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Karyopharm Therapeutics Inc.

KPTI
Healthcare|Biotechnology|US
$0.05
-0.01 (-8.65%)
Cash / Share
$2.25

Ownership Breakdown

65.4%
Float
22.7M
Shares Outstanding
14.8M
Float Shares

Major Holders (38)

Combined: 180.3%

Holders of 5%+ from their latest Schedule 13D/13G filing in the last two years. Percentages are as of each filing date.

HolderType% of ClassSharesFiledFiling
Rajeev ShahHC, IN9.90%2,302,504Aug 14, 202613D/G
RA Capital Healthcare Fund, L.P.Partnership9.90%2,302,504Aug 14, 202613D/G
Peter KolchinskyHC, IN9.90%2,302,504Aug 14, 202613D/G
RA Capital Management, L.P.IA, PN9.90%2,302,504Aug 14, 202613D/G
Affinity Asset Advisors, LLCIA, OO8.60%2,073,517May 14, 202613D/G
Michael ChoHC, IN8.60%2,073,517May 14, 202613D/G
Affinity Healthcare Fund, LPPartnership7.83%664,224Apr 10, 202513D/G
Adage Capital Management, L.P.IA, PN6.78%1,536,736Aug 12, 202613D/G
Phillip GrossHC, IN6.78%1,536,736Aug 12, 202613D/G
Robert AtchinsonHC, IN6.78%1,536,736Aug 12, 202613D/G
T. Rowe Price Investment Management, Inc.Investment adviser6.60%1,539,147Jun 5, 202613D/G
Goldman Sachs & Co. LLCBD, IA, OO6.30%1,429,197Aug 11, 202613D/G
The Goldman Sachs Group, Inc.HC, CO6.30%1,429,197Aug 11, 202613D/G
BlackRock, Inc.Holding company5.60%1,266,084Jul 28, 202613D/G
Jason WoodIndividual4.99%1,000,708Nov 3, 202513D/G
J. Wood Capital Advisors LLCOther4.99%1,000,708Nov 3, 202513D/G
Highbridge Capital Management, LLCIA, OO4.90%649,984Nov 14, 202513D/G
Jpmorgan Chase & Co.Holding company4.90%427,624Oct 17, 202513D/G
The Vanguard GroupInvestment adviser4.70%408,222Oct 30, 202513D/G
Anders HoveIndividual4.50%1,021,668Oct 8, 202613D/G
David WitzkeIndividual3.70%4,741,060Nov 14, 202413D/G
Avidity Capital Partners (GP) LLCOther3.70%4,741,060Nov 14, 202413D/G
Avidity Partners Management LPIA, PN3.70%4,741,060Nov 14, 202413D/G
Avidity Partners Management (GP) LLCOther3.70%4,741,060Nov 14, 202413D/G
Avidity Capital Partners Fund (GP) LPPN, OO3.70%4,741,060Nov 14, 202413D/G
Michael GregoryIndividual3.70%4,741,060Nov 14, 202413D/G
Opaleye Management Inc.IA, CO2.67%619,089May 11, 202613D/G
Opaleye, L.P.Partnership2.67%619,089May 11, 202613D/G
James SilvermanIndividual2.67%619,089May 11, 202613D/G
Acorn Bioventures 2, L.P.Partnership2.60%592,567Oct 8, 202613D/G
Acorn Capital Advisors GP 2, LLCOther2.60%592,567Oct 8, 202613D/G
Acorn Bioventures, L.P.Partnership1.90%429,101Oct 8, 202613D/G
Acorn Capital Advisors GP, LLCOther1.90%429,101Oct 8, 202613D/G
Avidity Master Fund LPPN, OO1.50%1,884,000Nov 14, 202413D/G
Integrated Core Strategies (US) LLCOther0.20%42,888Oct 28, 202613D/G
Israel A. EnglanderIndividual0.20%42,888Oct 28, 202613D/G
Millennium Group Management LLCOther0.20%42,888Oct 28, 202613D/G
Millennium Management LLCOther0.20%42,888Oct 28, 202613D/G

Insider Trades (100)

Last 4 quarters: 344,806 acquired · 37,669 disposed
InsiderPositionDateTypeSharesPriceValueFiling
Abate KristinChief Accounting OfficerOct 16, 2026SELL4,788$0.34$1.6KForm 4
Abate KristinChief Accounting OfficerOct 1, 2026SELL378$1.19$449.82Form 4
Abate KristinChief Accounting OfficerSep 1, 2026SELL19$2.02$38.38Form 4
Poulton StuartEVP, Chief Development OfficerJul 28, 2026SELL189$7.10$1.3KForm 4
Oliger Christy J.directorMay 21, 2026AWARD15,508——Form 4
PAKIANATHAN DEEPIKAdirectorMay 21, 2026AWARD15,508——Form 4
Schor ChendirectorMay 21, 2026AWARD15,508——Form 4
Su ZhendirectorMay 21, 2026AWARD15,508——Form 4
BOHLIN GAREN GdirectorMay 21, 2026AWARD15,508——Form 4
Greene Barry EdirectorMay 21, 2026AWARD15,508——Form 4
Poulton StuartEVP, Chief Development OfficerMay 13, 2026AWARD896——Form 4
Poulton StuartEVP, Chief Development OfficerMay 14, 2026SELL403$9.50$3.8KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerMay 13, 2026AWARD947——Form 4
Rangwala ReshmaEVP & Chief Medical OfficerMay 14, 2026SELL408$9.50$3.9KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerMay 13, 2026AWARD947——Form 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerMay 14, 2026SELL324$9.50$3.1KForm 4
Abate KristinChief Accounting OfficerMay 13, 2026AWARD121——Form 4
Abate KristinChief Accounting OfficerMay 14, 2026SELL53$9.50$503.50Form 4
Paulson Richard A.director, officer: President and CEOMay 13, 2026AWARD4,920——Form 4
Paulson Richard A.director, officer: President and CEOMay 14, 2026SELL2,203$9.50$20.9KForm 4
Mano MichaelEVP, CLO&SecretaryMay 13, 2026AWARD700——Form 4
Mano MichaelEVP, CLO&SecretaryMay 14, 2026SELL266$9.50$2.5KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerApr 21, 2026SELL449$8.94$4.0KForm 4
Mano MichaelEVP, CLO&SecretaryMar 2, 2026SELL3,526$9.41$33.2KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerMar 2, 2026SELL4,604$9.41$43.3KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerMar 2, 2026SELL5,066$9.41$47.7KForm 4
Paulson Richard A.director, officer: President and CEOMar 2, 2026SELL12,361$9.41$116.3KForm 4
Poulton StuartEVP, Chief Development OfficerMar 2, 2026SELL5,101$9.41$48.0KForm 4
Poulton StuartEVP, Chief Development OfficerFeb 17, 2026SELL378$8.63$3.3KForm 4
Paulson Richard A.director, officer: President and CEOFeb 5, 2026AWARD81,060——Form 4
Macomber LoriEVP, CFO & TreasurerFeb 3, 2026SELL1,626$6.30$10.2KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerJan 31, 2026AWARD32,415——Form 4
Rangwala ReshmaEVP & Chief Medical OfficerJan 31, 2026AWARD32,415——Form 4
Macomber LoriEVP, CFO & TreasurerJan 31, 2026AWARD32,415——Form 4
Mano MichaelEVP, CLO&SecretaryJan 31, 2026AWARD32,415——Form 4
Poulton StuartEVP, Chief Development OfficerJan 31, 2026AWARD32,415——Form 4
Abate KristinChief Accounting OfficerJan 27, 2026AWARD92——Form 4
Abate KristinChief Accounting OfficerJan 28, 2026SELL50$7.03$351.50Form 4
Abate KristinChief Accounting OfficerJan 21, 2026SELL265$5.96$1.6KForm 4
Abate KristinChief Accounting OfficerOct 15, 2025AWARD12,799——Form 4
Poulton StuartEVP, Chief Development OfficerOct 15, 2025AWARD39,682——Form 4
Mano MichaelSVP, General Counsel&SecretaryOct 15, 2025AWARD43,650——Form 4
Paulson Richard A.director, officer: President and CEOOct 15, 2025AWARD114,285——Form 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerOct 15, 2025AWARD43,650——Form 4
Macomber LoriEVP, CFO & TreasurerOct 15, 2025AWARD43,650——Form 4
Abate KristinChief Accounting OfficerOct 1, 2025SELL362$6.30$2.3KForm 4
Paulson Richard A.director, officer: President and CEOSep 12, 2025AWARD2,800——Form 4
Paulson Richard A.director, officer: President and CEOSep 15, 2025SELL1,257$6.43$8.1KForm 4
Mano MichaelSVP, General Counsel&SecretarySep 12, 2025AWARD612——Form 4
Mano MichaelSVP, General Counsel&SecretarySep 15, 2025SELL234$6.43$1.5KForm 4
Poulton StuartEVP, Chief Development OfficerSep 12, 2025AWARD888——Form 4
Poulton StuartEVP, Chief Development OfficerSep 15, 2025SELL401$6.43$2.6KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerSep 12, 2025AWARD945——Form 4
Rangwala ReshmaEVP & Chief Medical OfficerSep 15, 2025SELL408$6.43$2.6KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerSep 12, 2025AWARD945——Form 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerSep 15, 2025SELL325$6.43$2.1KForm 4
Abate KristinChief Accounting OfficerSep 12, 2025AWARD46——Form 4
Abate KristinChief Accounting OfficerSep 15, 2025SELL23$6.43$147.89Form 4
Abate KristinChief Accounting OfficerSep 3, 2025SELL12$6.78$81.36Form 4
Poulton StuartEVP, Chief Development OfficerJul 29, 2025SELL191$4.37$834.67Form 4
Abate KristinChief Accounting OfficerJul 22, 2025SELL238$4.00$952.00Form 4
Su ZhendirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
PAKIANATHAN DEEPIKAdirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
Oliger Christy J.directorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
Mirza Mansoor RazadirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
Greene Barry EdirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
Schor ChendirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
BOHLIN GAREN GdirectorMay 28, 2025AWARD4,600$4.48$20.6KForm 4
Paulson Richard A.director, officer: President and CEOMay 6, 2025SELL236$7.12$1.7KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerApr 23, 2025SELL419$6.17$2.6KForm 4
Paulson Richard A.director, officer: President and CEOApr 4, 2025SELL245$3.74$916.30Form 4
Mano MichaelSVP, General Counsel&SecretaryMar 4, 2025SELL2,793$6.29$17.6KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerFeb 28, 2025AWARD4,583——Form 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerFeb 28, 2025AWARD5,416——Form 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerFeb 28, 2025AWARD10,833$7.95$86.1KForm 4
Cheng Sohanya RoshanEVP & Chief Commercial OfficerFeb 28, 2025AWARD9,166$7.95$72.9KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerFeb 28, 2025AWARD4,583——Form 4
Rangwala ReshmaEVP & Chief Medical OfficerFeb 28, 2025AWARD5,416——Form 4
Rangwala ReshmaEVP & Chief Medical OfficerFeb 28, 2025AWARD10,833$7.95$86.1KForm 4
Rangwala ReshmaEVP & Chief Medical OfficerFeb 28, 2025AWARD9,166$7.95$72.9KForm 4
Poulton StuartEVP, Chief Development OfficerFeb 28, 2025AWARD4,583——Form 4
Poulton StuartEVP, Chief Development OfficerFeb 28, 2025AWARD5,000——Form 4
Poulton StuartEVP, Chief Development OfficerFeb 28, 2025AWARD10,000$7.95$79.5KForm 4
Poulton StuartEVP, Chief Development OfficerFeb 28, 2025AWARD9,166$7.95$72.9KForm 4
Abate KristinChief Accounting OfficerFeb 28, 2025AWARD933——Form 4
Abate KristinChief Accounting OfficerFeb 28, 2025AWARD1,866$7.95$14.8KForm 4
Paulson Richard A.director, officer: President and CEOFeb 28, 2025AWARD20,000——Form 4
Paulson Richard A.director, officer: President and CEOFeb 28, 2025AWARD40,000$7.95$318.0KForm 4
Mano MichaelSVP, General Counsel&SecretaryFeb 28, 2025AWARD2,250——Form 4
Mano MichaelSVP, General Counsel&SecretaryFeb 28, 2025AWARD3,333——Form 4
Mano MichaelSVP, General Counsel&SecretaryFeb 28, 2025AWARD6,666$7.95$53.0KForm 4
Mano MichaelSVP, General Counsel&SecretaryFeb 28, 2025AWARD4,500$7.95$35.8KForm 4
Poulton StuartEVP, Chief Development OfficerFeb 18, 2025SELL5,914$0.63$3.7KForm 4
Paulson Richard A.director, officer: President and CEOFeb 4, 2025SELL4,099$0.65$2.7KForm 4
Macomber LoriEVP, CFO & TreasurerJan 31, 2025AWARD650,000$0.62$404.4KForm 4
Macomber LoriEVP, CFO & TreasurerJan 31, 2025AWARD160,000——Form 4
Paulson Richard A.director, officer: President and CEOJan 6, 2025SELL4,055$0.78$3.2KForm 4
Macomber LoriJan 3, 2025OTHER0——Form 4
Paulson Richard A.director, officer: President and CEODec 4, 2024SELL3,620$0.81$2.9KForm 4
Abate KristinChief Accounting OfficerNov 6, 2024OTHER0——Form 4