Pacira BioSciences Inc

PCRX

Healthcare|Drug Manufacturers - Specialty & Generic|USA

$25.47

-0.01 (-0.04%)

DCF (FCF)

$43.62

Tangible Book

$7.15

Graham Number

$18.67

Earnings Power

$19.49

Clinical Trials (152)

Trial	Conditions	Phase	Status	Enrollment	Design	Drug
NCT06269705 ZILRETTA in Subjects With Shoulder Osteoarthritis	Glenohumeral Osteoarthritis	P3	Active	150	RCT, Single-blind	ZILRETTA
NCT07212114 Efficacy of EXPAREL vs. Bupivacaine	Total Ankle Arthroplasty, Postsurgical Analgesia	P3	Recruiting	104	RCT, Double-blind	EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
NCT06884865 A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee	Osteoarthritis (OA) of the Knee	P2	Active	135	RCT, Double-blind	Enekinragene Inzadenovec (PCRX-201), Placebo
NCT04119687 Study to Evaluate the Safety and Tolerability of FX201 in Patients with Osteoarthritis of the Knee	Osteoarthritis, Knee	P1	Active	72	Open-label	FX201
NCT06271265 Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery	Postoperative Pain	P1	Recruiting	48	RCT, Open-label	EXPAREL, bupivacaine
NCT06340451 Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity	Spasticity, Cerebral or Spinal Condition	N/A	Active	132	RCT, Double-blind	—
NCT07125833 Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)	Degenerative Joint Disease of Shoulder	N/A	Recruiting	20	RCT, Open-label	—
NCT06603051 The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction	ACL Repair	N/A	Recruiting	20	RCT, Open-label	—
NCT06958289 Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System	Spasticity as Sequela of Stroke	N/A	Recruiting	25	Open-label	—
NCT07214844 A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain	Low Back Pain, Chronic	N/A	Recruiting	110	RCT, Double-blind	—
NCT06946368 Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery	Total Knee Arthroplasty	N/A	Recruiting	60	RCT, Open-label	—
NCT05495334 Innovations in Genicular Outcomes Registry	Knee Osteoarthritis		Recruiting	10,000	—	—
NCT02142829 Pain Control in Bariatric Patients: EXPAREL(R) vs. the On-Q(R) Pain Ball	Obesity	P4	Completed	101	Open-label	EXPAREL, On-Q Pain Ball
NCT02353754 Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section	Pain	P4	Terminated	12	Open-label	Intrathecal morphine injection, EXPAREL
NCT01919190 EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries	Pain	P4	Terminated	67	RCT, Single-blind	EXPAREL, Placebo
NCT00029523 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor	Meningeal Neoplasms	P4	Completed	100	RCT, Open-label	Intrathecal (injected into the spinal fluid) DepoCyt, Intrathecal methotrexate, Intrathecal cytarabine (also known as ara-C)
NCT02787226 Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty	Postoperative Pain, Shoulder Arthritis	P4	Terminated	100	RCT, Open-label	Liposomal Bupivacaine Infiltration, Continuous Perineural Ropivicaine Infusion
NCT01509807 A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B504	Retraction of Colostomy	P4	Completed	33	Open-label	IV morphine sulfate or Sponsor-approved equivalent, EXPAREL
NCT06995352 Liposomal Bupivacaine Versus Continuous Peripheral Nerve Blocks for Analgesia Following Ankle Surgery	Moderate-to-severely Painful Ankle Surgery	P4	By Invite	140	RCT, Double-blind	Popliteal nerve block including liposomal bupivacaine, Adductor canal nerve block including liposomal bupivacaine, Continuous popliteal nerve block with normal saline, Popliteal nerve block with exclusively unencapsulated bupivacaine, Adductor canal nerve block with exclusively unencapsulated bupivacaine, Continuous popliteal nerve block with unencapsulated bupivacaine
NCT01582490 Study of EXPAREL in Patients Undergoing Breast Augmentation	Mammoplasty, Postoperative Pain	P4	Completed	19	Open-label	Instillation - EXPAREL, Infiltration - EXPAREL
NCT07584915 Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery	Total Knee Arthroplasty, Total Knee Arthroplasty Recovery	P4	By Invite	40	RCT, Single-blind	Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
NCT01507246 Adult Patients Undergoing Open Colectomy MA402S23B303	Bowel Obstruction	P4	Completed	42	Open-label	IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension)
NCT03927911 Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries	Postoperative Pain Management	P4	Terminated	65	Open-label	EXPAREL and Bupivacaine, Standard of Care
NCT02199574 Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy	Pain	P4	Completed	12	Open-label	EXPAREL
NCT01801124 EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair	Hernia	P4	Completed	13	Open-label	EXPAREL
NCT03975283 Use of Exparel for Postoperative Analgesia Following Bariatric Surgery	Post Operative Pain	P4	Unknown	80	RCT, Double-blind	Exparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.25% Inj
NCT02255500 EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty	Pain	P4	Completed	23	Open-label	Bupivacaine FNB, EXPAREL Infiltration
NCT03149887 Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair	Rotator Cuff Tear	P4	Completed	54	RCT, Double-blind	Liposomal bupivacaine, Placebo
NCT00134979 Formoterol Certihaler, Tiotropium HandiHaler and Tiotropium HandiHaler in Combination With Formoterol Certihaler in Patients With Stable Chronic Obstructive Pulmonary Disease	Chronic Obstructive Pulmonary Disease	P4	Completed	847	RCT, Double-blind	Formoterol
NCT03827291 QL Block With Exparel in Colectomy	Laparotomy, Colectomy	P4	Completed	35	Open-label	Exparel
NCT02058290 A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy	Bowel Obstruction	P4	Terminated	122	Open-label	IV morphine sulfate or Sponsor-approved equivalent, EXPAREL
NCT02586077 Foot and Ankle Clinic Application for Liposomal Related Anesthetic	Ankle Arthrodesis, Hindfoot Arthrodesis	P4	Completed	36	Open-label	Exparel
NCT03290196 The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics	Rotator Cuff Tear	P4	Terminated	13	Open-label	EXPAREL 1.3 % in 20 ML Injection
NCT03853694 Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section	Elective Cesarean Section, Pain Management	P4	Completed	167	RCT, Open-label	50 mcg Duramorph+ EXPAREL + multi-modal pain regimen, 150 mcg Duramorph + multi-modal pain regimen, Exparel TAP + multi-modal pain regimen
NCT02713490 Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty	Pain	P4	Completed	140	RCT, Double-blind	EXPAREL, Bupivacaine
NCT01507233 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302	Bowel Obstruction	P4	Terminated	5	Open-label	IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension)
NCT03015961 Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery	Postoperative Pain Management	P4	Terminated	38	RCT, Double-blind	EXPAREL and bupivacaine HCl, Bupivacaine HCl
NCT01507220 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301	Bowel Obstruction	P4	Terminated	2	Open-label	morphine sulfate, bupivacaine liposome extended-release injectable suspension
NCT04278846 Efficacy of Liposomal Bupivacaine for Prolonged Postoperative Analgesia in Patient Undergoing Breast Reconstruction With Tissue Expander	Pain, Postoperative, Mammaplasty	P4	Completed	50	RCT, Open-label	Depofoam bupivacaine, Bupivacaine hydrochloride (HCl)
NCT01582477 TAP-patients With Robotic Assisted Lap Prostatectomy	Postsurgical Pain, Analgesia	P4	Completed	24	Open-label	EXPAREL 20 mL, EXPAREL 40 mL
NCT03541941 Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair	Analgesia, Postoperative	P4	Completed	164	RCT, Double-blind	Exparel, Bupivacaine Hcl 0.25% Inj, Placebo
NCT05730920 IV Methadone Vs EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Idiopathic Scoliosis Correction	Adolescent Idiopathic Scoliosis, Juvenile Idiopathic Scoliosis	P4	Completed	30	RCT, Double-blind	Methadone, Liposomal bupivacaine (LB, Exparel)
NCT03907033 Liposomal Bupivacaine in Vaginal Hysterectomy	Vaginal Hysterectomy	P4	Terminated	28	RCT, Double-blind	Liposomal bupivacaine, Bupivacaine Hydrochloride
NCT01919606 EXPAREL Administered Into the TAP for Analgesia in Subjects Undergoing Open Total Abdominal Hysterectomy	Postoperative Pain	P4	Terminated	1	Open-label	EXPAREL
NCT01509638 A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501	Retraction of Colostomy	P4	Completed	47	Open-label	Group 1 Standard of Care, Group 2 EXPAREL
NCT02128646 Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair	Pain	P4	Completed	19	RCT, Open-label	EXPAREL, Ketorolac
NCT02058303 Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery	Hand Injuries, Wrist Injuries	P4	Terminated	37	RCT, Double-blind	Exparel Forearm block, Bupivacaine supraclavicular block
NCT03955458 EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture	Hip Fractures, Intertrochanteric Fractures	P4	Withdrawn	—	RCT, Open-label	EXPAREL, Ropivacaine, Bupivacaine Hydrochloride
NCT03176459 Evaluate the Safety and Efficacy of EXPAREL When Administered Via Infiltration Into the TAP vs. Bupivacaine Alone in Subjects Undergoing Elective C-Sections	C-Section, Pain Management	P4	Completed	186	RCT, Double-blind	Exparel + Bupivacaine, Bupivacaine
NCT02284386 Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty	Pain	P4	Completed	15	Open-label	Bupivacaine SNB, EXPAREL Infiltration
NCT03738696 Liposomal Bupivacaine in Rotator Cuff Repair	Rotator Cuff Injury	P4	Completed	64	RCT, Open-label	Exparel, Ropivacaine
NCT03802864 Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine	Male Infertility	P4	Completed	50	RCT, Double-blind	Liposomal Bupivacaine, Standard Bupivacaine
NCT04504812 A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain	Knee Osteoarthritis	P3	Completed	1,937	RCT, Single-blind	Duloxetine
NCT05139030 Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty	Knee Osteoarthritis, Pain Management	P3	Completed	167	RCT, Double-blind	bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
NCT00813111 Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation	Pain	P3	Terminated	136	RCT, Double-blind	SKY0402, Bupivacaine HCl
NCT00130351 A 3-week Study Investigating Patient Use and Functionality of Formoterol in a Novel Inhalation Device in Patients With Asthma	Asthma	P3	Completed	155	Open-label	—
NCT01379365 Cryo-Touch III Refinement Study Investigational Plan	Facial Wrinkles, Skin Aging	P2P3	Completed	88	Open-label	—
NCT05171179 The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery	Mammaplasty	P3	Completed	60	RCT, Single-blind	Exparel, Bupivacaine
NCT01683071 Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty	Postoperative Pain	P2P3	Completed	297	RCT, Double-blind	Placebo, EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
NCT02357459 Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P3	Completed	486	RCT, Double-blind	FX006, Placebo, TCA IR 40
NCT03793010 Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis	Osteoarthritis, Hip	P3	Terminated	70	RCT, Double-blind	FX006, Normal saline
NCT03739021 Exparel for Total Shoulder Pain	Chronic Shoulder Pain	P2P3	Not Yet Recruiting	60	RCT, Open-label	Exparel, Ropivacaine
NCT04117074 Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery	Surgery, Analgesia	P3	Completed	106	RCT, Open-label	Liposomal bupivacaine
NCT03046446 Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P3	Completed	208	Open-label	FX006 32 mg
NCT01447342 A Study to Evaluate the Safety and Effectiveness of the Cryo-Touch II Device for the Treatment of Forehead and/or Glabellar Lines	Facial Wrinkles, Skin Aging	P2P3	Completed	54	Open-label	—
NCT02713178 Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty	Pain	P3	Completed	232	RCT, Double-blind	bupivacaine liposome injectable suspension, Placebo
NCT03529942 Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee	Osteoarthritis, Knee	P3	Completed	129	Open-label	FX006 32 mg
NCT00890721 Study of Pain Control in Hemorrhoidectomy	Hemorrhoid	P3	Completed	189	RCT, Double-blind	SKY0402, Placebo
NCT03270514 Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride	Coronary Artery Disease, Coronary Artery Stenoses	P3	Completed	60	RCT, Double-blind	Exparel Injectable Product, Bupivacaine Hydrochloride
NCT02740114 Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway	Malignant Neoplasms of Female Genital Organs, Gynecologic Cancer	P3	Terminated	105	RCT, Single-blind	Bupivacaine, Liposomal Bupivacaine, Oxycodone
NCT01167140 Cryo-Touch II for the Treatment of Wrinkles	Facial Wrinkles	P2P3	Completed	42	Open-label	—
NCT00744848 Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy	Hemorrhoids	P3	Completed	204	RCT, Double-blind	Bupivacaine HCl, SKY0402
NCT02517905 Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction	Dental Pain	P3	Completed	166	RCT, Double-blind	Bupivacaine liposome, Placebo
NCT00745290 A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty	Postoperative Pain	P3	Completed	245	RCT, Double-blind	Bupivacaine HCl, SKY0402
NCT04518462 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries	Lower Extremity Surgery, Bunion	P3	Completed	121	RCT, Double-blind	Exparel, Bupivacaine Hydrochloride
NCT06350981 Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion	Back Pain, Surgery-Complications	P2P3	By Invite	76	RCT, Double-blind	Exparel, Bupivacain
NCT03954639 Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries	Bunion, Metatarsophalangeal Fusion	P3	Withdrawn	—	RCT, Double-blind	EXPAREL 13.3Mg/mL Suspension for Injection, Bupivacaine Hydrochloride
NCT06077422 Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain	Pain, Postoperative, Opioid Use	P2P3	By Invite	150	RCT, Double-blind	bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
NCT02713230 Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery	Pain	P3	Completed	156	RCT, Double-blind	bupivacaine liposome injectable suspension, bupivacaine liposome injectable suspension, Placebo
NCT05157841 Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy	Bunionectomy, Hallux Valgus	P3	Completed	185	RCT, Double-blind	Bupivacaine liposome injectable suspension 266 mg, Bupivacaine HCl, Bupivacaine liposome injectable suspension 133 mg
NCT00890682 Study of Postoperative Analgesia in Bunionectomy	Bunion, Hallux Valgus	P3	Completed	193	RCT, Double-blind	SKY0402, Placebo
NCT01802411 Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy	Posterolateral Thoracotomy, Postoperative Pain	P3	Completed	191	RCT, Double-blind	EXPAREL 266 mg, Placebo
NCT03682302 Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL	Postoperative Pain Management	P3	Completed	98	RCT, Open-label	Exparel, 0.5% Bupivacaine HCl
NCT03382262 Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip	Osteoarthritis of the Shoulder, Osteoarthritis of the Hip	P2	Completed	55	RCT, Open-label	FX006 32 mg, TAcs 40 mg
NCT01487200 Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P2	Completed	24	RCT, Double-blind	FX006 10 mg, FX006 40 mg, FX006 60 mg, TCA IR 40
NCT04065074 Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip	Osteoarthritis, Hip	P2	Completed	16	Open-label	FX006 32 mg
NCT03378076 Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA	Bilateral Knee Osteoarthritis	P2	Completed	24	RCT, Open-label	FX006 32 mg, TAcs 40 mg
NCT01487161 Study of FX006 in Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P2	Completed	229	RCT, Double-blind	FX006, TCA IR
NCT01203644 Evaluation of the Safety, Efficacy, and Pharmacokinetics of SKY0402 in Subjects Undergoing Inguinal Hernia Repair	Inguinal Hernia	P2	Completed	76	RCT, Double-blind	SKY0402, Bupivacaine HCl
NCT00529126 Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy	Postoperative Pain	P2	Completed	100	RCT, Double-blind	SKY0402, Bupivacaine HCl
NCT02468583 Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee	Post-traumatic Osteoarthritis of the Knee	P2	Terminated	6	RCT, Double-blind	FX006 32 mg, TCA IR 40 mg
NCT02922582 Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA	Total Knee Arthroplasty	P2	Terminated	16	RCT, Single-blind	DepoTXA, Tranexamic Acid
NCT01291914 Study of FX005 for the Treatment of Pain in Patients With Osteoarthritis of the Knee	Osteoarthritis, Knee	P1P2	Completed	140	RCT, Double-blind	FX005, Placebo 1 (Carrier), Placebo 2 (Diluent)
NCT03106545 Liposome Bupivacaine for ANKLE Blocks	Hallux Valgus (Bunions)	P2	Completed	40	RCT, Double-blind	Liposome bupivacaine
NCT02762370 Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes	Osteoarthritis of the Knee, Type 2 Diabetes Mellitus	P2	Completed	33	RCT, Double-blind	FX006 32 mg, TCA IR 40 mg
NCT00842062 Study of the MyoScience Tissue Remodeling Device for Facial Rejuvenation	Facial Rhytides	P1P2	Completed	380	Open-label	—
NCT02116972 Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P2	Completed	310	RCT, Double-blind	FX006 32 mg, Placebo, FX006 16 mg
NCT06977568 A Study to Evaluate an Intra-Articular Injection of ZILRETTA Versus Triamcinolone Acetonide, Immediate Release in Subjects With Osteoarthritis of the Hip	Osteoarthritis of Hip	P2	Terminated	1	RCT, Open-label	Zilretta, Triamcinolone Acetonide
NCT04160091 Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis	Osteoarthritis of the Shoulder, Adhesive Capsulitis	P2	Terminated	19	RCT, Double-blind	FX006, Normal Saline
NCT00485433 Dose-ranging Study for Postoperative Analgesia in Subjects Undergoing Primary Unilateral Inguinal Hernia Repair	Postoperative Pain	P2	Completed	98	RCT, Double-blind	Bupivacaine HCl, SKY0402
NCT01206608 Evaluation of the Safety and Efficacy of a Single Dose of SKY0402 in Subjects Undergoing Augmentation Mammoplasty	Postoperative Pain	P2	Completed	40	RCT, Double-blind	SKY0402 + bupivacaine HCl, Mid-dose SKY0402 + bupivacaine HCl
NCT02637323 Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee	Osteoarthritis of the Knee	P2	Completed	81	Open-label	FX006 32 mg, TCA IR 40
NCT00807209 Dose Finding Posterolateral Thoracotomy Study	Postoperative Pain	P2	Terminated	3	RCT, Open-label	Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural
NCT03106519 Liposome Bupivacaine for WRIST Blocks	Dupuytren's Contracture of the Hand (Viking's Disease)	P2	Completed	32	RCT, Double-blind	Liposome bupivacaine + bupivacaine
NCT00485693 Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty	Postoperative Pain	P2	Completed	138	RCT, Double-blind	Bupivacaine HCl, SKY0402
NCT02003365 Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee	Osteoarthritis of the Knee	P2	Completed	50	Open-label	FX006 10 mg, FX006 40 mg, TCA IR 40 mg
NCT04182672 Study to Assess the Safety and Efficacy of FX006 Administered to Patients With Greater Trochanteric Bursitis	Trochanteric Bursitis	P2	Completed	22	Open-label	FX006
NCT01206595 Safety, Efficacy, and Pharmacokinetics of SKY0402 Administered as a Nerve Block in Subjects Undergoing Bunionectomy	Postoperative Pain	P2	Completed	58	RCT, Double-blind	SKY0402, Bupivacaine HCl
NCT02985762 PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery	Spinal Fusion, Pain Management	P1	Completed	15	Open-label	EXPAREL
NCT05456490 Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers	Healthy	P1	Completed	54	RCT, Double-blind	Liposomal Bupivacaine 13.3, Bupivacaine
NCT00812305 Hepatic Impairment Study: Pharmacokinetics in Healthy and Hepatically Impaired Subjects	Pain, Hepatic Impairment	P1	Completed	16	Open-label	SKY0402 300mg in healthy patients, SKY0402 300mg in hepatically impaired patients
NCT01349140 EXPAREL Dose-Response for Single-Injection Femoral Nerve Blocks	Healthy Volunteers	P1	Completed	14	Double-blind	SKY0402
NCT00806806 Evaluate the Onset of Action of SKY0402 Following Local Infiltration in Healthy Volunteers	Postoperative Pain Management	P1	Completed	128	RCT, Single-blind	SKY0402, Placebo
NCT04826328 Study to Evaluate the Safety and Tolerability of FX301 in Patients Undergoing Bunionectomy	Pain, Postoperative, Bunion	P1	Completed	85	RCT, Double-blind	FX301, Normal Saline
NCT04002089 Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve Block (In Popliteal Fossa), for Postsurgical Analgesia in Subjects Undergoing Bunionectomy	Bunion	P1	Completed	45	Open-label	Exparel Injectable Product, Bupivacaine
NCT00003073 Chemotherapy in Treating Young Patients With Recurrent or Refractory Meningeal Leukemia, Lymphoma, or Solid Tumors	Brain and Central Nervous System Tumors, Leukemia	P1	Unknown	15	—	liposomal cytarabine
NCT03485014 Study in Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL	Postoperative Pain Management	P1	Completed	15	Open-label	Exparel
NCT00728832 A Pharmacokinetic (PK) Study of Extended-Release Epidural Morphine in Upper Abdominal Surgery	Postoperative Pain	P1	Completed	39	RCT, Open-label	DepoDur (extended-release epidural morphine)
NCT04261049 Effect of Zilretta Injection	Osteoarthritis, Knee	P1	Completed	35	Open-label	Triamcinolone Acetonide Extended-Release Injectable Suspension
NCT02210247 Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers	Healthy Volunteers	P1	Completed	60	Open-label	EXPAREL
NCT04173611 Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers	Healthy	P1	Terminated	20	RCT, Double-blind	EXPAREL, Bupivacaine Hydrochloride
NCT03428984 Study in Adult Subjects Undergoing Posterolateral Thoracotomy	Postoperative Pain Management	P1	Terminated	5	RCT, Open-label	EXPAREL
NCT04293809 Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation	Breast Augmentation	P1	Completed	30	RCT, Open-label	Exparel Injectable Product, Bupivacaine Hydrochloride
NCT00485667 Phase 1 Thorough QT Study in Young Healthy Volunteers	Postoperative Pain	P1	Completed	48	RCT, Double-blind	SKY0402, Moxifloxacin 400mg, Placebo injection, Placebo tablet
NCT06284109 Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain	Postoperative Pain	N/A	Withdrawn	—	RCT, Double-blind	—
NCT03327220 Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain	Total Knee Arthroplasty	N/A	Completed	124	RCT, Open-label	—
NCT01681745 Probe Configuration and Time-Temperature Dose Ranging for Understanding of Skin Lesion Effects	Histological Response of Tissue to Cold	N/A	Completed	30	Open-label	—
NCT06093776 Rib Fracture Cryoanalgesia	Pain Management Improvement		Completed	5	—	—
NCT06935539 Cryoneurolysis vs Radiofrequency Ablation for Chronic Sacroiliac Joint Pain	Chronic Sacroiliac Joint Pain	N/A	Not Yet Recruiting	30	RCT, Open-label	—
NCT02821325 Intra-articular Volumetric Assessment After Total Knee Arthroplasty	Hematoma		Completed	10	—	—
NCT01863901 Study Evaluating Treatment of Upper Limb Spasticity Using the Cryo-Touch III Device	Upper Limb Spasticity	N/A	Completed	19	Open-label	—
NCT01950065 Effectiveness and Safety Study of the Iovera Device for the Temporary Reduction in the Appearance of Forehead Wrinkles	Forehead Wrinkles	N/A	Completed	85	RCT, Single-blind	—
NCT01753778 Study Evaluating Treatment of Forefoot Pain Related to Nerve Entrapment Using the Cryo-Touch III Device	Entrapment Neuropathy	N/A	Completed	7	Open-label	—
NCT03578237 Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study	Mastectomy, Upper Limb Amputation Below Elbow	N/A	Completed	99	RCT, Double-blind	—
NCT03076710 Post-Operative Pain Management Following Spine Surgery	Pain Management, Analgesia		Withdrawn	—	—	Opioids delivered through PCA, EXPAREL® infiltration
NCT02284113 A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty	Arthritis of the Knee	N/A	Completed	150	RCT, Double-blind	—
NCT03836313 Assessing if Cryoneurolysis Improves Prehabilitation and Decreases Pain After Surgery With Less Opioid Use in TKA Patients	Arthropathy of Knee, Pain, Joint	N/A	Withdrawn	—	RCT, Double-blind	—
NCT05604144 Cryoanalgesia for the Treatment of Pain in Subjects With Morton's Neuroma	Morton's Neuroma, Pain Management	N/A	Unknown	5	Open-label	—
NCT02260921 Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain	Knee Osteoarthritis	N/A	Completed	180	RCT, Double-blind	—
NCT03909516 Evaluate the Iovera° Device in Treating Pain Associated With Anterior Cruciate Ligament Reconstruction	ACL Reconstruction	N/A	Withdrawn	—	RCT, Open-label	—
NCT01801826 A Prospective Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the Cryo-Touch IV Device	Frown Lines, Glabellar Frown Lines		Completed	61	—	—
NCT01704157 A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device	Osteoarthritis of the Knee	N/A	Completed	33	Open-label	—
NCT04191031 Study to Evaluate Iovera®° in Adult Patients Undergoing Total Knee Arthroplasty	Post-Operative Pain Management	N/A	Terminated	79	RCT, Double-blind	—
NCT06016127 Cryoneurolysis for Facet Mediated Chronic Low Back Pain	Low Back Pain, Facet Joint Pain	N/A	Completed	30	RCT, Open-label	—
NCT01984619 Prospective Study Evaluating the Treatment of Hyperdynamic Forehead Wrinkles	Wrinkles		Completed	47	—	—
NCT06340932 Impact of Opioid Avoidance Protocol for ACL Reconstruction	ACL Tear, Post Operative Pain		Completed	32	—	Celecoxib, Acetaminophen, Oxycodone, Tramadol, Bupivacaine Hydrochloride, Acetaminophen 500Mg Cap
NCT03081299 Characterization of Bio-psychosocial Pain Profiles in the Perioperative Period	Pain, Postoperative		Completed	471	—	—
NCT02554357 Quality of Analgesia After Interscalene Block After Arthroscopic Shoulder Surgery	Injury of Shoulder Region	N/A	Completed	50	RCT, Double-blind	Exparel block in arthroscopic shoulder surgery, Bupivacaine block in shoulder surgery
NCT01808742 Study Evaluating the Treatment of Forehead and/or Glabellar Lines With the CRYO-TOUCH III Device	Frown Lines, Glabellar Frown Lines		Completed	17	—	—
NCT01076686 Observational Study to Assess Long-Term Follow-Up of Breast Augmentation Subjects	Postoperative Pain		Completed	94	—	Questionnaire and Physical Exam
NCT03688477 Iovera° to Treat Pain Associated With ACL Reconstruction and Rehabilitation	Anterior Cruciate Ligament Reconstruction	N/A	Withdrawn	—	RCT, Single-blind	—
NCT01753765 Study Evaluating the Treatment of Occipital Neuralgia	Occipital Neuralgia	N/A	Completed	26	Open-label	—