
TG Therapeutics Inc
TGTXHealthcare|Biotechnology|USA
$57.12
-1.94 (-3.28%)
Tangible Book
$3.81
Graham Number
$15.81
Clinical Trials (54)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT07225361 Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis | Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting | P4 | Recruiting | 40 | Open-label | Ublituximab |
| NCT07389590 Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis | Multiple Sclerosis | P4 | Recruiting | 50 | RCT, Single-blind | Ublituximab, Ocrelizumab |
| NCT07211633 A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Radiological and Clinical Effects of Subcutaneous Ublituximab in Participants With Relapsing Multiple Sclerosis (RMS) | Relapsing Multiple Sclerosis | P3 | Active | 360 | RCT, Open-label | Ublituximab, Ublituximab |
| NCT04130997 An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosis | Relapsing Multiple Sclerosis (RMS) | P3 | Active | 1,100 | Open-label | Ublituximab |
| NCT07220252 Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis | Relapsing Multiple Sclerosis | P2P3 | Recruiting | 240 | RCT, Double-blind | Ublituximab, Placebo, Placebo, Fingolimod |
| NCT05877963 Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab | Relapsing Multiple Sclerosis | P3 | Recruiting | 800 | RCT, Double-blind | Ublituximab, Placebo |
| NCT07673744 A Study to Evaluate the Efficacy and Safety of Maintenance Ublituximab Following Induction With Efgartigimod Administration in Participants With Myasthenia Gravis (MG) | Myasthenia Gravis | P2 | Recruiting | 120 | RCT, Double-blind | Ublituximab, Placebo |
| NCT07103746 Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy | Autoimmune Disorders | P2 | Recruiting | 30 | RCT, Double-blind | Ublituximab, Placebo for Ublituximab |
| NCT07503873 A Study to Evaluate Pharmacokinetics (PK) and Safety of Subcutaneous (SC) Ublituximab Administered at Various Injection Sites and Relative Bioavailability Via Autoinjector (AI) Versus Syringe Subcutaneously in Participants With Multiple Sclerosis (MS) | Multiple Sclerosis | P2 | Recruiting | 350 | RCT, Open-label | Ublituximab, Ublituximab |
| NCT04624633 Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | P2 | Active | 29 | Open-label | Acalabrutinib, Umbralisib, Ublituximab |
| NCT06680037 A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders | B-cell Mediated Autoimmune Disorders | P1 | Recruiting | 100 | Open-label | Azercabtagene zapreleucel (azer-cel) |
| NCT07376707 A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors | CRC (Colorectal Cancer), Melanoma (Skin Cancer) | P1 | Recruiting | 194 | Open-label | TGI-5 |
| NCT05746897 A First-in-human, Phase I, Open-label, Multicenter Study of NM1F(Anti-PVRIG) in Patients With Advanced Solid Tumors | Ovarian Cancer, Melanoma | P1 | Recruiting | 38 | Open-label | NM1F Injection, Pembrolizumab injection |
| NCT06374173 A Phase 1 Study to Evaluate TGI-6 in Subjects With Locally Advanced/Metastatic Solid Tumors | Advanced or Metastatic Solid Tumors | P1 | Recruiting | 123 | Open-label | TGI-6 Injection |
| NCT06864936 Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis | Multiple Sclerosis (MS) - Relapsing-remitting | N/A | Recruiting | 30 | Open-label | Ublituximab |
| NCT06143514 A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk | Relapsing Multiple Sclerosis | Recruiting | 16 | — | — | |
| NCT06433765 A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS) | Multiple Sclerosis | Recruiting | 728 | — | — | |
| NCT06433752 A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS) | Relapsing Multiple Sclerosis, Multiple Sclerosis | Recruiting | 2,000 | — | — | |
| NCT03801525 Study to Assess the Efficacy and Safety of Ublituximab in Combination With Umbralisib and Venetoclax Compared to Ublituximab in Combination With Umbralisib in Subjects With CLL (ULTRA-V) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | P2P3 | Terminated | 277 | RCT, Open-label | Ublituximab, Umbralisib, Venetoclax |
| NCT02612311 Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | P3 | Terminated | 603 | RCT, Open-label | Obinutuzumab, Ublituximab, TGR-1202, Chlorambucil |
| NCT02793583 Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma | Diffuse Large B-Cell Lymphoma, Follicular Lymphoma | P2P3 | Terminated | 710 | RCT, Open-label | Ublituximab, Umbralisib, Bendamustine |
| NCT03277261 Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS) ( ULTIMATE 1 ) | Relapsing Multiple Sclerosis (RMS) | P3 | Completed | 549 | RCT, Double-blind | Ublituximab, Teriflunomide, Oral Placebo, IV Placebo |
| NCT02301156 Ublituximab in Combination With Ibrutinib Versus Ibrutinib Alone in Participants With Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P3 | Completed | 126 | RCT, Open-label | Ublituximab, Ibrutinib |
| NCT03277248 Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS) | Relapsing Multiple Sclerosis (RMS) | P3 | Completed | 545 | RCT, Double-blind | Ublituximab, Teriflunomide, Oral Placebo, IV Placebo |
| NCT07680946 Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia | Schizophrenia | P2 | Not Yet Recruiting | 60 | Open-label | Ublituximab |
| NCT03381170 An Extension of the TG1101-RMS201 Trial | Relapsing Remitting Multiple Sclerosis | P2 | Completed | 48 | Open-label | Ublituximab |
| NCT03207256 Extension Trial of Ublituximab and TGR-1202 in Combination or as Single Agents in Subjects Currently Receiving Treatment on Ublituximab and/or TGR-1202 Trials | Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma | P2 | Terminated | 51 | Open-label | TGR-1202, TGR-1202 + Ublituximab |
| NCT01647971 Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma | Non-Hodgkins Lymphoma, B-cell Lymphoma | P1P2 | Completed | 39 | Open-label | Ublituximab |
| NCT02738775 Phase IIa Study of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis | Multiple Sclerosis | P2 | Completed | 49 | RCT, Double-blind | Ublituximab, Placebo |
| NCT04016805 Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Participants With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax | Chronic Lymphocytic Leukemia | P2 | Terminated | 41 | Open-label | Ublituximab, Umbralisib, Ibrutinib, Venetoclax, Acalabrutinib Oral Capsule |
| NCT04163718 TGR-1202 (Umbralisib) in Treatment Naïve Patients With Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P2 | Terminated | 12 | Open-label | Umbralisib |
| NCT02656303 A Study to Evaluate the Safety and Efficacy of Ublituximab in Combination With Umbralisib for Participants Previously Enrolled in Protocol UTX-TGR-304 | Chronic Lymphocytic Leukemia | P2 | Terminated | 116 | Open-label | Ublituximab, Umbralisib |
| NCT03776864 Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma | Hodgkin's Lymphoma | P2 | Terminated | 6 | Open-label | Pembrolizumab, Umbralisib |
| NCT03178201 TGR1202 in Relapsed and Refractory Follicular Lymphoma | Follicular Lymphoma | P2 | Terminated | 5 | Open-label | TGR-1202 |
| NCT03379051 Phase I/II Study of Venetoclax or Lenalidomide in Combination With Ublituximab and Umbralisib in Subjects With Relapsed or Refractory CLL/SLL and NHL | Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma | P1P2 | Terminated | 78 | Open-label | Venetoclax, Umbralisib, Ublituximab, Lenalidomide |
| NCT04149821 Umbralisib Plus Ublituximab (U2) in Progressive CLL After Novel Therapy | Chronic Lymphocytic Leukemia, CLL Progression | P2 | Terminated | 1 | Open-label | Umbralisib, Ublituximab |
| NCT02742090 Evaluate the Efficacy and Safety of TGR-1202 in Participants With Chronic Lymphocytic Leukemia Who Are Intolerant to Prior Therapy | Chronic Lymphocytic Leukemia | P2 | Terminated | 51 | Open-label | Umbralisib |
| NCT02013128 Ublituximab + Ibrutinib in Select B-cell Malignancies | Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma | P1P2 | Completed | 66 | Open-label | Ublituximab, Ibrutinib |
| NCT03828448 Study to Assess Umbralisib Plus Ublituximab in Participants With Treatment Naïve Follicular Lymphoma | Follicular Lymphoma, Small Lymphocytic Lymphoma | P2 | Terminated | 34 | Open-label | Ublituximab, Umbralisib |
| NCT03364231 Study to Assess the Efficacy and Safety of Umbralisib in Participants With Non-Follicular Indolent Non-Hodgkin's Lymphoma | Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia | P2 | Completed | 21 | Open-label | Umbralisib |
| NCT03919175 Umbralisib and Rituximab as Initial Therapy for Patients With Follicular Lymphoma and Marginal Zone Lymphoma | Lymphoma, Follicular Lymphoma | P2 | Terminated | 18 | Open-label | Umbralisib, Rituximab |
| NCT04806035 Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia | CLL, SLL | P1 | Terminated | 21 | Open-label | TG-1801, Ublituximab |
| NCT01767766 Evaluate the Safety and Efficacy of TGR 1202 in Patients With Relapsed or Refractory Hematologic Malignancies | Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia | P1 | Completed | 90 | Open-label | TGR-1202 |
| NCT01744912 Ublituximab in Combination With Lenalidomide in Patients With B-Cell Lymphoid Malignancies | Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia | P1 | Terminated | 10 | Open-label | Ublituximab, Lenalidomide |
| NCT03804996 Study of TG-1801 in Subjects With B-Cell Lymphoma | B-Cell Lymphoma | P1 | Completed | 50 | Open-label | TG-1801, Ublituximab |
| NCT02164006 Novel PI3K Delta Inhibitor TGR-1202, in Combination With Brentuximab Vedotin for Hodgkin's Lymphoma Patients | Hodgkin's Lymphoma | P1 | Completed | 16 | Open-label | TGR-1202 + brentuximab vedotin |
| NCT02006485 Ublituximab in Combination With TGR-1202 +/- Ibrutinib or Bendamustine in Patients With B-cell Malignancies | Chronic Lymphocytic Leukemia, Non-Hodgkin's Lymphoma | P1 | Completed | 160 | Open-label | Ublituximab + TGR-1202, Ublituximab + TGR-1202 + ibrutinib, Ublituximab + TGR-1202 + bendamustine |
| NCT03671590 Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies | Non Hodgkin Lymphoma, Chronic Lymphocytic Leukemia | P1 | Terminated | 172 | Open-label | TG-1701, Umbralisib, Ublituximab |
| NCT02535286 Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation | Chronic Lymphocytic Leukemia, Richter Syndrome | P1 | Completed | 27 | Open-label | Umbralisib, ublituximab, TG-1501 |
| NCT03778073 Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma | B-cell Non Hodgkin Lymphoma, Richter's Transformation | P1 | Terminated | 18 | Open-label | Cosibelimab, Cosibelimab + Ublituximab + Bendamustine combination, Cosibelimab + Ublituximab + Bendamustine combination |
| NCT02268851 A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Mantle Cell Lymphoma | P1 | Completed | 45 | Open-label | TGR-1202, Ibrutinib |
| NCT02100852 TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL) | Chronic Lymphocytic Leukemia | P1 | Completed | 19 | Open-label | TGR-1202 + Obinutuzumab + Chlorambucil |
| NCT02574663 TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors | Pancreatic Cancer, Colorectal Cancer | P1 | Completed | 66 | Open-label | TGR-1202, nab-paclitaxel + gemcitabine, Oxaliplatin + Folinic acid + Fluorouracil, Oxaliplatin + Folinic acid + Fluorouracil + Bevacizumab |
| NCT07577583 Long-term Follow-up (LTFU) of Participants Who Received Azer-Cel | B-cell Mediated Autoimmune Disorders | Not Yet Recruiting | 32 | — | — |