SPRO logo

Spero Therapeutics, Inc.

SPRO
Healthcare|Biotechnology|US
$1.03
+0.01 (+0.98%)
Tangible Book / Share
$0.76
Graham Number
$1.48
Cash / Share
$0.88

Analyst Consensus

Buy13 analysts
Strong Buy
0
Buy
6
Hold
5
Sell
2
Strong Sell
0

Rating Trend

Dec 25
0 buy · 2 hold · 0 sell
Jan 26
0 buy · 2 hold · 0 sell
Feb 26
0 buy · 1 hold · 0 sell
Mar 26
0 buy · 1 hold · 0 sell
Apr 26
0 buy · 1 hold · 0 sell
May 26
0 buy · 1 hold · 0 sell
Jun 26
0 buy · 1 hold · 0 sell
Jul 26
0 buy · 1 hold · 0 sell
Aug 26
0 buy · 1 hold · 0 sell
Sep 26
1 buy · 1 hold · 0 sell
Oct 26
2 buy · 1 hold · 0 sell
Nov 26
2 buy · 1 hold · 0 sell

Recent Rating Actions

FirmActionRatingDate
HC Wainwright & Co.maintainBuySep 14, 2026
HC Wainwright & Co.maintainBuyJan 30, 2025
Evercore ISI GroupdowngradeOutperform →In LineDec 20, 2024
HC Wainwright & Co.maintainBuyDec 2, 2024
TD CowendowngradeBuy →HoldNov 18, 2024
HC Wainwright & Co.maintainBuyNov 4, 2024
HC Wainwright & Co.maintainBuyOct 3, 2024
HC Wainwright & Co.maintainBuyAug 6, 2024
TD CowenupgradeHold →BuyAug 6, 2024
HC Wainwright & Co.maintainBuyMay 16, 2024
HC Wainwright & Co.maintainBuyMar 18, 2024
HC Wainwright & Co.maintainBuyNov 14, 2023
HC Wainwright & Co.maintainBuySep 5, 2023
HC Wainwright & Co.maintainBuyAug 14, 2023
HC Wainwright & Co.maintainBuyAug 1, 2023
HC Wainwright & Co.maintainBuyJul 20, 2023
HC Wainwright & Co.maintainBuyApr 10, 2023
HC Wainwright & Co.maintainBuySep 26, 2022
Evercore ISI GroupupgradeIn Line →OutperformSep 23, 2022
HC Wainwright & Co.maintainBuyAug 15, 2022
HC Wainwright & Co.maintainBuyMay 23, 2022
BerenbergdowngradeBuy →HoldMay 20, 2022
Cantor FitzgeraldmaintainOverweightMay 17, 2022
Cowen & Co.downgradeOutperform →Market PerformMay 4, 2022
Evercore ISI GroupdowngradeOutperform →In LineMay 4, 2022

Earnings History

Next report: Nov 12, 2026 · EPS est. $-0.47
Report DateEPS ActualEPS Est.Revenue ActualRevenue Est.
Aug 12, 2026$-0.16$-0.17——
May 13, 2026$-0.13$-0.18$258.0K$258.0K
Mar 26, 2026$0.53$-0.20$41.3M$26.0M
Nov 13, 2025$-0.13$-0.25$3.0M$12.0M
Aug 12, 2025$-0.03$-0.38$11.8M$11.0M
May 13, 2025$-0.25$-0.55$5.9M$11.0M
Mar 27, 2025$-0.38$-0.35$9.4M$6.2M
Nov 14, 2024$-0.32$-0.27$13.5M$4.1M

News

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Nov. 04, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immune-mediated diseases, today announced that the Compensation Committee of Spero's Board of Directors approved a grant, made on November 2, 2026, of an aggregate of 217,000 restricted stock unit awards (RSUs) and 434,000 stock options to a new employee under the Spero Therapeutics, Inc. 2019 Inducement Equity I…

Nov 4, 2026globenewswire.com
Spero Therapeutics to Present at Investor Conferences in November

CAMBRIDGE, Mass., Nov. 02, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immune-mediated diseases, today announced that Esther Rajavelu, President and Chief Executive Officer, will participate in a “fireside chat” at the Guggenheim 3rd Annual Healthcare Innovation Conference in Boston, MA. The company's leadership team will be available for one-on-one meetings with investors. The team…

Nov 2, 2026globenewswire.com
This Spero Therapeutics Analyst Begins Coverage On A Bullish Note; Here Are Top 5 Initiations For Wednesday

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page.

Oct 28, 2026benzinga.com
Spero Therapeutics Strengthens Leadership Team to Advance Immunology Pipeline

Amy Rock, Ph.D., appointed Chief Regulatory and Quality Officer, bringing extensive experience in global regulatory strategy, clinical development, and with approvals of novel immunotherapies Dae Gon Ha, Ph.D.

Oct 26, 2026globenewswire.com
Spero Therapeutics Targets 2027 Phase II Launch for SP001 in IgG4-Related Disease

Spero Therapeutics NASDAQ: SPRO plans to initiate a Phase II trial of its lead immunology candidate, SP001, in immunoglobulin G4-related disease, or IgG4-RD, in the second quarter of 2027, Chief Executive Officer Esther Rajavelu said during a company presentation.

Oct 21, 2026marketbeat.com
Spero Therapeutics to Participate in the Chardan 10th Annual Healthcare Conference

CAMBRIDGE, Mass., Oct. 15, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that Esther Rajavelu, Spero's President and Chief Executive Officer, will participate in a fireside chat at the Chardan 10th Annual Healthcare Conference to be held in New York City, on October 20th, 2026. Spero's leadership team will also be available for one-on-one m…

Oct 15, 2026globenewswire.com
Russian plague outbreak could boost these under-the-radar pharma stocks

Global biosecurity alarms are flashing after an incident at an anti-plague research facility in Siberia sparked a severe public health response. Following the fatal lab exposure of a researcher in Irkutsk region to Yersinia pestis – the bacterium causing pneumonic plague – Russian officials placed several regional hospitals under quarantine and isolated nearly 200 contacts.

Oct 5, 2026invezz.com
Spero Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Oct. 02, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that the Compensation Committee of Spero's Board of Directors approved grants, made on October 1, 2026, of an aggregate of 233,000 restricted stock unit awards (RSUs) and 323,000 stock options to new employees under the Spero Therapeutics, Inc. 2019 Inducement Equity I…

Oct 2, 2026globenewswire.com
Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that the Compensation Committee of Spero's Board of Directors approved a grant, made on September 1, 2026, of an aggregate of 102,000 restricted stock unit awards (RSUs) and 67,600 stock options to new employees under the Spero Therapeutics, Inc. 2019 Inducement Equit…

Sep 3, 2026globenewswire.com
Spero Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

CAMBRIDGE, Mass., Sept. 02, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that Esther Rajavelu, President and Chief Executive Officer, will present at the H.C.

Sep 2, 2026globenewswire.com
Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

Aug 12, 2026seekingalpha.com
Spero Therapeutics Q2 Earnings Call Highlights

Spero Therapeutics NASDAQ: SPRO used its second-quarter update to outline a strategic shift toward immune-mediated diseases, supported by the FDA approval of Utebzi and a new licensing agreement for SP001, an antibody candidate the company plans to develop initially for IgG4-related disease.

Aug 12, 2026marketbeat.com
Spero Therapeutics Announces Second Quarter 2026 Operating Results and Provides Business Update

CAMBRIDGE, Mass., Aug. 12, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced financial results for the second quarter ended June 30, 2026, and provided a corporate update.

Aug 12, 2026globenewswire.com