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Puma Biotechnology, Inc.

PBYI
Healthcare|Biotechnology|US
$8.25
-1.52 (-15.56%)
DCF Value
$16.32
Tangible Book / Share
$2.10
Cash / Share
$2.10

About

Puma Biotechnology, Inc. is a biopharmaceutical company dedicated to the global development and commercialization of treatments aimed at advancing cancer care. Its lead drug candidate, orally administered neratinib (PB272), targets a range of indications. These include patients with early-stage HER2-overexpressed/amplified breast cancer, as well as adults suffering from advanced or metastatic HER2-positive breast cancer when used in combination with capecitabine. Furthermore, PB272 is being explored for solid tumors exhibiting HER2 mutations. The company holds a licensing agreement with Pfizer, Inc. for this drug and has established sub-licensing partnerships with Specialised Therapeutics Asia Pte Ltd., CANbridge BIOMED Limited, Pint Pharma International SA, Knight Therapeutics, Inc., Pierre Fabre Medicament SAS, and Bixink Therapeutics Co., Ltd. Established in 2010, Puma Biotechnology maintains its headquarters in Los Angeles, California.

Stock Price

+68.4%(1Y)
1M
-17.3%
3M
-7.4%
6M
+10.1%
YTD
+38.7%
1Y
+74.4%
3Y
+161.1%
5Y
+107.3%

Pipeline Summary

59 total trials
30
Phase 1
34
Phase 2
2
Phase 3
0
Phase 4
Completed: 39Suspended: 1Recruiting: 7Terminated: 4Active: 3Withdrawn: 3Unknown: 2

Active Trials (10)

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
NCT06369285Hormone Receptor Positive HER-2 Negative Breast Cancer
Phase 2Recruiting
Enrollment: 225 participants
Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer
NCT06109467GastroEsophageal Cancer
Phase 2Active
Enrollment: 8 participants
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
NCT05274048Gastric Cancer
Phase 1Recruiting
Enrollment: 18 participants
Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant Neratinib
NCT05252988Early-stage Breast Cancer
Phase 2Active
Enrollment: 177 participants
Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers
NCT05919108Anatomic Stage I Breast Cancer
Phase 2Recruiting
Enrollment: 30 participants

Key Facts

Market Cap$425.9M
Employees179 (+4% YoY)
CEOAlan H. Auerbach
IPO DateApr 24, 2012
Beta1.21
52-Week Range$4.58 – $11.5
Avg Volume349,571
ExchangeNASDAQ

Ownership

Float77.6%
Shares Outstanding51.6M

Recent Insider Trades

WILSON TROY EDWARDSELL
Sep 14, 20265,000 shares @ $9.10
Cesano AlessandraOPTION EX.
Sep 14, 202650,000 shares @ $2.93
Cesano AlessandraSELL
Sep 14, 202662,150 shares @ $9.12
Cesano AlessandraOPTION EX.
Sep 14, 202650,000 shares @ $2.93
AUERBACH ALAN HSELL
Jul 6, 202644,058 shares @ $8.26

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Data last updated: Nov 9, 2026, 04:27 AM