Rhythm Pharmaceuticals Inc
RYTMHealthcare|Biotechnology|USA
$108.40
-7.08 (-6.13%)
Tangible Book
$1.72
Clinical Trials (382)
| Trial | Conditions | Phase | Status | Enrollment | Design | Drug |
|---|---|---|---|---|---|---|
| NCT07674290 Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity | Bardet Biedl Syndrome (BBS), Bardet Biedl Syndrome | P4 | Recruiting | 200 | Open-label | Setmelanotide |
| NCT05774756 A Trial of Setmelanotide in Acquired Hypothalamic Obesity | Hypothalamic Obesity | P3 | Active | 143 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT05093634 EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway | Obesity, Genetic Obesity | P3 | Active | 296 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT06760546 A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) | Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form | P3 | Recruiting | 39 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT06239116 A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment | Hypothalamic Obesity, Prader-Willi Syndrome | P1P2 | Recruiting | 150 | RCT, Double-blind | Part A: RM-718 or placebo (matched to specific RM-718 dose cohort), Part B: RM-718 or placebo (matched to specific RM-718 dose cohort), Part C: RM-718, Part D: RM-718 |
| NCT06772597 A Study of Setmelanotide in Patients With Prader-Willi Syndrome | Prader-Willi Syndrome, Obesity | P2 | Active | 18 | Open-label | Setmelanotide |
| NCT06174220 Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy | Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy | P2 | Recruiting | 120 | RCT, Double-blind | Tideglusib, Placebo |
| NCT06239064 Early Genetic Identification of Obesity | Obesity, Childhood, Hyperphagia | Active | 1,000 | — | — | |
| NCT06910059 The CT-verified Data Collection Study to Investigate the Correlation Between the Leadless Pacemaker Tip Location and Echo, ECG | Bradycardia Sinus, AV Block | Active | 40 | — | — | |
| NCT07041125 Concomitant LAAC/AF Ablation (Watchman FLX Pro) | PFA Ablation and LAAC Procedures | Recruiting | 120 | — | — | |
| NCT04493970 HS Students Mandatory Universal Student Instruction in CPR Appraised Learning- Is the Mandate Working? | Sudden Cardiac Arrest | Recruiting | 5,000 | — | — | |
| NCT07552805 An Evaluation of Multisense® to Ensure a Safe Return Home Following High-risk Gastrointestinal Surgery, Compared With Standard Care. | Reduction in the Initial Length of Stay | N/A | Recruiting | 490 | RCT, Open-label | — |
| NCT06342492 Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure | Heart Failure With Reduced Ejection Fraction | Recruiting | 100 | — | — | |
| NCT06324201 The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation. | Paroxysmal Atrial Fibrillation | Recruiting | 250 | — | — | |
| NCT06436924 Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day | Atrial Fibrillation | Recruiting | 678 | — | — | |
| NCT07514286 Assessment of the Feasibility and Organisational Impact of a Care Pathway Incorporating the MultiSense® Medical Device for Post-operative Home Monitoring of Elderly Patients. | Average Length of Stay, Surgery | N/A | Recruiting | 80 | Open-label | — |
| NCT06745778 Evolution of Intracardiac Electrograms Recorded by Left Bundle Branch Pacing Lead in Patients With ICD or CRT-D | Ventricular Tachycardia (VT), Ventricular Fibrillation | Recruiting | 50 | — | — | |
| NCT06606288 Characterizing Outcomes and Real-World Experience of Cardiac Physiologic Pacing (The CORE-CPP Study) | Heart Failure | Active | 6,000 | — | — | |
| NCT06540521 Bolt CSP-M Holter Study | Heart Failure, Bradycardia | Recruiting | 75 | — | — | |
| NCT06289413 Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study | Autonomic Dysfunction, Orthostatic Intolerance | Recruiting | 400 | — | — | |
| NCT03681210 Destination Therapy Post Approval Study | Chronic Heart Failure | Active | 300 | — | — | |
| NCT06078735 Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study | Atrial Fibrillation, Hemostasis | N/A | Recruiting | 110 | RCT, Open-label | — |
| NCT06354777 REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry | Atrial Fibrillation | Active | 312 | — | — | |
| NCT04088071 Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | Recruiting | 20,000 | — | — | |
| NCT05061862 Cardiac Implantable Electronic Device (CIED) Research Study | Arrhythmias, Cardiac, Bradycardia | Active | 1,000 | — | — | |
| NCT07092774 Real-world Safety and Effectiveness Registry of Catheter Ablation of Paroxysmal Atrial Fibrillation as Initial Control Therapy With the Thermocool SmartTouch SF Catheter (A Sub-study of REAL AF Registry) | Paroxysmal Atrial Fibrillation (PAF) | Active | 344 | — | — | |
| NCT06061757 Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure | Atrial Fibrillation, Stroke | N/A | Recruiting | 52 | Open-label | — |
| NCT06678841 ELEVATE-HFpEF Clinical Study | Heart Failure With Preserved Ejection Fraction (HFpEF) | N/A | Recruiting | 700 | RCT, Double-blind | — |
| NCT05826665 Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System | Persistent Atrial Fibrillation | Recruiting | 200 | — | — | |
| NCT05856370 The Ailliance Post-Market Clinical Study | Spinal Deformity, Spinal Degenerative Disorder | N/A | Recruiting | 1,000 | Open-label | — |
| NCT06075628 Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry | Atrial Fibrillation, Ischemic Stroke, Acute | Recruiting | 100 | — | — | |
| NCT05839730 Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction | Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy | N/A | Recruiting | 105 | RCT, Double-blind | — |
| NCT06055751 Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry | Aortic Stenosis, Atrial Fibrillation New Onset | Recruiting | 50 | — | — | |
| NCT01321073 DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study | Pulmonary Arterial Hypertension | N/A | Active | 64 | Open-label | — |
| NCT06060548 Role of Novel ILR in the Management of PVCs | PVC - Premature Ventricular Contraction, Myocarditis | Recruiting | 50 | — | — | |
| NCT06056271 Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation | Atrial Fibrillation | Recruiting | 400 | — | — | |
| NCT02988128 Neurovascular Product Surveillance Registry | Intracranial Aneurysm, Stroke, Ischemic | Recruiting | 4,000 | — | — | |
| NCT05046132 Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Participants | Healthy | P4 | Completed | 77 | RCT, Double-blind | Setmelanotide, Moxifloxacin, Oral Placebo, SC Placebo |
| NCT01074671 CG Future® Annuloplasty Ring/Band Clinical Trial | Mitral Valve Insufficiency | P4 | Completed | 77 | Open-label | — |
| NCT00551499 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF | Heart Failure, Central Sleep Apnea | P4 | Completed | 44 | RCT, Single-blind | — |
| NCT02666742 DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation | Ventricular Tachycardia, Premature Ventricular Contraction | P4 | Completed | 246 | RCT, Open-label | DOAC, Aspirin |
| NCT00147277 ADVANCE-D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy | Tachycardia, Ventricular, Ventricular Fibrillation | P4 | Completed | 925 | RCT, Single-blind | — |
| NCT00170261 ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope | Syncope | P4 | Completed | 100 | RCT, Open-label | — |
| NCT00170313 CORE: Study to Evaluate the Conducted AF-Response-Algorithm in Patients Suffering From Heart Failure and Atrial Fibrillation | Heart Failure, Sudden Cardiac Death | P4 | Terminated | 100 | RCT, Single-blind | — |
| NCT00262119 MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure | Atrial Fibrillation, Heart Failure, Congestive | P4 | Completed | 1,300 | RCT, Single-blind | — |
| NCT00847288 OptiVol® Care Pathway | Heart Failure | P4 | Completed | 1,682 | RCT, Open-label | — |
| NCT00147290 ADVANCE CRT - D: Antitachycardia Pacing (ATP) Delivery for Painless Implantable Cardioverter Defibrillator (ICD) Therapy | Tachycardia, Ventricular, Ventricular Fibrillation | P4 | Completed | 526 | RCT, Single-blind | — |
| NCT00617084 Randomized, Two-arm, Non-inferiority Study Comparing Endeavor-Resolute Stent With Abbot Xience-V Stent | Coronary Artery Disease | P4 | Completed | 2,292 | RCT, Open-label | — |
| NCT01434615 Medtronic South Asian Systolic Heart Failure Registry | Heart Failure | P4 | Completed | 502 | Open-label | — |
| NCT00476957 Randomized Study Comparing Endeavor With Cypher Stents (PROTECT) | Ischemic Heart Disease | P4 | Completed | 8,709 | RCT, Single-blind | — |
| NCT00839566 PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial) | Atrial Fibrillation, Heart Failure | P4 | Terminated | 12 | RCT, Open-label | — |
| NCT00631709 REmote MOnitoring Transmission Evaluation of IPGs | Pacemaker | P4 | Completed | 120 | Open-label | — |
| NCT00821938 Cardiac Resynchronization Therapy (CRT)-Narrow-dp/Dt-Study | Heart Failure | P4 | Completed | 30 | Open-label | — |
| NCT00480077 Diagnostic Outcome Trial in Heart Failure (DOT-HF Trial) | Heart Failure | P4 | Terminated | 335 | RCT, Open-label | — |
| NCT00170287 SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD) | Tachycardia, Ventricular | P4 | Completed | 116 | RCT, Open-label | — |
| NCT00744874 Ablation of the Pulmonary Veins for Paroxysmal Afib | Paroxysmal Atrial Fibrillation | P4 | Completed | 55 | Open-label | — |
| NCT02277990 World-wide Randomized Antibiotic Envelope Infection Prevention Trial | CIED Related Infection | P4 | Completed | 7,075 | RCT, Single-blind | — |
| NCT00157846 X-Change HF - Exchange of the Existing Pacemaker/ICD in Bradycardia Patients Suffering From Heart Failure | Heart Failure, Congestive | P4 | Terminated | 36 | RCT, Open-label | — |
| NCT03035227 Catheter Ablation of Arrhythmias to Improve CRT Response | Arrhythmia, Cardiac | P4 | Terminated | 2 | RCT, Open-label | Anti-Arrhythmics |
| NCT01645917 Durability of Pulmonary Vein Isolation Following Cryoablation for Treatment of Paroxysmal Atrial Fibrillation | Paroxysmal Atrial Fibrillation | P4 | Completed | 21 | Open-label | — |
| NCT01539161 Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease | Chagas Disease, Heart Diseases | P4 | Terminated | 12 | RCT, Open-label | — |
| NCT00157781 LEAF - Low Energy In Atrial Fibrillation | Atrial Fibrillation, Atrial Tachyarrhythmia | P4 | Completed | 237 | RCT, Single-blind | — |
| NCT00293241 PreFER Managed Ventricular Pacing (MVP) For Elective Replacement | Cardiovascular Diseases | P4 | Completed | 630 | RCT, Single-blind | — |
| NCT00769457 OptiLink HF Study: Optimization of Heart Failure Management Using Medtronic OptiVol Fluid Status Monitoring and CareLink Network | Heart Failure | P4 | Completed | 1,002 | RCT, Open-label | — |
| NCT04473807 Feasibility and Safety of IV Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy | Arrhythmias, Cardiac, Atrial Fibrillation | P4 | Unknown | 80 | Open-label | Intravenous Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy in Adult Patients with Atrial Fibrillation |
| NCT00621621 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) | Tachycardia, Atrioventricular Nodal Reentry | P4 | Completed | 105 | Open-label | — |
| NCT00359203 ISSUE3: International Study on Syncope of Uncertain Etiology 3 | Syncope | P4 | Completed | 511 | RCT, Double-blind | — |
| NCT00157768 IRIS : Use of Implantable Defibrillator in High-risk Patients Early After Acute Myocardial Infarction | Acute Myocardial Infarction | P4 | Completed | 900 | RCT, Open-label | — |
| NCT00157794 EnTRINSIC - EnPulse Trial on Search AV+ Influence | Arrhythmia, Sinus | P4 | Terminated | 135 | RCT, Open-label | — |
| NCT00924638 Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke | Cryptogenic Symptomatic Transient Ischemic Attack, Cryptogenic Ischemic Stroke | P4 | Completed | 447 | RCT, Open-label | — |
| NCT01288352 Early Treatment of Atrial Fibrillation for Stroke Prevention Trial | Atrial Fibrillation, Stroke | P4 | Completed | 2,789 | RCT, Open-label | — |
| NCT00617175 Avoid DeliVering TherApies for Non-sustained Arrhythmias in ICD PatiEnts III | Heart Disease | P4 | Completed | 1,902 | RCT, Single-blind | — |
| NCT01037426 Falls and Cardiovascular Events in Pacemaker Patients | Bradycardia | P4 | Completed | 87 | Open-label | — |
| NCT03287960 Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity | Leptin Receptor Deficiency Obesity | P3 | Completed | 15 | Open-label | Setmelanotide, Placebo |
| NCT04966741 Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity | Bardet-Biedl Syndrome, POMC Deficiency Obesity | P3 | Completed | 12 | RCT, Open-label | Setmelanotide |
| NCT02896192 Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity | Pro-opiomelanocortin (POMC) Deficiency Obesity | P3 | Completed | 15 | Open-label | Setmelanotide, Placebo |
| NCT06596135 Open-Label Extension Study of Setmelanotide | Obesity Associated With Defects in Leptin-melanocortin Pathway | P3 | By Invite | 30 | Open-label | Setmelanotide |
| NCT03746522 Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity | Bardet Biedl Syndrome (BBS), Alström Syndrome (AS) | P3 | Completed | 52 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT03651765 Long Term Extension Trial of Setmelanotide | Obesity Associated With Defects in Leptin-melanocortin Pathway | P2P3 | Completed | 205 | Open-label | Setmelanotide |
| NCT05194124 Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway | Bardet-Biedl Syndrome, POMC Deficiency | P3 | Completed | 19 | RCT, Double-blind | Setmelanotide 2 mg, Setmelanotide 2.5 mg, Setmelanotide 3 mg, Setmelanotide 20 mg, Setmelanotide 25 mg, Setmelanotide 30 mg |
| NCT03884504 MDT-1118 Japan DT Study | Heart Failure | P3 | Completed | 10 | Open-label | — |
| NCT00525356 INSTEAD Trial: INvestigation of STEnt Grafts in Patients With Type B Aortic Dissection | Aortic Diseases | P3 | Completed | 136 | RCT, Open-label | — |
| NCT00846001 Resynchronization Surgery Combined Unified Efficacy | Ischemic Heart Failure | P3 | Completed | 178 | RCT, Single-blind | — |
| NCT00514735 Tailored Treatment of Permanent Atrial Fibrillation | Atrial Fibrillation | P3 | Completed | 210 | RCT, Open-label | Class I or III Antiarrhythmic Medications |
| NCT00523978 A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation | Paroxysmal Atrial Fibrillation | P3 | Completed | 245 | RCT, Open-label | Flecainide or Sotalol or Propafenone |
| NCT00887237 Triple Site Ventricular Stimulation for Cardiac Resynchronization Therapy (CRT) Candidates | Heart Failure | P3 | Completed | 76 | RCT, Open-label | — |
| NCT04963231 DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway | Genetic Obesity | P2 | Completed | 164 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT06046443 A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity | Hypothalamic Obesity | P2 | Completed | 28 | RCT, Double-blind | LB54640, Placebo |
| NCT03013543 Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity | Genetic Obesity, Obesity | P2 | Completed | 213 | Open-label | Setmelanotide |
| NCT04725240 Open-Label Study of Setmelanotide in Hypothalamic Obesity | Hypothalamic Obesity | P2 | Completed | 18 | Open-label | Setmelanotide |
| NCT02311673 Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome | Prader-Willi Syndrome | P2 | Completed | 40 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT01749137 Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants | Overweight | P2 | Completed | 74 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT02041195 Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients | Overweight and Obesity | P1P2 | Completed | 99 | RCT, Double-blind | Setmelanotide, Placebo |
| NCT07156578 A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO) | Hypothalamic Obesity | P2 | By Invite | 25 | Open-label | Bivamelagon |
| NCT03262610 Setmelanotide in a Single Patient With Partial Lipodystrophy | Hypertriglyceridemia, Obesity | P2 | Completed | 1 | Open-label | Setmelanotide |
| NCT01112579 Determining the Feasibility of Spinal Cord Neuromodulation for the Treatment of Chronic Heart Failure | Heart Failure | P2 | Completed | 81 | RCT, Single-blind | — |
| NCT01370564 Feasibility of an Integrated Patient Care (IPC) System Using Daily Filling Pressures | Heart Failure | P2 | Completed | 21 | Open-label | Diuretics |
| NCT02492243 Continuous Rhythm Monitoring in Patients After Acute Myocardial infaRction andpREServed Lef venTricle Ejection Fraction (ARREST) | Myocardial Infarction | P2 | Completed | 50 | Open-label | — |
| NCT01213251 Post-Myocardial Infarction Remodeling Prevention Therapy | Acute Myocardial Infarction, Pacing Therapy | P2 | Completed | 129 | RCT, Double-blind | — |
| NCT01867437 Effects of RM-493 on Energy Expenditure in Obese Individuals | Obesity, Morbid Obesity | P1 | Completed | 15 | RCT, Double-blind | Placebo, RM-493 |
| NCT04348175 A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment | Renal Insufficiency | P1 | Completed | 32 | Open-label | Setmelanotide |
| NCT02431442 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RM-493 Administered to Healthy, Obese, Non-diabetic Volunteers | Overweight, Obese | P1 | Completed | 57 | RCT, Double-blind | RM-493, Placebo |
| NCT05575999 Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain | Pain Management | P1 | Not Yet Recruiting | 200 | RCT, Open-label | Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination |
| NCT01944228 Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study | Inflammation | P1 | Completed | 22 | RCT, Double-blind | — |
| NCT00744835 Atrial Fibrillation Ablation Pilot Study | Atrial Fibrillation | P1 | Completed | 53 | Open-label | — |
| NCT03157297 Micra Atrial Tracking Using a Ventricular Accelerometer Study | Atrioventricular Conduction Block | P1 | Completed | 70 | Open-label | — |
| NCT01458483 Acute Carotid Sinus Endovascular Stimulation II Study | Hypertension | P1 | Completed | 9 | Open-label | — |
| NCT01365234 Model 20066 Left Ventricular (LV) Lead Study | Heart Failure | P1 | Completed | 40 | Open-label | — |
| NCT05183802 An Expanded Access Protocol for Setmelanotide for Treatment of Bardet-Biedl Syndrome (BBS) | Bardet-Biedl Syndrome (BBS), Obesity | APPROVED_FOR_MARKETING | — | — | Setmelanotide, administered subcutaneously [SC], once daily. | |
| NCT01849705 Melanocortin 4 Receptor Mutations and Obesity-associated Diseases | Obesity | Completed | 226 | — | — | |
| NCT02849977 Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers | Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations | Completed | 5,966 | — | — | |
| NCT03621007 An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes | POMC Deficiency Obesity, PCSK1 Deficiency Obesity | Completed | 8 | — | — | |
| NCT03479437 The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry | Genetic Forms of Extreme Obesity | Completed | 303 | — | — | |
| NCT06420622 INDIcators for Clarifying the bAckground of exTreme Obesity in childRen | Gene Abnormality, Child Obesity | Unknown | 1,000 | — | — | |
| NCT01574625 Post-Approval Study for the MOSAIC® Bioprostheses | Aortic Valve Stenosis and/or Insufficiency, Mitral Valve Stenosis and/or Insufficiency | Completed | 177 | — | — | |
| NCT03294317 Imaging Study of Lead Implant for His Bundle Pacing | Cardiac Pacemaker, Artificial | Completed | 70 | — | — | |
| NCT01755143 Evaluation of Approved Pacing Lead (Model 5076) for Use in MRI Environment | Magnetic Resonance Imaging (MRI), Cardiac Pacing | N/A | Completed | 266 | RCT, Open-label | — |
| NCT04881136 Frailty and Falls Implantable System for Prediction and Prevention | Fall Patients, Frailty | N/A | Unknown | 30 | Open-label | — |
| NCT06335082 A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF | Atrial Fibrillation | By Invite | 10,000 | — | — | |
| NCT00730548 Compare Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Effect on Heart Failure | Heart Failure, Ventricular Tachycardia | N/A | Completed | 180 | RCT, Open-label | — |
| NCT07589452 Impact of Allometric Pacing Rate on Ventricular Diastolic Function and Cerebral Blood Flow in Hypertensive Patients With Sinus Node Dysfunction | Bradycardia | N/A | Not Yet Recruiting | 70 | RCT, Double-blind | — |
| NCT05044585 Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers | Hypoxia | N/A | Completed | 18 | Open-label | — |
| NCT01532921 EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty | Tricuspid Valve Insufficiency | Completed | 85 | — | — | |
| NCT00307073 Adapta Pacing System Clinical Study | Pacemaker, Bradycardia | N/A | Completed | 120 | RCT, Open-label | — |
| NCT00627328 The Atrial High Rate Episodes in Pacemaker Patients | Arrhythmia, Atrial Fibrillation | Completed | 427 | — | — | |
| NCT02023775 Non Interventional Study on Pulmonary Valve Replacement by Thranscatheter Pulmonary Valve Melody™ | Right Ventricular Congenital Cardiopathies | Completed | 409 | — | — | |
| NCT03009175 PRoMOTE Follow-up Observational Study | Heart Failure | Completed | 287 | — | — | |
| NCT06352060 Dynamic Data-Driven Management of Atrial Fibrillation Using Implantable Cardiac Monitors: The MONITOR-AF Study | Atrial Fibrillation | Completed | 598 | — | — | |
| NCT00478933 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. | Death, Sudden, Cardiac, Ventricular Fibrillation | N/A | Completed | 1,223 | Double-blind | — |
| NCT01166347 The HeartWare™ Ventricular Assist System as Destination Therapy of Advanced Heart Failure: the ENDURANCE Trial | Chronic Heart Failure | N/A | Completed | 451 | RCT, Open-label | — |
| NCT03624504 China Micra Transcatheter Pacing Study | Bradycardia | N/A | Completed | 82 | Open-label | — |
| NCT05766462 Allometric-Pace Study | Sinus Node Dysfunction | Completed | 73 | — | — | |
| NCT05356546 TYRX™ Pocket Health Study | Cardiac Disease, Healing Surgical Wounds | Completed | 36 | — | — | |
| NCT00751972 Evaluation of the HeartWare Left Ventricular Assist Device for the Treatment of Advanced Heart Failure | Chronic Heart Failure | N/A | Completed | 140 | Open-label | — |
| NCT03715790 Improve SCA Bridge Study | Sudden Cardiac Arrest, Acute Myocardial Infarction | Completed | 1,491 | — | — | |
| NCT05398991 Coronary Covered Stents Implantation for the Treatment of Coronary Artery Perforation | Coronary Artery Perforation | N/A | Unknown | 28 | Open-label | — |
| NCT00294645 PREFER (Pacemaker Remote Follow-Up Evaluation and Review) | Bradycardia, Arrhythmia | N/A | Completed | 980 | RCT, Open-label | — |
| NCT01676727 ADVANCE Direct Aortic Study | Aortic Stenosis, Valvular Heart Disease | Completed | 100 | — | — | |
| NCT02914457 Left Ventricular Synchronous Versus Sequential MultiSpot Pacing for Cardiac Resynchronization Therapy (CRT) | Heart Failure | N/A | Completed | 31 | Open-label | — |
| NCT01051310 Medtronic CoreValve REDO Study | Aortic Valve Stenosis | N/A | Completed | 18 | Open-label | — |
| NCT01965899 Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System | Syncope, Recurrent Symptomatic Atrial Fibrillation | N/A | Completed | 151 | Open-label | — |
| NCT01695564 Safety and Efficacy of Left Atrial Appendage Occlusion Devices | Atrial Fibrillation | Completed | 169 | — | — | |
| NCT04863664 Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP) | Tachyarrhythmia | N/A | Completed | 998 | Open-label | — |
| NCT01832610 Post- Approval Study on Patients Who Received a HeartWare HVAD® During IDE Trials | Heart Failure | Completed | 101 | — | — | |
| NCT00688571 Melody Transcatheter Pulmonary Valve (TPV) Post-Market Surveillance Study | Heart Valve Diseases | N/A | Completed | 63 | Open-label | — |
| NCT04465552 Arrhythmic Manifestations and Management in Hospitalized COVID-19 Patients | Coronavirus Infections | Completed | 666 | — | — | |
| NCT03099655 Attain Stability™ Quad Clinical Study | Heart Failure | N/A | Completed | 471 | Open-label | — |
| NCT07354035 The Coronary Sinus Balloon Pump in STEMI | STEMI | N/A | Not Yet Recruiting | 177 | RCT, Single-blind | — |
| NCT01513538 Analysis of the Acceptance and Changes to Parameters Programming Suggested by the TherapyGuide Function | Bradyarrhythmia | Completed | 700 | — | — | |
| NCT05818098 Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR) | Coronary Artery Calcification | N/A | Unknown | 189 | Open-label | — |
| NCT00853593 Model 4396 Left Ventricular (LV) Lead Study | Heart Failure | N/A | Completed | 197 | Open-label | — |
| NCT04442113 RandOmised Controlled Trial of STAR Mapping™ Guided Ablation for AF. | Atrial Fibrillation | N/A | Withdrawn | — | RCT, Open-label | — |
| NCT01110915 Advisa MRI Clinical Study | Magnetic Resonance Imaging, Cardiac Pacemaker, Artificial | N/A | Completed | 269 | RCT, Open-label | — |
| NCT06783868 Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control | Atrial Fibrillation, Stroke | Not Yet Recruiting | 100 | — | Market-approved AVNB, OAC and AAD | |
| NCT04926857 DEFINE AFib (Atrial Fibrillation) | Atrial Fibrillation | Terminated | 973 | — | — | |
| NCT01831544 A Clinical Trial to Evaluate the HeartWare MVAD® System (MVAdvantage) | Heart Failure | N/A | Terminated | 11 | Open-label | — |
| NCT02594488 Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction | Myocardial Infarction, Autonomic Nervous System Diseases | N/A | Completed | 400 | RCT, Open-label | — |
| NCT03833323 Implantable System for Remodulin Post-Approval Study | Pulmonary Arterial Hypertension | Withdrawn | — | — | — | |
| NCT00305214 MASTER II - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients | Myocardial Infarction, Arrhythmia, Ventricular | N/A | Completed | 405 | Open-label | — |
| NCT01609738 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum | Left Ventricular Dysfunction, Cardiac Conduction Defect | Completed | 12 | — | — | |
| NCT04543747 Mechanical Circulatory Support Korea Post Market Surveillance Study (PMS) | End-stage Heart Failure | Completed | 77 | — | — | |
| NCT04757142 PLASMA Chile (PLASMA Chile) | Heart Failure | Completed | 246 | — | — | |
| NCT06052358 Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry | Atrial Fibrillation, GI Bleeding | Terminated | 73 | — | — | |
| NCT01561144 UMBRELLA - Incidence of Arrhythmias in Spanish Population With a Medtronic Implantable Cardiac Defibrillator (ICD) Implant | Cardiomyopathies, Cardiac Arrhythmias | Terminated | 4,648 | — | — | |
| NCT01565967 Registry AutoLog Lipid Removal and Blood Component Characterization | Trauma | Completed | 199 | — | — | |
| NCT01751022 Attain Performa(TM) Quadripolar Lead Study | Heart Failure | N/A | Completed | 1,202 | Open-label | — |
| NCT05242250 Real-World Evidence Registry to Assess Outcomes of Catheter Ablation for Atrial Fibrillation (DYNAMIC AF Registry) | Atrial Fibrillation | Terminated | 392 | — | — | |
| NCT04895540 South Asian Arrhythmogenic Cardiomyopathy Registry | Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia | Unknown | 100 | — | — | |
| NCT01509378 4P Study: Predictive Quality With Painfree Therapies | Cardiac Arrhythmias | Completed | 200 | — | — | |
| NCT00284830 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction | Sick Sinus Syndrome, Heart Failure, Congestive | N/A | Completed | 1,070 | RCT, Single-blind | — |
| NCT05813704 Coronary Crossing System in Patients With Coronary Chronic Total Occlusions | Chronic Total Occlusion of Coronary Artery | N/A | Unknown | 156 | Open-label | — |
| NCT00279279 PREPARE - Primary Prevention Parameters Evaluation | Tachycardia, Ventricular, Implantable Cardioverter Defibrillator (ICD) | N/A | Completed | 700 | Open-label | — |
| NCT00991120 Extension Phase of the Chronicle® Offers Management to Patients With Advanced Signs & Symptoms of Heart Failure Study | Heart Failure | Completed | 165 | — | — | |
| NCT00839384 AdvisaTM IPG Clinical Evaluation Study | Bradycardia, Atrial Tachyarrhythmia | N/A | Completed | 79 | Open-label | — |
| NCT07091916 ExtraVascular Implantable Cardioverter Defibrillator (EV ICD) Japan Study | Tachycardia, Ventricular Arrythmia | N/A | Completed | 14 | Open-label | — |
| NCT04361838 The COVID-19 ICU PRAYER Study | Coronavirus Infection | N/A | Terminated | 200 | RCT, Double-blind | — |
| NCT00266682 Clinical Investigation of the SelectSecure Pacing Lead | Bradycardia | N/A | Completed | 365 | Open-label | — |
| NCT03608826 Relationship Between LINQ™ Subcutaneous Impedance and Right-sided Hemodynamic Measurements | Heart Failure | N/A | Completed | 12 | Open-label | — |
| NCT00850213 Assessment of Clinical Performance and Costs of the Endeavor Resolute Stent "in Real Life" in Spain. | Coronary Artery Disease | Completed | 448 | — | — | |
| NCT01089634 Left Ventricular Capture Management Study | Ventricular Fibrillation, Ventricular Tachycardia | Completed | 151 | — | — | |
| NCT02982200 Medina Embolization Device In Neurovascular Aneurysm Study | Intracranial Aneurysm | Terminated | 15 | — | — | |
| NCT03518658 BlueSync Field Evaluation | Bradycardia | Completed | 257 | — | — | |
| NCT01996397 Acute Feedback on Left ventrIcular Lead Implantation Location for Cardiac Resynchronization Therapy | Heart Failure, Resynchronization Therapy | N/A | Completed | 34 | Open-label | — |
| NCT00982397 Safety and Clinical Performance of the Protecta ICD and CRT-D | Tachyarrhythmias, Heart Failure | N/A | Completed | 2,770 | Open-label | — |
| NCT01720342 Enable® Aortic Sutureless Bioprosthesis Evaluation | Aortic Valve Stenosis, Aortic Valve Insufficiency | Completed | 225 | — | — | |
| NCT00889681 Continued Access Protocol | Atrial Fibrillation | N/A | Completed | 81 | Open-label | — |
| NCT06669637 Amplify EP Registry | Atrial Fibrillation | Not Yet Recruiting | 1,100 | — | — | |
| NCT04452149 Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure | Heart Failure NYHA Class II, Heart Failure NYHA Class III | N/A | Completed | 826 | RCT, Double-blind | — |
| NCT01778426 Post-reimbursement Study to Follow Spinal Neurostimulator Devices for Pain Therapy (French SCS Registry) | Chronic Pain Syndrome | Completed | 414 | — | — | |
| NCT00279968 INSIGHTS ICD Registry | Ventricular Tachycardia, Ventricular Fibrillation | Completed | 1,326 | — | — | |
| NCT04222868 Indonesian Registry on Atrial Fibrillation | Atrial Fibrillation | Unknown | 1,000 | — | — | |
| NCT04738396 Electrogram and Hemodynamic Characteristics of Adaptive LBBAP in Patients With Heart Failure or Bradycardia | Cardiac Pacing, Pacing Therapy | Completed | 52 | — | — | |
| NCT01039467 A Comparison of the Pacemaker Automatic Features in Reduction of Ventricular Pacing | Bradycardia | N/A | Completed | 385 | RCT, Open-label | — |
| NCT02698241 Integrated Diagnostics Driven Diuretic and Chronic Medication Management for Heart Failure | Heart Failure | N/A | Terminated | 79 | Open-label | — |
| NCT02781779 Comparison of Outcomes Between the Use of Silverlon® Dressing and AQUACEL® AG Dressing Post Cardiac Device Implant | Infections, Wounds and Injuries | N/A | Completed | 147 | RCT, Open-label | — |
| NCT02004873 Micra Transcatheter Pacing Study | Class I or II Indication for Implantation of a Single Chamber Ventricular Pacemaker According to ACC/AHA/HRS 2001 Guidelines and Any National Guidelines | N/A | Completed | 744 | Open-label | — |
| NCT01297283 Leadless Electrocardiogram (ECG) Evaluation Study | Heart Failure | N/A | Completed | 195 | RCT, Open-label | — |
| NCT01883141 Left Ventricular MultiSpot Pacing for CRT (iSPOT) | Heart Failure | N/A | Completed | 31 | Open-label | — |
| NCT07526896 Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing | Heart Failure, Systolic Bundle Branch Block, Left | N/A | Not Yet Recruiting | 80 | RCT, Double-blind | — |
| NCT01023022 CareLink® Network Evaluation | Heart Failure | Completed | 176 | — | — | |
| NCT00253357 PROSPECT: Predictors of Response to Cardiac Re-Synchronization Therapy | Heart Failure, Congestive Heart Failure | Completed | 450 | — | — | |
| NCT03706677 FIRE AND ICE II Trial Pilot | Persistent Atrial Fibrillation, Atrial Arrhythmia | N/A | Completed | 69 | RCT, Double-blind | — |
| NCT02976181 Brady MX a Quality Improvement Study | Sinus Node Disfunction | Completed | 113 | — | — | |
| NCT07082153 The First-In-Man Use of Coronary Sinus Balloon Pump in STEMI Patients Treated by Primary PCI | STEMI | N/A | Not Yet Recruiting | 10 | Open-label | — |
| NCT02099721 Improve Sudden Cardiac Arrest Study | Sudden Cardiac Arrest, Ventricular Arrythmia | N/A | Completed | 4,222 | Open-label | — |
| NCT05606367 Coronary Non-slip Balloon Catheter in Patients With Coronary Artery Stenosis(CREST) | Coronary Artery Stenosis | N/A | Unknown | 200 | RCT, Open-label | — |
| NCT02209298 CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis. | Aortic Valve Stenosis | Completed | 202 | — | — | |
| NCT00289289 Reducing Episodes by Septal Pacing Efficacy Confirmation Trial (RESPECT) | Atrial Fibrillation, Tachycardia, Supraventricular | N/A | Completed | 400 | RCT, Single-blind | — |
| NCT06939478 AI Powered Mapping Technology for Identifying Arrhythmias | Arrhythmias, Cardiac | Completed | 112 | — | — | |
| NCT04807049 Clinical Survey on the Stroke Prevention in Atrial Fibrillation in Asia | Atrial Fibrillation | Completed | 4,504 | — | — | |
| NCT01636648 Enable I Long-term Follow-up Study | Aortic Valve Stenosis, Aortic Valve Insufficiency | Terminated | 42 | — | — | |
| NCT00477555 Hemodynamic Assessment of Mosaic Ultra Stented Heart Valve in the Aortic Position | Aortic Valve Replacement, Coronary Artery Bypass Grafting | Completed | 43 | — | — | |
| NCT01348438 Transapical Implantation of the Medtronic Engager Transcatheter Aortic Valve Implantation System - The Engager European Pivotal Trial | Aortic Valve Stenosis | N/A | Completed | 125 | Open-label | — |
| NCT00291564 Ensure Cardiac Resynchronization Therapy Study | Heart Failure | Completed | 430 | — | — | |
| NCT00752128 RESOLUTE International Registry: Evaluation of the Resolute Zotarolimus-Eluting Stent System in a 'Real-World' Patient Population | Coronary Artery Disease, Cardiovascular Diseases | Completed | 2,349 | — | — | |
| NCT00354159 Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic Heart Failure (HF) (REDUCEhf) | Heart Failure | N/A | Completed | 442 | RCT, Single-blind | — |
| NCT00289276 FAST (Fluid Accumulation Status Trial) | Congestive Heart Failure, Cardiomyopathy | N/A | Completed | 156 | Double-blind | — |
| NCT04905290 Conduction System Pacing Optimized Therapy | Heart Failure | N/A | Completed | 60 | Open-label | — |
| NCT04471584 Comparative Analysis in Detection of Atrial Arrhythmia and ECG Quality in Three Different Insertable Cardiac Monitors | Arrhythmias, Cardiac | N/A | Unknown | 150 | RCT, Open-label | — |
| NCT00170326 Progressive Ventricular Dysfunction Prevention in Pacemaker Patients | Cardiac Pacing Indication classI/IIa According AHA/ACC | N/A | Completed | 108 | RCT, Single-blind | — |
| NCT00294060 P3: Pacemaker Patient Profiling Study | Bradycardia | Terminated | 2,013 | — | — | |
| NCT01045343 Feasibility Study of an Integrated Diagnostic System to Manage Heart Failure | Heart Failure | N/A | Completed | 136 | RCT, Open-label | — |
| NCT01574144 REducing 30-day ADMIssions in posT-discharge Subjects (READMIT) | Acute Decompensated Heart Failure | Completed | 70 | — | — | |
| NCT02326519 Electrical Signal Collection From a 20 Pole Catheter During Routine Cardiac Procedures | Cardiac Arrhythmias | N/A | Completed | 31 | Open-label | — |
| NCT03608670 Extravascular ICD Pilot Study | Tachycardia, Ventricular Arrythmia | N/A | Completed | 26 | Open-label | — |
| NCT00267098 Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF) | Atrioventricular Block, Heart Diseases | N/A | Completed | 918 | RCT, Double-blind | — |
| NCT00893386 Attain StarFix® 4195 Lead Extraction Study | Heart Failure, Indications for Lead Removal | Completed | 227 | — | — | |
| NCT04169529 Reveal LINQ for Chronic Obstructive Pulmonary Disease (COPD) | Chronic Obstructive Pulmonary Disease (COPD) | Completed | 42 | — | — | |
| NCT01213615 Hancock II Ultra Porcine Bioprosthesis Hemodynamic Study | Aortic Heart Valve Diseases | Completed | 179 | — | — | |
| NCT01168427 Reveal In-Office Implants | Arrhythmias, Cardiac | Completed | 66 | — | — | |
| NCT00980057 Adaptive Cardiac Resynchronization Therapy Study | Heart Failure | N/A | Completed | 522 | RCT, Double-blind | — |
| NCT03941275 SelectSecure 3830 Lead Imaging | Heart Diseases | Completed | 51 | — | — | |
| NCT01074658 CoreValve Advance International Post Market Study | Severe Aortic Stenosis | Completed | 1,015 | — | — | |
| NCT00271232 InSync III Marquis Model 7279 Cardioverter Defibrillator Cardiac Resynchronization System | Heart Failure | N/A | Completed | 238 | RCT, Double-blind | — |
| NCT01721369 Applicability of Syncope Guidelines in Cataluña | Brief Loss of Consciousness | Completed | 581 | — | — | |
| NCT04023890 Ventricular Electrical Synchronization by Stimulating Left and Right Bundle Branches Area in Pacing-indicated Patients | Cardiac Pacing, Pacing Therapy | Completed | 22 | — | — | |
| NCT05131308 Multimodality Evaluation of LAA Leaks Arising After Incomplete LAAC: Insights From the LAA-Leak Registry | Left Atrail Appendage Closure: Peri-device Leaks | Completed | 160 | — | — | |
| NCT05139329 The ORCHESTRATE-Myocarditis Registry | Myocarditis, Ischemia | Not Yet Recruiting | 382 | — | — | |
| NCT06672861 Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) | Cardiac Dysautonomia | N/A | Not Yet Recruiting | 100 | Open-label | — |
| NCT05464537 Efficacy Rate of Unipolar Polarity Switch for Lesion Assessment in Pulmonary Vein Isolation | Atrial Fibrillation | N/A | Terminated | 8 | RCT, Open-label | — |
| NCT02401659 Importance of Patient´s Satisfaction With Telemedicine Based on Monitoring Systems | Arrythmia | Completed | 187 | — | — | |
| NCT07671677 BOdygUardian MOnitoriNg for ReCurrencE of AF | Atrial Fibrillation (AF) | Not Yet Recruiting | 100 | — | — | |
| NCT05229848 ICE Based Atrial Flutter Ablation Vs Conventional Fluoroscopy/Anatomical Mapping Based Ablation - ICE Flutter Study | Atrial Flutter | N/A | Unknown | 60 | RCT, Open-label | — |
| NCT00157820 DATAS: The Dual Chamber & Atrial Tachyarrhythmias Adverse Events Study | Ventricular Tachycardia, Ventricular Fibrillation | N/A | Completed | 354 | RCT, Open-label | — |
| NCT01522755 Predictive Factors of a Successful Implant of the CapsureFix MRI Model 5086 | Bradyarrhythmia | Completed | 409 | — | — | |
| NCT00279955 PARTNERS HF: Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Heart Failure | Heart Failure, Congestive | Completed | 1,024 | — | — | |
| NCT01972126 MAGNetic QRS-Fragmentation in Patients With Myocardial InfarcTion and Moderately RedUceD Ejection Fraction | Acute Myocardial Infarction | Terminated | 9 | — | — | |
| NCT00271544 Attain Model 4196 Left Ventricular (LV) Lead | Heart Failure | N/A | Completed | 190 | Open-label | — |
| NCT04060680 Extravascular ICD Pivotal Study | Tachycardia, Ventricular Arrythmia | N/A | Completed | 393 | Open-label | — |
| NCT02719522 Pipeline Flex With SHield Technology Embolization - An International MulticEnter ObservationaL Post Market StuDy | Intracranial Aneurysm | Completed | 205 | — | — | |
| NCT00922402 Heart & Diabetes - Feasibility Study | Acute Heart Failure | N/A | Withdrawn | — | Open-label | — |
| NCT03752151 Micra Atrial TRacking Using A Ventricular AccELerometer 2 | Atrioventricular Conduction Block | N/A | Completed | 77 | Open-label | — |
| NCT00277524 OMNI Study--Assessing Therapies in Medtronic Pacemaker, Defibrillator, and Cardiac Resynchronization Therapy Devices. | Tachycardia, Ventricular, Heart Failure, Congestive | Terminated | 3,032 | — | — | |
| NCT01112566 EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty | Mitral Valve Insufficiency | Completed | 152 | — | — | |
| NCT05466942 RDS MultiSense® SpO2 Calibration | Hypoxia | N/A | Completed | 16 | Open-label | — |
| NCT01624870 CoreValve Advance-II Study: Prospective International Post-market Study | Aortic Valve Stenosis, Valvular Heart Disease | Completed | 200 | — | — | |
| NCT06038123 China 3T MRI Study | Bradycardia, Tachycardia | N/A | Completed | 64 | Open-label | — |
| NCT00271154 REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE) | Heart Failure | N/A | Completed | 684 | RCT, Double-blind | — |
| NCT00170274 APART: Prevention and Automatic Therapy of Atrial Arrhythmias in Patients With Paroxysmal Supraventricular Tachycardias | Tachyarrhythmia | N/A | Completed | 156 | RCT, Open-label | — |
| NCT00878527 Safety and Performance Evaluation of CircuLite Synergy | Heart Failure | N/A | Completed | 63 | Open-label | — |
| NCT05359328 RDS MultiSense® SpO2 Validation Study | Hypoxia | N/A | Completed | 10 | Open-label | — |
| NCT00269230 Attain StarFix™ Model 4195 Left Ventricular Lead | Heart Failure | N/A | Completed | 441 | Open-label | — |
| NCT04172883 Management of Device Detected AT and Impact of Device Treatment Algorithms on Atrial Fibrillation | Cardiovascular Diseases | N/A | Terminated | 79 | RCT, Single-blind | — |
| NCT01277783 ALternate Site Cardiac ReSYNChronization (ALSYNC) Study | Heart Failure | N/A | Completed | 138 | Open-label | — |
| NCT02412488 Reveal LINQ™ In-Office 2 (RIO2) Study International | Arrhythmia | N/A | Completed | 191 | Open-label | — |
| NCT00303979 IMPROVE HF: Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting | Heart Failure, Congestive, Myocardial Infarction | Completed | 34,810 | — | — | |
| NCT00949715 Optimize RV Follow-up Selective Site Pacing Clinical Trial | Cardiac Pacing, Right Ventricular Pacing | N/A | Completed | 67 | Open-label | — |
| NCT04476524 Clinical and Economic Impact of an Organized Treatment Pathway on AFib Patient Management From the ER | Cardiac Arrhythmia, Atrial Fibrillation | Unknown | 200 | — | — | |
| NCT02930980 Micra Accelerometer Sensor Study 2 | Bradyarrhythmia | N/A | Completed | 43 | Open-label | — |
| NCT03160625 Evaluation of Rate Adaptive Pacing on Chronotropic Response in Preserved Ejection Fraction HF | Heart Failure With Preserved Ejection Fraction | N/A | Withdrawn | — | RCT, Double-blind | — |
| NCT04499807 Accuracy of Rhythm Detection by a Wearable Smart Watch for Cardiac Arrhythmias (The WATCH-RHYTHM Study) | Atrial Fibrillation | N/A | Terminated | 16 | Open-label | — |
| NCT01789567 Engager Direct Aortic Clinical Study | Aortic Valve Stenosis | N/A | Completed | 20 | Open-label | — |
| NCT01727297 REVEAL AF: Incidence of AF in High Risk Patients | Atrial Fibrillation | N/A | Completed | 446 | Open-label | — |
| NCT04119323 Image Location and Performance of Left Bundle Branch Pacing | Cardiac Pacing, Pacing Therapy | Completed | 50 | — | — | |
| NCT04065997 Apogee International | Chronic Heart Failure | Terminated | 147 | — | — | |
| NCT00526227 SecuraTM ICD Clinical Evaluation Study | Tachyarrhythmias | N/A | Completed | 81 | Open-label | — |
| NCT05488470 QT Changes as Detected From LINQ ECG During Antiarrhythmic Loading (LINQ QT) | Atrial Arrhythmia, QT Interval, Variation in | Completed | 22 | — | — | |
| NCT02275923 Reveal LINQ™ Evaluation of Fluid | End Stage Renal Disease | N/A | Terminated | 9 | Open-label | — |
| NCT02943941 Pressure Variability Study | Heart Failure | N/A | Completed | 16 | Open-label | — |
| NCT05158751 Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry | Myocarditis, Premature Ventricular Contractions | Not Yet Recruiting | 100 | — | — | |
| NCT00703157 Surgical or Catheter Ablation of Lone Atrial Fibrillation (AF) Patients | Atrial Fibrillation | N/A | Terminated | 80 | RCT, Open-label | — |
| NCT00433654 EMRI SureScan™ Clinical Study | Bradycardia, Slow Heart Beat | N/A | Completed | 484 | RCT, Open-label | — |
| NCT01520532 Evaluation of the Incidence of Cerebral Lesions Post Pulmonary Vein Ablation Catheter (PVAC) | Atrial Fibrillation | N/A | Completed | 60 | Open-label | — |
| NCT04480385 REmote Data Acquisition After SURgery | Visceral and Digestive Surgery | N/A | Completed | 63 | Open-label | — |
| NCT04506684 Reveal LINQ Respiration Clinical Study | Respiratory Rate | Completed | 79 | — | — | |
| NCT03402126 Tachy Prediction Download Study | Ventricular Tachycardia | Completed | 138 | — | — | |
| NCT03261063 China Evera MRI® Study | Arrhythmias, Cardiac | N/A | Completed | 15 | Open-label | — |
| NCT01771172 Acute Subcutaneous Defibrillation | Ventricular Arrhythmias | Completed | 50 | — | — | |
| NCT00268281 Left Ventricular Capture Management (LVCM) Software Download Clinical Trial | Heart Failure | N/A | Completed | 107 | Open-label | — |
| NCT05450302 Assessing the Predictive Value of High Frequency Algorithm of PURE EP for Low Amplitude Signal Detection | Cardiac Arrhythmias | Unknown | 150 | — | — | |
| NCT00170300 Care-HF CArdiac Resynchronization in Heart Failure | Heart Failure | N/A | Completed | 813 | RCT, Open-label | — |
| NCT01832493 Sensor Optimization of Cardiac Resynchronization Therapy Response | Heart Failure | N/A | Completed | 50 | Open-label | — |
| NCT00382525 PANORAMA Observational Study | Arrhythmia, Sinus Node Disease | Completed | 8,586 | — | — | |
| NCT01558635 Evaluation of the Cardioblate CryoFlex Surgical Ablation System in Longstanding Persistent Atrial Fibrillation | Longstanding Persistent Atrial Fibrillation | N/A | Terminated | 17 | Open-label | — |
| NCT05464940 Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction | Atrial Fibrillation | N/A | Not Yet Recruiting | 100 | RCT, Double-blind | — |
| NCT00273182 InSync Model 8040 (InSync) and InSync III Model 8042 (InSync III) Registry | Heart Failure, Cardiomyopathy | Completed | 1,999 | — | — | |
| NCT00422669 Optimize RV Selective Site Pacing Clinical Trial | Cardiac Pacing, Artificial, Cardiac Pacemaker, Artificial | N/A | Terminated | 205 | RCT, Single-blind | — |
| NCT02746471 Reveal LINQ Registry | Arrhythmias, Cardiac | Completed | 1,604 | — | — | |
| NCT02395536 Medtronic Reveal LINQ™ In-Office 2 (RIO 2) Study United States | Arrhythmia | N/A | Completed | 525 | RCT, Open-label | — |
| NCT00822146 Cardiac Resynchronization Therapy (CRT) Efficacy Study | Heart Failure | N/A | Completed | 9 | Open-label | — |
| NCT02755129 FRailty WAlking Patterns (FRAP) Study | Heart Failure | N/A | Completed | 15 | Open-label | — |
| NCT00400985 Sensitivity of the InSync Sentry OptiVol Feature for the Prediction of Heart Failure | Heart Failure, Congestive | N/A | Completed | 501 | Double-blind | — |
| NCT03589664 CT Data Collection Study | Cardiac Disease | Completed | 100 | — | — | |
| NCT06465706 Assessing the Safety and Efficacy of the LAmbre™ Plus Device | Atrial Fibrillation | N/A | Not Yet Recruiting | 1,826 | RCT, Single-blind | — |
| NCT05309577 Self-Care for Dementia Caregivers | Aging, Mental Disorder | N/A | Completed | 21 | Open-label | — |
| NCT00930969 ST Segment Detection Study | Coronary Artery Disease | Terminated | 175 | — | — | |
| NCT02700945 Rate of Atrial Fibrillation Through 12 Months in Patients With Recent Ischemic Stroke of Presumed Known Origin | Stroke, Acute | N/A | Completed | 496 | RCT, Open-label | — |
| NCT00402246 CONNECT Study - Clinical Evaluation Of Remote NotificatioN to rEduCe Time to Clinical Decision | Arrhythmia, Tachycardia | N/A | Completed | 2,009 | RCT, Open-label | — |
| NCT01723566 PANORAMA 2 Observational Study | Heart Rhythm Disorders | Completed | 4,706 | — | — | |
| NCT02227121 Acute Defibrillation Study | Ventricular Arrhythmias | N/A | Terminated | 16 | Open-label | — |
| NCT01626768 Medtronic Market-Released DF4 Lead Imaging | Tachycardia | Completed | 37 | — | — | |
| NCT00623441 E-Five Registry: A World-Wide Registry With The Endeavor Zotarolimus Eluting Coronary Stent | Coronary Artery Disease | Completed | 8,314 | — | — | |
| NCT01809652 Feasibility Study of Remote Support for Implantable Pulse Generator (IPG)/Implantable Cardioverter Defibrillator (ICD) Implant | Bradycardia, Sudden Cardiac Arrest | N/A | Completed | 37 | Open-label | — |
| NCT03091959 Profiling Implantable Cardiac Device Diagnostics Trends During Clinical Events . | Cardiovascular Diseases | Completed | 200 | — | — | |
| NCT00885677 MOnitoring REsynchronization deviCes and cARdiac patiEnts | Heart Failure | N/A | Terminated | 918 | RCT, Open-label | — |
| NCT01059175 Dual-Site LV Pacing in CRT Non Responders: Multicenter Randomized Trial | Heart Failure | N/A | Completed | 84 | RCT, Single-blind | — |
| NCT02484898 SEEQ™ Performance Study | Arrhythmia Type Unknown | Completed | 200 | — | — | |
| NCT00270933 MAVRIC VR ICD Registry | Ventricular Tachycardia, Ventricular Fibrillation | Completed | 742 | — | — | |
| NCT05447585 Coronary Atherectomy System in Patients With Coronary Calcification (CORECT) | Calcification of Coronary Artery | N/A | Unknown | 239 | RCT, Single-blind | — |
| NCT01486316 Diagnostic Device Risk Management of Atrial Fibrillation and Heart Failure | Atrial Fibrillation, Heart Failure | N/A | Completed | 24 | RCT, Open-label | — |
| NCT01735916 MIRACLE EF Clinical Study | Congestive Heart Failure, Left Bundle Branch Block | N/A | Terminated | 44 | RCT, Double-blind | — |
| NCT00990964 Attain Success Clinical Trial | Heart Failure | Completed | 2,014 | — | — | |
| NCT06089694 Crome/Cobalt Respiration Study | Heart Failure | Completed | 61 | — | — | |
| NCT00279981 TRENDS: A Prospective Study of the Clinical Significance of Atrial Arrhythmias Detected by Implanted Device Diagnostics | Atrial Fibrillation, Stroke | Completed | 3,100 | — | — | |
| NCT01362465 Characterization of Interventricular Conduction Measurements | Heart Failure | Early P1 | Completed | 25 | Open-label | — |
| NCT04245345 Accelerometer Sensing for Micra AV Study | AV Block, AV Block Complete | N/A | Completed | 157 | Open-label | — |
| NCT01526629 Full Automaticity and Remote Follow-up | Tachyarrhythmia | Completed | 354 | — | — | |
| NCT04214899 PLASMA Mexico (PLASMA Mexico) | Heart Failure | Completed | 254 | — | — | |
| NCT00927251 Model 4296 Left Ventricular (LV) Lead Study | Heart Failure | N/A | Completed | 90 | Open-label | — |
| NCT02117414 Confirmatory Clinical Trial of the Evera MRI System for Conditionally-safe MRI Access | Implantable Defibrillator | N/A | Completed | 275 | RCT, Open-label | — |
| NCT02091440 Clinical Evaluation of HW005 Ventricular Assist System for the Treatment of Advanced Heart Failure in Japan | Heart Failure | N/A | Completed | 6 | Open-label | — |
| NCT03071978 Application of Right Atrial Left Ventricular Fusion Pacing in Patients With CRT Indications | Heart Failure | N/A | Completed | 63 | RCT, Open-label | — |
| NCT02222818 Cardiac Resynchronization Therapy Efficacy Enhancements | Atrial Fibrillation | N/A | Completed | 71 | RCT, Open-label | — |
| NCT04661423 Use of RDS MultiSense® in Post-ICU Patients in the COVID-19 Era | Post ICU Rehabilitation | N/A | Completed | 60 | Open-label | — |
| NCT02358603 Chronotropic Incompetence (CI) Diagnostic Algorithm in Heart Failure Patients | Heart Failure | N/A | Terminated | 48 | RCT, Open-label | — |
| NCT02268942 HW006 LATERAL Thoracotomy | Left Sided Heart Failure | N/A | Completed | 144 | Open-label | — |
| NCT00145119 CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction | Acute Myocardial Infarction | Completed | 312 | — | — | |
| NCT05357729 Safety and Performance Study of the MultiSense® Ambulatory Telemonitoring System for Non-critical Patient Management | Visceral and Digestive Surgery, Post-surgical Monitoring | N/A | Completed | 20 | Open-label | — |
| NCT01475175 Adaptive Cardiac Resynchronization Therapy Optimization at Rest and During Exercise (AdOPT CRT) | Heart Failure | N/A | Terminated | 12 | Open-label | — |
| NCT03501836 Wireless Handheld 8-lead ECG Device Performance in Heart Patients (Rapid Rhythm) | Atrial Fibrillation, Heart Murmurs | N/A | Completed | 271 | Open-label | — |
| NCT01714921 Protecta Smart Analysis Register | Patients With an Indication for an ICD Implantation According to the Guidelines | Completed | 504 | — | — | |
| NCT00281099 Managed Ventricular Pacing ("MVP") Trial | Heart Disease | N/A | Terminated | 1,031 | RCT, Single-blind | — |
| NCT00268294 Restoring Sinus Rhythm With Cardiac Resynchronization in Patients With Atrial Fibrillation (ReSync AF) | Heart Failure, Atrial Arrhythmia | N/A | Completed | 20 | Open-label | — |
| NCT04180696 Mid-Q Response Study | Heart Failure, Left Bundle-Branch Block | N/A | Completed | 177 | RCT, Single-blind | — |
| NCT02158728 Supraventricular Tachycardia Collection Study | Supraventricular Arrhythmias | Completed | 80 | — | — | |
| NCT04854200 HVAD(TM) SMART 1.0 Study | Chronic Heart Failure | Withdrawn | — | — | — | |
| NCT00510198 Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure | Congestive Heart Failure | N/A | Terminated | 120 | RCT, Open-label | — |
| NCT03626649 Evaluation for the Characterization of the Safety Profile of the DiamondTemp™ System for Fast Treatment of Patients With Atrial Fibrillation | Atrial Fibrillation | N/A | Completed | 60 | Open-label | — |
| NCT00273195 Clinical Investigation of the Medtronic EnTrust™ Implantable Cardioverter Defibrillator (ICD), Model D153ATG | Ventricular Arrhythmias | N/A | Completed | 500 | Open-label | — |
| NCT00289302 InSync Implantable Cardioverter Defibrillator Registry: Cardiac Resynchronization Therapy | Heart Failure, Cardiomyopathy | Completed | 600 | — | — | |
| NCT01297257 DELIVER Study: DELiverability of the Resolute Integrity Stent in All-Comer Vessels and Cross-OvER Stenting | Coronary Artery Disease | Completed | 7,845 | — | — | |
| NCT05464511 Impact of Steerable Delivery Sheaths on Successful Closure of LA A With AMULET | Atrial Fibrillation, Stroke | N/A | Not Yet Recruiting | 300 | Open-label | — |
| NCT03210402 REmodeling the Left Ventricle With Atrial Modulated Pacing | Heart Failure | N/A | Completed | 22 | RCT, Single-blind | — |
| NCT03125382 PORTuguese Research on Telemonitoring With CareLink® (PORTLink) | Arrhythmia | N/A | Completed | 141 | RCT, Open-label | — |
| NCT03210142 Minimally Invasive Hypoglossal Nerve Stimulation Study (Lingual Study) | Sleep Apnea, Obstructive | N/A | Completed | 23 | Open-label | — |
| NCT03504020 ECG Belt for CRT Response | Heart Failure | N/A | Completed | 498 | RCT, Single-blind | — |
| NCT00275769 CAPTURE - Complete Automatic Pacing Threshold Utilization Recorded by EnPulse | Arrhythmia, Bradycardia | N/A | Completed | 860 | RCT, Open-label | — |
| NCT01966458 A Clinical Trial to Evaluate the HeartWare™ Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL) | Chronic Heart Failure | N/A | Completed | 494 | RCT, Open-label | — |
| NCT00461734 PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing | Left Ventricular Dysfunction | N/A | Completed | 248 | RCT, Single-blind | — |
| NCT00526162 ConsultaTM CRT-D Clinical Evaluation Study | Tachyarrhythmias, Heart Failure | N/A | Completed | 83 | Open-label | — |
| NCT01643707 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) | Sinus Node Dysfunction | Completed | 1,342 | — | — | |
| NCT03697980 Apogee, A HeartWare HVAD Destination Product Surveillance Registry (PSR) Platform | Chronic Heart Failure | Completed | 136 | — | — | |
| NCT03440762 Atrial Fibrillation Screening and Education Study | Atrial Fibrillation | N/A | Completed | 83 | Open-label | — |
| NCT03071952 Assessment of AAIR Pacing Treatment for Heart Failure Patients With Chronotropic Incompetence | Heart Failure | Completed | 11 | — | — | |
| NCT00643279 Chronicle Offers Management to Patients With Advanced Signs and Symptoms of Heart Failure (COMPASS-HF) | Heart Failure | N/A | Completed | 277 | RCT, Single-blind | — |
| NCT00305240 MASTER I - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients | Myocardial Infarction, Arrhythmia, Ventricular | N/A | Completed | 656 | Open-label | — |
| NCT01767558 PRECISION GOLD Post Market Study in Europe of Pulmonary Vein Ablation Catheter (PVAC GOLD) | Atrial Fibrillation | N/A | Completed | 56 | Open-label | — |
| NCT00268320 Clinical Investigation of the Medtronic Concerto™ Device | Congestive Heart Failure, Atrial Arrhythmia, Atrial Tachyarrhythmia, Atrial Fibrillation | N/A | Completed | 270 | Open-label | — |
| NCT02205359 AdaptResponse Clinical Trial | Heart Failure With Left Bundle Branch Block | N/A | Completed | 3,797 | RCT, Single-blind | — |
| NCT01609985 Cutaneous Heart Sounds Data Collection During Cardiac Resynchronization Therapy (CRT) Optimization Study | Heart Failure | Completed | 52 | — | — | |
| NCT01051518 Clinical Evaluation of Percutaneous Implantation of the Medtronic CoreValve Aortic Valve Prosthesis (18Fr-Study) | Aortic Valve Stenosis | N/A | Completed | 126 | Open-label | — |
| NCT02758301 Reveal LINQ™ Heart Failure | Heart Failure | Completed | 112 | — | — | |
| NCT00328705 D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management | Heart Diseases | N/A | Completed | 65 | Open-label | — |
| NCT00856349 Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming | Cardiovascular Disease | Completed | 4,384 | — | — | |
| NCT01045291 Pacing for Heart Failure With Preserved Ejection Fraction | Heart Failure | N/A | Completed | 22 | RCT, Single-blind | — |
| NCT02772380 Acute Study to Collect Electrical Signals From the Heart Using a Special Lead | Tachycardia, Ventricular Arrhythmias | N/A | Completed | 87 | — | — |
| NCT06199414 Vascular Closure With Novel External Compression Device: The LockeT Study | Atrial Fibrillation, Hemostasis | Unknown | 70 | — | — | |
| NCT00318357 CARE-HF Long Term Follow-up | Heart Failure | Completed | 309 | — | — | |
| NCT00294034 VIBRANT Registry: Value of Information Based From Pacemaker Recordings and New Technologies | Pacemaker, Bradycardia | Completed | 950 | — | — | |
| NCT01264484 ADVANTAGE® Prosthetic Heart Valve Long-term Follow-up Trial | Heart Valve Stenosis | Terminated | 212 | — | — | |
| NCT02942667 Magnetic Resonance Imaging of Human Biometrics | Volunteers | Completed | 12 | — | — | |
| NCT02149654 Engager Align Post-market Clinical Study | Aortic Valve Stenosis | Completed | 27 | — | — |