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Rhythm Pharmaceuticals Inc

RYTM
Healthcare|Biotechnology|USA
$108.40
-7.08 (-6.13%)
Tangible Book
$1.72

About

Rhythm Pharmaceuticals Inc is a commercial-stage biopharmaceutical company engaged in the development and commercialization of therapies for patients with rare neuroendocrine diseases. The company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its main asset, IMCIVREE (setmelanotide), as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. In addition, it has two early-stage investigational MC4R agonists in clinical development, RM-718 and bivamelagon, designed not to cause hyperpigmentation. The company is also focused on advancing potential candidates for congenital hyperinsulinism. It currently operates in two business segments: the United States, which generates maximum revenue, and International.

Stock Price

+21.7%(1Y)

Pipeline Summary

382 total trials
11
Phase 1
17
Phase 2
16
Phase 3
37
Phase 4
Recruiting: 26Completed: 271Active: 11APPROVED_FOR_MARKETING: 1ENROLLING_BY_INVITATION: 3Unknown: 15NOT_YET_RECRUITING: 14Terminated: 36Withdrawn: 5

Active Trials (37)

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
NCT06239116Hypothalamic Obesity
Phase 1Phase 2Recruiting
Enrollment: 150 participants
A Trial of Setmelanotide in Acquired Hypothalamic Obesity
NCT05774756Hypothalamic Obesity
Phase 3Active
Enrollment: 143 participants
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
NCT05093634Obesity
Phase 3Active
Enrollment: 296 participants
A Study of Setmelanotide in Patients With Prader-Willi Syndrome
NCT06772597Prader-Willi Syndrome
Phase 2Active
Enrollment: 18 participants
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
NCT06760546Hypothalamic Obesity
Phase 3Recruiting
Enrollment: 39 participants

BioScore

6.1/10
Watchlist

Ownership

Recent Insider Trades

TETRAULT LYNN A.SELL
2026-06-2237,000 shares @ $100.32
German Christopher PaulSELL
2026-05-154,643 shares @ $92.21
German Christopher PaulSELL
2026-03-045,614 shares @ $89.56
Smith Hunter CSELL
2026-02-197,954 shares @ $101.31
Smith Hunter CSELL
2026-02-127,071 shares @ $100.21

Recent News

2026-07-07 17:01:38
2026-06-16 16:36:14
2026-06-15 13:38:40
2026-06-14 20:51:02
2026-06-13 18:00:04
Data last updated: Jul 12, 2026, 07:36 PM