insulin Glulisine, Diabetes Mellitus Type 1 | Diabetes Mellitus, Type 1 | P3 | Completed | 104 | Open-label | Insulin glulisine |
| NCT00272051 XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy | Metastases, Colorectal Neoplasms | P3 | Completed | 620 | RCT, Double-blind | SR57746A |
| NCT00318448 Efficacy, Safety, and Tolerability of Ambien (Zolpidem) in the Treatment of Children Ages 6 to 17 With Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia | Attention Deficit Hyperactivity Disorder | P3 | Completed | 201 | RCT, Double-blind | Zolpidem (SL800750) |
| NCT02234323 An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Previously Untreated Males With Severe Hemophilia A | Hemophilia A | P3 | Completed | 108 | Open-label | rFVIIIFc |
| NCT07079670 Safety and Immunogenicity of NVX-CoV2705 | COVID-19, SARS-CoV-2 Infection | P3 | Completed | 676 | Open-label | NVX-CoV2705 |
| NCT01676220 Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes on Non-insulin Antidiabetic Therapy | Type 2 Diabetes Mellitus | P3 | Completed | 878 | RCT, Open-label | HOE901-U300 (new formulation of insulin glargine), Lantus (insulin glargine) |
| NCT00261703 Docetaxel in Head and Neck Cancer | Head and Neck Neoplasms | P2P3 | Completed | 439 | RCT, Open-label | Docetaxel, Cisplatin, 5-fluorouracil (5-FU), radiotherapy, Cisplatin, 5-fluorouracil (5-FU), radiotherapy |
| NCT00546325 REASSURE: The Effect of Rimonabant on HbA1c in Overweight or Obese Patients With Type 2 Diabetes Not Adequately Controlled on 2 Oral Antidiabetic Agents | Diabetes Mellitus, Type 2 | P3 | Completed | 358 | RCT, Double-blind | Rimonabant, Placebo |
| NCT00912925 Clinical Study of Aldurazyme in Patients With Mucopolysaccharidosis (MPS) I | Mucopolysaccharidosis I, Hurlers Syndrome | P3 | Completed | 45 | RCT, Double-blind | rhIDU (recombinant human-Alpha-L-Iduronidase), Placebo |
| NCT00803049 Long Term Safety and Efficacy Study of Teriflunomide 7 mg or 14 mg in Patients With Relapsing-Remitting Multiple Sclerosis | Multiple Sclerosis | P3 | Completed | 742 | RCT, Double-blind | Teriflunomide (HMR1726) |
| NCT04478084 Study of Purified Vero Rabies Vaccine Compared With a Reference Rabies Vaccine as Simulated Rabies Post-Exposure Prophylaxis in Adult and Pediatric Population in Thaïland | Rabies (Healthy Volunteers) | P3 | Completed | 403 | RCT, Double-blind | Purified vero rabies vaccine - serum free VRVg-2, Purified inactivated rabies vaccine, Equine rabies immunoglobulins (ERIG) (only Group 3 and Group 4), Human rabies immunoglobulins (HRIG) (only Group 5 and Group 6) |
| NCT01346293 Study of DTap-IPV Compared to DAPTACEL® and IPOL® as the 5th Dose in Children 4 to 6 Years of Age | Tetanus, Diphtheria | P3 | Completed | 3,372 | RCT, Open-label | Diphtheria and Tetanus Toxoids and Acellular Pertussis + Measles, Mumps, Rubella + Varicella Virus, Diphtheria and Tetanus Toxoids and Acellular Pertussis + Poliovirus + MMR + Varicella Virus, Diphtheria and Tetanus Toxoids and Acellular Pertussis + Measles, Mumps, Rubella + Varicella Virus, Diphtheria and Tetanus Toxoids and Acellular Pertussis + Poliovirus + MMR + Varicella Virus |
| NCT03549871 A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prophylaxis | Hemophilia | P3 | Completed | 80 | Open-label | Fitusiran, BPA prophylaxis, Factor (FVIII or FIX) prophylaxis |
| NCT00327444 Study of the Effect of Intravenous AVE0005 (VEGF Trap) in Advanced Ovarian Cancer Patients With Recurrent Symptomatic Malignant Ascites | Ovarian Neoplasms, Ascites | P2P3 | Completed | 58 | RCT, Double-blind | aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®), Placebo, aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®) |
| NCT00576667 An Efficacy and Safety Study of Rimonabant for Treatment of Nonalcoholic Steatohepatitis (NASH) in Patients Without Diabetes | Fatty Liver | P3 | Terminated | 165 | RCT, Double-blind | Rimonabant, Placebo (for Rimonabant) |
| NCT04544267 Study on a High-Dose Quadrivalent Influenza Vaccine Compared With Standard-Dose Quadrivalent Influenza Vaccine in Children 6 Months Through 35 Months of Age | Influenza | P3 | Terminated | 100 | RCT, Double-blind | Quadrivalent influenza vaccine, high-dose, Quadrivalent influenza vaccine, standard dose |
| NCT00622700 Phase III Study With Teriflunomide Versus Placebo in Patients With First Clinical Symptom of Multiple Sclerosis | Multiple Sclerosis | P3 | Completed | 618 | RCT, Double-blind | Teriflunomide, Placebo |
| NCT01027364 Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia B | Severe Hemophilia B | P3 | Completed | 123 | Open-label | Factor IX (rFIXFc), rFIX |
| NCT02234310 Study to Determine the Safety and Efficacy of rFIXFc in Previously Untreated Males With Severe Hemophilia B | Hemophilia B | P3 | Completed | 33 | Open-label | rFIXFc |
| NCT00077844 Safety and Efficacy of Enoxaparin in Percutaneous Coronary Intervention (PCI) Patients, an International Randomized Evaluation (STEEPLE) | Percutaneous Coronary Intervention | P2P3 | Completed | 3,532 | RCT, Open-label | Enoxaparin sodium |
| NCT00206713 Efficacy Study of Sargramostim in the Retreatment of Patients Who Have Crohn's Disease Who Have Previously Responded to Treatment With Sargramostim | Crohn Disease | P3 | Terminated | 264 | RCT, Double-blind | Sargramostim (Leukine), Placebo |
| NCT00132925 An Efficacy and Safety Evaluation of Nasacort AQ in Children Ages 2-5 Years With Perennial Allergic Rhinitis | Rhinitis, Allergic, Perennial | P3 | Completed | 460 | RCT, Double-blind | Triamcinolone |
| NCT01768559 Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic Patients | Type 2 Diabetes | P3 | Completed | 894 | RCT, Open-label | Lixisenatide (AVE0010), Insulin glulisine QD, Insulin glulisine TID, Insulin Glargine (Mandatory background drug), Metformin (Background drug) |
| NCT00766688 Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia | Hypercholesterolemia | P3 | Terminated | 643 | RCT, Double-blind | AVE5530, Placebo |
| NCT04681729 Dupilumab for the Treatment of Chronic Inducible Cold Urticaria in Patients Who Remain Symptomatic Despite the Use of H1-antihistamine (LIBERTY-CINDU CUrIADS) | Cold Urticaria | P3 | Completed | 82 | RCT, Double-blind | Dupilumab SAR231893, Placebo, Non sedating H1-antihistamine |
| NCT04492254 Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients | COVID-19 | P3 | Terminated | 219 | RCT, Open-label | Enoxaparin |
| NCT00454402 ALF-STONE: Alfuzosin in Uretheric Stones | Prostatic Hyperplasia | P3 | Terminated | 220 | RCT, Double-blind | Alfuzosin |
| NCT00619957 Efficacy and Safety of Risedronate Therapy Administered 35 mg Once A Week in Men With Osteoporosis | Other Osteoporosis | P3 | Completed | 285 | RCT, Double-blind | Placebo tablet, Risedronate |
| NCT00434681 Paracetamol Oral Paediatric Suspension at 4.8% : Study of Acceptability and Safety. | Fever, Pain | P3 | Completed | 48 | Open-label | paracetamol 4.8% paediatric oral suspension |
| NCT00309556 Randomized Neoadjuvant Study of Epirubicin and Docetaxel With/Without Capecitabine in Early Breast Cancer | Breast Cancer | P3 | Completed | 536 | RCT, Open-label | Epirubicin, Docetaxel, Capecitabine, Trastuzumab |
| NCT00316329 ATAQ EASY: Artesunate + Amodiaquine Fixed Dose Combination in the Treatment of Uncomplicated Plasmodium Falciparum Malaria | Malaria | P3 | Completed | 1,032 | RCT, Single-blind | Artesunate + Amodiaquine |
| NCT00312377 ZACTIMA (an Anti-EGFR / Anti-VEGF Agent) Combined With Docetaxel Compared to Docetaxel in Non-small Cell Lung Cancer | Non-small Cell Lung Cancer, Lung Cancer | P3 | Completed | 1,690 | RCT, Double-blind | Docetaxel, Vandetanib |
| NCT00785681 Dermacyd PH_DETINBACK (Lactic Acid) Sweet Flower - Compatibility | Hygiene | P3 | Completed | 53 | Open-label | Dermacyd PH_DETINBACK (Lactic Acid) |
| NCT00712673 GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Diabetes Mellitus, Type 2 | P3 | Completed | 680 | RCT, Double-blind | Lixisenatide (AVE0010), Placebo, Metformin |
| NCT00705276 Dermacyd Femina Delicata (Lactic Acid)- Photo Dermatological Evaluation of the Irritation and Sensitivity Potential | Hygiene | P3 | Completed | 26 | Open-label | Lactic acid (Dermacyd Femina Delicata) |
| NCT00458718 Efficacy and Safety of Rimonabant as an Aid to Smoking Cessation With or Without Nicotine Patch | Smoking Cessation | P3 | Completed | 755 | RCT, Double-blind | rimonabant (SR141716) |
| NCT00576823 Alfuzosin Treatment in Children and Adolescents With Hydronephrosis of Neuropathic Etiology | Hydronephrosis, Neurogenic Bladder | P3 | Completed | 25 | Open-label | Alfuzosin |
| NCT00290979 Efficacy and Safety of Insulin Glulisine in Type 1 Diabetes Mellitus | Diabetes Mellitus, Type 1 | P3 | Completed | 250 | RCT, Open-label | insulin glulisine |
| NCT03600818 Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica | Polymyalgia Rheumatica | P3 | Terminated | 118 | RCT, Double-blind | Sarilumab SAR153191 (REGN88), Sarilumab-matching placebo, Prednisone, Prednisone-matching placebo, Prednisone |
| NCT00754689 Study of Rimonabant/Metformin Combinations to Investigate Diabetes (Blood Sugar) Control in Patients With Type 2 Diabetes | Diabetes Mellitus, Type 2 | P3 | Withdrawn | — | RCT, Double-blind | Rimonabant, Metformin, placebo |
| NCT06705140 A Study on the Immunogenicity and Safety of 3 Different Dose Concentrations of a Respiratory Syncytial Virus Vaccine in Infants and Toddlers | RSV Immunisation | P3 | Terminated | 947 | RCT, Double-blind | Low Dose (LD) RSVt vaccine, Standard Dose (SD) RSVt vaccine, High Dose (HD) RSVt vaccine, Placebo |
| NCT00325390 Efficacy and Safety in Patients With Acute Coronary Syndrome Without ST-Segment Elevation | Platelet Aggregation Inhibitors, NSTEACS | P3 | Completed | 800 | RCT, Double-blind | clopidogrel (SR25990C) |
| NCT00353080 Risedronate In The Prevention Of Osteoporosis In Osteopenic Postmenopausal Women | Osteoporosis, Postmenopausal | P3 | Completed | 171 | RCT, Double-blind | risedronate (HMR4003) |
| NCT03521934 Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial) | Heart Failure, Type 2 Diabetes Mellitus | P3 | Terminated | 1,222 | RCT, Double-blind | Sotagliflozin, Placebo |
| NCT00694122 Comparison of Lantus and Neutral Protamine Hagedorn (NPH) Insulin in the Dawn Phenomenon | Type 1 Diabetes, Dawn Phenomenon | P3 | Completed | 27 | Open-label | Lantus (glargine) |
| NCT00345098 A Study of SR58611A in the Prevention of Depression Relapse in Patients With Major Depressive Disorder | Depressive Disorder, Major Depression | P3 | Completed | 704 | RCT, Double-blind | SR58611A |
| NCT00563225 20 Week Bridging Study in Type II DM | Diabetes Mellitus Type II | P3 | Completed | 90 | Open-label | Insulin Glargine |
| NCT00284128 AVE7688 in Patients With Mild to Moderate Blood Pressure | Hypertension | P2P3 | Completed | 1,940 | RCT, Double-blind | AVE7688, Losartan-potassium |
| NCT00531622 An Eight-week Study of Saredutant and Escitalopram as Combination Treatment for Major Depressive Disorder | Major Depressive Disorder | P3 | Completed | 643 | RCT, Double-blind | saredutant (SR48968), escitalopram, placebo |
| NCT00345618 Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach | Embolism, Thrombosis | P3 | Completed | 3,202 | RCT, Double-blind | Idrabiotaparinux sodium, Warfarin, Placebo (for idrabiotaparinux sodium), Avidin, Placebo (for warfarin), Enoxaparin |
| NCT01378286 Efficacy and Tolerability of Artesunate Amodiaquine Versus Chloroquine in the Treatment of Uncomplicated Plasmodium Vivax Malaria | Malaria | P3 | Completed | 380 | RCT, Open-label | ARTESUNATE + AMODIAQUINE, Chloroquine |
| NCT00115570 Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children and Adolescents | Diabetes Mellitus, Insulin-Dependent | P3 | Completed | 572 | RCT, Open-label | Insulin glulisine, insulin lispro, insulin glargine, NPH insulin |
| NCT01644188 Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Ezetimibe on Top of Statin in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY COMBO II) | Hypercholesterolemia | P3 | Completed | 720 | RCT, Double-blind | Alirocumab, Placebo (for alirocumab), Ezetimibe, Placebo (for ezetimibe), Lipid Modifying Therapy (LMT) |
| NCT00418886 Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients | Non Small Cell Lung Cancer, Lung Cancer | P3 | Completed | 698 | RCT, Double-blind | Vandetanib, Pemetrexed |
| NCT00763451 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Diabetes Mellitus, Type 2 | P3 | Completed | 484 | RCT, Double-blind | Lixisenatide (AVE0010), Placebo, Metformin |
| NCT05132569 Efficacy and Safety of Tolebrutinib (SAR442168) Tablets in Adult Participants With Generalized Myasthenia Gravis | Myasthenia Gravis | P3 | Terminated | 6 | RCT, Double-blind | Tolebrutininb, Placebo |
| NCT00632866 Hydroxychloroquine Versus Placebo in Primary Sjögren's Syndrome | Primary Sjögren's Syndrome | P3 | Completed | 120 | RCT, Double-blind | Hydroxychloroquine, Placebo |
| NCT00323778 Prospective Assessment of the Efficacy of Hyaluronate Knee Injections in Patients With Osteoarthritis | Knee Osteoarthritis | P3 | Terminated | 40 | Open-label | Hyalgan |
| NCT00688740 Docetaxel in Node Positive Adjuvant Breast Cancer | Breast Cancer | P3 | Completed | 1,491 | RCT, Open-label | Docetaxel, 5-fluorouracil, Doxorubicin, Cyclophosphamide |
| NCT00326378 Efficacy Study of Additional Chemotherapy After Concurrent Chemoradiation in Non-small Cell Lung Cancer | Carcinoma, Non-Small-Cell Lung | P3 | Completed | 434 | RCT, Open-label | consolidation chemotherapy with Docetaxel plus cisplatin, CCRT arm without consolidation chemotherapy |
| NCT02004691 Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency | Sphingomyelin Lipidosis | P2P3 | Completed | 36 | RCT, Double-blind | placebo (saline), Olipudase alfa |
| NCT00273546 Induction Chemotherapy Comparing Taxotere® Cisplatin and 5-Fluorouracil (TPF) With Standard Cisplatin and 5-Fluorouracil (PF) Followed by Chemoradiation in Locally Advanced Head and Neck Cancer | Cancer | P3 | Completed | 500 | RCT, Open-label | XRP6976 (Docetaxel/Taxotere) |
| NCT00489736 Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation | Atrial Fibrillation | P3 | Completed | 504 | RCT, Double-blind | dronedarone (SR33589), amiodarone |
| NCT00561964 Randomized, Parallel, Comparison, Double-Blind Efficacy & Safety Study of APROVEL Versus Placebo in Chinese Patients With Hypertensive Type II Diabetic Patients With Microalbuminuria | Hypertension | P3 | Completed | 241 | RCT, Double-blind | Irbesartan, placebo |
| NCT03762265 A Study of PRN1008 in Patients With Pemphigus | Pemphigus | P3 | Terminated | 131 | RCT, Double-blind | Rilzabrutinib, Placebo |
| NCT03760965 Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Diet and Exercise | Type 2 Diabetes Mellitus | P3 | Terminated | 276 | RCT, Double-blind | sotagliflozin (SAR439954), placebo |
| NCT00129935 EC Followed Docetaxel Versus ET Followed Capecitabine as Adjuvant Chemotherapy for Node Positive Operable Breast Cancer | Breast Cancer | P3 | Completed | 1,384 | RCT, Open-label | Docetaxel, Capecitabine, Epirubicin, Cyclophosphamide |
| NCT03025789 Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage | Trypanosomiasis, African, Sleeping Sickness | P3 | Completed | 174 | Open-label | Fexinidazole |
| NCT06641180 Study to Evaluate Immunogenicity and Safety of a High-Dose Influenza Vaccine in Adults 50 Through 64 Years of Age | Influenza | P3 | Completed | 1,180 | RCT, Double-blind | High-Dose trivalent influenza vaccine (Split virion, Inactivated), Standard-dose trivalent influenza vaccine (Split virion, Inactivated) |
| NCT00243178 Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W) | Atrial Fibrillation, Vascular Risk | P3 | Terminated | 6,706 | RCT, Open-label | clopidogrel (SR25990C) |
| NCT01359449 Study of Two Doses of Menactra® or One Dose of Monovalent Meningococcal Group C Vaccine With Routine Immunizations | Meningitis, Meningococcal Infection | P3 | Completed | 123 | RCT, Open-label | Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate: Menactra®, Meningococcal Group C Conjugate vaccine: MenC |
| NCT00303316 Immunogenicity Study of Antibody Persistence and Booster Effect of PENTAXIM™ at 18 Months in Healthy Argentinean Infants | Diphtheria, Tetanus | P3 | Completed | 458 | Open-label | DTaP-IPV//PRP~T combined vaccine, DTaP-IPV//PRP~T combined vaccine |
| NCT01890759 Immunogenicity and Safety of Menactra® Vaccine in Subjects Aged 9 to 23 Months in India and in the Russian Federation | Meningitis, Meningococcal Infection | P3 | Completed | 300 | Open-label | Meningococcal Diphtheria Toxoid Vaccine |
| NCT03713684 Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in Combination With Oral Antidiabetic Drug(s) | Type 2 Diabetes Mellitus | P3 | Terminated | 370 | RCT, Double-blind | Efpeglenatide SAR439977, Placebo, Background therapy |
| NCT00401531 Comparison of a DTaP-IPV-HB-PRP~T Combined Vaccine to Infanrix™-Hexa, When Administered With Prevnar® in Thai Infants | Hepatitis B, Polio | P3 | Completed | 412 | RCT, Single-blind | DTaP-IPV-HB-PRP~T and Pneumococcal polysaccharide vaccines, DTaP-HB-IPV and Pneumococcal polysaccharide vaccines |
| NCT00932945 Dermacyd PH_DESILSTY_FR (Lactic Acid) - Acceptability - Stay on Frutal | Hygiene | P3 | Completed | 32 | Open-label | LACTIC ACID(ND) |
| NCT03156621 Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH) | Homozygous Familial Hypercholesterolemia | P3 | Completed | 69 | RCT, Double-blind | Alirocumab, Placebo |
| NCT00103610 Mobilization of Stem Cells With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma Patients | Lymphoma, Non-Hodgkin | P3 | Completed | 298 | RCT, Double-blind | Granulocyte colony-stimulating factor plus plerixafor, Granulocyte colony-stimulating factor plus placebo |
| NCT01240746 Study of Quadrivalent Influenza Vaccine Among Children | Influenza | P3 | Completed | 4,363 | RCT, Double-blind | Licensed 2010-2011 Trivalent Influenza Vaccine, No Preservative, Investigational Trivalent Influenza Vaccine with alternate B strain, No Preservative, Quadrivalent Influenza Vaccine, No Preservative |
| NCT00325546 Study of Weight-Reducing Effect and Safety of Rimonabant In Obesity in ASIA (RIO-ASIA) | Obesity | P3 | Completed | 643 | RCT, Double-blind | Rimonabant (SR141716), Placebo |
| NCT00784160 Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid)- Compatibility | Hygiene | P3 | Completed | 53 | Open-label | Lactic Acid (Dermacyd PH_DETINBACK Tangerine Mix) |
| NCT01861730 Phase 1/II, Safety and Immunogenicity Study of AERAS-404 in BCG-Primed Infants | Tuberculosis | P1P2 | Completed | 243 | RCT, Double-blind | AERAS-404, Placebo |
| NCT04491877 Study of an Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers | Respiratory Syncytial Virus Infection | P1P2 | Completed | 259 | RCT, Double-blind | RSV vaccine formulation 1, RSV vaccine formulation 2, Placebo |
| NCT00771602 Alemtuzumab + Rituximab Consolidation in CLL | Chronic Lymphocytic Leukemia, Leukemia | P2 | Terminated | 1 | RCT, Open-label | Rituximab, Alemtuzumab |
| NCT03145766 Immunogenicity and Safety of a Purified Vero Rabies Vaccine | Rabies Virus | P2 | Completed | 320 | RCT, Double-blind | VRVg 2, VRVg 1, Imovax Rabies, VRVg 2, VRVg 2, Human Rabies Immunoglobulins (HRIG) |
| NCT00688883 Fludara (Oral) Phase II Study for Indolent Lymphoma | Lymphoma | P2 | Completed | 52 | Open-label | Fludarabine Phosphate (Fludara) |
| NCT00542828 Rabbit Anti-thymocyte Globulin in the Treatment of Patients With Low to Intermediate-1 Risk Myelodysplastic Syndrome | Myelodysplastic Syndrome (MDS) | P2 | Terminated | 16 | Open-label | Thymoglobulin®, Rabbit Anti-thymocyte Globulin (rATG) |
| NCT03418571 Evaluation of ALX-0171 in Japanese Children Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection | Respiratory Syncytial Virus Lower Respiratory Tract Infection | P2 | Terminated | 15 | RCT, Double-blind | ALX-0171 1.5 mg/kg |
| NCT00193128 Preoperative Therapy With Oxaliplatin/Docetaxel/Capecitabine and Radiation in Resectable Esophagus Cancer | Esophagus Cancer | P1P2 | Completed | 59 | Open-label | Oxaliplatin, Docetaxel, Capecitabine |
| NCT01576029 Continued Treatment With Docetaxel Versus Switch to Cabazitaxel After Minor Prostate Specific Antigen Response to Docetaxel in Patients With Castration-Resistant Metastatic Prostate Cancer | Prostatic Neoplasms | P2 | Completed | 2 | RCT, Open-label | CABAZITAXEL (XRP6258), DOCETAXEL (XRP6976) |
| NCT00406302 Immune Response on Neoadjuvant Therapy in Non-small-cell Lung Cancer (NSCLC) | Carcinoma, Non-small-cell Lung | P2 | Completed | 41 | Open-label | Docetaxel, oxaliplatin, cetuximab |
| NCT00830544 Study of Neoadjuvant Chemotherapy of Breast Cancer | Breast Cancer | P2 | Unknown | 54 | Open-label | Neoadjuvant chemotherapy, Chemotherapy, Neoadjuvant chemotherapy |
| NCT00461344 Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer | Ductal Carcinoma | P2 | Terminated | 20 | Open-label | Docetaxel, Doxorubicin |
| NCT00811395 Long Term Safety of Teriflunomide When Added to Interferon-Beta or Glatiramer Acetate in Patients With Multiple Sclerosis | Multiple Sclerosis | P2 | Completed | 182 | RCT, Double-blind | Teriflunomide, Placebo (for teriflunomide), Interferon-β [IFN-β], Glatiramer Acetate [GA] |
| NCT01882868 A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan | Colorectal Cancer Metastatic | P2 | Completed | 62 | Open-label | Aflibercept, Levofolinate, Irinotecan, 5-FU |
| NCT00181168 Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer | Thyroid Cancer | P2 | Completed | 63 | RCT, Open-label | Euthyroid Group |
| NCT00493649 Adj TC + Herceptin Early Stage Breast Cancer | Breast Cancer | P2 | Completed | 493 | Open-label | Taxotere, Cytoxan, Herceptin |
| NCT06914908 Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Clinical Study | Chronic Rhinosinusitis With Nasal Polyps | P2 | By Invite | 71 | Open-label | Lunsekimig, Mometasone furoate nasal spray (MFNS) |
| NCT04398706 Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants | Pneumococcal Immunisation, Diphtheria Immunisation | P2 | Completed | 852 | RCT, Double-blind | Pneumococcal Conjugate Vaccine formulation 1, Pneumococcal Conjugate Vaccine formulation 2, Pneumococcal Conjugate Vaccine formulation 3, Varicella Virus Vaccine Live, Measles, Mumps, and Rubella Virus Vaccine Live, Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein], Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate), Rotavirus Vaccine, Live, Oral, Pentavalent, Hepatitis B Vaccine* [Recombinant] *as applicable |
| NCT02812706 Isatuximab Single Agent Study in Japanese Relapsed AND Refractory Multiple Myeloma Patients | Multiple Myeloma | P1P2 | Completed | 36 | Open-label | Isatuximab SAR650984 |
| NCT03594955 First in Human Testing of Dose-escalation of SAR440234 in Patients With Acute Myeloid Leukemia, Acute Lymphoid Leukemia and Myelodysplastic Syndrome | Leukaemia | P1P2 | Terminated | 7 | Open-label | SAR440234 |
| NCT00816543 Docetaxel + Oxaliplatin + S-1 in Potentially Operable Gastric or Gastroesophageal Adenocarcinoma | Gastric Cancer | P2 | Completed | 41 | Open-label | DOCETAXEL, S-1, OXALIPLATIN |
| NCT01368848 Combination of Cisplatin, Docetaxel and Bevacizumab in Patients With Non-small Cell Lung Carcinoma (NSCLC) | NSCLC | P2 | Completed | 7 | Open-label | Bevacizumab, Cisplatin, Docetaxel |
| NCT00914277 SAR407899 Single-dose in Treatment of Mild to Moderate Erectile Dysfunction | Erectile Dysfunction | P2 | Completed | 24 | RCT, Double-blind | SAR407899, Placebo, Sildenafil |
| NCT00126009 SOLMANIA - Comparison of Valproate-Amisulpride and Valproate-Haloperidol in Bipolar I Patients | Bipolar Disorder | P2 | Completed | 120 | RCT, Open-label | Amisulpride |
| NCT00982137 Study of Live Attenuated Japanese Encephalitis Vaccine (ChimeriVax™-JE) and Yellow Fever Vaccine (STAMARIL®) | Japanese Encephalitis, Yellow Fever | P2 | Completed | 108 | RCT, Double-blind | Live attenuated Japanese encephalitis virus; Yellow fever virus, Yellow fever virus; Live attenuated Japanese encephalitis virus, Live attenuated Japanese encephalitis virus; Yellow fever virus, Live attenuated Japanese encephalitis virus; Yellow fever virus |
| NCT01531205 Neoadjuvant Chemohormonal Therapy Followed by Salvage Surgery for High Risk PSA | Prostate Cancer | P2 | Terminated | 2 | Open-label | Androgen Ablation, Cabazitaxel, Salvage Therapy, Neoadjuvant Treatment - Hormonal Therapy, Neoadjuvant Treatment - Cabazitaxel |
| NCT00263354 Oxaliplatin in Gastric Cancer | Stomach Neoplasms | P2 | Completed | 20 | Open-label | Oxaliplatin |
| NCT00047840 This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer. | Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line | P2 | Completed | 129 | RCT, Double-blind | ZD6474, Placebo, Docetaxel |
| NCT00600249 Assessment of the Efficacy of a Neoadjuvant Combination: "Chemotherapy-targeted Therapy" in Breast Cancer. | Breast Cancer | P2 | Completed | 35 | Open-label | Cetuximab, Docetaxel |
| NCT03205358 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Healthy Toddlers | Meningitis, Meningococcal Meningitis | P2 | Completed | 188 | RCT, Open-label | Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine, Meningococcal Polysaccharide groups A, C, W-135 and Y Conjugate Vaccine |
| NCT00206726 Alemtuzumab/Fludarabine for Relapsed/Refractory B-cell Chronic Lymphocytic Leukemia (B-CLL) | Leukemia, Lymphocytic, Chronic, B-Cell | P2 | Completed | 60 | Open-label | Alemtuzumab plus Fludarabine |
| NCT01011049 Study of Influenza Vaccine Revaccination in Healthy Adults Previously Vaccinated With Fluzone ID or Fluzone IM | Influenza | P2 | Completed | 1,250 | RCT, Open-label | Influenza Virus Vaccine USP Trivalent Types A and B, Influenza Virus Vaccine USP Trivalent Types A and B, Influenza Virus Vaccine USP Trivalent Types A and B, Influenza Virus Vaccine USP Trivalent Types A and B |
| NCT03749148 Cholinergic Urticaria - Efficacy of Dupilumab | Cholinergic Urticaria | P2 | Completed | 48 | RCT, Double-blind | Dupilumab, Placebo |
| NCT02973321 A Study to Assess the Safety and Efficacy of SAR425899 in Patients With Type 2 Diabetes Mellitus | Type 2 Diabetes Mellitus | P2 | Completed | 296 | RCT, Double-blind | SAR425899, Placebo, Liraglutide, Metformin |
| NCT02844582 Cabazitaxel and Prednisone in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer | Hormone-Resistant Prostate Cancer, Stage IV Prostate Adenocarcinoma | P2 | Terminated | 2 | Open-label | Cabazitaxel, Prednisone |
| NCT00625755 A Phase I/II Study to Assess the Safety and Efficacy of Vaccinations With Allogeneic Dendritic Cells: Autologous Tumor-Derived Cells Subjected to Electrofusions in Patients With AJCC Stage IV Renal Cell Carcinoma | Renal Cell Carcinoma | P1P2 | Completed | 40 | Open-label | Electrofusion DC vaccine |
| NCT00480987 Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndromes (MDS) | Myelodysplastic Syndromes, Acute Myeloid Leukemia | P1P2 | Terminated | 27 | Open-label | Oxaliplatin, Fludarabine, Cytarabine |
| NCT06066255 PROPHYLAXIS OF GVH IN ELDERLY PATIENTS RECEIVING HAPLOIDENTICAL ALLOGENIC HEMATOPOIETIC STEM CELL TRASNPLANTATION USE OF A LOW DOSE ANTI-LYMPHOCYTIC SERUM | Hematological Malignancy | P2 | Unknown | 27 | Open-label | Thymoglobulin Injectable Product |
| NCT00066313 ZD6474 in Treating Patients With Small Cell Lung Cancer | Lung Cancer | P2 | Completed | — | RCT, Double-blind | vandetanib |
| NCT05179603 A Study of SAR444245 With or Without Other Anticancer Therapies for the Treatment of Adults and Adolescents With Relapsed or Refractory B Cell Lymphoma (Master Protocol) [Pegathor Lymphoma 205] | Classic Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma | P2 | Terminated | 14 | Open-label | THOR-707, Pembrolizumab |
| NCT04781816 Proof of Concept Study of SAR443122 in Patients With Cutaneous Lupus Erythematosus | Cutaneous Lupus Erythematosus | P2 | Completed | 78 | RCT, Double-blind | SAR443122, Placebo |
| NCT00510107 Weekly Docetaxel Plus Cisplatin or Oxaliplatin for AGC | Stomach Neoplasm, Stage IV | P2 | Unknown | 90 | RCT, Open-label | oxaliplatin, Cisplatin |
| NCT00491257 A Study of the Immunogenicity and Safety of the 2007-2008 Influenza Vaccine | Influenza, Orthomyxoviridae Infections | P2 | Completed | 130 | Open-label | Inactivated influenza vaccine (split virion) NH 2007-2008 formulation |
| NCT00098345 Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer | Thyroid Cancer | P2 | Completed | 40 | Open-label | ZD6474 (vandetanib) |
| NCT01661972 Phase I/II Study of Capecitabine Plus Aflibercept to Treat Metastatic Colorectal Cancer | Metastatic Colorectal Cancer | P1P2 | Completed | 63 | Open-label | Capecitabine and aflibercept |
| NCT00991172 A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain | Sciatica | P2 | Completed | 159 | RCT, Double-blind | REGN475, REGN475, Placebo Injection |
| NCT00950066 Irbesartan and Amlodipine Combination in Controlling Blood Pressure | Hypertension | P2 | Completed | 270 | RCT, Double-blind | IRBESARTAN (SR47436), Amlodipine, Irbesartan / Amlodipine, Placebo |
| NCT02287922 A Phase IIb Study for ALX-0061 Monotherapy in Subjects With Rheumatoid Arthritis | Rheumatoid Arthritis | P2 | Completed | 251 | RCT, Double-blind | ALX-0061, Placebo, Tocilizumab |
| NCT00504257 Avastin in Combination With Docetaxel in Ovarian/Fallopian Tube/Peritoneum Carcinoma | Fallopian Tube Cancer, Ovarian Cancer | P2 | Completed | 45 | Open-label | Avastin, Docetaxel |
| NCT01258595 A Study of High-Dose Trivalent Inactivated Influenza Vaccine in Adults 50 to 64 Years of Age | Influenza | P2 | Completed | 300 | RCT, Double-blind | High-Dose Trivalent Inactivated Influenza Vaccine, Trivalent Inactivated Influenza Vaccine |
| NCT00133731 The SEPIA-PCI Trial: Otamixaban in Comparison to Heparin in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention | Angioplasty, Transluminal, Percutaneous Coronary | P2 | Completed | 947 | RCT, Double-blind | Otamixaban (XRP0673), Unfractionated Heparin |
| NCT00611962 Phase II Study of Oxaliplatine-Paclitaxel in Patients With Metastatic Germ Cell Tumor Refractory to Cisplatin | Neoplasms, Germ Cell and Embryonal | P2 | Completed | 27 | Open-label | Oxaliplatin, Paclitaxel |
| NCT00382720 Docetaxel and Oxaliplatin in Gastric Cancer | Stomach Neoplasms | P2 | Completed | 275 | RCT, Open-label | Docetaxel + Oxaliplatin, Docetaxel + Oxaliplatin + 5-FU, Docetaxel + Oxaliplatin + Capecitabine |
| NCT00924443 A Study of Clofarabine in Older Patients With Acute Myeloid Leukemia (AML) for Whom Chemotherapy Is Not Suitable | Acute Myeloid Leukemia | P2 | Completed | 69 | Open-label | clofarabine |
| NCT00851084 Study of Aflibercept And Modified FOLFOX6 As First-Line Treatment In Patients With Metastatic Colorectal Cancer | Colorectal Neoplasms, Neoplasm Metastasis | P2 | Completed | 268 | RCT, Open-label | aflibercept, oxaliplatin, 5-FU, Folinic Acid |
| NCT00464633 Alvocidib in Patients With Previously Treated Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Arising From Chronic Lymphocytic Leukemia (CLL) | Leukemia, Lymphocytic, Chronic | P2 | Completed | 165 | Open-label | alvocidib |
| NCT00988143 A Study of Influenza Virus Vaccines in Children and Adults | Influenza | P2 | Completed | 600 | RCT, Open-label | 2009-2010 Trivalent Influenza Virus Vaccine, 2008-2009 Trivalent Influenza Virus Vaccine, Quadrivalent Influenza Virus Vaccine |
| NCT01574326 An Efficacy and Safety Study of Sevelamer Carbonate in Hyperphosphatemic Pediatric Participants With Chronic Kidney Disease | Hyperphosphatemia, Chronic Kidney Disease | P2 | Completed | 101 | RCT, Double-blind | Placebo, Sevelamer carbonate |
| NCT03159143 Study of Docetaxel and Oxaliplatin in Metastatic Transitional Cell Cancer (TCC) of the Urothelial Tract | Metastatic Transitional Cell Cancer of the Urothelial Tract | P2 | Completed | 22 | Open-label | Docetaxel, Oxaliplatin |
| NCT05018806 Proof of Concept Study of Rilzabrutinib in Adult Patients With Moderate-to-severe Atopic Dermatitis | Atopic Dermatitis | P2 | Completed | 124 | RCT, Double-blind | Placebo, Rilzabrutinib |
| NCT02435121 A Study Assessing Efficacy and Safety of SAR125844 in NSCLC Patients With MET Amplification | Neoplasm Malignant | P2 | Completed | 1 | Open-label | SAR125844 |
| NCT00322491 Mobilization of Stem Cells With AMD3100 (Plerixafor) and G-CSF in Non-Hodgkin's Lymphoma and Multiple Myeloma Patients | Lymphoma, Non-Hodgkin, Multiple Myeloma | P2 | Completed | 49 | Open-label | G-CSF Plus Plerixafor |
| NCT01463397 Efficacy and Safety of SAR292833 Administration for 4 Weeks in Patients With Chronic Peripheral Neuropathic Pain | Neuropathic Pain | P2 | Completed | 191 | RCT, Double-blind | SAR292833, placebo |
| NCT00226460 Phase 2, Double-blind, Randomized, Controlled Multi-center Clinical Trial of the Safety and Efficacy of Transplanted Fetal Porcine Cells in Patients With Parkinson's Disease. | Parkinson's Disease | P2 | Completed | — | RCT, Double-blind | Fetal porcine cells, Neurocell-PD |
| NCT03284710 Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine | HIV Infections | P1P2 | Completed | 132 | RCT, Double-blind | ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension, Bivalent Subtype C gp120 |
| NCT01963598 Study of the Safety and Efficacy of REGN1033 (SAR391786) in Patients With Sarcopenia | Sarcopenia | P2 | Completed | 253 | RCT, Double-blind | REGN1033 (SAR391786), placebo |
| NCT03530267 Aflibercept and 5-FU vs. FOLFOX as 1st Line Treatment for Elderly or Frail Elderly Patients With Met. Colorectal Cancer | Colorectal Cancer | P2 | Completed | 124 | RCT, Open-label | Aflibercept + mLV5FU2, mFOLFOX7 |
| NCT00174798 MILADY: A Randomized, Placebo-controlled Safety and Efficacy Trial of SSR240600C in Treatment of Overactive Bladder or Urge Urinary Incontinence. | Overactive Bladder | P2 | Completed | 118 | RCT, Double-blind | SSR240600C, Placebo, Tolterodine |
| NCT00952003 Oxaliplatin/Irinotecan/Bevacizumab Followed by Docetaxel/Bevacizumab in Inoperable Locally Advanced or Metastatic Gastric Cancer Patients | Gastric Cancer, Unresectable | P2 | Completed | 40 | Open-label | Oxaliplatin, Irinotecan, Bevacizumab, Docetaxel |
| NCT04270942 At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension) | Diabetes Mellitus, Type 1 | P2 | Completed | 6 | Open-label | teplizumab 1 mg/mL |
| NCT04394624 Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04) | Non-small Cell Lung Cancer Metastatic | P2 | Terminated | 31 | Open-label | SAR408701, ramucirumab, pembrolizumab |
| NCT00669370 Biweekly Docetaxel in Combination With Capecitabine as First-Line Treatment in Patients With Advanced Gastric Cancer | Stomach Neoplasms | P2 | Unknown | 50 | Open-label | docetaxel and capecitabine |
| NCT00988897 Colorectal Cancer RECHALLENGE | Colorectal Neoplasms | P2 | Withdrawn | — | Open-label | OXALIPLATIN (SR96669), 5-FLUOROURACIL (5-FU), LEUCOVORIN (LV), BEVACIZUMAB |
| NCT00875524 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects | Dengue Virus, Dengue Fever | P2 | Completed | 180 | RCT, Double-blind | CYD dengue vaccine serotypes (1, 2, 3, 4)., Meningococcal Polysaccharide A+C; NaCl; Typhoid Vi polysaccharide |
| NCT01034995 A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disorder | Major Depression | P2 | Completed | 580 | RCT, Double-blind | SSR125543, escitalopram, placebo |
| NCT00580073 Phase II Trial of Neoadjuvant FOLFOX4 and Cetuximab for Localized Adenocarcinoma of Rectum | Rectal Cancer | P2 | Terminated | 6 | Open-label | FOLFOX4, Cetuximab |
| NCT00494481 E3 Breast Cancer Taxotere Combination | Advanced Breast Cancer | P2 | Completed | 64 | RCT, Double-blind | Vandetanib (ZD6474), Docetaxel |
| NCT01025154 Clofarabine, Idarubicin, and Cytarabine Combination in Acute Myeloid Leukemia (AML) Induction | Acute Myeloid Leukemia | P2 | Completed | 63 | Open-label | Clofarabine, Idarubicin, Cytarabine |
| NCT03367819 Isatuximab in Combination With REGN2810 (Cemiplimab) in Patients With Advanced Malignancies | Prostate Cancer, Non-small Cell Lung Cancer | P1P2 | Terminated | 44 | RCT, Open-label | Isatuximab SAR650984, Cemiplimab REGN2810 |
| NCT04424927 PRV-015 in Gluten-free Diet Non-responsive Celiac Disease | Celiac Disease | P2 | Completed | 388 | RCT, Double-blind | PRV-015 |
| NCT00356122 Docetaxel & Oxaliplatin in Combination With Bevacizumab as First-Line Treatment in Subjects With Non-Small Cell Lung Cancer (NSCLC) | Non-Small Cell Lung Cancer | P2 | Completed | 53 | Open-label | Docetaxel, Oxaliplatin, Bevacizumab |
| NCT03203642 Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD | Autosomal Dominant Polycystic Kidney, ADPKD | P2 | Completed | 80 | RCT, Double-blind | Tesevatinib, Placebo |
| NCT01440179 SAR3419 in Acute Lymphoblastic Leukemia | Acute Lymphocytic Leukaemia | P2 | Terminated | 100 | Open-label | SAR3419 |
| NCT00504491 R-CHOP and Alemtuzumab in Patients With Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukaemia, Patients Resistant to a Purine Analogous | P2 | Withdrawn | — | Open-label | Rituximab-CHOP-Alemtuzumab |
| NCT00297596 Trastuzumab and Oxaliplatin in Patients With Metastatic Breast Cancer | Breast Cancer | P2 | Completed | 25 | Open-label | Trastuzumab, Oxaliplatin |
| NCT01669720 Adjuvant Aflibercept for Metastatic Colorectal Cancer | Metastatic Colorectal Cancer | P2 | Terminated | 10 | RCT, Open-label | Aflibercept |
| NCT01173497 A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis | Estrogen Receptor Negative (ER-Negative) Breast Cancer, Progesterone Receptor Negative (PR-Negative) Breast Cancer | P2 | Completed | 44 | Open-label | INIPARIB + irinotecan |
| NCT00209092 Randomized Phase II Trial Induction Therapy for Early Stage Breast Cancer | Breast Cancer | P2 | Completed | 51 | RCT, Open-label | Docetaxel, Capecitabine |
| NCT00235300 An Open-label, Prospective, Randomized, Multi-center, Phase II Comparative Trial of Thymoglobulin Versus Simulect for the Prevention of Delayed Graft Function and Acute Allograft Rejection in Renal Allograft Recipients. | Cadaveric Donor Renal Transplantation, Acute Renal Allograft Rejection | P2 | Completed | 240 | RCT, Open-label | Thymoglobulin [Anti-thymocyte Globulin (rabbit)], Simulect (basliximab) |
| NCT00903760 Decitabine and Clofarabine in Higher Risk Myelodysplastic Syndromes (MDS) | Myelodysplastic Syndrome | P2 | Completed | 42 | RCT, Open-label | Decitabine, Clofarabine |
| NCT02331927 PERMAD: Personalized Marker-driven Early Switch to Aflibercept in Patients With Metastatic Colorectal Cancer | Metastatic Colorectal Cancer | P2 | Unknown | 150 | RCT, Open-label | Aflibercept |
| NCT06444451 A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Adult Participants With Severe Alopecia Areata | Alopecia Areata | P2 | Terminated | 166 | RCT, Double-blind | Amlitelimab, Placebo |
| NCT00268710 Docetaxel in Hormone Refractory Prostate Cancer (HRPC)[Weekly or 3weekly TAX + Prednisone in HRPC] | Prostatic Neoplasms | P2 | Completed | — | Open-label | docetaxel |
| NCT06454240 A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | P2 | Completed | 79 | RCT, Double-blind | lunsekimig, placebo |
| NCT00315705 A Study of Clofarabine in Combination With Etoposide and Cyclophosphamide in Children With Acute Leukemias. | Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | P1P2 | Completed | 50 | Open-label | clofarabine, Etoposide, Cyclophosphamide |
| NCT00311129 Efficacy and Safety Study of SH T 586 in Combination With Rituximab to Treat Low-Grade NHL | Lymphoma, Low-Grade | P2 | Completed | 41 | RCT, Open-label | Fludarabine Phosphate (Fludara), Rituximab |
| NCT00303056 Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis | Joint Disease | P2 | Completed | 590 | RCT, Double-blind | HOE140 Icatibant |
| NCT00508001 Phase II Study of Best Support Care (BSC) Plus ZD6474(Vandetanib) in Patients With Inoperable Hepatocellular Carcinoma (HCC) | Carcinoma, Hepatocellular | P2 | Completed | 67 | RCT, Double-blind | Vandetanib, Vandetanib, Best Supportive Care |
| NCT06609239 Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma | Asthma | P2 | By Invite | 900 | Open-label | Lunsekimig |
| NCT00813956 A Phase 2 Study of Standard Chemotherapy Plus BSI-201 (a PARP Inhibitor) in the Neoadjuvant Treatment of Triple Negative Breast Cancer | Triple Negative Breast Cancer | P2 | Completed | 80 | Open-label | gemcitabine plus carboplatin plus BSI-201 |
| NCT00442169 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults | West Nile Fever | P2 | Completed | 208 | RCT, Double-blind | ChimeriVax-WN02 Low Dose, ChimeriVax-WN02 Medium Dose, ChimeriVax-WN02 High Dose, 0.9% Saline solution, ChimeriVax-WN02 High Dose, 0.9 % NaCl solution |
| NCT00434668 Evaluation of Tolerability of Adjuvant Cisplatin/Docetaxel in Completely Resected Stage IB/II Non-Small Cell Lung Cancer | Non-small Cell Lung Cancer | P2 | Completed | 99 | RCT, Open-label | cisplatin/docetaxel, cisplatin/vinorelbine |
| NCT03279289 Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen | Metastatic Colorectal Cancer | P2 | Completed | 170 | RCT, Open-label | Aflibercept, Irinotecan, folinic acid (dl racemic), 5Fluorouracil, 5-FU |
| NCT00239174 A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients | Obesity | P2 | Completed | 394 | RCT, Double-blind | SR147778 |
| NCT00396591 AVE0005 (VEGF Trap) in Patients With Recurrent Symptomatic Malignant Ascites | Ovarian Neoplasms | P2 | Completed | 16 | Open-label | Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®) |
| NCT00117650 Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication | Intermittent Claudication, Peripheral Vascular Disease | P2 | Completed | 289 | RCT, Double-blind | Ad2/HIF-1α/VP16, Ad2/HIF-1α/VP16, Ad2/HIF-1α/VP16 |
| NCT06067425 Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SAR442501 in Pediatric Participants With Achondroplasia | Osteochondrodysplasia | P2 | Terminated | 16 | RCT, Open-label | SAR442501 |
| NCT00074958 A Study of Fabrazyme in Pediatric Patients With Fabry Disease | Fabry Disease | P2 | Completed | 16 | Open-label | Fabrazyme (agalsidase beta) |
| NCT06949358 A Study to Evaluate Safety and Tolerability of Olipudase Alfa in Pediatric and Adult Participants With Acid Sphingomyelinase Deficiency (ASMD) Who Completed the DFI12712 or the LTS13632 Study in France | Acid Sphingomyelinase Deficiency | P2 | Completed | 3 | Open-label | Olipudase alfa |
| NCT02040636 Study of Tetanus and Diphtheria Toxoids Adsorbed Combined With Component Pertussis Vaccine and Inactivated Poliomyelitis | Pertussis, Tetanus | P2 | Completed | 277 | RCT, Open-label | Tetanus and Diphtheria Toxoids Adsorbed Combined with Component Pertussis Vaccine and IPV, Hepatitis B vaccine |
| NCT00475865 Phase II Study of Teriflunomide as Adjunctive Therapy to Glatiramer Acetate in Subjects With Multiple Sclerosis | Multiple Sclerosis | P2 | Completed | 123 | RCT, Double-blind | Teriflunomide, Placebo (for teriflunomide), Glatiramer Acetate (GA) |
| NCT00228163 Long Term Safety and Efficacy of Teriflunomide (HMR1726) in Multiple Sclerosis With Relapses | Multiple Sclerosis | P2 | Completed | 147 | RCT, Open-label | teriflunomide (HMR1726) |
| NCT00217282 Study of Oxaliplatin and Gemcitabine With or Without Bevacizumab to Treat Advanced Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer | P2 | Completed | 45 | Open-label | oxaliplatin, gemcitabine, bevacizumab |
| NCT00771849 Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children | Meningitis, Meningococcemia | P2 | Completed | 103 | RCT, Double-blind | Meningococcal Polysaccharide Diphtheria Toxoid Conjugate, Haemophilus Influenzae Type b (Hib) vaccine |
| NCT00774878 Study of AVE1642 (IGF-1R/CD221) in Combination With Fulvestrant (Faslodex®) in Postmenopausal Patients With Advanced Hormono-dependent Breast Cancer | Breast Neoplasms | P2 | Terminated | 18 | RCT, Open-label | AVE1642, Fulvestrant |
| NCT00612677 Pemetrexed &Oxaliplatin in Patients w Recurrent NSCLCa After Failure to Platinum Based Adjuvant Chem | Lung Cancer | P2 | Terminated | 1 | Open-label | Oxaliplatin, Pemetrexed |
| NCT00043706 Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients With Early Stage Diffuse Systemic Sclerosis | Systemic Sclerosis, Scleroderma | P1P2 | Completed | — | — | Human Anti-Transforming Growth Factor Beta-1 Monoclonal Antibody |
| NCT05071053 Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab in Pretreated Participants With Gastric Cancer | Adenocarcinoma Gastric, Gastrooesophageal Cancer | P2 | Terminated | 35 | Open-label | Ramucirumab (CYRAMZA®), Tusamitamab ravtansine (SAR408701) |
| NCT00101075 Title XELOX FOR SALIVARY GLAND CANCERS | Head and Neck Cancer | P2 | Terminated | 9 | Open-label | Capecitabine, Oxaliplatin |
| NCT01511536 Cabazitaxel and Abiraterone Acetate in Patients With Metastatic Castrate-Resistant Prostate Cancer | Prostate Cancer | P1P2 | Completed | 38 | Open-label | Cabazitaxel XRP6258, Abiraterone acetate, Prednisone 5 mg |
| NCT00174616 CORE: Capecitabine, Oxaliplatin, Radiotherapy and Excision | Rectal Neoplasms | P2 | Completed | 87 | Open-label | Oxaliplatin, capecitabine, radiotherapy |
| NCT00343239 Docetaxel in Locally Advanced Gastric Adenocarcinoma | Stomach Neoplasms | P2 | Completed | 59 | Open-label | Docetaxel, Cisplatin, Fluorouracil |
| NCT00842530 Efficacy and Safety of Dengue Vaccine in Healthy Children | Dengue Virus, Dengue Fever | P2 | Completed | 4,002 | RCT, Double-blind | CYD Dengue Vaccine, Inactivated rabies virus vaccine, Placebo |
| NCT03546907 Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) | Chronic Obstructive Pulmonary Disease | P2 | Completed | 343 | RCT, Double-blind | SAR440340, Placebo, Any Inhaled Corticosteroids as prescribed by treating physician as standard of care, Any Long Acting Beta Agonist as prescribed by treating physician as standard of care, Any Long Acting Muscarinic Agonist as prescribed by treating physician as standard of care, Any short-acting β agonist as prescribed by treating physician as standard of care |
| NCT02694718 A Study of Capecitabine Plus Oxaliplatin in Combination With Pre-operative Pelvic Radiotherapy in Rectal Cancer | Rectal Cancer | P2 | Completed | 60 | Open-label | Capecitabine, Oxaliplatin |
| NCT00526110 Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients | Gastrointestinal Diseases | P1P2 | Completed | 98 | Open-label | 5-Fluorouracil, Docetaxel, Oxaliplatin |
| NCT05450562 Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors | Neoplasm | P1P2 | Terminated | 33 | Open-label | SAR444200, Atezolizumab |
| NCT00298675 Phase 1/1b Dose Escalation Study Evaluating BSI-201 as a Single Agent and in Combination With Irinotecan in Subjects With Advanced Solid Tumors | Tumors | P1 | Completed | 59 | Open-label | BSI-201 (iniparib), irinotecan |
| NCT01673737 A Phase I/Ib Trial for the Evaluation of SAR260301 in Monotherapy or in Combination With Vemurafenib in Patients With Various Advanced Cancer | Neoplasm Malignant | P1 | Completed | 75 | Open-label | SAR260301, Vemurafenib |
| NCT00170053 Comparison of Sirolimus to Tacrolimus for Long Term Therapy in Kidney Transplant With no Steroids | Kidney Diseases | P1 | Completed | 177 | Open-label | Sirolimus |
| NCT00716716 Phase I/IIa Study of FIXFc in Hemophilia B Patients | Hemophilia B | P1 | Completed | 10 | Open-label | rFIXFc |
| NCT01839526 A Study of Renal Function in Treatment-naïve, Young Male Patients With Fabry Disease | Fabry Disease | P1 | Terminated | 39 | Open-label | Iohexol |
| NCT01146678 Relative Bioavailability and Activity of Different Formulations of Insulin Glargine and Lixisenatide in Patients With Diabetes Mellitus Type 1 | Type 1 Diabetes Mellitus | P1 | Completed | 22 | RCT, Open-label | Insulin glargine HOE901, Lixisenatide AVE0010 |
| NCT00486135 Study of the Safety and Pharmacokinetics of XL147 (SAR245408) in Adults With Solid Tumors or Lymphoma | Cancer, Lymphoma | P1 | Completed | 118 | Open-label | XL147 (SAR245408), XL147 (SAR245408) |
| NCT01390818 Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors | Locally Advanced Solid Tumor, Metastatic Solid Tumor | P1 | Completed | 146 | Open-label | MSC1936369B (pimasertib), SAR245409 (PI3K and mTOR inhibitor), MSC1936369B (pimasertib), SAR245409 (PI3K and mTOR inhibitor) |
| NCT00981240 Dose Escalation, Safety and Pharmacokinetic Study of SAR103168 in Patients Refractory/ Relapsed Acute Leukemias or High-risk Myelodysplastic Syndromes | Acute Myelogenous Leukemia | P1 | Completed | 30 | Open-label | SAR103168 |
| NCT00496509 Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer | Colorectal Cancer | P1 | Completed | 24 | RCT, Open-label | ZD6474 (Zactima) 100mg, ZD6474 (Zactima) 300mg |
| NCT01465646 Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets | Pharmacokinetics | P1 | Completed | 24 | RCT, Open-label | levothyroxine, levothyroxine |
| NCT05845996 Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous and Subcutaneous Single and Repeated Doses of SAR441344 in Healthy Adult Subjects | Healthy Volunteers | P1 | Completed | 56 | RCT, Double-blind | SAR441344, placebo, Keyhole limpet hemocyanin |
| NCT05844735 A Randomized Placebo- and Active Comparator-controlled Study to Evaluate the Photosafety of SAR441566 | Rheumatoid Arthritis | P1 | Completed | 60 | RCT, Double-blind | SAR441566, Placebo, Ciprofloxacin |
| NCT00254826 Yellow Fever Virus Vaccine and Immune Globulin Study | Viremia | P1 | Completed | 80 | RCT, Double-blind | YF-VAX® plus saline, 17D YF Vaccine plus Ig, |
| NCT04521738 First-in-human Study to Assess Safety and Tolerability of a Single Subcutaneous Dose of SAR441255 in Lean to Overweight Subjects | Overweight, Healthy Subjects | P1 | Completed | 48 | RCT, Double-blind | SAR441255, placebo |
| NCT06193304 A Study to Evaluate Pharmacokinetic Parameters and Safety of Eliglustat Absorption Through the Mouth | Gaucher's Disease | P1 | Completed | 6 | Open-label | Eliglustat |
| NCT01657214 Phase I, Dose Escalation of SAR125844 in Asian Solid Tumor Patients | Neoplasm Malignant | P1 | Completed | 70 | Open-label | SAR125844 |
| NCT02049203 Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis | Aortic Valve Stenosis | P1 | Completed | 44 | RCT, Double-blind | Ataciguat, Placebo |
| NCT04770935 To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD) | Von Willebrand's Disease (VWD) | P1 | Completed | 6 | Open-label | efanesoctocog alfa (BIVV001) |
| NCT04748926 Food Effect and Relative Bioavailability Study of Rilzabrutinib in Healthy Participants | Healthy Volunteers | P1 | Completed | 24 | RCT, Open-label | rilzabrutinib SAR444671, rilzabrutinib SAR444671, rilzabrutinib SAR444671 |
| NCT01444352 Study of an Investigational Pneumococcal Vaccine at Three Dose Levels in Healthy Adults | Pneumococcal Infections, Streptococcus Pneumoniae Infections | P1 | Completed | 100 | RCT, Double-blind | Pneumococcal vaccine Formulation 1, Pneumococcal vaccine Formulation 2, Pneumococcal vaccine Formulation 3, Placebo |
| NCT01193595 Dose-escalation, Safety, Pharmacokinetics Study of AVE8062 Combined With Bevacizumab in Patients With Advanced Solid Tumors | Neoplasms, Malignant | P1 | Completed | 39 | Open-label | Ombrabulin (AVE8062), bevacizumab |
| NCT00559429 Study of Docetaxel +153 Sm-EDTMP in Patients With Hormone-Refractory Prostate Cancer | Prostate Cancer | P1 | Completed | 13 | Open-label | Docetaxel, Docetaxel, Docetaxel, Docetaxel |
| NCT01785329 Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects | Hypercholesterolemia | P1 | Completed | 60 | RCT, Open-label | alirocumab SAR236553 (REGN727) |
| NCT01074372 Ascending Dose Study of the Safety and Tolerability of REGN727 (SAR236553) in Healthy Volunteers | Healthy Volunteers | P1 | Completed | 32 | RCT, Double-blind | REGN727, Placebo |
| NCT01561781 Study in Healthy Volunteers to Assess the Pharmacokinetics (PK) of Digoxin Administered Alone and in Combination With Vandetanib | Healthy Volunteers | P1 | Completed | 14 | Open-label | Digoxin, Vandetanib |
| NCT00125827 Study of Oral Clofarabine Administered Daily for 5 Days in Adult Patients With Refractory Solid Tumors | Solid Tumors | P1 | Completed | 24 | Open-label | clofarabine (oral formulation) |
| NCT04333654 Hydroxychloroquine in Outpatient Adults With COVID-19 | Coronavirus Infection | P1 | Terminated | 8 | RCT, Double-blind | Hydroxychloroquine SAR321068, Placebo |
| NCT06118151 Safety and Immunogenicity of a Monovalent mRNA Vaccine Encoding Influenza Hemagglutinin in Adult Participants 18 Years of Age and Older | Influenza, Influenza Immunization | P1 | Completed | 388 | RCT, Double-blind | Influenza Hemagglutinin mRNA vaccine, Quadrivalent Recombinant Influenza Vaccine |
| NCT02803918 A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM) | Type 2 Diabetes Mellitus | P1 | Completed | 23 | RCT, Single-blind | Lixisenatide (AVE0010), Placebo, Basal Insulin, Metformin |
| NCT01463488 Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part I | Knee Osteoarthritis | P1 | Completed | 24 | RCT, Double-blind | SAR113945, placebo |
| NCT05918614 A Study to Determine the Effect of 500 mg Oral Dose of KD025 in Healthy Male and Post-menopausal Female Subjects | Immune System Disorder (Healthy Volunteer) | P1 | Completed | 8 | RCT, Double-blind | Belumosudil mesylate, Placebo |
| NCT01197391 Ascending Dose Study of the Safety and Tolerability of REGN728 in Healthy Volunteers | Healthy | P1 | Completed | 48 | RCT, Double-blind | REGN728 |
| NCT03310944 Comparison of Sotagliflozin Prototype Tablets With Reference Tablet in Healthy Subjects | Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus | P1 | Completed | 12 | RCT, Open-label | sotagliflozin (SAR439954) |
| NCT01484600 Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy Volunteers | Healthy | P1 | Completed | 36 | RCT, Open-label | REGN668: Injection Rate 1, REGN668: Injection Rate 2 |
| NCT00916110 Study Of Single Dose Of ATN-103 Administered To Healthy Japanese Male Subjects | Healthy | P1 | Completed | 72 | RCT, Double-blind | ATN-103, ATN-103, ATN-103, ATN-103, ATN-103, ATN-103, ATN-103, ATN-103, ATN-103 |
| NCT02101073 ALX-0061 Phase I Bioavailability Study in Healthy Volunteers | Rheumatoid Arthritis | P1 | Completed | 70 | Open-label | ALX-0061, ALX-0061 |
| NCT01063946 A Study to Investigate the Disposition of Radio-labeled AVE8062 Compound Administered as a 30-minute IV Infusion to Patients With Advanced Solid Tumor | Neoplasms, Malignant | P1 | Completed | 3 | Open-label | Ombrabulin (AVE8062) |
| NCT02422654 Taste Evaluation of Different Liquid Formulations With Eliglustat | Gaucher Disease | P1 | Completed | 8 | RCT, Single-blind | eliglustat |
| NCT01340157 Fexinidazole (1200mg) Bioavailability Under Different Food Intake Conditions | PK in Healthy Volunteers | P1 | Completed | 12 | RCT, Open-label | Fexinidazole |
| NCT05795907 Single & Multiple Ascending Dose Study of SAR443820 in Healthy Adult Participants | Amyotrophic Lateral Sclerosis (Healthy Volunteers) | P1 | Completed | 84 | RCT, Double-blind | SAR443820, Placebo |
| NCT02283775 SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients | Plasma Cell Myeloma | P1 | Completed | 54 | Open-label | Isatuximab SAR650984, Pomalidomide, Dexamethasone |
| NCT04802057 Safety and Tolerability Study in Adults With Cold Agglutinin Disease Previously Treated With SAR445088 or Never Treated With SAR445088 | Autoimmune Haemolytic Anaemia | P1 | Terminated | 9 | Open-label | SAR445088 |
| NCT02536937 A Study of the Effects of Renal Impairment on the Pharmacokinetics and Tolerability of Eliglustat Tartrate | Gaucher Disease | P1 | Completed | 32 | Open-label | eliglustat |
| NCT01544140 Study in Healthy Volunteers to Assess the Pharmacokinetics of Midazolam Administered Alone and in Combination With Vandetanib | Healthy Volunteers | P1 | Completed | 16 | Open-label | Midazolam, vandetanib |
| NCT00692900 Safety Study Involving Oxaliplatin With Docetaxel for Recurrent Ovarian,Primary Peritoneal, and Fallopian Tube Cancer | Ovarian Cancer, Peritoneal Cancer | P1 | Completed | 25 | Open-label | intravenous docetaxel with intraperitoneal oxaliplatin, intravenous oxaliplatin with intraperitoneal docetaxel |
| NCT01483911 ALX-0171 Phase I Study, Evaluating Single Ascending Dose and Multiple Dose in Healthy Male Volunteers | RSV Infection | P1 | Completed | 60 | RCT, Double-blind | ALX-0171, Placebo |
| NCT01015027 Ascending Dose Study of the Safety and Tolerability of REGN668(SAR231893) in Normal Healthy Volunteers | Healthy | P1 | Completed | 48 | RCT, Double-blind | REGN668 |
| NCT00297583 Insulin Glulisine in Type 1 Diabetes Mellitus | Type 1 Diabetes Mellitus | P1 | Completed | — | RCT, Double-blind | Insulin Glulisine |
| NCT06106074 Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult Participants | Multiple Sclerosis | P1 | Completed | 71 | RCT, Double-blind | Tolebrutinib, Placebo |
| NCT01041508 Clofarabine and Low Dose Total Body Irradiation as a Preparative Regimen for Stem Cell Transplant in Leukemia. | Leukemia Lymphoblastic, Acute, Acute Myeloid Leukemia | P1 | Completed | 18 | Open-label | Clofarabine, Cyclosporine, Mycophenolate Mofetil |
| NCT01723735 Effect of Alirocumab (SAR236553/REGN727) Administered on Top of Ezetimibe or Fenofibrate on Lipid Profiles in Healthy Subjects | Hypercholesterolemia | P1 | Completed | 79 | RCT, Open-label | Alirocumab, Ezetimibe, Ezetimibe Placebo, Fenofibrate |
| NCT01636479 Phase 1 Safety Testing of SAR405838 | Neoplasm Malignant | P1 | Completed | 77 | Open-label | SAR405838 |
| NCT00282581 Safety Study of MVA Smallpox Vaccine in HIV-positive Subjects Who Are Vaccinia Naive | HIV Infections, Smallpox | P1 | Terminated | 2 | RCT, Double-blind | MVA Smallpox Vaccine |
| NCT07272629 A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants. | Cardiac Repolarization, Healthy Volunteers | P1 | Completed | 48 | RCT, Double-blind | Balinatunfib, Moxifloxacin, Placebo |
| NCT01349855 Repeated Dosing Study With a New Insulin Glargine Formulation and Lantus® in Patients With Type 1 Diabetes Mellitus | Type 1 Diabetes Mellitus | P1 | Completed | 30 | RCT, Double-blind | Insulin glargine HOE901 |
| NCT00479076 A Phase I Study of Intravenous Aflibercept in Combination With S-1 in Japanese Cancer Patients | Neoplasms | P1 | Completed | 22 | RCT, Open-label | aflibercept (AVE0005), S-1 |
| NCT04982991 Single Ascending Dose Study of SAR443820 in Healthy Adult Chinese and Japanese Female and Male Participants | Multiple Sclerosis Healthy Subjects | P1 | Completed | 14 | Open-label | RIPK1 inhibitor |
| NCT07071558 Study to Evaluate the Safety and Immunogenicity of Investigational Vaccines Using the RSV (Respiratory Syncytial Virus) Monovalent Antigen in Healthy Participants 18 to 49 Years of Age | Respiratory Syncytial Virus Immunization | P1 | Completed | 240 | RCT, Double-blind | RSV vaccine formulation 1 dose, RSV vaccine formulation 2 dose, RSV vaccine formulation 3 dose, RSV vaccine formulation 4 dose, RSV vaccine formulation 5 dose, RSV vaccine formulation 6 dose, RSV vaccine formulation 7 dose, RSV vaccine formulation 8 dose |
| NCT06444204 A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008) | Hepatic Function Abnormal, Healthy Volunteers | P1 | Completed | 29 | Open-label | Rilzabrutinib |
| NCT03634982 Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors | Solid Tumors | P1 | Unknown | 133 | Open-label | RMC-4630 |
| NCT05839626 A Study to Investigate Safety and Efficacy With SAR445514 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) and Relapsed/Refractory Light-chain Amyloidosis (RRLCA) | Relapsed/Refractory Multiple Myeloma, Amyloid Light-chain Amyloidosis | P1 | Terminated | 32 | RCT, Open-label | SAR445514 |
| NCT01909843 ALX-0171 Safety Study in Adults With Hyperresponsive Airways | Respiratory Syncytial Virus Infection | P1 | Completed | 24 | Open-label | ALX-0171 |
| NCT04045795 Multi-center, Open-label, Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) | Multiple Myeloma | P1 | Completed | 56 | RCT, Open-label | isatuximab SAR650984 IV, pomalidomide, dexamethasone, isatuximab SAR650984 SC |
| NCT01233895 Study of AVE1642 Anti-IGF1R Monoclonal Antibody in Patients With Advanced Multiple Myeloma | Multiple Myeloma | P1 | Completed | 26 | RCT, Open-label | AVE1642, Velcade |
| NCT02395237 COMPOUND (INN): HOE490O - GLIMEPIRIDE / METFORMIN HCl (Amaryl® M)0 (Glimepiride/Metformin Hydrochloride Immediate Release Combination Tablet) in Fed Conditions in Healthy Male and/or Female Subjects. | Healthy | P1 | Withdrawn | — | RCT, Open-label | : Amaryl® M IR 2/1000 |
| NCT04189029 PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study | Heart Failure, Heart Failure With Preserved Ejection Fraction | Unknown | 175 | — | — | |
| NCT01693302 Timing of Meal Insulin Boluses for Optimal Postprandial Glycemic Control in Type 1 Diabetes | Type 1 Diabetes | N/A | Completed | 23 | RCT, Open-label | — |
| NCT00728364 Anderson-Fabry Disease in Chronic Kidney Disease Patients Not on Renal Replacement Therapy | Focus of Study: Prevalence of Fabry Disease in CKD Population | Completed | 4,353 | — | — | |
| NCT02824068 Long-term Outcome in Late-onset Pompe Disease Treated Beyond 36 Months (STIG-Pompe-Study) | Pompe Disease | Completed | 112 | — | glucosidase alfa | |
| NCT00212849 Autologous Chondrocyte Implantation in the Patellofemoral Joint | Chondrosis, Patellar Articular Cartilage Lesions | Completed | 35 | — | — | |
| NCT05819125 Comparison of the Risk of Venous Thromboembolism (i.e., Blood Clots in the Veins) and Bleeding Events in a Population of Obese Patients Receiving Higher-Dose or Extended-Duration Versus Conventional-Dose or Conventional-Duration of Prophylaxis (i.e., Preventive Treatment) With Enoxaparin | Venous Thromboembolism | Terminated | 21,000 | — | — | |
| NCT03954717 Pilot Study Evaluating Functional and Wellness Outcomes of the Shepherd CAN DO MS Program | Multiple Sclerosis | Completed | 111 | — | — | |
| NCT00665730 Evaluation of the Safety and Effectiveness of Sepraspray™ in Reducing Post-surgical Adhesions | Abdominal Adhesions | N/A | Terminated | 5 | RCT, Single-blind | — |
| NCT00709293 Role of Intraoperative Thymoglobulin in Decreasing Ischemia-Reperfusion Injury in Pediatric Heart Transplant Recipients | Ischemia Reperfusion Injury, Heart Transplantation | N/A | Withdrawn | — | RCT, Double-blind | Anti-Thymocyte Globulin, Normal Saline |
| NCT03147898 Observational Study Describing the Immune Profile Induced By Pertussis Vaccines | Whooping Cough, Pertussis | Completed | 90 | — | — | |
| NCT01764152 Clinical Trial to Assess the Influenza Vaccination (FLUVAC 02) | Adult Hospitalized | N/A | Completed | 450 | Open-label | — |
| NCT01659294 Diabetes Outcomes and Nurse Case Manager Study | Type 2 Diabetes | N/A | Completed | 140 | RCT, Open-label | — |
| NCT01010464 An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen | Open Abdomen | N/A | Withdrawn | — | RCT, Open-label | — |
| NCT03406663 The Korean TITRATION Study: Comparison of the Self-titration Methods for Glargine-300 | Type 2 Diabetes Mellitus | N/A | Completed | 130 | RCT, Open-label | — |
| NCT00804284 Database Surveillance Safety Study of PENTACEL® Vaccine | Diphtheria, Tetanus | Completed | 62,538 | — | DTaP-IPV/Hib, Other DTap Vaccines | |
| NCT04958070 The Intensively Follow-up Examinations for Asymptomatic MPS I Infants in Taiwan | MPS I | Unknown | 20 | — | — | |
| NCT01237314 The Impact of Food on Blood Sugar in People With Type 2 Diabetes | Type 2 Diabetes | Completed | 46 | — | — | |
| NCT05075499 Immune Response to COVID-19 Vaccine in Multiple Sclerosis Patients Treated With Teriflunomide and Alemtuzumab | Multiple Sclerosis | N/A | Unknown | 70 | Open-label | COVID-19 vaccination |
| NCT03643328 Ex Vivo Evaluation of Immunity Activation Face to S. Aureus Antigens and Adjuvants of a Vaccine Candidate in Cells From Haemodialysis Patients | Staphylococcus Aureus | N/A | Completed | 50 | Open-label | blood samples, nasal swabs |
| NCT04997772 Digital Health Platform Customized for Patients With Gaucher Disease | Gaucher Disease, Patient Reported Outcome | Completed | 80 | — | — | |
| NCT07411638 Non-interventional Translational Study in Mild, Moderate and Severe Acne Patients | Acne | Not Yet Recruiting | 200 | — | — | |
| NCT05442645 A Study in Male and Female Adult Patients With Atopic Dermatitis Treated With Dupilumab in Taiwan | Atopic Dermatitis | Completed | 80 | — | — | |
| NCT00337181 Follow up of Thai Adult Volunteers With Breakthrough HIV Infection After Participation in a Preventive HIV Vaccine Trial | HIV-1 | Completed | 114 | — | — | |
| NCT02580669 Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis | Progressive Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | N/A | Terminated | 70 | Open-label | — |
| NCT00995748 The RECORD Asia-Pacific Atrial Fibrillation Registry | Atrial Fibrillation | Completed | 2,674 | — | — | |
| NCT01165697 Establishment of Biomarkers for Fabry Disease | Fabry Disease | Completed | 4 | — | — | |
| NCT04057859 PCa Patients Managed With ADT to Examine the Effect of Nutritional Guidance and Aerobic/Resistance Fitness Training | Cancer of the Prostate | Completed | 271 | — | — | |
| NCT00716352 Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes | Acute Coronary Syndromes, Coronary Artery Disease | N/A | Completed | 1,340 | RCT | — |
| NCT05906706 Compassionate Use of Dupilumab for Adult Patients With Bullous Pemphigoid | Bullous Pemphigoid | APPROVED_FOR_MARKETING | — | — | dupilumab | |
| NCT05629260 The Optimization of Haploidentical Hematopoietic Stem Cell Transplantation | Hematological Malignancy | Unknown | 300 | — | ATG, Post-transplantation cyclophosphamide | |
| NCT02061124 Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota | Type 2 Diabetes | N/A | Completed | 50 | RCT, Double-blind | Sevelamer 1600 mg TID for 7 days, Placebo 1600 mg TID for 7 days |
| NCT00394524 Trial Between a Computer-Guided Insulin Infusion Protocol Versus a Standard Insulin Infusion Algorithm in Medical ICU | Diabetes or With New Hyperglycemia | N/A | Completed | 160 | RCT, Open-label | — |
| NCT07663136 Finding Immune Nascent Type 1 Diabetes | Healthy Adult, Type 1 Diabetes (T1D) | N/A | Not Yet Recruiting | 3,800 | RCT, Open-label | — |
| NCT01929473 Seroepidemiological Study of Pertussis and Other Infectious Diseases | Pertussis Infection | Completed | 3,830 | — | — | |
| NCT00971074 Study of Viscosupplementation for the Treatment of Knee Pain After Menisectomy | Arthralgia | N/A | Withdrawn | — | RCT, Double-blind | Hylan G-F 20 |
| NCT04430881 A National Study in Patients With Unexplained Splenomegaly | Gaucher Disease, Splenomegaly | Completed | 506 | — | — | |
| NCT05622331 Burden of Respiratory Syncytial Virus (RSV) in Children in Sweden (BRICS): A Retrospective Study in Sweden | Respiratory Syncytial Virus (RSV) | Completed | 1,100,000 | — | — | |
| NCT01206712 Beta Cell Relieving and Cardiovascular Protective Effects of LANTUS Treatment in Type 2 Diabetes Patients | Diabetes Mellitus, Type 2 | Completed | 106 | — | — | |
| NCT00992251 Eligard Observational Registry for Patients With Prostate Cancer | Cancer of the Prostate | Completed | 354 | — | — | |
| NCT00275717 A Study That Will Look at the Impact of Immunosuppression on Antibody Production in Kidney Transplant Recipients. | Kidney Transplant | Completed | 60 | — | — | |
| NCT00270712 A Study of Factors That Affect Long-Term Kidney Transplant Function | Kidney Transplant | Completed | 3,175 | — | — | |
| NCT02207075 Measuring Active Microglia in Progressive Multiple Sclerosis | Secondary Progressive Multiple Sclerosis | Completed | 50 | — | [C11]PK-1195 PET scan | |
| NCT00748839 Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical | Heparin-induced Thrombocytopenia | Completed | 2,700 | — | — | |
| NCT07692217 TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies | Hemophilia A, Factor VIII (FVIII) | Not Yet Recruiting | 60 | — | Half-life factor VIII based replacement therapy, Non-FVIII based replacement therapy | |
| NCT05687474 Baby Detect : Genomic Newborn Screening | Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1 | Completed | 6,824 | — | — | |
| NCT04725669 Seroprevalence of Pertussis Among Children and Adolescents in Croatia | Immunogenicity, Vaccine | N/A | Unknown | 1,500 | Open-label | — |
| NCT04173442 Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy | Atopic Dermatitis (AD), Asthma | Completed | 581 | — | dupilumab | |
| NCT02672137 Knowledge Translation for Patients With Acute Coronary Syndromes | Acute Coronary Syndromes | N/A | Completed | 4,604 | RCT, Open-label | — |
| NCT01043757 Financial Incentives for Increasing Exercise | Sedentary Lifestyle, Obesity | N/A | Withdrawn | — | RCT, Double-blind | — |
| NCT01104740 Dengue Seroprevalence Study in Blood Donors in the French West Indies | Blood Donors, Dengue | Completed | 817 | — | — | |
| NCT02490982 Teriflunomide Observational Effectiveness Study | Relapsing Remitting Multiple Sclerosis | Completed | 106 | — | Teriflunomide | |
| NCT01737372 A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis | Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | Completed | 49 | — | — | |
| NCT00248352 A Study Comparing Standard Care for Diabetes to Case-managed Care for Diabetes in Patients With Coronary Artery Disease | Diabetes Mellitus, Type 2, Coronary Disease | N/A | Completed | 169 | RCT, Open-label | — |
| NCT00344825 Vitalis Study - Observational Study on the Quality of Life in Patients Under Treatment for B-Chronic Lymphocytic Leukemia (B-CLL) | Leukemia, B-Cell, Chronic | Completed | 300 | — | Alemtuzumab (MabCampath, BAY86-5045) and Fludarabine Phosphate (Fludara, BAY86-4864) | |
| NCT03492489 Expanded Access Protocol for Cemiplimab in Metastatic or Locally Advanced Cutaneous Squamous Cell Carcinoma | Cutaneous Squamous Cell Carcinoma | NO_LONGER_AVAILABLE | — | — | cemiplimab | |
| NCT03197597 EUpertstrain 4 Study of Bordetella Pertussis Isolates | Bordetella Pertussis, Whooping Cough | Completed | 265 | — | — | |
| NCT00582309 Comparative Trial Between 3 Types of Insulin Infusion Protocols | Hyperglycemia | N/A | Completed | 151 | RCT, Open-label | — |
| NCT02890147 Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Case-control | Healthy Subjects | Completed | 649 | — | — | |
| NCT03694392 Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years | Influenza, Pneumonia | Completed | 2,776,278 | — | Flublok Quadrivalent, Standard Dose Inactivated Influenza Vaccine (SD-IIV) | |
| NCT06258577 Screening for Gaucher Disease and Acid Sphingomyelinase Deficiency | Gaucher Disease | Not Yet Recruiting | 50 | — | — | |
| NCT01747759 Evaluation of a Preoperative Education in Total Knee Arthroplasty | Knee Osteoarthritis (Knee OA) | N/A | Completed | 44 | RCT, Double-blind | — |
| NCT00186940 Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients | Leukemia, Lymphoma | Completed | 16 | — | Rasburicase |