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Upstream Bio, Inc.

UPB
Healthcare|Biotechnology|US
$3.23
+0.02 (+0.62%)
Tangible Book / Share
$4.97
Cash / Share
$4.79

Ownership Breakdown

36.9%
Float
54.8M
Shares Outstanding
20.2M
Float Shares

Major Holders (11)

Combined: 57.2%

Holders of 5%+ from their latest Schedule 13D/13G filing in the last two years. Percentages are as of each filing date.

HolderType% of ClassSharesFiledFiling
Norges BankFI, OO7.73%4,206,586Aug 12, 202613D/G
FMR LLCHolding company6.90%3,793,955Nov 6, 202613D/G
Abigail P. JohnsonIndividual6.90%3,793,955Nov 6, 202613D/G
BlackRock, Inc.Holding company5.20%2,814,714Jul 30, 202613D/G
Decheng Capital Global Life Sciences Fund IV, L.P.Partnership4.90%2,724,868Oct 29, 202613D/G
Decheng Capital Management IV (Cayman), LLCOther4.90%2,724,868Oct 29, 202613D/G
Xiangmin CuiIndividual4.90%2,724,868Oct 29, 202613D/G
HBM Healthcare Investments (Cayman) Ltd.Corporation4.10%2,195,111Nov 14, 202513D/G
Chen YuIndividual3.90%2,117,103Nov 14, 202513D/G
TCG Crossover GP I, LLCOther3.90%2,117,103Nov 14, 202513D/G
TCG Crossover Fund I, L.P.Partnership3.90%2,117,103Nov 14, 202513D/G

Insider Trades (100)

Last 4 quarters: 923,152 acquired · 15,061 disposed
InsiderPositionDateTypeSharesPriceValueFiling
GRAY MICHAELCFO and COOSep 16, 2026SELL853$5.49$4.7KForm 4
Ambrose AllisonGeneral CounselSep 16, 2026SELL485$5.49$2.7KForm 4
Deykin AaronChief Medical OfficerSep 16, 2026SELL895$5.49$4.9KForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerSep 16, 2026SELL2,095$5.49$11.5KForm 4
Houghton AdamChief Business OfficerSep 16, 2026SELL700$5.49$3.8KForm 4
GRAY MICHAELCFO and COOJun 16, 2026SELL853$6.10$5.2KForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerJun 16, 2026SELL2,095$6.10$12.8KForm 4
Houghton AdamChief Business OfficerJun 16, 2026SELL700$6.10$4.3KForm 4
Deykin AaronChief Medical OfficerJun 16, 2026SELL895$6.10$5.5KForm 4
Ambrose AllisonGeneral CounselJun 16, 2026SELL477$6.10$2.9KForm 4
Ruddy Marcella K.directorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
Renaud Ronald C JRdirectorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
Fleming Harold EdwarddirectorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
Beckman DanielladirectorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
Ratcliffe LiamdirectorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
Chimovits ErezdirectorJun 9, 2026AWARD17,096$6.69$114.4KForm 4
GRAY MICHAELCFO and COOMar 16, 2026SELL852$9.29$7.9KForm 4
Deykin AaronChief Medical OfficerMar 16, 2026SELL894$9.29$8.3KForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerMar 16, 2026SELL2,093$9.29$19.4KForm 4
Ambrose AllisonGeneral CounselMar 16, 2026SELL475$9.29$4.4KForm 4
Houghton AdamChief Business OfficerMar 16, 2026SELL699$9.29$6.5KForm 4
GRAY MICHAELCFO and COOJan 2, 2026AWARD91,500$27.07$2.5MForm 4
GRAY MICHAELCFO and COOJan 2, 2026AWARD30,500——Form 4
Deykin AaronChief Medical OfficerJan 2, 2026AWARD96,000$27.07$2.6MForm 4
Deykin AaronChief Medical OfficerJan 2, 2026AWARD32,000——Form 4
Ambrose AllisonGeneral CounselJan 2, 2026AWARD51,000$27.07$1.4MForm 4
Ambrose AllisonGeneral CounselJan 2, 2026AWARD17,000——Form 4
Houghton AdamChief Business OfficerJan 2, 2026AWARD75,000$27.07$2.0MForm 4
Houghton AdamChief Business OfficerJan 2, 2026AWARD25,000——Form 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerJan 2, 2026AWARD225,000$27.07$6.1MForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerJan 2, 2026AWARD75,000——Form 4
Renaud Ronald C JRdirectorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Chimovits ErezdirectorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Ruddy Marcella K.directorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Beckman DanielladirectorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Fleming Harold EdwarddirectorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Ratcliffe LiamdirectorJun 10, 2025AWARD17,096$11.59$198.1KForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerFeb 6, 2025AWARD500,000$8.53$4.3MForm 4
GRAY MICHAELCFO and COOFeb 6, 2025AWARD195,000$8.53$1.7MForm 4
Houghton AdamChief Business OfficerFeb 6, 2025AWARD140,000$8.53$1.2MForm 4
Deykin AaronChief Medical OfficerFeb 6, 2025AWARD165,000$8.53$1.4MForm 4
Ambrose AllisonGeneral CounselFeb 6, 2025AWARD25,000$8.53$213.2KForm 4
Ambrose AllisonGeneral CounselDec 16, 2024AWARD100,000$19.01$1.9MForm 4
Ambrose AllisonDec 16, 2024OTHER0——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024BUY660,000$17.00$11.2MForm 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024CONVERSION2,887,833——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024BUY165,000$17.00$2.8MForm 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024CONVERSION721,956——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024CONVERSION2,098,000——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 15, 2024CONVERSION789,833——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024BUY660,000$17.00$11.2MForm 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024CONVERSION2,887,833——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024BUY165,000$17.00$2.8MForm 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024CONVERSION721,956——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024CONVERSION2,098,000——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 15, 2024CONVERSION789,833——Form 4
AI Upstream LLC10 percent ownerOct 15, 2024CONVERSION1,172,410——Form 4
AI Upstream LLC10 percent ownerOct 15, 2024CONVERSION3,147,000——Form 4
AI Upstream LLC10 percent ownerOct 15, 2024BUY1,175,000$17.00$20.0MForm 4
AI Upstream LLC10 percent ownerOct 15, 2024CONVERSION3,147,000——Form 4
AI Upstream LLC10 percent ownerOct 15, 2024CONVERSION1,172,410——Form 4
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.10 percent ownerOct 15, 2024CONVERSION894,733——Form 4
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.10 percent ownerOct 15, 2024CONVERSION852,940——Form 4
Chimovits ErezdirectorOct 10, 2024AWARD17,096$17.00$290.6KForm 4
Ruddy Marcella K.directorOct 10, 2024AWARD17,096$17.00$290.6KForm 4
Renaud Ronald C JRdirectorOct 10, 2024AWARD17,096$17.00$290.6KForm 4
Fleming Harold EdwarddirectorOct 10, 2024AWARD17,096$17.00$290.6KForm 4
Beckman DanielladirectorOct 10, 2024AWARD34,681$17.00$589.6KForm 4
Ratcliffe LiamdirectorOct 10, 2024AWARD17,096$17.00$290.6KForm 4
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.10 percent ownerOct 10, 2024OTHER894,733——Form 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerOct 10, 2024OTHER866,704$5.69$4.9MForm 4
Sutherland Everett Randdirector, officer: Chief Executive OfficerOct 10, 2024OTHER1,053,799$6.59$6.9MForm 4
Chimovits Erezdirector, 10 percent owner: Oct 10, 2024OTHER0——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 10, 2024OTHER0——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 10, 2024OTHER2,098,000——Form 4
Chimovits Erezdirector, 10 percent owner: Oct 10, 2024OTHER789,833——Form 4
Beckman DaniellaOct 10, 2024OTHER0——Form 4
Houghton AdamChief Business OfficerOct 10, 2024OTHER134,140$3.45$462.8KForm 4
Houghton AdamChief Business OfficerOct 10, 2024OTHER11,954$4.27$51.0KForm 4
Houghton AdamChief Business OfficerOct 10, 2024OTHER11,853$4.87$57.7KForm 4
Houghton AdamChief Business OfficerOct 10, 2024OTHER62,940$6.59$414.8KForm 4
Ruddy Marcella K.directorOct 10, 2024OTHER13,159$3.45$45.4KForm 4
Ruddy Marcella K.directorOct 10, 2024OTHER43,115$4.27$184.1KForm 4
Ruddy Marcella K.directorOct 10, 2024OTHER7,867$4.87$38.3KForm 4
Ratcliffe LiamOct 10, 2024OTHER0——Form 4
Deykin AaronChief Medical OfficerOct 10, 2024OTHER182,431$3.45$629.4KForm 4
Deykin AaronChief Medical OfficerOct 10, 2024OTHER16,258$4.27$69.4KForm 4
Deykin AaronChief Medical OfficerOct 10, 2024OTHER11,853$4.87$57.7KForm 4
Deykin AaronChief Medical OfficerOct 10, 2024OTHER107,207$6.59$706.5KForm 4
Fleming Harold EdwardOct 10, 2024OTHER0——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 10, 2024OTHER0——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 10, 2024OTHER0——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 10, 2024OTHER2,098,000——Form 4
ORBIMED ADVISORS LLCdirector, 10 percent owner: Oct 10, 2024OTHER789,833——Form 4
Renaud Ronald C JRdirectorOct 10, 2024OTHER107,312$3.45$370.2KForm 4
Renaud Ronald C JRdirectorOct 10, 2024OTHER9,563$4.27$40.8KForm 4
Renaud Ronald C JRdirectorOct 10, 2024OTHER31,470$4.87$153.3KForm 4
Renaud Ronald C JRdirectorOct 10, 2024OTHER113,554$6.59$748.3KForm 4
GRAY MICHAELCFO and COOOct 10, 2024OTHER152,450$5.69$867.4KForm 4
AI Upstream LLC10 percent ownerOct 10, 2024OTHER3,000,000——Form 4